Genes expressed in C3A liver cell cultures treated with steroids

ABSTRACT

The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in human C3A liver cell cultures treated with steroids or synthetic steroid analogues and which may be used entirely or in part to detect metabolic and toxicological responses to treatment with steroids and steroid antagonists, to diagnose, to stage, to treat, or to monitor the treatment of a subject with an steroid responsive disorder.

This application claims the benefit of provisional application, No. 60/240,409 filed Oct. 12, 2000.

CD-R 1 contains Table 4 formatted in tab-delimited ASCII text and the Sequence Listing formatted in plain ASCII text. The file containing Table 4 is entitled Pa41us˜1.TXT, created on Oct. 12, 2001, and is 110 KB in size. The Sequence Listing is entitled Pa41us˜2.TXT, created on Oct. 12, 2001, and is 2,965 KB in size.

CD-R 2 is an exact copy of CD-R 1. CD-R 2 is labeled with Identification No. PA-0041 US, Copy 2.

CD-R 3 contains the Computer Readable Form of the Sequence Listing in compliance with 37 C.F.R. §1.821(e), and specified by 37 C.F.R. §1.824. CD-R 3 is labeled with Identification No. PA-0041 US, copy 3.

The disclosure of Tables 1-25 and the Sequence Listing submitted as an electronic document on compact disc as described above are to be part of the permanent USPTO record of this patent application and are hereby expressly incorporated by reference.

FIELD OF THE INVENTION

The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in human C3A liver cell cultures treated with steroids or synthetic steroid analogues and which may be used entirely or in part to detect metabolic and toxicological responses to treatment with steroids and steroid antagonists.

BACKGROUND OF THE INVENTION

Array technology can provide a simple way to explore the expression of a single polymorphic gene or the expression profile of a large number of related or unrelated genes. When the expression of a single gene is examined, arrays are employed to detect the expression of a specific gene or its variants. When an expression profile is examined, arrays provide a platform for examining which genes are tissue specific, carrying out housekeeping functions, parts of a signaling cascade, or specifically related to a particular genetic predisposition, condition, disease, or disorder.

The potential application of gene expression profiling is particularly relevant to measuring the toxic response to potential therapeutic compounds and of the metabolic response to therapeutic agents. Diseases treated with steroids and disorders caused by the metabolic response to treatment with steroids include adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease. Response may be measured by comparing both the levels and sequences expressed in tissues from subjects exposed to or treated with steroid compounds such as mifepristone, progesterone, beclomethasone, medroxyprogesterone, budesonide, prednisone, dexamethasone, betamethasone, or danazol with the levels and sequences expressed in normal untreated tissue.

Steroids are a class of lipid-soluble molecules, including cholesterol, bile acids, vitamin D, and hormones, that share a common four-ring structure based on cyclopentanoperhydrophenanthrene and that carry out a wide variety of functions. Cholesterol, for example, is a component of cell membranes that controls membrane fluidity. It is also a precursor for bile acids which solubilize lipids and facilitate absorption in the small intestine during digestion. Vitamin D regulates the absorption of calcium in the small intestine and controls the concentration of calcium in plasma. Steroid hormones, produced by the adrenal cortex, ovaries, and testes, include glucocorticoids, mineralocorticoids, androgens, and estrogens. They control various biological processes by binding to intracellular receptors that regulate transcription of specific genes in the nucleus. Glucocorticoids, for example, increase blood glucose concentrations by regulation of gluconeogenesis in the liver, increase blood concentrations of fatty acids by promoting lipolysis in adipose tissues, modulate sensitivity to catcholamines in the central nervous system, and reduce inflammation. The principal mineralocorticoid, aldosterone, is produced by the adrenal cortex and acts on cells of the distal tubules of the kidney to enhance sodium ion reabsorption. Androgens, produced by the interstitial cells of Leydig in the testis, include the male sex hormone testosterone, which triggers changes at puberty, the production of sperm and maintenance of secondary sexual characteristics. Female sex hormones, estrogen and progesterone, are produced by the ovaries and also by the placenta and adrenal cortex of the fetus during pregnancy. Estrogen regulates female reproductive processes and secondary sexual characteristics. Progesterone regulates changes in the endometrium during the menstrual cycle and pregnancy.

Steroid hormones are widely used for fertility control and in anti-inflammatory treatments for physical injuries and diseases such as arthritis, asthma, and auto-immune disorders. Progesterone, a naturally occurring progestin, is primarily used to treat amenorrhea, abnormal uterine bleeding, or as a contraceptive. Endogenous progesterone is responsible for inducing secretory activity in the endometrium of the estrogen-primed uterus in preparation for the implantation of a fertilized egg and for the maintenance of pregnancy. It is secreted from the corpus luteum in response to luteinizing hormone (LH). The primary contraceptive effect of exogenous progestins involves the suppression of the midcycle surge of LH. At the cellular level, progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone from the hypothalamus and blunt the pre-ovulatory LH surge preventing follicular maturation and ovulation. Progesterone has minimal estrogenic and androgenic activity. Progesterone is metabolized hepatically to pregnanediol and conjugated with glucuronic acid.

Medroxyprogesterone (MAH), also known as 6α-methyl-17-hydroxyprogesterone, is a synthetic progestin with a pharmacological activity about 15 times greater than progesterone. MAH is used for the treatment of renal and endometrial carcinomas, amenorrhea, abnormal uterine bleeding, and endometriosis associated with hormonal imbalance. MAH has a stimulatory effect on respiratory centers and has been used in cases of low blood oxygenation caused by sleep apnea, chronic obstructive pulmonary disease, or hypercapnia.

Mifepristone, also known as RU-486, is an antiprogesterone drug that blocks receptors of progesterone. It counteracts the effects of progesterone, which is needed to sustain pregnancy. Mifepristone induces spontaneous abortion when administered in early pregnancy followed by treatment with the prostaglandin, misoprostol. Further, studies show that mifepristone at a substantially lower dose can be highly effective as a postcoital contraceptive when administered within five days after unprotected intercourse. This is the “morning-after pill” used in case of contraceptive failure or sexual assault. Mifepristone also has potential uses in the treatment of breast and ovarian cancers in cases in which tumors are progesterone-dependent. It interferes with steroid-dependent growth of brain meningiomas, and may be useful in treatment of endometriosis by blocking the estrogen-dependent growth of endometrial tissues. It may also be useful in treatment of uterine fibroid tumors and Cushing's syndrome. Mifepristone binds to glucocorticoid receptors and interferes with cortisol binding. Mifepristone also may act as an anti-glucocorticoid and be effective for treating conditions where cortisol levels are elevated such as AIDS, anorexia nervosa, ulcers, diabetes, Parkinson's disease, multiple sclerosis, and Alzheimer's disease.

Danazol is a synthetic steroid derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by lowering pituitary synthesis of follicle-stimulating hormone and LH. Danazol also binds to sex hormone receptors in target tissues, producing anabolic, antiestrogenic, and weakly androgenic activity. Danazol does not possess any progestogenic activity and does not suppress normal pituitary release of corticotropin or release of cortisol by the adrenal glands. Danazol is used in the treatment of endometriosis to relieve pain and inhibit endometrial cell growth. It is also used to treat fibrocystic breast disease and hereditary angioedema.

Corticosteroids are used to relieve inflammation and to suppress the immune response. They inhibit eosinophil, basophil, and airway epithelial cell function by regulation of cytokines that mediate the inflammatory response. They inhibit leukocyte infiltration at the site of inflammation, interfere in the function of mediators of the inflammatory response, and suppress the humoral immune response. Corticosteroids are used to treat allergies, asthma, arthritis, and skin conditions. Beclomethasone is a synthetic glucocorticoid that is used to treat steroid-dependent asthma, to relieve symptoms associated with allergic or nonallergic (vasomotor) rhinitis, or to prevent recurrent nasal polyps following surgical removal. The anti-inflammatory and vasoconstrictive effects of intranasal beclomethasone are 5000 times greater than those produced by hydrocortisone. Budesonide is a corticosteroid used to control symptoms associated with allergic rhinitis or asthma. Budesonide has high topical anti-inflammatory activity but low systemic activity. Dexamethasone is a synthetic glucocorticoid used in anti-inflammatory or immunosuppressive compositions. It is also used in inhalants to prevent symptoms of asthma. Due to its greater ability to reach the central nervous system, dexamethasone is usually the treatment of choice to control cerebral edema. Dexamethasone is approximately 20-30 times more potent than hydrocortisone and 5-7 times more potent than prednisone. Prednisone is metabolized in the liver to its active form, prednisolone, a glucocorticoid with anti-inflammatory properties. Prednisone is approximately 4 times more potent than hydrocortisone and the duration of action of prednisone is intermediate between hydrocortisone and dexamethasone. Prednisone is used to treat allograft rejection, asthma, systemic lupus erythematosus, arthritis, ulcerative colitis, and other inflammatory conditions. Betamethasone is a synthetic glucocorticoid with antiinflammatory and immunosuppressive activity and is used to treat psoriasis and fungal infections such as athlete's foot and ringworm.

The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A₂ inhibitory proteins, collectively called lipocortins. Lipocortins, in turn, control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of the precursor molecule arachidonic acid. Proposed mechanisms of action include decreased IgE synthesis, increased number of β-adrenergic receptors on leukocytes, and decreased arachidonic acid metabolism. During an immediate allergic reaction such as in chronic bronchial asthma, allergens bridge the IgE antibodies on the surface of mast cells and trigger these cells to release chemotactic substances. Mast cell influx and activation is partially responsible for the inflammation and hyperirritability of the oral mucosa in asthmatic patients. This inflammation can be retarded by administration of corticosteroids.

The effects of steroids on liver metabolism and hormone clearance mechanisms are important to understand the pharmacodynamics of a drug. The human C3A cell line is a clonal derivative of HepG2/C3 (hepatoma cell line, isolated from a 15-year-old male with liver tumor), which was selected for strong contact inhibition of growth. The use of a clonal population enhances the reproducibility of the cells. C3A cells have many characteristics of primary human hepatocytes in culture including i) expression of insulin receptor and insulin-like growth factor II receptor; ii) secretion of a high ratio of serum albumin compared with α-fetoprotein iii) conversion of ammonia to urea and glutamine; iv) metabolism of aromatic amino acids; and v) proliferation in glucose-free and insulin-free medium. The C3A cell line is well established as an in vitro model of the mature human liver (Mickelson et al. (1995) Hepatology 22:866-875; Nagendra et al. (1997) Am J Physiol 272:G408-G416).

The present invention provides a combination comprising a plurality of cDNAs for use in detecting changes in expression of genes encoding proteins that are associated with steroid treatment. Such a combination satisfies a need in the art by providing a set of differentially expressed genes which may be used entirely or in part to detect metabolic and toxicological responses to steroid compounds and therapeutics.

SUMMARY

The present invention provides a combination comprising a plurality of cDNAs and their complements which are differentially expressed in human C3A cells treated with steroid compounds and which are selected from SEQ ID NOs:1, 2, 3, 5, 6, 8, 9, 11-14, 16-18, 20, 21, 23-34, 36, 38-40, 42-50, 52-63, 65, 66, 68-71, 73-75, 77-84, 86-111, 113-115, 117-126, 128-142, 145-160, 162-164, 166, 167, 169-172, 174-176, 178-186, 188-197, 199-202, 204-211, 213, 215, 217-228, 230-246, 248-251, 253-259, 261-266, 268-277, 279, 281, 283, 284, 286, 288-292, 294, 295, 297-300, 302-308, 310, 311, 313, 315-320, 322, 323, 325, 327-346, 348-350, 352-357, 359-368, 370-372, 374, 376, 378, 380-389, 391-400, 402, 403, 405-413, 415, 416, 418, 420, 422-426, 428, 429, 431-446, 448, 450-453, 455, 457, 459, 461, 463-466, 468-470, 472-478, 480-488, 490-492, 494-502, 504-506, 508-520, 522-526, 528-530, 532, 534, 535, 537-561, 563-565, 567, 569-575, 577, 579-581, 583, 585-589, 591-614, 616, 618, 619, 621, 623, 625, 627, 629-641, 643, 645-654, 656-663, 665-680, 682-698, 700-708, 710, 712-720, 722-725, 727-730, 732, 734, 735, 737-741, 743-754, 756, 758-768, 770-780, 782-786, 788-792, 794, 796-802, 804-806, 808, 809, 811-814, 816, 817, 819-829, 831, 833, 835, 836, 838-840, 842-888, 890-892, 894-908, 910, 912, 914-927, 929, 930, 932-937, 939-944, 946, 948-957, 959-964, 966-976, 978-988, 990-999, 1001-1008, 1010-1028, 1030-1034, 1036-1085, 1087-1096, 1098-1143 as presented in the Sequence Listing. The level of each cDNA is downregulated or upregulated at least 2.5-fold. In one aspect, the combination is useful to diagnose a liver disorder selected from adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease and for detecting metabolic and toxicological responses to treatment with steroids. In another aspect, the combination is immobilized on a substrate.

The invention also provides a high throughput method to detect differential expression of one or more of the cDNAs of the combination. The method comprises hybridizing the substrate comprising the combination with the nucleic acids of a sample, thereby forming one or more hybridization complexes, detecting the hybridization complexes, and comparing the hybridization complexes with those of a standard, wherein differences in the size and signal intensity of each hybridization complex indicates differential expression of nucleic acids in the sample. In one aspect, the sample is from a subject with a liver disorder associated with steroid therapy such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease and differential expression determines an early, mid, and late stage of that disorder.

The invention further provides a high throughput method of screening a library or a plurality of molecules or compounds to identify a ligand. The method comprises combining the substrate comprising the combination with a library or plurality of molecules or compounds under conditions to allow specific binding and detecting specific binding, thereby identifying a ligand. The library or plurality of molecules or compounds are selected from DNA molecules, RNA molecules, peptide nucleic acid molecules, mimetics, peptides, transcription factors, repressors, and other regulatory proteins. The invention additionally provides a method for purifying a ligand, the method comprising combining a cDNA of the invention with a sample under conditions which allow specific binding, recovering the bound cDNA, and separating the cDNA from the ligand, thereby obtaining purified ligand.

The invention still further provides an isolated cDNA selected from SEQ ID NOs:2, 17, 23, 24, 31, 32, 54, 57, 58, 60, 69, 73, 81-83, 86, 88, 90, 94-98, 102-105, 108, 113, 120-124, 129, 130, 133-135, 137, 140, 142, 145, 146, 148, 152, 154, 156, 157, 166, 174, 182, 185, 188, 189, 192, 194, 199, 205, 206, 208, 221, 234, 235-239, 253, 256, 258, 261, 271, 290, 297, 304, 307, 331, 338, 342, 343, 352, 354, 355, 360, 362, 364, 365, 380, 381, 395, 396, 402, 410, 412, 424, 428, 432, 435, 436, 438, 440, 444, 450, 464, 465, 472, 476, 477, 480, 487-490, 499-501, 510-512, 515, 519, 524, 528, 529, 538-542, 544, 545, 547, 549, 550, 554, 556, 558, 559, 563, 564, 570-572, 574, 580, 585, 588, 591, 594, 599-607, 648, 649, 651-653, 657, 658, 669, 670, 675, 677, 678, 684, 685, 688, 692-696, 700-705, 716, 728, 729, 739, 743, 748, 749, 751, 761, 763, 766, 767, 772, 783, 785, 790, 797, 798, 800, 805, 812, 813, 821, 825, 828, 839, 843, 846, 851-854, 857-859, 863-867, 873, 875, 879, 881-884, 887, 896, 901, 902, 905, 914, 916, 919, 923, 929, 933, 935, 936, 942, 948, 949-956, 959, 962, 963, 966, 969, 970, 972, 980, 984, 990-993, 998, 1003, 1004, 1007, 1013, 1016, 1020, 1026, 1027, 1030, 1037, 1038, 1040, 1042, 1046, 1051, 1056, 1059, 1063, 1068-1070, 1075, 1078, 1081, 1087, 1088, 1090, 1092-1095, 1099, 1105, 1107, 1108, 1113, 1117, 1118, 1121, 1128, 1129, 1132, 1140, 1141, and 1143 as presented in the Sequence Listing. The invention also provides a vector comprising the cDNA, a host cell comprising the vector, and a method for producing a protein comprising culturing the host cell under conditions for the expression of a protein and recovering the protein from the host cell culture.

The present invention provides a purified protein encoded and produced by a cDNA of the invention. The invention also provides a high-throughput method for using a protein to screen a library or a plurality of molecules or compounds to identify a ligand. The method comprises combining the protein or a portion thereof with the library or plurality of molecules or compounds under conditions to allow specific binding and detecting specific binding, thereby identifying a ligand which specifically binds the protein. The library or plurality of molecules or compounds is selected from aptamers, DNA molecules, RNA molecules, peptide nucleic acid molecules, mimetics, peptides, proteins, agonists, antagonists, antibodies or their fragments, immunoglobulins, inhibitors, drug compounds, and pharmaceutical agents. The invention further provides for using a protein to purify a ligand. The method comprises combining the protein or a portion thereof with a sample under conditions to allow specific binding, recovering the bound protein, and separating the protein from the ligand, thereby obtaining purified ligand. The invention still further provides a composition comprising the protein and a pharmaceutical carrier.

The invention also provides methods for using a protein to prepare and purify polyclonal and monoclonal antibodies which specifically bind the protein. The method for preparing a polyclonal antibody comprises immunizing a animal with protein under conditions to elicit an antibody response, isolating animal antibodies, attaching the protein to a substrate, contacting the substrate with isolated antibodies under conditions to allow specific binding to the protein dissociating the antibodies from the protein, thereby obtaining purified polyclonal antibodies. The method for preparing and purifying monoclonal antibodies comprises immunizing a animal with a protein under conditions to elicit an antibody response, isolating antibody producing cells from the animal, fusing the antibody producing cells with immortalized cells in culture to form monoclonal antibody producing hybridoma cells, culturing the hybridoma cells, and isolating from culture monoclonal antibodies which specifically bind the protein.

The invention provides a purified antibody that specifically binds a protein expressed in a liver disorder. The invention also provides a method for using an antibody to detect expression of a protein in a sample comprising combining the antibody with a sample under conditions which allow the formation of antibody:protein complexes and detecting complex formation, wherein complex formation indicates expression of the protein in the sample.

DESCRIPTION OF THE SEQUENCE LISTING AND TABLES

A portion of the disclosure of this patent document contains material that is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.

The Sequence Listing is a compilation of cDNAs obtained by sequencing and extending clone inserts. Each sequence is identified by a sequence identification number (SEQ ID NO) and by the Incyte identification number (Incyte ID) from which it was obtained.

Table 1 lists the functional annotation of the cDNAs of the present invention. Columns 1 and 2 show the SEQ ID NO and TEMPLATE ID, respectively. Columns 3, 4, and 5 show the GenBank ID, probability score (E-value), and functional annotation, respectively, as determined by BLAST analysis (version 1.4 using default parameters; Altschul (1993) J Mol Evol 36: 290-300; Altschul et al. (1990) J Mol Biol 215:403-410) of the cDNA against GenBank (release 117; National Center for Biotechnology Information (NCBI), Bethesda Md.).

Table 2 shows Pfam annotations of the cDNAs of the present invention. Columns 1 and 2 show the SEQ ID NO and Clone ID, respectively. Columns 3, 4, and 5 show the first residue (START), last residue (STOP), and reading frame, respectively, for the segment of the cDNA identified by Pfam analysis. Columns 6 and 7 show the Pfam description and E-values, respectively, corresponding to the polypeptide domain encoded by the cDNA segment.

Table 3 shows the region of each cDNA encompassed by the clone present on a microarray and identified as differentially expressed. Columns 1 and 2 show the SEQ ID NO and TEMPLATE ID, respectively. Column 3 shows the CLONE ID and columns 4 and 5 show the first residue (START) and last residue (STOP) encompassed by the clone on the template sequence.

Table 4 shows signal peptide and transmembrane regions predicted within the cDNAs of the present invention. Columns 1 and 2 show the SEQ ID NO and TEMPLATE ID, respectively. Columns 3, 4, and 5 show the first residue (START), last residue (STOP), and reading frame (FRAME), respectively, for a segment of the cDNA, and column 6 (HIT TYPE) identifies the polypeptide encoded by the segment as either a signal peptide (SP) or transmembrane (TM) domain.

Table 5 lists the tissue distribution of the nucleotide templates. Columns 1 and 2 list the SEQ ID NO and TEMPLATE ID, respectively. Column 3 lists the predominant tissue distribution (TISSUE DISTRIBUTION) as a percentage of total tissues in the LIFESEQ GOLD database (Incyte Genomics, Palo Alto Calif.).

Tables 6-14 show the differentially expressed genes associated with treatment of human C3A cells with various steroid compounds. Differentially expressed genes associated with mifepristone (mife) treatment are shown in Table 6; with progesterone (Prog) treatment in Table 7; with beclomethasone (Beclo) treatment in Table 8; with medroxyprogesterone (MAH) treatment in Table 9; with budesonide (bude) treatment in Table 10; with prednisone (Prdsne) treatment in Table 11; with dexamethasone (Dex) treatment in Table 12; with betamethasone (Betam) treatment in Table 13; and with danazol treatment in Table 14. In each table, genes are grouped by similarity in response to the compound as determined by K-means clustering algorithms; cluster numbers are associated with specific GEM designs.

In Tables 6-14, column 1 shows the Incyte clone ID number; column 2 shows the average log2 differential expression value for treated C3A cells, column 3 shows the range of log2 mean differential expression values for treated C3A cells, columns 4 through 12 show the log2 mean differential expression values for C3A cells treated with the steroid compound at concentrations of 1, 10, and 100 μM for 1, 3, and 6 hours; column 13 shows the cluster number to which the gene was assigned, and column 14 shows the GEM microarray (Incyte Genomics) designation for the gene.

Table 15 lists the genes that showed differential expression with all of the steroid compounds. Column 1 shows the Incyte clone ID number, columns 2 and 3 show the GenBank ID and functional annotation respectively, column 4 shows the average log2 differential expression value for treated C3A cells, and column 5 shows the steroid used in treatment of human C3A liver cells.

Table 16 lists the genes that showed differential expression selectively with only one of the steroid compounds. Column 1 shows the Incyte clone ID number, column 2 shows the average log2 differential expression value for treated C3A cells, and column 3 shows the steroid used in treatment of human C3A liver cells.

Tables 17-25 show groups of genes that are regulated selectively by two or three of the steroids. Table 17 shows groups of genes that are differentially expressed selectively in response to progesterone and either MAH or betamethasone. Table 18 shows groups of genes that are differentially expressed selectively in response to mifepristone and either MAH or danazol. Table 19 shows groups of genes that are differentially expressed selectively in response to MAH and each of the other steroids. Table 20 shows groups of genes that are differentially expressed selectively in response to danazol and mifepristone, MAH or betamethasone. Table 21 shows groups of genes that are differentially expressed selectively in response to dexamethasone and either other corticosteroids or MAH. Table 22 shows groups of genes that are differentially expressed selectively in response to betamethasone and either other corticosteroids, or MAH, progesterone, or danazol. Table 23 shows groups of genes that are differentially expressed selectively in response to beclomethasone and either other corticosteroids or MAH. Table 24 shows groups of genes that are differentially expressed selectively in response to budesonide and either other corticosteroids or MAH. Table 25 shows groups of genes that are differentially expressed selectively in response to prednisone and either other corticosteroids or MAH.

In Tables 17-25, column 1 shows the Incyte clone ID number, column 2 shows the average log2 differential expression value for treated C3A cells, and column 3 shows the steroid used in treatment of human C3A liver cells.

DESCRIPTION OF THE INVENTION

Definitions

“Array” refers to an ordered arrangement of at least two cDNAs on a substrate. At least one of the cDNAs represents a control or standard sequence, and the other, a cDNA of diagnostic interest. The arrangement of from about two to about 40,000 cDNAs on the substrate assures that the size and signal intensity of each labeled hybridization complex formed between a cDNA and a sample nucleic acid is individually distinguishable.

The “complement” of a nucleic acid molecule of the Sequence Listing refers to a nucleotide sequence which is completely complementary over the full length of the sequence and which will hybridize to the nucleic acid molecule under conditions of high stringency.

A “combination” comprises at least two and up to 1143 sequences selected from the group consisting of SEQ ID NOs:1-1143 as presented in the Sequence Listing.

“cDNA” refers to a chain of nucleotides, an isolated polynucleotide, nucleic acid molecule, or any fragment or complement thereof. It may have originated recombinantly or synthetically, be double-stranded or single-stranded, coding and/or noncoding, an exon with or without an intron from a genomic DNA molecule, and purified or combined with carbohydrate, lipids, protein or inorganic elements or substances. Preferably, the cDNA is from about 400 to about 10000 nucleotides.

The phrase “cDNA encoding a protein” refers to a nucleic acid sequence that closely aligns with sequences which encode conserved regions, motifs or domains that were identified by employing analyses well known in the art. These analyses include BLAST (Basic Local Alignment Search Tool; Altschul (1993) J Mol Evol 36: 290-300; Altschul et al. (1990) J Mol Biol 215-410) which provides identity within the conserved region. Brenner et al. (1998; Proc Natl Acad Sci 95:6073-6078) who analyzed BLAST for its ability to identify structural homologs by sequence identity found 30% identity is a reliable threshold for sequence alignments of at least 150 residues and 40% is a reasonable threshold for alignments of at least 70 residues (Brenner et al., page 6076, column 2).

“Derivative” refers to a cDNA or a protein that has been subjected to a chemical modification. Derivatization of a cDNA can involve substitution of a nontraditional base such as queosine or of an analog such as hypoxanthine. These substitutions are well known in the art. Derivatization of a protein involves the replacement of a hydrogen by an acetyl, acyl, alkyl, amino, formyl, or morpholino group. Derivative molecules retain the biological activities of the naturally occurring molecules but may confer advantages such as longer lifespan or enhanced activity.

“Differential expression” refers to an increased or upregulated or a decreased or downregulated expression as detected by absence, presence, or at least 2.5-fold change in the amount of transcribed messenger RNA or translated protein in a sample.

“Disorder” refers to conditions, diseases or syndromes such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, Wilson disease, and toxicological responses associated with the use of steroid compounds.

“Fragment” refers to a chain of consecutive nucleotides from about 200 to about 700 base pairs in length. Fragments may be used in PCR or hybridization technologies to identify related nucleic acid molecules and in binding assays to screen for a ligand. Nucleic acids and their ligands identified in this manner are useful as therapeutics to regulate replication, transcription or translation.

A “hybridization complex” is formed between a cDNA and a nucleic acid of a sample when the purines of one molecule hydrogen bond with the pyrimidines of the complementary molecule, e.g., 5′-A-G-T-C-3′ base pairs with 3′-T-C-A-G-5′. The degree of complementarity and the use of nucleotide analogs affect the efficiency and stringency of hybridization reactions.

“Identity” as applied to sequences, refers to the quantification (usually percentage) of nucleotide or residue matches between at least two sequences aligned using a standardized algorithm such as Smith-Waterman alignment (Smith and Waterman (1981) J Mol Biol 147:195-197), CLUSTALW (Thompson et al. (1994) Nucleic Acids Res 22:4673-4680), or BLAST2 (Altschul et al. (1997) supra). BLAST2 may be used in a standardized and reproducible way to insert gaps in one of the sequences in order to optimize alignment and to achieve a more meaningful comparison between them. “Similarity” as applied to proteins uses the same algorithms but takes into account conservative substitutions of nucleotides or residues.

“Ligand” refers to any agent, molecule, or compound which will bind specifically to a complementary site on a cDNA molecule or polynucleotide, or to an epitope or a protein. Such ligands stabilize or modulate the activity of polynucleotides or proteins and may be composed of inorganic or organic substances including nucleic acids, proteins, carbohydrates, fats, and lipids.

“Oligonucleotide” refers a single stranded molecule from about 18 to about 60 nucleotides in length which may be used in hybridization or amplification technologies or in regulation of replication, transcription or translation. Substantially equivalent terms are amplimer, primer, and oligomer.

“Portion” refers to any part of a protein used for any purpose which retains at least one biological or antigenic characteristic of a native protein; but especially, to an epitope for the screening of ligands or for the production of antibodies.

“Post-translational modification” of a protein can involve lipidation, glycosylation, phosphorylation, acetylation, racemization, proteolytic cleavage, and the like. These processes may occur synthetically or biochemically. Biochemical modifications will vary by cellular location, cell type, pH, enzymatic milieu, and the like.

“Probe” refers to a cDNA that hybridizes to at least one nucleic acid molecule in a sample. Where targets are single stranded, probes are complementary single strands. Probes can be labeled with reporter molecules for use in hybridization reactions including Southern, northern, in situ, dot blot, array, and like technologies or in screening assays.

“Protein” refers to a polypeptide or any portion thereof. An “oligopeptide” is an amino acid sequence from about five residues to about 15 residues that is used as part of a fusion protein to produce an antibody.

“Purified” refers to any molecule or compound that is separated from its natural environment and is preferably about 60% free and more preferably about 90% free from other components with which it is naturally associated.

“Sample” is used in its broadest sense as containing nucleic acids, proteins, antibodies, and the like. A sample may comprise a bodily fluid; the soluble fraction of a cell preparation, or an aliquot of media in which cells were grown; a chromosome, an organelle, or membrane isolated or extracted from a cell; genomic DNA, RNA, or cDNA in solution or bound to a substrate; a cell; a tissue or a tissue biopsy; a tissue print; a fingerprint, buccal cells, skin, or hair; and the like.

“Specific binding” refers to a special and precise interaction between two molecules which is dependent upon their structure, particularly their molecular side groups. For example, the intercalation of a regulatory protein into the major groove of a DNA molecule, the hydrogen bonding along the backbone between two single stranded nucleic acids, or the binding between an epitope of a protein and an agonist, antagonist, or antibody.

“Substrate” refers to any rigid or semi-rigid support to which cDNAs or proteins are bound and includes membranes, filters, chips, slides, wafers, fibers, magnetic or nonmagnetic beads, gels, capillaries or other tubing, plates, polymers, and microparticles with a variety of surface forms including wells, trenches, pins, channels and pores.

“Variant” refers to molecules that are recognized variations of a cDNA or a protein encoded by the cDNA. Splice variants may be determined by BLAST score, wherein the score is at least 100, and most preferably at least 400. Allelic variants have a high percent identity to the cDNAs and may differ by about three bases per hundred bases. “Single nucleotide polymorphism” (SNP) refers to a change in a single base as a result of a substitution, insertion or deletion. The change may be conservative (purine for purine) or non-conservative (purine to pyrimidine) and may or may not result in a change in an encoded amino acid.

The Invention

The present invention provides for a combination comprising a plurality of cDNAs or their complements, SEQ ID NOs:1, 2, 3, 5, 6, 8, 9, 11-14, 16-18, 20, 21, 23-34, 36, 38-40, 42-50, 52-63, 65, 66, 68-71, 73-75, 77-84, 86-111, 113-115, 117-126, 128-142, 145-160, 162-164, 166, 167, 169-172, 174-176, 178-186, 188-197, 199-202, 204-211, 213, 215, 217-228, 230-246, 248-251, 253-259, 261-266, 268-277, 279, 281, 283, 284, 286, 288-292, 294, 295, 297-300, 302-308, 310, 311, 313, 315-320, 322, 323, 325, 327-346, 348-350, 352-357, 359-368, 370-372, 374, 376, 378, 380-389, 391-400, 402, 403, 405-413, 415, 416, 418, 420, 422-426, 428, 429, 431-446, 448, 450-453, 455, 457, 459, 461, 463-466, 468-470, 472-478, 480-488, 490-492, 494-502, 504-506, 508-520, 522-526, 528-530, 532, 534, 535, 537-561, 563-565, 567, 569-575, 577, 579-581, 583, 585-589, 591-614, 616, 618, 619, 621, 623, 625, 627, 629-641, 643, 645-654, 656-663, 665-680, 682-698, 700-708, 710, 712-720, 722-725, 727-730, 732, 734, 735, 737-741, 743-754, 756, 758-768, 770-780, 782-786, 788-792, 794, 796-802, 804-806, 808, 809, 811-814, 816, 817, 819-829, 831, 833, 835, 836, 838-840, 842-888, 890-892, 894-908, 910, 912, 914-927, 929, 930, 932-937, 939-944, 946, 948-957, 959-964, 966-976, 978-988, 990-999, 1001-1008, 1010-1028, 1030-1034, 1036-1085, 1087-1096, 1098-1143 which may be used on a substrate to detect metabolic and toxicological responses to treatment with steroids and steroid antagonists and as diagnostics for liver disorders associated with steroid therapy such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease. These cDNAs represent known and novel genes differentially expressed in human C3A liver cells treated with mifepristone, progesterone, beclomethasone, medroxyprogesterone, budesonide, prednisone, dexamethasone, betamethasone, or danazol. The combination may be used in its entirety or in part, as subsets of downregulated cDNAs or of upregulated cDNAs. SEQ ID NOs:2, 17, 23, 24, 31, 32, 54, 57, 58, 60, 69, 73, 81-83, 86, 88, 90, 94-98, 102-105, 108, 113, 120, 121, 123, 124, 129, 130, 133-135, 137, 140, 142, 145, 146, 148, 152, 154, 156, 157, 166, 174, 182, 185, 188, 189, 192, 194, 199, 205, 206, 208, 221, 234-239, 253, 256, 258, 261, 271, 290, 297, 304, 307, 331, 338, 342, 343, 352, 354, 355, 360, 362, 364, 365, 380, 381, 395, 396, 402, 410, 412, 424, 428, 432, 435, 436, 438, 440, 444, 450, 464, 465, 472, 476, 477, 480, 487-490, 499, 500, 501, 510-512, 515, 519, 524, 528, 529, 538-542, 544, 545, 547, 549, 550, 554, 556, 558, 559, 563, 564, 570-572, 574, 580, 585, 588, 591, 594, 599, 600-607, 648, 649, 651-653, 657, 658, 669, 670, 675, 677, 678, 684, 685, 688, 692-696, 700-705, 716, 728, 729, 739, 743, 748, 749, 751, 761, 763, 766, 767, 772, 783, 785, 790, 797, 798, 800, 805, 812, 813, 821, 825, 828, 839, 843, 846, 851-854, 857-859, 863-867, 873, 875, 879, 881-884, 887, 896, 901, 902, 905, 914, 916, 919, 923, 929, 933, 935, 936, 942, 948, 949, 952-956, 959, 962, 963, 966, 969, 970, 972, 980, 984, 990-993, 998, 1003, 1004, 1007, 1013, 1016, 1020, 1026, 1027, 1030, 1037, 1038, 1040, 1042, 1046, 1051, 1056, 1059, 1063, 1068-1070, 1075, 1078, 1081, 1087, 1088, 1090, 1092-1095, 1099, 1105, 1107, 1108, 1113, 1117, 1118, 1121, 1128, 1129, 1132, 1140, 1141, and 1143 represent novel cDNAs associated with the response of C3A cells to treatment with steroids. Since the novel cDNAs were identified solely by their differential expression, it is not essential to know a priori the name, structure, or function of the gene or the encoded protein. The usefulness of the novel cDNAs exists in their immediate value as diagnostics for liver disorders associated with steroid therapy such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease, and for detection of metabolic and toxicological responses to treatment with steroids and steroid antagonists.

The invention also provides isolated proteins, SEQ ID NOs:4, 7, 10, 15, 19, 22, 35, 37, 41, 51, 64, 67, 72, 76, 85, 112, 116, 127, 143, 144, 161, 165, 168, 173, 177, 187, 198, 203, 212, 214, 216, 229, 247, 252, 260, 267, 278, 280, 282, 285, 287, 293, 296, 301, 309, 312, 314, 321, 324, 326, 347, 351, 358, 369, 373, 375, 377, 379, 390, 401, 404, 414, 417, 419, 421, 427, 430, 443, 447, 449, 454, 456, 458, 460, 462, 467, 471, 479, 489, 493, 503, 507, 521, 527, 531, 533, 536, 562, 566, 568, 576, 578, 582, 584, 590, 615, 617, 620, 622, 624, 626, 628, 642, 644, 655, 664, 681, 699, 709, 711, 721, 726, 731, 733, 736, 742, 755, 757, 769, 781, 787, 793, 795, 803, 807, 810, 815, 818, 830, 832, 834, 837, 841, 889, 893, 909, 911, 913, 928, 931, 938, 945, 947, 958, 965, 977, 989, 1000, 1009, 1029, 1035, 1086, and 1097 which are encoded by the cDNAs of SEQ ID NOs:3, 6, 9, 14, 18, 21, 34, 36, 40, 50, 63, 66, 71, 75, 84, 111, 115, 126, 143, 160, 164, 167, 172, 176, 186, 197, 202, 211, 213, 215, 228, 246, 251, 259, 266, 277, 279, 281, 284, 286, 292, 295, 300, 308, 311, 313, 320, 323, 325, 346, 350, 357, 368, 372, 374, 376, 378, 389, 400, 403, 413, 416, 418, 420, 426, 429, 442, 446, 448, 453, 455, 457, 459, 461, 466, 470, 478, 488, 492, 502, 506, 520, 526, 530, 532, 535, 561, 565, 567, 575, 577, 581, 583, 589, 614, 616, 619, 621, 623, 625, 627, 641, 643, 654, 663, 680, 698, 708, 710, 720, 725, 730, 732, 735, 741, 754, 756, 768, 780, 786, 792, 794, 802, 806, 809, 814, 817, 829, 831, 833, 836, 840, 888, 892, 908, 910, 912, 927, 930, 937, 944, 946, 957, 964, 976, 988, 999, 1008, 1028, 1034, 1085, and 1096 respectively as shown in Table 1.

Agglomerative cluster analysis was used to identify response patterns and to establish relationships between different gene expression profiles. Each gene measurement was normalized by dividing the expression ratios by the maximum value for each time series. The clustering process defined a hierarchical tree with the number of branches intersecting at each branch level of the tree equal to the number of clusters at that level.

Table 1 shows those genes on the array having differential expression (2.5-fold or greater increase or decrease) in treated human C3A liver cell cultures, the encoded protein sequences which correspond to the upregulated or downregulated clones present on the array, and the functional annotation of the template cDNAs as determined by BLAST analysis. Table 2 shows the functional annotation as determined by Pfam analysis. Table 3 shows the positional information of the clone present on the array relative to the nucleotide template sequence. Table 4 shows the functional annotation as determined by Hidden Markov Model analysis for signal peptide (SP) or for transmembrane (TM) regions. Table 5 shows the tissue distribution of the nucleotide template sequences. Tables 6-14 show those genes on the array having differential expression (2.5-fold or greater increase or decrease) in human C3A cells treated with mifepristone, progesterone, beclomethasone, medroxyprogesterone, budesonide, prednisone, dexamethasone, betamethasone, or danazol respectively. Table 15 lists the genes, identified by Incyte Clone ID, that showed differential expression with all of the steroid compounds. Genes represented by Incyte clones 279898 and 4287327 on the microarray are upregulated by all of the steroid compounds. Genes represented by Incyte clones 560115, 1619292, 2769888, 3120209, 3135460, 4408943, 5047895, 5166479, and 5427710 on the microarray are downregulated by all of the steroid compounds. Table 16 lists the genes that showed differential expression selectively with only one of the steroid compounds. Table 17 shows the group of genes that are differentially expressed selectively in response to progesterone and are regulated similarly by either the synthetic progestin MAH or the glucocorticoid betamethasone. Table 18 shows the group of genes that are differentially expressed selectively in response to mifepristone and are regulated similarly by other steroids which bind to sex hormone receptors including MAH or danazol. Table 19 shows the group of genes that are differentially expressed selectively in response to MAH. The synthetic progestin MAH alters the expression of a wider range of genes than progesterone. Table 20 shows the group of genes that are differentially expressed selectively in response to danazol and mifepristone, MAH or betamethasone. Danazol, mifepristone, and MAH show similar effects on differential expression. Danazol and betamethasone show opposing effects on expression. Table 21 shows the group of genes that are differentially expressed selectively in response to dexamethasone and are regulated similarly by either other corticosteroids or MAH. Beclomethasone, compared with the other corticosteroids, regulates the most genes in common with dexamethasone and shows the most similarity in its effects on gene expression. Table 22 shows the group of genes that are differentially expressed selectively in response to betamethasone and are regulated similarly by other corticosteroids, MAH, progesterone, or danazol. Budesonide, compared with the other corticosteroids, regulates the most genes in common with betamethasone and shows the most similarity in its effects on gene expression. Betamethasone in contrast to the other corticosteroids, regulates a significant number of genes in common with progesterone and other steroids which bind sex hormone receptors. Table 23 shows the group of genes that are differentially expressed selectively in response to beclomethasone and are regulated similarly by either other corticosteroids or MAH. Table 24 shows that group of genes that are differentially expressed selectively in response to budesonide and are regulated similarly by either other corticosteroids or MAH. Betamethasone, compared with the other corticosteroids, regulates the most genes in common with budesonide. Table 25 shows the group of genes that are differentially expressed selectively in response to prednisone and are regulated similarly by either other corticosteroids or MAH.

The cDNAs of the invention define a differential expression pattern against which to compare the expression pattern of biopsied and/or in vitro treated human liver tissues. Experimentally, differential expression of the cDNAs can be evaluated by methods including, but not limited to, differential display by spatial immobilization or by gel electrophoresis, genome mismatch scanning, representational discriminant analysis, clustering, transcript imaging and array technologies. These methods may be used alone or in combination.

The combination may be arranged on a substrate and hybridized with tissues from subjects with diagnosed liver disorders associated with steroid therapy such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease to identify those sequences which are differentially expressed and for detection of metabolic and toxicological responses to treatment with steroids and steroid antagonists. This allows identification of those sequences of highest diagnostic and potential therapeutic value. In one embodiment, an additional set of cDNAs, such as cDNAs encoding signaling molecules, are arranged on the substrate with the combination. Such combinations may be useful in the elucidation of pathways which are affected in particular liver disorders associated with steroid therapy or to identify new, coexpressed, candidate, toxicological markers.

In another embodiment, the combination can be used for large scale genetic or gene expression analysis of a large number of novel, nucleic acid molecules. These samples are prepared by methods well known in the art and are from mammalian cells or tissues which are in a certain stage of development; have been treated with a known molecule or compound, such as a cytokine, growth factor, a drug, and the like; or have been extracted or biopsied from a mammal with a known or unknown condition, disorder, or disease before or after treatment. The sample nucleic acid molecules are hybridized to the combination for the purpose of defining a novel gene profile associated with that developmental stage, treatment, or disorder.

cDNAs and Their Uses

cDNAs can be prepared by a variety of synthetic or enzymatic methods well known in the art. cDNAs can be synthesized, in whole or in part, using chemical methods well known in the art (Caruthers et al. (1980) Nucleic Acids Symp Ser (7)215-233). Alternatively, cDNAs can be produced enzymatically or recombinantly, by in vitro or in vivo transcription.

Nucleotide analogs can be incorporated into cDNAs by methods well known in the art. The only requirement is that the incorporated analog must base pair with native purines or pyrimidines. For example, 2,6-diaminopurine can substitute for adenine and form stronger bonds with thymidine than those between adenine and thymidine. A weaker pair is formed when hypoxanthine is substituted for guanine and base pairs with cytosine. Additionally, cDNAs can include nucleotides that have been derivatized chemically or enzymatically.

cDNAs can be synthesized on a substrate. Synthesis on the surface of a substrate may be accomplished using a chemical coupling procedure and a piezoelectric printing apparatus as described by Baldeschweiler et at. (PCT publication WO95/251116). Alternatively, the cDNAs can be synthesized on a substrate surface using a self-addressable electronic device that controls when reagents are added as described by Heller et al. (U.S. Pat. No. 5,605,662). cDNAs can be synthesized directly on a substrate by sequentially dispensing reagents for their synthesis on the substrate surface or by dispensing preformed DNA fragments to the substrate surface. Typical dispensers include a micropipette delivering solution to the substrate with a robotic system to control the position of the micropipette with respect to the substrate. There can be a multiplicity of dispensers so that reagents can be delivered to the reaction regions efficiently.

cDNAs can be immobilized on a substrate by covalent means such as by chemical bonding procedures or UV irradiation. In one method, a cDNA is bound to a glass surface which has been modified to contain epoxide or aldehyde groups. In another method, a cDNA is placed on a polylysine coated surface and UV cross-linked to it as described by Shalon et al. (WO95/35505). In yet another method, a cDNA is actively transported from a solution to a given position on a substrate by electrical means (Heller, supra). cDNAs do not have to be directly bound to the substrate, but rather can be bound to the substrate through a linker group. The linker groups are typically about 6 to 50 atoms long to provide exposure of the attached cDNA. Preferred linker groups include ethylene glycol oligomers, diamines, diacids and the like. Reactive groups on the substrate surface react with a terminal group of the linker to bind the linker to the substrate. The other terminus of the linker is then bound to the cDNA. Alternatively, polynucleotides, plasmids or cells can be arranged on a filter. In the latter case, cells are lysed, proteins and cellular components degraded, and the DNA is coupled to the filter by UV cross-linking.

The cDNAs may be used for a variety of purposes. For example, the combination of the invention may be used on an array. The array, in turn, can be used in high-throughput methods for detecting a related polynucleotide in a sample, screening a plurality of molecules or compounds to identify a ligand, diagnosing liver disorders associated with steroid therapy such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease, detecting metabolic and toxicological responses to treatment with steroids and steroid antagonists, or inhibiting or inactivating a therapeutically relevant gene related to the cDNA.

When the cDNAs of the invention are employed on a microarray, the cDNAs are arranged in an ordered fashion so that each cDNA is present at a specified location. Because the cDNAs are at specified locations on the substrate, the hybridization patterns and intensities, which together create a unique expression profile, can be interpreted in terms of expression levels of particular genes and can be correlated with a particular metabolic process, condition, disorder, disease, stage of disease, or treatment.

Hybridization

The cDNAs or fragments or complements thereof may be used in various hybridization technologies. The cDNAs may be labeled using a variety of reporter molecules by either PCR, recombinant, or enzymatic techniques. For example, a commercially available vector containing the cDNA is transcribed in the presence of an appropriate polymerase, such as T7 or SP6 polymerase, and at least one labeled nucleotide. Commercial kits are available for labeling and cleanup of such cDNAs. Radioactive (Amersham Pharmacia Biotech (APB), Piscataway N.J.), fluorescent (Operon Technologies, Alameda Calif.), and chemiluminescent labeling (Promega, Madison Wis.) are well known in the art.

A cDNA may represent the complete coding region of an mRNA or be designed or derived from unique regions of the mRNA or genomic molecule, an intron, a 3′ untranslated region, or from a conserved motif. The cDNA is at least 18 contiguous nucleotides in length and is usually single stranded. Such a cDNA may be used under hybridization conditions that allow binding only to an identical sequence, a naturally occurring molecule encoding the same protein, or an allelic variant. Discovery of related human and mammalian sequences may also be accomplished using a pool of degenerate cDNAs and appropriate hybridization conditions. Generally, a cDNA for use in Southern or northern hybridizations may be from about 400 to about 6000 nucleotides long. Such cDNAs have high binding specificity in solution-based or substrate-based hybridizations. An oligonucleotide, a fragment of the cDNA, may be used to detect a polynucleotide in a sample using PCR.

The stringency of hybridization is determined by G+C content of the cDNA, salt concentration, and temperature. In particular, stringency is increased by reducing the concentration of salt or raising the hybridization temperature. In solutions used for some membrane based hybridizations, addition of an organic solvent such as formamide allows the reaction to occur at a lower temperature. Hybridization may be performed with buffers, such as 5×saline sodium citrate (SSC) with 1% sodium dodecyl sulfate (SDS) at 60° C., that permit the formation of a hybridization complex between nucleic acid sequences that contain some mismatches. Subsequent washes are performed with buffers such as 0.2×SSC with 0.1% SDS at either 45° C. (medium stringency) or 65°-68° C. (high stringency). At high stringency, hybridization complexes will remain stable only where the nucleic acid molecules are completely complementary. In some membrane-based hybridizations, preferably 35% or most preferably 50%, formamide may be added to the hybridization solution to reduce the temperature at which hybridization is performed. Background signals may be reduced by the use of detergents such as Sarkosyl or Triton X-100 (Sigma Aldrich, St. Louis Mo.) and a blocking agent such as denatured salmon sperm DNA. Selection of components and conditions for hybridization are well known to those skilled in the art and are reviewed in Ausubel et al. (1997, Short Protocols in Molecular Biology, John Wiley & Sons, New York N.Y., Units 2.8-2.11, 3.18-3.19 and 4.6-4.9).

Dot-blot, slot-blot, low density and high density arrays are prepared and analyzed using methods known in the art. cDNAs from about 18 consecutive nucleotides to about 5000 consecutive nucleotides in length are contemplated by the invention and used in array technologies. The preferred number of cDNAs on an array is at least about 100,000, a more preferred number is at least about 40,000, an even more preferred number is at least about 10,000, and a most preferred number is at least about 600 to about 800. The array may be used to monitor the expression level of large numbers of genes simultaneously and to identify genetic variants, mutations, and SNPs. Such information may be used to determine gene function; to understand the genetic basis of a disorder; to diagnose a disorder; and to develop and monitor the activities of therapeutic agents being used to control or cure a disorder. (See, e.g., U.S. Pat. No. 5,474,796; WO95/11995; WO95/35505; U.S. Pat. Nos. 5,605,662; and 5,958,342.)

Screening and Purification Assays

A cDNA may be used to screen a library or a plurality of molecules or compounds for a ligand which specifically binds the cDNA. Ligands may be DNA molecules, RNA molecules, peptide nucleic acid molecules, peptides, proteins such as transcription factors, promoters, enhancers, repressors, and other proteins that regulate replication, transcription, or translation of the polynucleotide in the biological system. The assay involves combining the cDNA or a fragment thereof with the molecules or compounds under conditions that allow specific binding and detecting the bound cDNA to identify at least one ligand that specifically binds the cDNA.

In one embodiment, the cDNA may be incubated with a library of isolated and purified molecules or compounds and binding activity determined by methods such as a gel-retardation assay (U.S. Pat. No. 6,010,849) or a reticulocyte lysate transcriptional assay. In another embodiment, the cDNA may be incubated with nuclear extracts from biopsied and/or cultured cells and tissues. Specific binding between the cDNA and a molecule or compound in the nuclear extract is initially determined by gel shift assay. Protein binding may be confirmed by raising antibodies against the protein and adding the antibodies to the gel-retardation assay where specific binding will cause a supershift in the assay.

In another embodiment, the cDNA may be used to purify a molecule or compound using affinity chromatography methods well known in the art. In one embodiment, the cDNA is chemically reacted with cyanogen bromide groups on a polymeric resin or gel. Then a sample is passed over and reacts with or binds to the cDNA. The molecule or compound which is bound to the cDNA may be released from the cDNA by increasing the salt concentration of the flow-through medium and collected.

The cDNA may be used to purify a ligand from a sample. A method for using a cDNA to purify a ligand would involve combining the cDNA or a fragment thereof with a sample under conditions to allow specific binding, recovering the bound cDNA, and using an appropriate agent to separate the cDNA from the purified ligand.

Protein Production and Uses

The full length cDNAs or fragment thereof may be used to produce purified proteins using recombinant DNA technologies described herein and taught in Ausubel et al. (sunra; Units 16.1-16.62). One of the advantages of producing proteins by these procedures is the ability to obtain highly-enriched sources of the proteins thereby simplifying purification procedures.

The proteins may contain amino acid substitutions, deletions or insertions made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved. Such substitutions may be conservative in nature when the substituted residue has structural or chemical properties similar to the original residue (e.g., replacement of leucine with isoleucine or valine) or they may be nonconservative when the replacement residue is radically different (e.g., a glycine replaced by a tryptophan). Computer programs included in LASERGENE software (DNASTAR, Madison Wis.), MACVECTOR software (Genetics Computer Group, Madison Wis.) and RasMol software (Roger Sayles, University of Massachusetts, Amherst Mass.) may be used to help determine which and how many amino acid residues in a particular portion of the protein may be substituted, inserted, or deleted without abolishing biological or immunological activity.

Expression of Encoded Proteins

Expression of a particular cDNA may be accomplished by cloning the cDNA into a vector and transforming this vector into a host cell. The cloning vector used for the construction of cDNA libraries in the LIFESEQ databases may also be used for expression. Such vectors usually contain a promoter and a polylinker useful for cloning, priming, and transcription. An exemplary vector may also contain the promoter for β-galactosidase, an amino-terminal methionine and the subsequent seven amino acid residues of β-galactosidase. The vector may be transformed into competent E. coli cells. Induction of the isolated bacterial strain with isopropylthiogalactoside (IPTG) using standard methods will produce a fusion protein that contains an N terminal methionine, the first seven residues of β-galactosidase, about 15 residues of linker, and the protein encoded by the cDNA.

The cDNA may be shuttled into other vectors known to be useful for expression of protein in specific hosts. Oligonucleotides containing cloning sites and fragments of DNA sufficient to hybridize to stretches at both ends of the cDNA may be chemically synthesized by standard methods. These primers may then be used to amplify the desired fragments by PCR. The fragments may be digested with appropriate restriction enzymes under standard conditions and isolated using gel electrophoresis. Alternatively, similar fragments are produced by digestion of the cDNA with appropriate restriction enzymes and filled in with chemically synthesized oligonucleotides. Fragments of the coding sequence from more than one gene may be ligated together and expressed.

Signal sequences that dictate secretion of soluble proteins are particularly desirable as component parts of a recombinant sequence. For example, a chimeric protein may be expressed that includes one or more additional purification-facilitating domains. Such domains include, but are not limited to, metal-chelating domains that allow purification on immobilized metals, protein A domains that allow purification on immobilized immunoglobulin, and the domain utilized in the FLAGS extension/affinity purification system (Immunex, Seattle Wash.). The inclusion of a cleavable-linker sequence such as ENTEROKINASEMAX (Invitrogen, San Diego Calif.) between the protein and the purification domain may also be used to recover the protein.

Suitable host cells may include, but are not limited to, mammalian cells such as Chinese Hamster Ovary (CHO) and human 293 cells, insect cells such as Sf9 cells, plant cells such as Nicotiana tabacum, yeast cells such asSaccharomyces cerevisiae, and bacteria such as E. coli. For each of these cell systems, a useful vector may also include an origin of replication and one or two selectable markers to allow selection in bacteria as well as in a transformed eukaryotic host. Vectors for use in eukaryotic host cells may require the addition of 3′poly(A) tail if the cDNA lacks poly(A).

Additionally, the vector may contain promoters or enhancers that increase gene expression. Many promoters are known and used in the art. Most promoters are host specific and exemplary promoters includes SV40 promoters for CHO cells; T7 promoters for bacterial hosts; viral promoters and enhancers for plant cells; and PGH promoters for yeast. Adenoviral vectors with the rous sarcoma virus enhancer or retroviral vectors with long terminal repeat promoters may be used to drive protein expression in mammalian cell lines. Once homogeneous cultures of recombinant cells are obtained, large quantities of secreted soluble protein may be recovered from the conditioned medium and analyzed using chromatographic methods well known in the art. An alternative method for the production of large amounts of secreted protein involves the transformation of mammalian embryos and the recovery of the recombinant protein from milk produced by transgenic cows, goats, sheep, and the like.

In addition to recombinant production, proteins or portions thereof may be produced manually, using solid-phase techniques (Stewart et al. (1969) Solid-Phase Peptide Synthesis, W H Freeman, San Francisco Calif.; Merrifield (1963) J Am Chem Soc 5:2149-2154), or using machines such as the ABI 431A peptide synthesizer (Applied Biosystems, Foster City Calif.). Proteins produced by any of the above methods may be used as pharmaceutical compositions to treat disorders associated with null or inadequate expression of the genomic sequence.

Screening and Purification Assays

A protein or a portion thereof encoded by the cDNA may be used to screen a library or a plurality of molecules or compounds for a ligand with specific binding affinity or to purify a molecule or compound from a sample. The protein or portion thereof employed in such screening may be free in solution, affixed to an abiotic or biotic substrate, or located intracellularly. For example, viable or fixed prokaryotic host cells that are stably transformed with recombinant nucleic acids that have expressed and positioned a protein on their cell surface can be used in screening assays. The cells are screened against a library or a plurality of ligands and the specificity of binding or formation of complexes between the expressed protein and the ligand may be measured. The ligands may be DNA, RNA, or PNA molecules, agonists, antagonists, antibodies, immunoglobulins, inhibitors, peptides, pharmaceutical agents, proteins, drugs, or any other test molecule or compound that specifically binds the protein. An exemplary assay involves combining the mammalian protein or a portion thereof with the molecules or compounds under conditions that allow specific binding and detecting the bound protein to identify at least one ligand that specifically binds the protein.

This invention also contemplates the use of competitive drug screening assays in which neutralizing antibodies capable of binding the protein specifically compete with a test compound capable of binding to the protein or oligopeptide or fragment thereof. One method for high throughput screening using very small assay volumes and very small amounts of test compound is described in U.S. Pat. No. 5,876,946. Molecules or compounds identified by screening may be used in a model system to evaluate their toxicity, diagnostic, or therapeutic potential.

The protein may be used to purify a ligand from a sample. A method for using a protein to purify a ligand would involve combining the protein or a portion thereof with a sample under conditions to allow specific binding, recovering the bound protein, and using an appropriate chaotropic agent to separate the protein from the purified ligand.

Production of Antibodies

A protein encoded by a cDNA of the invention may be used to produce specific antibodies. Antibodies may be produced using an oligopeptide or a portion of the protein with inherent immunological activity. Methods for producing antibodies include: 1) injecting an animal, usually goats, rabbits, or mice, with the protein, or an antigenically-effective portion or an oligopeptide thereof, to induce an immune response; 2) engineering hybridomas to produce monoclonal antibodies; 3) inducing in vivo production in the lymphocyte population; or 4) screening libraries of recombinant immunoglobulins. Recombinant immunoglobulins may be produced as taught in U.S. Pat. No. 4,816,567.

Antibodies produced using the proteins of the invention are useful for the diagnosis of prepathologic disorders as well as the diagnosis of chronic or acute diseases characterized by abnormalities in the expression, amount, or distribution of the protein. A variety of protocols for competitive binding or immunoradiometric assays using either polyclonal or monoclonal antibodies specific for proteins are well known in the art. Immunoassays typically involve the formation of complexes between a protein and its specific binding molecule or compound and the measurement of complex formation. Immunoassays may employ a two-site, monoclonal-based assay that utilizes monoclonal antibodies reactive to two noninterfering epitopes on a specific protein or a competitive binding assay (Pound (1998) Immunochemical Protocols, Humana Press, Totowa N.J.).

Immunoassay procedures may be used to quantify expression of the protein in cell cultures, in subjects with a particular disorder or in model animal systems under various conditions. Increased or decreased production of proteins as monitored by immunoassay may contribute to knowledge of the cellular activities associated with developmental pathways, engineered conditions or diseases, or treatment efficacy. The quantity of a given protein in a given tissue may be determined by performing immunoassays on freeze-thawed detergent extracts of biological samples and comparing the slope of the binding curves to binding curves generated by purified protein.

Labeling of Molecules for Assay

A wide variety of reporter molecules and conjugation techniques are known by those skilled in the art and may be used in various cDNA, polynucleotide, protein, peptide or antibody assays. Synthesis of labeled molecules may be achieved using commercial kits for incorporation of a labeled nucleotide such as ³²P-dCTP, Cy3-dCTP or Cy5-dCTP or amino acid such as ³⁵S-methionine. Polynucleotides, cDNAs, proteins, or antibodies may be directly labeled with a reporter molecule by chemical conjugation to amines, thiols and other groups present in the molecules using reagents such as BIODIPY or FITC (Molecular Probes, Eugene Oreg.).

The proteins and antibodies may be labeled for purposes of assay by joining them, either covalently or noncovalently, with a reporter molecule that provides for a detectable signal. A wide variety of labels and conjugation techniques are known and have been reported in the scientific and patent literature including, but not limited to U.S. Pat. Nos. 3,817,837; 3,850,752; 3,939,350; 3,996,345; 4,277,437; 4,275,149; and 4,366,241.

Diagnostics

The cDNAs, or fragments thereof, may be used to detect and quantify differential gene expression; absence, presence, or excess expression of mRNAs; or to monitor mRNA levels during therapeutic intervention. Disorders associated with altered expression include liver disorders associated with steroid therapy such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease, and toxicological responses to treatment with steroids and steroid antagonists. These cDNAs can also be utilized as markers of treatment efficacy against the disorders noted above and other disorders, conditions, and diseases over a period ranging from several days to months. The diagnostic assay may use hybridization or amplification technology to compare gene expression in a biological sample from a patient to standard samples in order to detect altered gene expression. Qualitative or quantitative methods for this comparison are well known in the art.

For example, the cDNA may be labeled by standard methods and added to a biological sample from a patient under conditions for hybridization complex formation. After an incubation period, the sample is washed and the amount of label (or signal) associated with hybridization complexes is quantified and compared with a standard value. If the amount of label in the patient sample is significantly altered in comparison to the standard value, then the presence of the associated condition, disease or disorder is indicated.

In order to provide a basis for the diagnosis of a condition, disease or disorder associated with gene expression, a normal or standard expression profile is established. This may be accomplished by combining a biological sample taken from normal subjects, either animal or human, with a probe under conditions for hybridization or amplification. Standard hybridization may be quantified by comparing the values obtained using normal subjects with values from an experiment in which a known amount of a substantially purified target sequence is used. Standard values obtained in this manner may be compared with values obtained from samples from patients who are symptomatic for a particular condition, disease, or disorder. Deviation from standard values toward those associated with a particular condition is used to diagnose that condition.

Such assays may also be used to evaluate the efficacy of a particular therapeutic treatment regimen in animal studies and in clinical trial or to monitor the treatment of an individual patient. Once the presence of a condition is established and a treatment protocol is initiated, diagnostic assays may be repeated on a regular basis to determine if the level of expression in the patient begins to approximate that which is observed in a normal subject. The results obtained from successive assays may be used to show the efficacy of treatment over a period ranging from several days to months.

Gene Expression Profiles

A gene expression profile comprises a plurality of cDNAs and a plurality of detectable hybridization complexes, wherein each complex is formed by hybridization of one or more probes to one or more complementary sequences in a sample. The cDNAs of the invention are used as elements on a microarray to analyze gene expression profiles. In one embodiment, the microarray is used to monitor the progression of disease. Researchers can assess and catalog the differences in gene expression between healthy and diseased tissues or cells. By analyzing changes in patterns of gene expression, disease can be diagnosed at earlier stages before the patient is symptomatic. The invention can be used to formulate a prognosis and to design a treatment regimen. The invention can also be used to monitor the efficacy of treatment. For treatments with known side effects, the microarray is employed to improve the treatment regimen. A dosage is established that causes a change in genetic expression patterns indicative of successful treatment. Expression patterns associated with the onset of undesirable side effects are avoided. This approach may be more sensitive and rapid than waiting for the patient to show inadequate improvement, or to manifest side effects, before altering the course of treatment.

In another embodiment, animal models which mimic a human disease can be used to characterize expression profiles associated with a particular condition, disorder or disease; or treatment of the condition, disorder or disease. Novel treatment regimens may be tested in these animal models using microarrays to establish and then follow expression profiles over time. In addition, microarrays may be used with cell cultures or tissues removed from animal models to rapidly screen large numbers of candidate drug molecules, looking for ones that produce an expression profile similar to those of known therapeutic drugs, with the expectation that molecules with the same expression profile will likely have similar therapeutic effects. Thus, the invention provides the means to rapidly determine the molecular mode of action of a drug.

Assays Using Antibodies

Antibodies directed against epitopes on a protein encoded by a cDNA of the invention may be used in assays to quantify the amount of protein found in a particular human cell. Such assays include methods utilizing the antibody and a label to detect expression level under normal or disease conditions. The antibodies may be used with or without modification, and labeled by joining them, either covalently or noncovalently, with a labeling moiety.

Protocols for detecting and measuring protein expression using either polyclonal or monoclonal antibodies are well known in the art. Examples include ELISA, RIA, and fluorescent activated cell sorting (FACS). Such immunoassays typically involve the formation of complexes between the protein and its specific antibody and the measurement of such complexes. These and other assays are described in Pound (supra). The method may employ a two-site, monoclonal-based immunoassay utilizing monoclonal antibodies reactive to two non-interfering epitopes, or a competitive binding assay. (See, e.g., Coligan et al. (1997) Current Protocols in Immunology, Wiley-Interscience, New York N.Y.; Pound, supra)

Therapeutics

The cDNAs and fragments thereof can be used in gene therapy. cDNAs can be delivered ex vivo to target cells, such as cells of bone marrow. Once stable integration and transcription and or translation are confirmed, the bone marrow may be reintroduced into the subject. Expression of the protein encoded by the cDNA may correct a disorder associated with mutation of a normal sequence, reduction or loss of an endogenous target protein, or overepression of an endogenous or mutant protein. Alternatively, cDNAs may be delivered in vivo using vectors such as retrovirus, adenovirus, adeno-associated virus, herpes simplex virus, and bacterial plasmids. Non-viral methods of gene delivery include cationic liposomes, polylysine conjugates, artificial viral envelopes, and direct injection of DNA (Anderson (1998) Nature 392:25-30; Dachs et al. (1997) Oncol Res 9:313-325; Chu et al. (1998) J Mol Med 76(3-4):184-192; Weiss et al. (1999) Cell Mol Life Sci 55(3):334-358; Agrawal (1996) Antisense Therapeutics, Humana Press, Totowa N.J.; and August et al. (1997) Gene Therapy (Advances in Pharmacology, Vol. 40), Academic Press, San Diego Calif.).

In addition, expression of a particular protein can be regulated through the specific binding of a fragment of a cDNA to a genomic sequence or an mRNA which encodes the protein or directs its transcription or translation. The cDNA can be modified or derivatized to any RNA-like or DNA-like material including peptide nucleic acids, branched nucleic acids, and the like. These sequences can be produced biologically by transforming an appropriate host cell with a vector containing the sequence of interest.

Molecules which regulate the activity of the cDNA or encoded protein are useful as therapeutics for liver disorders associated with steroid therapy such as adenomatosis, cholestasis, cirrhosis, hemangioma, Henoch-Schonlein purpura, hepatitis, hepatocellular and metastatic carcinomas, idiopathic thrombocytopenic purpura, porphyria, sarcoidosis, and Wilson disease, and for regulating metabolic and toxicological responses to treatment with steroids and steroid antagonists. Such molecules include agonists which increase the expression or activity of the polynucleotide or encoded protein, respectively; or antagonists which decrease expression or activity of the polynucleotide or encoded protein, respectively. In one aspect, an antibody which specifically binds the protein may be used directly as an antagonist or indirectly as a delivery mechanism for bringing a pharmaceutical agent to cells or tissues which express the protein.

Additionally, any of the proteins, or their ligands, or complementary nucleic acid sequences may be administered as pharmaceutical compositions or in combination with other appropriate therapeutic agents. Selection of the appropriate agents for use in combination therapy may be made by one of ordinary skill in the art, according to conventional pharmaceutical principles. The combination of therapeutic agents may act synergistically to affect the treatment or prevention of the conditions and disorders associated with an immune response. Using this approach, one may be able to achieve therapeutic efficacy with lower dosages of each agent, thus reducing the potential for adverse side effects. Further, the therapeutic agents may be combined with pharmaceutically-acceptable carriers including excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. Further details on techniques for formulation and administration used by doctors and pharmacists may be found in the latest edition of Remington's Pharmaceutical Sciences (Mack Publishing, Easton Pa.).

Model Systems

Animal models may be used as bioassays where they exhibit a phenotypic response similar to that of humans and where exposure conditions are relevant to human exposures. Mammals are the most common models, and most infectious agent, cancer, drug, and toxicity studies are performed on rodents such as rats or mice because of low cost, availability, lifespan, reproductive potential, and abundant reference literature. Inbred and outbred rodent strains provide a convenient model for investigation of the physiological consequences of underexpression or overexpression of genes of interest and for the development of methods for diagnosis and treatment of diseases. A mammal inbred to overexpress a particular gene (for example, secreted in milk) may also serve as a convenient source of the protein expressed by that gene.

Transgenic Animal Models

Transgenic rodents that overexpress or underexpress a gene of interest may be inbred and used to model human diseases or to test therapeutic or toxic agents. (See, e.g., U.S. Pat. Nos. 5,175,383 and 5,767,337.) In some cases, the introduced gene may be activated at a specific time in a specific tissue type during fetal or postnatal development. Expression of the transgene is monitored by analysis of phenotype, of tissue-specific mRNA expression, or of serum and tissue protein levels in transgenic animals before, during, and after challenge with experimental drug therapies.

Embryonic Stem Cells

Embryonic (ES) stem cells isolated from rodent embryos retain the potential to form embryonic tissues. When ES cells such as the mouse 129/SvJ cell line are placed in a blastocyst from the C57BL/6 mouse strain, they resume normal development and contribute to tissues of the live-born animal. ES cells are preferred for use in the creation of experimental knockout and knockin animals. The method for this process is well known in the art and the steps are: the cDNA is introduced into a vector, the vector is transformed into ES cells, transformed cells are identified and microinjected into mouse cell blastocysts, blastocysts are surgically transferred to pseudopregnant dams. The resulting chimeric progeny are genotyped and bred to produce heterozygous or homozygous strains.

Knockout Analysis

In gene knockout analysis, a region of a gene is enzymatically modified to include a non-natural intervening sequence such as the neomycin phosphotransferase gene (neo; Capecchi (1989) Science 244:1288-1292). The modified gene is transformed into cultured ES cells and integrates into the endogenous genome by homologous recombination. The inserted sequence disrupts transcription and translation of the endogenous gene.

Knockin Analysis

ES cells can be used to create knockin humanized animals or transgenic animal models of human diseases. With knockin technology, a region of a human gene is injected into animal ES cells, and the human sequence integrates into the animal cell genome. Transgenic progeny or inbred lines are studied and treated with potential pharmaceutical agents to obtain information on the progression and treatment of the analogous human condition.

As described herein, the uses of the cDNAs, provided in the Sequence Listing of this application, and their encoded proteins are exemplary of known techniques and are not intended to reflect any limitation on their use in any technique that would be known to the person of average skill in the art. Furthermore, the cDNAs provided in this application may be used in molecular biology techniques that have not yet been developed, provided the new techniques rely on properties of nucleotide sequences that are currently known to the person of ordinary skill in the art, e.g., the triplet genetic code, specific base pair interactions, and the like. Likewise, reference to a method may include combining more than one method for obtaining or assembling full length cDNA sequences that will be known to those skilled in the art. It is also to be understood that this invention is not limited to the particular methodology, protocols, and reagents described, as these may vary. It is also understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims. The examples below are provided to illustrate the subject invention and are not included for the purpose of limiting the invention.

EXAMPLES

I Construction of cDNA Libraries

RNA was purchased from Clontech Laboratories (Palo Alto Calif.) or isolated from various tissues. Some tissues were homogenized and lysed in guanidinium isothiocyanate, while others were homogenized and lysed in phenol or in a suitable mixture of denaturants, such as TRIZOL reagent (Life Technologies, Rockville Md.). The resulting lysates were centrifuged over CsCl cushions or extracted with chloroform. RNA was precipitated with either isopropanol or ethanol and sodium acetate, or by other routine methods.

Phenol extraction and precipitation of RNA were repeated as necessary to increase RNA purity. In most cases, RNA was treated with DNAse. For most libraries, poly(A) RNA was isolated using oligo d(T)-coupled paramagnetic particles (Promega), OLIGOTEX latex particles (Qiagen, Valencia Calif.), or an OLIGOTEX mRNA purification kit (Qiagen). Alternatively, poly(A) RNA was isolated directly from tissue lysates using other kits, including the POLY(A)PURE mRNA purification kit (Ambion, Austin Tex.).

In some cases, Stratagene (La Jolla Calif.) was provided with RNA and constructed the corresponding cDNA libraries. Otherwise, cDNA was synthesized and cDNA libraries were constructed with the UNIZAP vector system (Stratagene) or SUPERSCRIPT plasmid system (Life Technologies) using the recommended procedures or similar methods known in the art. (See Ausubel, supra, Units 5.1 through 6.6.) Reverse transcription was initiated using oligo d(T) or random primers. Synthetic oligonucleotide adapters were ligated to double stranded cDNA, and the cDNA was digested with the appropriate restriction enzyme or enzymes. For most libraries, the cDNA was size-selected (300-1000 bp) using SEPHACRYL S1000, SEPHAROSE CL2B, or SEPHAROSE CL4B column chromatography (APB) or preparative agarose gel electrophoresis. cDNAs were ligated into compatible restriction enzyme sites of the polylinker of the pBLUESCRIPT phagemid (Stratagene), pSPORT1 plasmid (Life Technologies), or pINCY plasmid (Incyte Genomics, Palo Alto Calif.). Recombinant plasmids were transformed into XL1-BLUE, XL1-BLUEMRF, or SOLR competent E. coli cells (Stratagene) or DH5α,

DH10B, or ELECTROMAX DH10B competent E. coli cells (Life Technologies).

In some cases, libraries were superinfected with a 5× excess of the helper phage, M13K07, according to the method of Vieira et al. (1987, Methods Enzymol. 153:3-11) and normalized or subtracted using a methodology adapted from Soares (1994, Proc Natl Acad Sci 91:9228-9232), Swaroop et al. (1991, Nucleic Acids Res 19:1954), and Bonaldo et al. (1996, Genome Research 6:791-806). The modified Soares normalization procedure was utilized to reduce the repetitive cloning of highly expressed high abundance cDNAs while maintaining the overall sequence complexity of the library. Modification included significantly longer hybridization times which allowed for increased gene discovery rates by biasing the normalized libraries toward those infrequently expressed low-abundance cDNAs which are poorly represented in a standard transcript image (Soares et al., supra).

II Isolation and Sequencing of cDNA Clones

Plasmids were recovered from host cells by in vivo excision using the UNIZAP vector system (Stratagene) or by cell lysis. Plasmids were purified using one of the following: the Magic or WIZARD MINIPREPS DNA purification system (Promega); the AGTC MINIPREP purification kit (Edge BioSystems, Gaithersburg Md.); the QIAWELL 8, QIAWELL 8 Plus, or QIAWELL 8 Ultra plasmid purification systems, or the REAL PREP 96 plasmid purification kit (Qiagen). Following precipitation, plasmids were resuspended in 0.1 ml of distilled water and stored, with or without lyophilization, at 4° C.

Alternatively, plasmid DNA was amplified from host cell lysates using direct link PCR in a high-throughput format (Rao (1994) Anal Biochem 216:1-14). Host cell lysis and thermal cycling steps were carried out in a single reaction mixture. Samples were processed and stored in 384-well plates, and the concentration of amplified plasmid DNA was quantified fluorometrically using PICOGREEN dye (Molecular Probes) and a FLUOROSKAN II fluorescence scanner (Labsystems Oy, Helsinki, Finland).

cDNA sequencing reactions were processed using standard methods or high-throughput instrumentation such as the ABI CATALYST 800 thermal cycler (Applied Biosystems) or the DNA ENGINE thermal cycler (MJ Research, Watertown Mich.) in conjunction with the HYDRA microdispenser (Robbins Scientific, Sunnyvale Calif.) or the MICROLAB 2200 system (Hamilton, Reno Nev). cDNA sequencing reactions were prepared using reagents provided by APB or supplied in ABI sequencing kits such as the ABI PRISM BIGDYE cycle sequencing kit (Applied Biosystems). Electrophoretic separation of cDNA sequencing reactions and detection of labeled cDNAs were carried out using the MEGABACE 1000 DNA sequencing system (APB); the ABI PRISM 373 or 377 sequencing systems (Applied Biosystems) in conjunction with standard ABI protocols and base calling software; or other sequence analysis systems known in the art. Reading frames within the cDNA sequences were identified using standard methods (reviewed in Ausubel, supra, Unit 7.7).

III Extension of cDNA Sequences

Nucleic acid sequences were extended using the cDNA clones and oligonucleotide primers. One primer was synthesized to initiate 5′ extension of the known fragment, and the other, to initiate 3′ extension of the known fragment. The initial primers were designed using OLIGO primer analysis software (Molecular Biology Insights, Cascade Colo.), or another appropriate program, to be about 22 to 30 nucleotides in length, to have a GC content of about 50% or more, and to anneal to the target sequence at temperatures of about 68° C. to about 72° C. Any stretch of nucleotides which would result in hairpin structures and primer-primer dimerizations was avoided.

Selected human cDNA libraries were used to extend the sequence. If more than one extension was necessary or desired, additional or nested sets of primers were designed. Preferred libraries are ones that have been size-selected to include larger cDNAs. Also, random primed libraries are preferred because they will contain more sequences with the 5′ and upstream regions of genes. A randomly primed library is particularly useful if an oligo d(T) library does not yield a full-length cDNA.

High fidelity amplification was obtained by PCR using methods well known in the art. PCR was performed in 96-well plates using the DNA ENGINE thermal cycler (MJ Research). The reaction mix contained DNA template, 200 nmol of each primer, reaction buffer containing Mg²⁺, (NH₄)₂SO₄, and β-mercaptoethanol, Taq DNA polymerase (APB), ELONGASE enzyme (Life Technologies), and Pfu DNA polymerase (Stratagene), with the following parameters for primer pair PCI A and PCI B (Incyte Genomics): Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 60° C., 1 min; Step 4: 68° C., 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68° C., 5 min; Step 7: storage at 4° C. In the alternative, the parameters for primer pair T7 and SK+(Stratagene) were as follows: Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 57° C., 1 min; Step 4: 68° C., 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68° C., 5 min; Step 7: storage at 4° C.

The concentration of DNA in each well was determined by dispensing 100 μl PICOGREEN reagent (0.25% reagent in 1×TE, v/v; Molecular Probes) and 0.5 μl of undiluted PCR product into each well of an opaque fluorimeter plate (Corning Costar, Acton Mich.) and allowing the DNA to bind to the reagent. The plate was scanned in a FLUOROSKAN II (Labsystems Oy) to measure the fluorescence of the sample and to quantify the concentration of DNA. A 5 μl to 10 μl aliquot of the reaction mixture was analyzed by electrophoresis on a 1% agarose mini-gel to determine which reactions were successful in extending the sequence.

The extended nucleic acids were desalted and concentrated, transferred to 384-well plates, digested with CviJI cholera virus endonuclease (Molecular Biology Research, Madison Wis.), and sonicated or sheared prior to religation into pUC18 vector (APB). For shotgun sequencing, the digested nucleic acids were separated on low concentration (0.6 to 0.8%) agarose gels, fragments were excised, and agar digested with AGARACE enzyme (Promega). Extended clones were religated using T4 DNA ligase (New England Biolabs, Beverly Mich.) into pUC18 vector (APB), treated with Pfu DNA polymerase (Stratagene) to fill-in restriction site overhangs, and transformed into competent E. coli cells. Transformed cells were selected on antibiotic-containing media, and individual colonies were picked and cultured overnight at 37° C. in 384-well plates in LB/2×carbenicillin liquid media.

The cells were lysed, and DNA was amplified by PCR using Taq DNA polymerase (APB) and Pfu DNA polymerase (Stratagene) with the following parameters: Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 60° C., 1 min; Step 4: 72° C., 2 min; Step 5: steps 2, 3, and 4 repeated 29 times; Step 6: 72° C., 5 min; Step 7: storage at 4° C. DNA was quantified using PICOGREEN reagent (Molecular Probes) as described above. Samples with low DNA recoveries were reamplified using the same conditions described above. Samples were diluted with 20% dimethylsulfoxide (DMSO; 1:2, v/v), and sequenced using DYENAMIC energy transfer sequencing primers and the DYENAMIC DIRECT cycle sequencing kit (APB) or the ABI PRISM BIGDYE terminator cycle sequencing kit (Applied Biosystems).

IV Assembly and Analysis of Sequences

Component nucleotide sequences from chromatograms were subjected to PHRED analysis (Phil Green, University of Washington, Seattle Wash.) and assigned a quality score. The sequences having at least a required quality score were subject to various pre-processing algorithms to eliminate low quality 3′ ends, vector and linker sequences, polyA tails, Alu repeats, mitochondrial and ribosomal sequences, bacterial contamination sequences, and sequences smaller than 50 base pairs. Sequences were screened using the BLOCK 2 program (Incyte Genomics), a motif analysis program based on sequence information contained in the SWISS-PROT and PROSITE databases (Bairoch et al. (1997) Nucleic Acids Res 25:217-221; Attwood et al. (1997) J Chem Inf Comput Sci 37:417-424).

Processed sequences were subjected to assembly procedures in which the sequences were assigned to bins, one sequence per bin. Sequences in each bin were assembled to produce consensus sequences, templates. Subsequent new sequences were added to existing bins using BLAST (Altschul (supra); Altschul et al. (supra); Karlin et al. (1988) Proc Natl Acad Sci 85:841-845), BLASTn (vers.1.4, WashU), and CROSSMATCH software (Phil Green, supra). Candidate pairs were identified as all BLAST hits having a quality score greater than or equal to 150. Alignments of at least 82% local identity were accepted into the bin. The component sequences from each bin were assembled using PHRAP (Phil Green, supra). Bins with several overlapping component sequences were assembled using DEEP PHRAP (Phil Green, supra).

Bins were compared against each other, and those having local similarity of at least 82% were combined and reassembled. Reassembled bins having templates of insufficient overlap (less than 95% local identity) were re-split. Assembled templates were also subjected to analysis by STITCHER/EXON MAPPER algorithms which analyzed the probabilities of the presence of splice variants, alternatively spliced exons, splice junctions, differential expression of alternative spliced genes across tissue types, disease states, and the like. These resulting bins were subjected to several rounds of the above assembly procedures to generate the template sequences found in the LWESEQ GOLD database (Incyte Genomics).

The assembled templates were annotated using the following procedure. Template sequences were analyzed using BLASTn (vers. 2.0, NCBI) versus GBpri (GenBank vers. 117). “Hits” were defined as an exact match having from 95% local identity over 200 base pairs through 100% local identity over 100 base pairs, or a homolog match having an E-value equal to or greater than 1×10⁻⁸. (The “E-value” quantifies the statistical probability that a match between two sequences occurred by chance). The hits were subjected to frameshift FASTx versus GENPEPT (GenBank version 109). In this analysis, a homolog match was defined as having an E-value of 1×10⁻⁸. The assembly method used above was described in U.S. Ser. No. 09/276,534, filed Mar. 25, 1999, and the LIFESEQ GOLD user manual (Incyte Genomics).

Following assembly, template sequences were subjected to motif, BLAST, Hidden Markov Model (HMM; Pearson and Lipman (1988) Proc Natl Acad Sci 85:2444-2448; Smith and Waterman (1981) J Mol Biol 147:195-197), and functional analyses, and categorized in protein hierarchies using methods described in U.S. Ser. No. 08/812,290, filed Mar. 6, 1997; U.S. Ser. No. 08/947,845, filed Oct. 9, 1997; U.S. Pat. No. 5,953,727; and U.S. Ser. No. 09/034,807, filed Mar. 4, 1998. Template sequences may be further queried against public databases such as the GenBank rodent, mammalian, vertebrate, eukaryote, prokaryote, and human EST databases.

V Selection of Sequences, Microarray Preparation and Use

Incyte clones represent template sequences derived from the LWESEQ GOLD assembled human sequence database (Incyte Genomics). In cases where more than one clone was available for a particular template, the 5′-most clone in the template was used on the microarray. The HUMAN GENOME GEM series 1-4 microarrays (Incyte Genomics) contain 28,626 array elements which represent 10,068 annotated clusters and 18,558 unannotated clusters. For the UNIGEM series microarrays (Incyte Genomics), Incyte clones were mapped to non-redundant Unigene clusters (Unigene database (build 46), NCBI; Shuler (1997) J Mol Med 75:694-698), and the 5′ clone with the strongest BLAST alignment (at least 90% identity and 100 bp overlap) was chosen, verified, and used in the construction of the microarray. The UNIGEM V microarray (Incyte Genomics) contains 7075 array elements which represent 4610 annotated genes and 2,184 unannotated clusters. Table 1 shows the GenBank annotations for the polynucleotide sequences selected from SEQ ID NOs: 1-1143 of this invention as produced by BLAST analysis.

To construct microarrays, cDNAs were amplified from bacterial cells using primers complementary to vector sequences flanking the cDNA insert. Thirty cycles of PCR increased the initial quantity of cDNAs from 1-2 ng to a final quantity greater than 5 μg. Amplified cDNAs were then purified using SEPHACRYL-400 columns (APB). Purified cDNAs were immobilized on polymer-coated glass slides. Glass microscope slides (Corning, Corning N.Y.) were cleaned by ultrasound in 0.1% SDS and acetone, with extensive distilled water washes between and after treatments. Glass slides were etched in 4% hydrofluoric acid (VWR Scientific Products, West Chester Pa.), washed thoroughly in distilled water, and coated with 0.05% aminopropyl silane (Sigma Aldrich) in 95% ethanol. Coated slides were cured in a 110° C. oven. cDNAs were applied to the coated glass substrate using a procedure described in U.S. Pat. No. 5,807,522. One microliter of the cDNA at an average concentration of 100 ng/μl was loaded into the open capillary printing element by a high-speed robotic apparatus which then deposited about 5 nl of cDNA per slide.

Microarrays were UV-crosslinked using a STRATALINKER UV-crosslinker (Stratagene), and then washed at room temperature once in 0.2% SDS and three times in distilled water. Non-specific binding sites were blocked by incubation of microarrays in 0.2% casein in phosphate buffered saline (Tropix, Bedford Mich.) for 30 minutes at 60° C. followed by washes in 0.2% SDS and distilled water as before.

VI Preparation of Samples

Steroid Treatment of Human Liver C3A Cells

Early confluent C3A cells were treated with mifepristone, progesterone, beclomethasone, medroxyprogesterone, budesonide, prednisone, dexamethasone, betamethasone, or danazol at concentrations of 1 μM, 10 μM, and 100 μM for 1, 3, and 6 hours. In all cases, mRNA from untreated early confluent C3A cells were prepared in parallel as described below.

Isolation and Labeling of Sample cDNAs

Cells were harvested and lysed in 1 ml of TRIZOL reagent (5×10⁶ cells/ml; Life Technologies). Lysates were vortexed thoroughly, incubated at room temperature for 2-3 minutes, and extracted with 0.5 ml chloroform. The extract was mixed, incubated at room temperature for 5 minutes, and centrifuged at 15,000 rpm for 15 minutes at 4° C. The aqueous layer was collected, and an equal volume of isopropanol was added. Samples were mixed, incubated at room temperature for 10 minutes, and centrifuged at 15,000 rpm for 20 minutes at 4° C. The supernatant was removed, and the RNA pellet was washed with 1 ml of 70% ethanol, centrifuged at 15,000 rpm at 4° C., and resuspended in RNAse-free water. The concentration of the RNA was determined by measuring the optical density at 260 nm.

Poly(A) RNA was prepared using an OLIGOTEX mRNA kit (Qiagen) with the following modifications: OLIGOTEX beads were washed in tubes instead of on spin columns, resuspended in elution buffer, and then loaded onto spin columns to recover mRNA. To obtain maximum yield, the mRNA was eluted twice.

Each poly(A) RNA sample was reverse transcribed using MMLV reverse-transcriptase, 0.05 pg/μl oligo-d(T) primer (21mer), 1× first strand buffer, 0.03 units/ul RNAse inhibitor, 500 uM dATP, 500 uM dGTP, 500 uM dTTP, 40 uM dCTP, and 40 uM either dCTP-Cy3 or dCTP-Cy5 (APB). The reverse transcription reaction was performed in a 25 ml volume containing 200 ng poly(A) RNA using the GEMBRIGHT kit (Incyte Genomics). Specific control poly(A) RNAs (YCFR06, YCFR45, YCFR67, YCFR85, YCFR43, YCFR22, YCFR23, YCFR25, YCFR44, YCFR26) were synthesized by in vitro transcription from non-coding yeast genomic DNA (W. Lei, unpublished). As quantitative controls, control mRNAs (YCFR06, YCFR45, YCFR67, and YCFR85) at 0.002 ng, 0.02 ng, 0.2 ng, and 2 ng were diluted into reverse transcription reaction at ratios of 1:100,000, 1:10,000, 1:1000, 1:100 (w/w) to sample mRNA, respectively. To sample differential expression patterns, control mRNAs (YCFR43, YCFR22, YCFR23, YCFR25, YCFR44, YCFR26) were diluted into reverse transcription reaction at ratios of 1:3, 3:1, 1:10, 10:1, 1:25, 25:1 (w/w) to sample mRNA. Reactions were incubated at 37° C. for 2 hr, treated with 2.5 ml of 0.5M sodium hydroxide, and incubated for 20 minutes at 85° C. to the stop the reaction and degrade the RNA.

cDNAs were purified using two successive CHROMA SPIN 30 gel filtration spin columns (Clontech). Cy3- and Cy5-labeled reaction samples were combined as described below and ethanol-precipitated using 1 ml of glycogen (1 mg/ml), 60 ml sodium acetate, and 300 ml of 100% ethanol. The cDNAs were then dried to completion using a SpeedVAC system (Savant Instruments, Holbrook N.Y.) and resuspended in 14 μl 5×SSC/0.2% SDS.

VII Hybridization and Detection

Hybridization reactions contained 9 μl of sample mixture containing 0.2 μg each of Cy3 and Cy5 labeled cDNA synthesis products in 5×SSC, 0.2% SDS hybridization buffer. The mixture was heated to 65° C. for 5 minutes and was aliquoted onto the microarray surface and covered with an 1.8 cm² coverslip. The microarrays were transferred to a waterproof chamber having a cavity just slightly larger than a microscope slide. The chamber was kept at 100% humidity internally by the addition of 140 μl of 5×SSC in a corner of the chamber. The chamber containing the microarrays was incubated for about 6.5 hours at 60° C. The microarrays were washed for 10 min at 45° C. in low stringency wash buffer (1×SSC, 0.1% SDS), three times for 10 minutes each at 45° C. in high stringency wash buffer (0.1×SSC), and dried.

Reporter-labeled hybridization complexes were detected with a microscope equipped with an Innova 70 mixed gas 10 W laser (Coherent, Santa Clara Calif.) capable of generating spectral lines at 488 nm for excitation of Cy3 and at 632 nm for excitation of Cy5. The excitation laser light was focused on the microarray using a 20× microscope objective (Nikon, Melville N.Y.). The slide containing the microarray was placed on a computer-controlled X-Y stage on the microscope and raster-scanned past the objective. The 1.8 cm×1.8 cm microarray used in the present example was scanned with a resolution of 20 micrometers.

In two separate scans, the mixed gas multiline laser excited the two fluorophores sequentially. Emitted light was split, based on wavelength, into two photomultiplier tube detectors (PMT R1477; Hamamatsu Photonics Systems, Bridgewater N.J.) corresponding to the two fluorophores. Appropriate filters positioned between the microarray and the photomultiplier tubes were used to filter the signals. The emission maxima of the fluorophores used were 565 nm for Cy3 and 650 nm for Cy5. Each microarray was typically scanned twice, one scan per fluorophore using the appropriate filters at the laser source, although the apparatus was capable of recording the spectra from both fluorophores simultaneously.

The sensitivity of the scans was calibrated using the signal intensity generated by a cDNA control species. Samples of the calibrating cDNA were separately labeled with the two fluorophores and identical amounts of each were added to the hybridization mixture. A specific location on the microarray contained a complementary DNA sequence, allowing the intensity of the signal at that location to be correlated with a weight ratio of hybridizing species of 1:100,000.

The output of the photomultiplier tube was digitized using a 12-bit RTI-835H analog-to-digital (A/D) conversion board (Analog Devices, Norwood, Mich.) installed in an IBM-compatible PC computer. The digitized data were displayed as an image where the signal intensity was mapped using a linear 20-color transformation to a pseudocolor scale ranging from blue (low signal) to red (high signal). The data was also analyzed quantitatively. Where two different fluorophores were excited and measured simultaneously, the data were first corrected for optical crosstalk (due to overlapping emission spectra) between the fluorophores using each fluorophore's emission spectrum.

A grid was superimposed over the fluorescence signal image such that the signal from each spot was centered in each element of the grid. The fluorescence signal within each element was then integrated to obtain a numerical value corresponding to the average intensity of the signal. The software used for signal analysis was the GEMTOOLS gene expression analysis program (Incyte Genomics). Significance was defined as signal to background ratio exceeding 2× and area hybridization exceeding 40%.

VIII Data Analysis and Results

Array elements that exhibited at least 2.5-fold change in expression at one or more time points, a signal intensity over 250 units, a signal-to-background ratio of at least 2.5, and an element spot size of at least 40% were identified as differentially expressed using the GEMTOOLS program (Incyte Genomics). Differential expression values were converted to log base 2 scale. The cDNAs that are differentially expressed are shown in Tables 1-14. Table 1 identifies upregulated and downregulated cDNAs. The cDNAs are identified by their SEQ ID NO and TEMPLATE ID, and by the description associated with at least a fragment of a polynucleotide found in GenBank. The descriptions were obtained using the sequences of the Sequence Listing and BLAST analysis. Tables 6-14 show differential expression values for each clone differentially regulated in the experiment.

An agglomerative cluster analysis was used to identify the typical response patterns and establish the relationships between the different gene expression profiles. Each gene measurement was first normalized by dividing the expression ratios by the maximum value for each time series. To emphasize the variation from one time point to the next, slopes were added to the expression vectors by taking the expression differences between consecutive time points. The Euclidean distance was used as a similarity measure for the expression responses.

The agglomerative algorithm employed constructs a dendrogram. Starting with N clusters each containing a single gene, at each step in the iteration the two closest clusters were merged into a larger cluster. The distance between clusters was defined as the distance between their average expression patterns. After N−1 steps all the data points were merged together. The clustering process defines a hierarchical tree. Genes were automatically assigned to a cluster by cutting the tree between the root and each gene branch with a set of 10 lines (“branch levels”) separated by fixed distances. The branch level cut-off forms a cluster. The tree was first ‘normalized’ so that each branch was at the same distance from the root. In order to preserve the distance between the closest genes, the tree was distorted at the branch furthest from the leaf. The number of branches intersecting at each branch level of the tree equals the number of clusters at that level.

IX Other Hybridization Technologies and Analyses

Other hybridization technologies utilize a variety of substrates such as nylon membranes, capillary tubes, etc. Arranging cDNAs on polymer coated slides is described in Example V; sample cDNA preparation and hybridization and analysis using polymer coated slides is described in examples VI and VII, respectively.

The cDNAs are applied to a membrane substrate by one of the following methods. A mixture of cDNAs is fractionated by gel electrophoresis and transferred to a nylon membrane by capillary transfer. Alternatively, the cDNAs are individually ligated to a vector and inserted into bacterial host cells to form a library. The cDNAs are then arranged on a substrate by one of the following methods. In the first method, bacterial cells containing individual clones are robotically picked and arranged on a nylon membrane. The membrane is placed on LB agar containing selective agent (carbenicillin, kanamycin, ampicillin, or chloramphenicol depending on the vector used) and incubated at 37° C. for 16 hr. The membrane is removed from the agar and consecutively placed colony side up in 10% SDS, denaturing solution (1.5 M NaCl, 0.5 M NaOH ), neutralizing solution (1.5 M NaCl, 1 M Tris, pH 8.0), and twice in 2×SSC for 10 min each. The membrane is then TV irradiated in a STRATALINKER UV-crosslinker (Stratagene).

In the second method, cDNAs are amplified from bacterial vectors by thirty cycles of PCR using primers complementary to vector sequences flanking the insert. PCR amplification increases a starting concentration of 1-2 ng nucleic acid to a final quantity greater than 5 μg. Amplified nucleic acids from about 400 bp to about 5000 bp in length are purified using SEPHACRYL-400 beads (APB). Purified nucleic acids are arranged on a nylon membrane manually or using a dot/slot blotting manifold and suction device and are immobilized by denaturation, neutralization, and UV irradiation as described above.

Hybridization probes derived from cDNAs of the Sequence Listing are employed for screening cDNAs, mRNAs, or genomic DNA in membrane-based hybridizations. Probes are prepared by diluting the cDNAs to a concentration of 40-50 ng in 45 μl TE buffer, denaturing by heating to 100° C. for five min and briefly centrifuging. The denatured cDNA is then added to a REDIPRIME tube (APB), gently mixed until blue color is evenly distributed, and briefly centrifuged. Five microliters of [³²P]dCTP is added to the tube, and the contents are incubated at 37° C. for 10 min. The labeling reaction is stopped by adding 5 μl of 0.2M EDTA, and probe is purified from unincorporated nucleotides using a PROBEQUANT G-50 microcolumn (APB). The purified probe is heated to 100° C. for five min and then snap cooled for two min on ice.

Membranes are pre-hybridized in hybridization solution containing 1% Sarkosyl and 1× high phosphate buffer (0.5 M NaCl, 0.1 M Na₂HPO₄, 5 mM EDTA, pH 7) at 55° C. for two hr. The probe, diluted in 15 ml fresh hybridization solution, is then added to the membrane. The membrane is hybridized with the probe at 55° C. for 16 hr. Following hybridization, the membrane is washed for 15 min at 25° C. in 1 mM Tris (pH 8.0), 1% Sarkosyl, and four times for 15 min each at 25° C. in 1 mM Tris (pH 8.0). To detect hybridization complexes, XOMAT-AR film (Eastman Kodak, Rochester N.Y.) is exposed to the membrane overnight at −70° C., developed, and examined.

X Further Characterization of Differentially Expressed cDNAs and Proteins

Clones were blasted against the LIFESEQ Gold 5.1 database (Incyte Genomics) and an Incyte template and its sequence variants were chosen for each clone. The template and variant sequences were blasted against GenBank database to acquire annotation. The nucleotide sequences were translated into amino acid sequence which was blasted against the GenPept and other protein databases to acquire annotation and characterization, i.e., structural motifs.

Percent sequence identity can be determined electronically for two or more amino acid or nucleic acid sequences using the MEGALIGN program (DNASTAR). The percent identity between two amino acid sequences is calculated by dividing the length of sequence A, minus the number of gap residues in sequence A, minus the number of gap residues in sequence B, into the sum of the residue matches between sequence A and sequence B, times one hundred. Gaps of low or of no homology between the two amino acid sequences are not included in determining percentage identity.

Sequences with conserved protein motifs may be searched using the BLOCKS search program. This program analyses sequence information contained in the Swiss-Prot and PROSITE databases and is useful for determining the classification of uncharacterized proteins translated from genomic or cDNA sequences (Bairoch et al.(supra); Attwood et al. (supra). PROSITE database is a useful source for identifying functional or structural domains that are not detected using motifs due to extreme sequence divergence. Using weight matrices, these domains are calibrated against the SWISS-PROT database to obtain a measure of the chance distribution of the matches.

The PRINTS database can be searched using the BLIMPS search program to obtain protein family “fingerprints”. The PRINTS database complements the PROSITE database by exploiting groups of conserved motifs within sequence alignments to build characteristic signatures of different protein families. For both BLOCKS and PRINTS analyses, the cutoff scores for local similarity were: >1300=strong, 1000-1300=suggestive; for global similarity were: p<exp−3; and for strength (degree of correlation) were: >1300=strong, 1000-1300=weak.

XI Expression of the Encoded Protein

Expression and purification of a protein encoded by a cDNA of the invention is achieved using bacterial or virus-based expression systems. For expression in bacteria, cDNA is subcloned into a vector containing an antibiotic resistance gene and an inducible promoter that directs high levels of cDNA transcription. Examples of such promoters include, but are not limited to, the trp-lac (tac) hybrid promoter and the T5 or T7 bacteriophage promoter in conjunction with the lac operator regulatory element. Recombinant vectors are transformed into bacterial hosts, such as BL21(DE3). Antibiotic resistant bacteria express the protein upon induction with IPTG. Expression in eukaryotic cells is achieved by infecting Spodoptera frugiperda (Sf9) insect cells with recombinant baculovirus, Autographica californica nuclear polyhedrosis virus. The polyhedrin gene of baculovinis is replaced with the cDNA by either homologous recombination or bacterial-mediated transposition involving transfer plasmid intermediates. Viral infectivity is maintained and the strong polyhedrin promoter drives high levels of transcription.

For ease of purification, the protein is synthesized as a fusion protein with glutathione-S-transferase (GST; APB) or a similar alternative such as FLAG. The fusion protein is purified on immobilized glutathione under conditions that maintain protein activity and antigenicity. After purification, the GST moiety is proteolytically cleaved from the protein with thrombin. A fusion protein with FLAG, an 8-amino acid peptide, is purified using commercially available monoclonal and polyclonal anti-FLAG antibodies (Eastman Kodak, Rochester N.Y.).

XII Production of Specific Antibodies

A denatured protein from a reverse phase HPLC separation is obtained in quantities up to 75 mg. This denatured protein is used to immunize mice or rabbits following standard protocols. About 100 μg is used to immunize a mouse, while up to 1 mg is used to immunize a rabbit. The denatured protein is radioiodinated and incubated with murine B-cell hybridomas to screen for monoclonal antibodies. About 20 mg of protein is sufficient for labeling and screening several thousand clones.

In another approach, the amino acid sequence translated from a cDNA of the invention is analyzed using PROTEAN software (DNASTAR) to determine regions of high antigenicity, essentially antigenically-effective epitopes of the protein. The optimal sequences for immunization are usually at the C-terminus, the N-terminus, and those intervening, hydrophilic regions of the protein that are likely to be exposed to the external environment when the protein is in its natural conformation. Typically, oligopeptides about 15 residues in length are synthesized using an ABI 431 peptide synthesizer (Applied Biosystems) using Fmoc-chemistry and then coupled to keyhole limpet hemocyanin (KLH; Sigma Aldrich) by reaction with M-maleimidobenzoyl-N-hydroxysuccinimide ester. If necessary, a cysteine may be introduced at the N-terminus of the peptide to permit coupling to KLH. Rabbits are immunized with the oligopeptide-KLH complex in complete Freund's adjuvant. The resulting antisera are tested for antipeptide activity by binding the peptide to plastic, blocking with 1% BSA, reacting with rabbit antisera, washing, and reacting with radioiodinated goat anti-rabbit IgG.

Hybridomas are prepared and screened using standard techniques. Hybridomas of interest are detected by screening with radioiodinated protein to identify those fusions producing a monoclonal antibody specific for the protein. In a typical protocol, wells of 96 well plates (FAST, Becton-Dickinson, Palo Alto Calif.) are coated with affinity-purified, specific rabbit-anti-mouse (or suitable anti-species Ig) antibodies at 10 mg/ml. The coated wells are blocked with 1% BSA and washed and exposed to supernatants from hybridomas. After incubation, the wells are exposed to radiolabeled protein at 1 mg/ml. Clones producing antibodies bind a quantity of labeled protein that is detectable above background.

Such clones are expanded and subjected to 2 cycles of cloning at 1 cell/3 wells. Cloned hybridomas are injected into pristane-treated mice to produce ascites, and monoclonal antibody is purified from the ascitic fluid by affinity chromatography on protein A (APB). Monoclonal antibodies with affinities of at least 10⁸ M⁻¹, preferably 10⁹ to 10¹⁰ M⁻¹ or stronger, are made by procedures well known in the art.

XIII Purification of Naturally Occurring Protein Using Specific Antibodies

Naturally occurring or recombinant protein is substantially purified by immunoaffinity chromatography using antibodies specific for the protein. An immunoaffinity column is constructed by covalently coupling the antibody to CNBr-activated SEPHAROSE resin (APB). Media containing the protein is passed over the immunoaffinity column, and the column is washed using high ionic strength buffers in the presence of detergent to allow preferential absorbance of the protein. After coupling, the protein is eluted from the column using a buffer of pH 2-3 or a high concentration of urea or thiocyanate ion to disrupt antibody/protein binding, and the protein is collected.

XIV Screening Molecules for Specific Binding with the cDNA or Protein

The cDNA or fragments thereof and the protein or portions thereof are labeled with ³²P-dCTP, Cy3-dCTP, Cy5-dCTP (APB), or BIODIPY or FITC (Molecular Probes), respectively. Candidate molecules or compounds previously arranged on a substrate are incubated in the presence of labeled nucleic or amino acid. After incubation under conditions for either a cDNA or a protein, the substrate is washed, and any position on the substrate retaining label, which indicates specific binding or complex formation, is assayed. The binding molecule is identified by its arrayed position on the substrate. Data obtained using different concentrations of the nucleic acid or protein are used to calculate affinity between the labeled nucleic acid or protein and the bound molecule. High throughput screening using very small assay volumes and very small amounts of test compound is fully described in Burbaum et al. U.S. Pat. No. 5,876,946.

All patents and publications mentioned in the specification are incorporated herein by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention that are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims.

TABLE 1 SEQ ID NO Template ID GenBank ID E-Value Annotation 1 230040.1 g1032587 0 Human CpG island DNA genomic Mse1 fragment, clone 25g3, forward read 2 175138.1 3 1863336CB1 g177109 0 Human leucine-rich protein mRNA, complete 4 1863336CD1 g177109 0 Human leucine-rich protein mRNA, complete 5 343861.16 g5262661 0 Human mRNA; cDNA DKFZp434O071 (from clone DKFZp434O071). 6 3170236CB1 g6318544 0 retinal short-chain dehydrogenase/reductase retSDR2 7 3170236CD1 g6318544 0 retinal short-chain dehydrogenase/reductase retSDR2 8 259805.54 g6979641 0 Human alpha gene sequence. 9 1460258CB1 g1658462 0 Human isopeptidase T-3 (ISOT-3) mRNA, complete cds. 10 1460258CD1 g1658462 0 Human isopeptidase T-3 (ISOT-3) mRNA, complete cds. 11 1016903.1 g179501 0 Human bone morphogenetic protein 2A (BMP-2A) mRNA. 12 65385.7 g1694632 2.00E-70 Human mRNA for nonhepatic arginase, complete cds. 13 3714.1 g220051 0 Human RCC1 gene, exons 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, complete cds. 14 1720920CB1 g1617313 0 Human mRNA for melanoma-associated chondroitin sulfate proteoglycan (MCSP). 15 1720920CD1 g1617313 0 Human mRNA for melanoma-associated chondroitin sulfate proteoglycan (MCSP). 16 256009.48 g178280 0 Human AHNAK nucleoprotein mRNA, 5′ end. 17 1055233.1 18 2114865CB1 g177808 0 Human alpha-1-antichymotrypsin (AACT) mRNA, complete cds. 19 2114865CD1 g177808 0 Human alpha-1-antichymotrypsin (AACT) mRNA, complete cds. 20 1383740.1 g3342399 1.00E-08 Human mineralocorticoid receptor (MLR), 21 2700132CB1 g415818 0 Human mki67a mRNA (long type) for antigen of monoclonal antibody Ki-67. 22 2700132CD1 g415818 0 Human mki67a mRNA (long type) for antigen of monoclonal antibody KI-67. 23 231621.1 24 216485.1 25 406004.2 g1296799 8.00E-16 Human TPR gene (1365bp). 26 1399930.1 g7768702 8.00E-10 Human genomic DNA, chromosome 21q, section 36/105. 27 414171.33 g5689564 0 Human mRNA for KIAA1114 protein, 28 230895.1 g5630076 0 N-acetylgalactosaminyltransferase; similar to Q10473 (PID:g1709559) 29 22827.1 g7302960 4.00E-45 fidipidine gene product 30 346663.6 g4582689 3.00E-94 connexin 57 31 96422.1 32 405833.1 33 995839.2 g37120 0 Human mRNA for metallothionein from cadmium-treated cells. 34 2517374CB1 g24444 0 Human mRNA for alpha1-acid glycoprotein (orosomucoid). 35 2517374CD1 g24444 0 Human mRNA for alpha1-acid glycoprotein (orosomucoid). 36 1255456CB1 g30371 0 Human mRNA for cysteine protease inhibitor precursor cystatin C. 37 1255456CD1 g30371 0 Human mRNA for cysteine protease inhibitor precursor cystatin C. 38 3084.1 g1212991 2.00E-41 Human mRNA for titin protein (clone hh1- 39 302123.12 g7243188 5.00E-50 Human mRNA for KIAA1404 protein, partial 40 533825CB1 g3041881 0 LNXp70 41 533825CD1 g3041881 0 LNXp70 42 220845.2 g190029 4.00E-83 Human L-plastin polypeptide mRNA, complete cds, clone p107. 43 985475.8 g2982672 0 Human mRNA for p27, complete cds. 44 198309.7 g7023447 0 Human cDNA FLJ11034 fis, clone 45 1382869.18 g337452 0 Human hnRNP B1 protein mRNA. 46 1382869.1 g337452 0 Human hnRNP B1 protein mRNA. 47 352049.1 g671734 3.00E-84 Human DNA, pseudoautosomal boundary- like sequence PABL2. 48 215990.2 g1420919 0 Human fetal brain oculocerebrorenal syndrome (OCRL1) mRNA, complete cds. 49 428335.59 g339646 0 Human thyroid hormone binding protein (p55) mRNA, complete cds. 50 1561192CB1 g1107697 0 Human mRNA for GAIP protein. 51 1561192CD1 g1107697 0 Human mRNA for GAIP protein. 52 1330151.46 g28596 0 Human fibroblast mRNA for aldolase A. 53 1330151.49 g178350 0 Human aldolase A mRNA, complete cds. 54 404028.1 55 996427.2 g179892 0 Human cAMP phosphodiesterase PDE7 (PDE7A1) mRNA, complete cds. 56 21971.1 g1302657 1.00E-13 Human Xq28 genomic DNA In the region of the L1CAM locus containing the genes for neural cell adhesion molecule L1 (L1CAM), arginine-vasopressin receptor (AVPR2), C1 p115 (C1), ARD1 N-acetyltransferase related protein (TE2), renin-binding protein (RbP), ho 57 215205.1 58 400650.3 59 344524.1 g4769007 0 Human ring finger protein BAP-1 mRNA, complete cds. 60 196709.1 61 37502.4 g3419877 0 Human mRNA for MDC3, complete cds. 62 235687.5 g7020304 0 Human cDNA FLJ20301 fis, clone HEP06569. 63 085596CB1 g184391 0 Human histidine-rich glycoprotein mRNA, complete cds. 64 085596CD1 g184391 0 Human histidine-rich glycoprotein mRNA, complete cds. 65 234811.3 g2330874 1.00E-12 hypothetical protein 66 3393396CB1 g29471 0 Human mRNA for B-myb gene. 67 3393396CD1 g29471 0 Human mRNA for B-myb gene. 68 978439.4 g4500094 0 Human mRNA; cDNA DKFZp564D156 (from clone DKFZp564D156). 69 11390.1 70 1382924.42 g388031 0 Human ribosomal protein L11 mRNA, complete cds. 71 1256895CB1 g2618612 0 Human mRNA for prion protein, complete 72 1256895CD1 g2618612 0 Human mRNA for prion protein, complete 73 11115.1 74 291267.1 g6900101 0 Human mRNA for myeloid DAP12-associating lectin (MDL-1 gene). 75 3125723CB1 g2645430 0 Human CHD2 mRNA, complete cds. 76 3125723CD1 g2645430 0 Human CHD2 mRNA, complete cds. 77 980593.1 g1663705 0 Human mRNA for KIAA0244 gene. partial cds. 78 980593.6 g1663705 0 Human mRNA for KIAA0244 gene. partial cds. 79 410739.1 g7020036 8.00E-26 Human cDNA FLJ20135 fis, clone COL06818. 80 405773.2 g6850949 1.00E-41 dJ202121.4 (novel protein similar to dynein beta heavy chain) 81 210871.1 82 20265.2 83 39840.1 84 088564CB1 g1778716 0 Human chemokine exodus-1 mRNA, 85 088564CD1 g1778716 0 Human chemokine exodus-1 mRNA, 86 28889.1 87 410611.1 g8050709 1.00E-11 Human microsomal epoxide hydrolase (EPHX1) gene, complete cds. 88 212533.1 89 24081.12 g5630079 2.00E-29 similar to zinc finger proteins: similar to AAC01956 (PID:g2843171) 90 983961.1 91 1383290.2 g433415 0 Human mRNA for DNA-binding protein, TAXREB107, complete cds. 92 337221.11 g7020432 0 Human cDNA FLJ20374 fis, clone HUV00348. 93 290344.1 g1353781 0 Human dystrophin-related protein 2 (DRP2) mRNA, complete cds. 94 290344.3 95 222714.1 96 2230.1 97 34424.1 98 153237.1 99 272843.14 g409404 0 Human SREBP-1 mRNA, complete cds. 100 234729.3 g6731234 0 Human myoferlin (MYOF) mRNA, complete 101 349647.1 g8272454 6.00E-09 Human genomic DNA, clone:#7. 102 236457.1 103 230193.1 104 213429.1 105 5124.22 106 88974.2 g7291566 0.001 CG3493 gene product 107 903909.1 g2443342 2.00E-07 alpha 2 type I collagen 108 196981.1 109 337888.3 g4240565 0 Human BAC526N18 neurexin III gene, partial 110 795.1 g6649102 2.00E-10 Human gonadotropin-regulated testicular 111 RNA helicase mRNA, complete cds. 3070147CB1 g6330145 0 Human mRNA for KIAA1159 protein, partial 112 3070147CD1 g6330145 0 Human mRNA for KIAA1159 protein, partial 113 20525.1 114 1382924.38 g6102909 0 Human mRNA: cDNA DKFZp434M1115 (from clone DKFZp434M1115); partial cds. 115 4349106CB1 g5353532 0 Human zinc finger transcription factor GKLF mRNA, complete cds. 116 4349106CD1 g5353532 0 Human zinc finger transcription factor GKLF mRNA, complete cds. 117 247185.1 g3483187 0 Human full length insert cDNA clone 118 197587.3 g1563884 0 Human fibroblast growth factor homologous factor 1 (FHF-1) mRNA, complete cds. 119 403872.1 g7020302 0 Human cDNA FLJ20300 fis, clone HEP06465. 120 900993.1 121 228511.1 g3874171 5.00E-29 weak similarity to microtubule associated proteins-cDNA EST EMBL:T01154 comes from this gene-cDNA EST EMBL:T02016 comes from this gene-cDNA EST EMBL:D34307 comes from this gene-cDNA EST EMBL:D37339 comes from this gene-cDNA EST 122 406975.2 g7768723 1.00E-29 Human genomic DNA, chromosome 21q, section 70/105. 123 200171.17 124 291155.1 125 1383047.1 g7768705 0 Human genomic DNA, chromosome 21q, section 41/105. 126 3230770CB1 g187460 0 Human mineralocorticoid receptor mRNA (hMR), complete cds. 127 3230770CD1 g187460 0 Human mineralocorticoid receptor mRNA (hMR), complete cds. 128 481453.1 g6143592 0 Human AP-2 gene for transcription factor AP- 129 216141.1 130 158318.1 131 408751.3 g3878837 0 Similarity to Rat TOAD_64 protein (PIR Acc. No. S49985) 132 998310.1 g3243117 8.00E-89 Human cyclin-dependent kinase inhibitor (CDKN2C) mRNA, complete cds. 133 1097471.1 134 983843.2 135 983843.1 136 985607.8 g6382019 0 Human mRNA for KIAA1204 protein, partial 137 152298.2 138 246336.2 g1552548 0 Human mRNA for rab geranylgeranyl transferase, beta-subunit. 139 246336.18 g1552548 0 Human mRNA for rab geranylgeranyl transferase, beta-subunit. 140 405126.1 141 253855.2 g3158350 0 Human acyl-CoA synthetase 4 (ACS4) mRNA, complete cds. 142 337187.1 143 932244CB1 g180065 0 Human thymocyte antigen CD1c mRNA, complete cds. 144 932244CD1 g180065 0 Human thymocyte antigen CD1c mRNA, complete cds. 145 160952.1 146 13343.1 147 399488.4 g7208437 0 Human long-chain 2-hydroxy acid oxidase HAOX2 (HAOX2) mRNA, complete cds. 148 399488.5 149 28048.1 g1432163 2.00E-72 Human LIM-kinase1 and alternatively spliced LIM-kinase1 (LIMK1) gene, complete cds. 150 237622.11 g7023263 0 Human cDNA FLJ10917 fis, clone OVARC1000321. 151 237622.6 g7023263 0 Human cDNA FLJ10917 fis, clone OVARC1000321. 152 26612.1 153 413806.9 g703109 0 Human thyroid receptor interactor (TRIP3) mRNA, 3′ end of cds. 154 162569.1 155 334116.1 g1504011 0 Human mRNA for KIAA0215 gene, complete 156 396837.1 157 406507.1 158 407612.1 g506335 0 Human gene for histamine H1-receptor, complete cds. 159 399501.1 g6013005 8.00E-86 Human mRNA for Rab5 GDP/GTP exchange factor homologue (Rabex5 gene). 160 1004517CB1 g189980 0 Human cAMP-dependent protein kinase subunit RII-beta mRNA, complete cds. 161 1004517CD1 g189980 0 Human cAMP-dependent protein kinase subunit RII-beta mRNA, complete cds. 162 199601.12 g189359 0 Human oncostatin M gene, exon 3. 163 232946.1 g4958922 2.00E-73 NADPH oxidoreductase homolog 164 988491CB1 g7959898 0 Human PRO2386 mRNA, partial cds. 165 988491CD1 g7959898 0 Human PRO2386 mRNA, partial cds. 166 199882.12 167 1674368CB1 g188675 0 Human mannose receptor mRNA, complete 168 1674368CD1 g188675 0 Human mannose receptor mRNA, complete 169 115268.8 g7020748 3.00E-91 Human cDNA FLJ20559 fis, clone KAT11917. 170 464689.54 g30257 0 Human CST3 gene for cystatin C. 171 222181.1 g1144296 0 Human orphan opio:d receptor mRNA, complete cds. 172 2951538CB1 g2668504 0 Human putative cyclin G1 interacting protein mRNA, complete cds. 173 2951538CD1 g2668504 0 Human putative cyclin G1 interacting protein mRNA, complete cds. 174 1087445.1 175 1079625.3 g32070 0 Human HF.10 gene mRNA. 176 1275616CB1 g190235 0 Human acidic ribosomal phosphoprotein P2 mRNA, complete cds. 177 1275616CD1 g190235 0 Human acidic ribosomal phosphoprotein P2 mRNA, complete cds. 178 228046.5 g3413917 0 Human mRNA for KIAA0478 protein, 179 1225513.1 g435674 0 Human MT-1l mRNA. 180 203438.2 g174924 2.00E-31 Human initiator Met-tRNA-i. 181 232849.13 g4589524 0 KIAA0940 protein 182 19598.1 183 411148.3 g3021408 0 Human mRNA for transducin (beta) like 1 184 444619.13 g188712 0 Human (clone 14VS) metallothionein-IG (MT1G) gene, complete cds. 185 1383714.1 186 1273641CB1 g861347 3.00E-09 C18A3.4 gene product 187 1273641CD1 g861347 3.00E-09 C18A3.4 gene product 188 403717.1 189 332165.8 190 1098877.1 g7959918 0 Human PR02640 mRNA, complete cds. 191 251867.2 g4100453 0 Human ER71 mRNA, partial cds. 192 5597.1 193 235356.1 g5531902 1.00E-06 sodium-dicarboxylate cotransporter 194 47593.1 195 995887.12 g1679673 0 Human Meis1-related protein 2 (MRG2), mRNA, partial cds. 196 245687.1 g1000493 6.00E-12 Human DNA for matrix attachment region. 197 1571349CB1 g6526362 0 Human mRNA for hMBF1beta, complete cds. 198 1571349CD1 g6526362 0 Human mRNA for hMBF1beta, complete cds. 199 336735.1 200 40322.1 g36035 0 Human rhoG mRNA for GTPase. 201 205542.2 g3366801 0 Human orphan G-protein-coupled receptor HG38 mRNA, complete cds. 202 1867417CB1 g292829 0 Human DNA topoisomerase II (top2) mRNA, complete cds. 203 1867417CD1 g292829 0 Human DNA topoisomerase II (top2) mRNA, complete cds. 204 402521.1 g1031335 0 Human CpG island DNA genomic Mse1 fragment, clone 153e2, reverse read 205 219537.2 206 219537.1 207 1041138.7 g2738512 0 Human candidate tumor suppressor pp32r1 (PP32R1) gene, complete cds. 208 49272.1 209 221433.21 g3875538 1.00E-05 similar to cuticle collagen 210 232386.18 g3142287 0 Human protein kinase C-binding protein RACK7 mRNA, partial cds. 211 2598244CB1 g3851170 0 Human Ste-20 related kinase SPAK mRNA, complete cds. 212 2598244CD1 g3851170 0 Human Ste-20 related kinase SPAK mRNA, complete cds. 213 2173757CB1 g3882322 0 Human mRNA for KIAA0801 protein, 214 2173757CD1 g3882322 0 Human mRNA for KIAA0801 protein, 215 1405844CB1 g180925 0 Human CO-029. 216 1405844CD1 g180925 0 Human CO-029. 217 1143377.5 g6691162 0 Human endoollgopeptidase A mRNA, partial 218 235147.1 g3153208 0 Human calumein (Calu) mRNA, complete 219 235147.2 g3153208 0 Human calumein (Calu) mRNA, complete 220 1099294.6 g36114 0 Human mRNA for ribosomal protein L26. 221 330927.1 222 50695.1 g7768699 2.00E-13 Human genomic DNA, chromosome 21q, section 31/105. 223 241234.1 g388031 0 Human ribosomal protein L11 mRNA, complete cds. 224 282397.77 g6683696 0 Human mRNA for KIAA0393 protein, partial 225 984009.2 g863023 0 Human high-mobility group phosphoprotein isoform I-C (HMGIC) mRNA, complete cds. 226 138709.5 g6031211 0 Human heat shock protein hsp40 homolog mRNA, complete cds. 227 998926.1 g7296138 5.00E-30 BcDNA:GH12144 gene product 228 1448817CB1 g183117 0 Human insulin-like growth factor binding protein mRNA, complete cds. 229 1448817CD1 g183117 0 Human insulin-like growth factor binding protein mRNA, complete cds. 230 332521.1 g7768716 2.00E-10 Human genomic DNA, chromosome 21q, section 59/105. 231 245136.4 g5001720 1.00E-99 odd-skipped related 1 protein 232 237485.3 g3360498 0 Human clone 24431 mRNA sequence. 233 350851.2 g413863 1.00E-25 Human A3 adenosine receptor mRNA, complete cds. 234 403794.3 235 227489.1 236 268110.1 237 268244.1 238 268253.1 239 270049.1 240 997142.1 g3893154 0 Human mRNA for ankyrin repeat protein, complete cds. 241 997080.1 g4753765 0 Human mRNA for UDP- 242 243369.1 g184021 3.00E-22 hexokinase 1 243 379571.7 g6634036 0 Human mRNA for KIAA0453 protein, partial 244 322303.15 g31431 0 Human fit mRNA for receptor-related tyrosine kinase. 245 232935.2 g632775 0 N-CAM=145 kda neural cell adhesion molecule (Human, small cell lung cancer cell line OS2-R, mRNA, 2960 nt). 246 1445507CB1 g2406564 0 Human nuclear VCP-like protein NVLp.2 (NVL.2) mRNA, complete cds. 247 1445507CD1 g2406564 0 Human nuclear VCP-like protein NVLp.2 (NVL.2) mRNA, complete cds. 248 69812.3 g309217 2.00E-40 Eps8 249 444648.12 g187542 0 Human metallothionein (MT)I-F gene, 250 25194.1 g7303944 0.0002 CG8073 gene product 251 1518310CB1 g4481752 0 Human connexin 26 (GJB2) mRNA, complete 252 1518310CD1 g4481752 0 Human connexin 26 (GJB2) mRNA, complete 253 241335.1 254 22651.1 g1088437 0 Human gene for vascular endothelial growth factor receptor, promoter and exon 1. 255 25911.1 g4406612 0 Human clone 25194 mRNA sequence. 256 336470.1 257 978673.2 g7023272 0 Human cDNA FLJ10922 fis, clone OVARC1000420. 258 54242.1 259 1823159CB1 g1378039 0 Human myotubularin (MTM1) mRNA 260 1823159CD1 g1378039 0 Human myotubularin (MTM1) mRNA, 261 20602.1 262 1090531.28 g6997359 0 Human clone L50 polyadenylated HERV LTR sequence and flanking cellular sequence, 263 399872.1 g7023004 5.00E-10 Human cDNA FLJ10770 fis, clone 264 229176.4 g603816 0 Human gene for glucosephosphate isomerase (exon 15, 16, 17 and 18). 265 229176.5 g189237 0 Human neuroleukin mRNA, complete cds. 266 124600CB1 g1203983 0 Human NAD+-dependent 15 hydroxyprostaglandin dehydrogenase 267 124600CD1 g1203983 0 Human NAD+-dependent 15 hydroxyprostaglandin dehydrogenase 268 994387.65 g6808190 0 Human mRNA: cDNA DKFZp434H2218 (from clone DKFZp434H2218). 269 201462.7 g4581462 4.00E-90 Human mRNA for MEMA protein. 270 991497.1 g6807964 0 Human mRNA; cDNA DKFZp434M092 (from clone DKFZp434M092). 271 347444.1 272 238660.5 g6624921 0 Human mRNA for DMBT1 protein 8kb transcript variant 1 (DMBT1/8kb.1). 273 404601.11 g3483442 0 Human full length insert cDNA clone YZ88E05. 274 1329936.3 g186803 0 Human tumor antigen (L6) mRNA, complete 275 370489.47 g183363 0 Human granulocyte-macrophage colony stimulating factor (GM-CSF) mRNA. 276 197185.2 g1209634 0 Human putative holocytochrome c-type synthetase mRNA, complete cds. 277 1822864CB1 g3647274 0 Human mRNA for matrilin-3. 278 1822864CD1 g3647274 0 Human mRNA for matrilin-3. 279 2258794CB1 g3327213 0 Human mRNA for KIAA0700 protein, partial 280 2258794CD1 g3327213 0 Human mRNA for KIAA0700 protein, partial 281 000506CB1 g2697102 0 Human heterogeneous nuclear ribonucleoprotein R mRNA, complete cds. 282 000506CD1 g2697102 0 Human heterogeneous nuclear ribonucleoprotein R mRNA, complete cds. 283 407263.1 g2565047 0 Human CAGF9 mRNA, partial cds. 284 1630551CB1 g30302 0 Human mRNA for cytochrome c1. 285 1630551CD1 g30302 0 Human mRNA for cytochrome c1. 286 2558815CB1 g1049218 0 Human gamma-aminobutyraldehyde dehydrogenase mRNA, complete cds. 287 2558815CD1 g1049218 0 Human gamma-aminobutyraldehyde dehydrogenase mRNA, complete cds. 288 347411.1 g4835382 5.00E-12 Human DNA, DLEC1 to ORCTL4 gene region, section 1/2 (DLEC1, ORCTL3, ORCTL4 genes, complete cds). 289 92230.2 g871428 1.00E-39 Hox-4.6 290 333989.1 291 333542.1 g809021 2.00E-49 Human mRNA for DGCR2. 292 2426210CB1 g3702688 0 Human mRNA for carbonyl reductase 3, complete cds. 293 2426210CD1 g3702688 0 Human mRNA for carbonyl reductase 3, complete cds. 294 476760.12 g3169829 1.00E-34 Human epithelial V-like antigen precursor (EVA) mRNA, complete cds. 295 064987CB1 g3327051 0 Human mRNA for KIAA0619 protein, 296 064987CD1 g3327051 0 Human mRNA for KIAA0619 protein, 297 8450.1 298 197652.3 g4156193 0 supported by GENSCAN prediction and spliced EST; similar to Z35641 (PlD:g3874821) and AI059600 (NID:g3333377) 299 248203.2 g7768678 0 Human genomic DNA, chromosome 21q, section 61/105. 300 2023351CB1 g7295793 0 CG17593 gene product 301 2023351CD1 g7295793 0 CG17593 gene product 302 228610.1 g1028003 3.00E-30 Human CpG island DNA genomic Mse1 fragment, clone 13g6, forward read 303 92268.1 g22599 1.00E-10 APG 304 16566.1 305 1329120.1 g7020677 1.00E-58 Human cDNA FLJ20517 fis, clone KAT10235. 306 898877.6 g4559297 0 Human silencing mediator of retinoic acid and thyroid hormone receptor extended isoform (SMRTE) mRNA, complete cds. 307 29490.1 308 2619838CB1 g2280483 0 Human mRNA for KIAA0372 gene, complete 309 2619838CD1 g2280483 0 Human mRNA for KIAA0372 gene, complete 310 369213.42 g306496 4.00E-45 Human antigen CD9 gene, exon 4. 311 3557818CB1 g306777 0 Human guanine nucleotide exchange factor mRNA, complete cds. 312 3557818CD1 g306777 0 Human guanine nucleotide exchange factor mRNA, complete cds. 313 001622CB1 g632971 0 Human clk3 mRNA, complete cds. 314 001622CD1 g632971 0 Human clk3 mRNA, complete cds. 315 223407.4 g7020909 0 Human cDNA FLJ20662 fis, clone KAIA804. 316 899334.1 g4691727 0 Human ARF GTPase-activating protein GIT2 (KIAA0148) mRNA, complete cds. 317 237299.13 g6102929 0 Human mRNA; cDNA DKFZp434M1827 (from clone DKFZp434M1827). 318 1149046.1 g6137021 0 Human mRNA: cDNA DKFZp566E034 (from clone DKFZp566E034); complete cds. 319 404011.3 g3218467 3.00E-20 putative phosphatase 320 3768043CB1 g2231998 0 Human meningioma-expressed antigen 6 (MEA6) mRNA, complete cds. 321 3768043CD1 g2231998 0 Human meningioma-expressed antigen 6 (MEA6) mRNA, complete cds. 322 39946.19 g1916671 0 Human meningioma-expressed antigen 11 (MEA11) mRNA, partial cds. 323 1723834CB1 g434752 0 Human mRNA for KIAA0030 gene, partial cds. 324 1723834CD1 g434752 0 Human mRNA for KIAA0030 gene, partial cds. 325 2551987CB1 g473948 0 Human mRNA for KIAA0116 gene, partial cds. 326 2551987CD1 g473948 0 Human mRNA for KIAA0116 gene, partial cds. 327 232772.13 g473948 0 Human mRNA for KIAA0116 gene, partial cds. 328 407451.3 g3169292 0 Human anti-Fas-induced apoptosis (TOSO) mRNA, complete cds. 329 1382931.2 g190231 0 Human acidic ribosomal phosphoprotein P0 mRNA, complete cds. 330 1382931.39 g190231 0 Human acidic ribosomal phosphoprotein P0 mRNA, complete cds. 331 411059.1 332 474862.8 g484101 4.00E-85 Human guanine nucleotide regulatory protein (tim1) mRNA, complete cds. 333 402366.1 g7959228 0 Human mRNA for KIAA1484 protein, partial 334 401532.3 g1764161 0 Human canalicular multispecific organic anion transporter (cMOAT) mRNA complete 335 401532.2 g1574997 0 Human canalicular multispecific organic anion transporter (cMOAT), gene, complete 336 407896.4 g3387952 0 Human clone 24527 mRNA sequence. 337 982625.1 g6329972 0 Human mRNA for KIAA1144 protein, partial 338 59947.1 339 902471.11 g1438934 0 Human SH3 domain-containing protein SH3P18 mRNA, complete cds. 340 442308.1 g3955193 0 Human homeodomain protein (Nkx2.2) gene, exon 2 and complete cds. 341 193755.1 g4808463 0 Human NDRF gene for neuroD-related factor, complete cds. 342 60957.1 343 5124.23 344 344166.2 g8347613 0 Human PNGase mRNA, partial cds. 345 1129157.1 g3288916 0 aortic carboxypeptidase-like protein ACLP 346 1804734CB1 g6606075 0 Human aquaporin 8 (AQP8) mRNA, 347 1804734CD1 g6606075 0 Human aquaporin 8 (AQP8) mRNA, 348 43646.7 g338243 0 Human synexin mRNA, complete cds. 349 43646.1 g338245 0 Human synexin mRNA, 3′ end. 350 4674640CB1 g7959864 0 Human PRO2032 mRNA, complete cds. 351 4674640CD1 g7959864 0 Human PRO2032 mRNA, complete cds. 352 25423.3 353 415378.3 g3882244 0 Human mRNA for KIAA0762 protein, partial 354 25685.3 355 400427.1 356 198008.8 g2916801 0 Human mRNA for AMP-activated protein kinase beta 2 subunit. 357 1825508CB1 g398710 0 Human mRNA for cystatin D. 358 1825508CD1 g398710 0 Human mRNA for cystatin D. 359 236957.9 g6482371 0 Human ASC mRNA, complete cds. 360 980807.1 361 1095192.1 g36417 0 Human mRNA for brain type 1 sodium channel alpha-subunit (SCN1A). 362 167559.1 363 1383286.12 g34508 0 Human, gene for Membrane cofactor 364 40790.1 365 53059.11 g7259242 4.00E-70 unnamed protein product 366 337156.2 g999212 0 PEPT 2=H+/peptide cotransporter (Human, kidney, mRNA Partial, 2685 nt). 367 349630.7 g414047 0 Human mRNA for variant hepatic nuclear factor 1 (vHNF1). 368 2125081CB1 g531819 0 Human B lymphocyte serine/threonine protein kinase mRNA, complete cds. 369 2125081CD1 g531819 0 Human B lymphocyte serine/threonine protein kinase mRNA complete cds. 370 1400574.1 g498721 4.00E-90 zinc finger protein 371 994430.15 g6807956 0 Human mRNA; cDNA DKFZp434J052 (from clone DKFZp434J052). 372 2631218CB1 g4886440 0 Human mRNA; cDNA DKFZp564O1716 (from clone DKFZp564O1716); complete cds. 373 2631218CD1 g4886440 0 Human mRNA; cDNA DKFZp564O1716 (from clone DKFZp564O1716); complete cds. 374 3688791CB1 g1770525 0 Human mRNA for SRcyp protein. 375 3688791CD1 g1770525 0 Human mRNA for SRcyp protein. 376 3283554CB1 g1173542 0 Human N-sulphoglucosamine sulfohydrolase mRNA, complete cds. 377 3283554CD1 g1173542 0 Human N-sulphoglucosamine sulfohydrolase mRNA, complete cds. 378 4960375CB1 g347313 0 Human hnRNP H mRNA, complete cds. 379 4960375CD1 g347313 0 Human hnRNP H mRNA, complete cds. 380 222956.22 381 222956.24 382 973308.1 g1215670 0 Human alpha-CP1 mRNA, complete cds. 383 238026.4 g8164036 0 Human vascular endothelial cadherin 2 mRNA, complete cds. 384 1094829.52 g220087 0 Human mRNA for DNA binding protein 385 1094829.54 g220087 0 Human mRNA for DNA binding protein 386 899802.1 g2463524 0 Human mRNA for CIS4, complete cds. 387 107569.15 g3360439 0 Human clone 23704 mRNA sequence. 388 236605.2 g2338034 2.00E-06 putative immediate early protein 389 2705321CB1 g3005697 0 Human clone 23831 aldolase C mRNA, complete cds. 390 2705321CD1 g3005697 0 Human clone 23831 aldolase C mRNA, complete cds. 391 383863.2 g3426297 0 Human HIC protein isoform p40 and HIC protein isoform p32 mRNAs, complete cds. 392 903491.4 g6688221 0 Human mRNA for TESS 2 protein (TESS 2 393 332755.5 g7243218 0 Human mRNA for KIAA1419 protein, partial 394 201694.5 g7303230 1.00E-13 CG13018 gene product 395 65367.1 396 199140.9 397 1088542.9 g1922290 0 Human gene encoding enoyl-CoA hydratase, exon 8. 398 233513.2 g854065 2.00E-23 U88 399 1330257.53 g6563245 0 Human matrin 3 mRNA, complete cds. 400 3676741CB1 g3882166 0 Human mRNA for KIAA0723 protein, 401 3676741CD1 g3882166 0 Human mRNA for KIAA0723 protein, 402 346636.6 403 1640555CB1 g1276898 0 Human limbic system-associated membrane protein LAMP mRNA, complete cds. 404 1640555CD1 g1276898 0 Human limbic system-associated membrane protein LAMP mRNA, complete cds. 405 199286.3 g6599264 8.00E-05 hypothetical protein 406 199286.2 g6599264 0.0002 hypothetical protein 407 474200.1 g7022530 0 Human cDNA FLJ10474 fis, clone 408 206397.1 g3719360 1.00E-34 Human CC chemokine gene cluster, complete sequence. 409 199584.1 g7582297 0 Human BM-013 mRNA complete cds. 410 401736.1 411 1100773.2 g6688198 0 Human mRNA for AMP-activated protein kinase gamma2 subunit (AMPK gamma2 412 167854.1 413 1693903CB1 g7689018 0 Human uncharacterized hypothalamus protein HT010 mRNA, complete cds. 414 1693903CD1 g7689018 0 Human uncharacterized hypothalamus protein HT010 mRNA, complete cds. 415 351432.23 g6672211 0 Human anion exchanger 2 (SLC4A2) gene, exons 17 to 23 and alternatively spliced products, complete cds. 416 1252096CB1 g399757 0 D10S102=FBRNP (Human, fetal brain, mRNA, 3043nt). 417 1252096CD1 g399757 0 D10S102=FBRNP (Human, fetal brain, mRNA, 3043nt). 418 2545475CB1 g7328161 0 Human mRNA; cDNA DKFZp762B2310 (from clone DKFZp762B2310); complete cds. 419 2545475CD1 g7328161 0 Human mRNA; cDNA DKFZp762B2310 (from clone DKFZp762B2310); complete cds. 420 1756951CB1 g7020528 0 Human cDNA FLJ20432 fis, clone KAT03764. 421 1756951CD1 g7020528 0 Human cDNA FLJ20432 fis, clone KAT03764. 422 220134.6 g1546096 0 Human hbc647 mRNA sequence. 423 220134.5 g1546096 0 Human hbc647 mRNA sequence. 424 202164.1 425 406846.4 g5262542 0 Human mRNA: cDNA DKFZp564G0222 (from clone DKFZp564G0222); complete cds. 426 2716815CB1 g6807723 0 Human mRNA; cDNA DKFZp434J1114 (from clone DKFZp434J1114); partial cds. 427 2716815CD1 g6807723 0 Human mRNA; cDNA DKFZp434J1114 (from clone DKFZp434J1114); partial cds. 428 222278.1 g4186183 1.00E-60 unknown 429 1273292CB1 g179103 0 Human mitochondrial aspartate aminotransferase mRNA, complete cds. 430 1273292CD1 g179103 0 Human mitochondrial aspartate aminotransferase mRNA, complete cds. 431 67855.1 g340123 4.00E-10 Human U4 RNA pseudogene U4/8. 432 27185.1 433 240057.2 g105019 0 Human mRNA for mitochondrial capsule selenoprotein. 434 17090.1 g7300213 7.00E-05 CG5225 gene product 435 17021.2 436 235682.5 437 399329.3 g4589654 2.00E-12 KIAA1005 protein 438 68862.1 439 8603.3 g7321169 3.00E-17 dJ860F19.4 (PUTATIVE novel protein) 440 337647,1 441 200268.3 g5911954 0 Human mRNA; cDNA DKFZp727M111 (from clone DKFZp727M111); partial cds. 442 168861CB1 g2662410 0 Human homeodomain-containing protein F-(HANF) mRNA, complete cds. 443 168861CD1 g2662410 0 Human homeodomain-containing protein (HANF) mRNA, complete cds. 444 334738.1 445 410042.1 g214042 6.00E-07 alpha-1 type II collagen 446 2026270CB1 g190725 0 Human parathyroid hormone-related protein mRNA, complete cds. 447 2026270CD1 g190725 0 Human parathyroid hormone-related protein mRNA, complete cds. 448 522433CB1 g2674084 0 Human macrophage inhibitory cytokine-1 (MIC-1) mRNA, complete cds. 449 522433CD1 g2674084 0 Human macrophage inhibitory cytokine-1 (MIC-1) mRNA, complete cds. 450 234987.1 451 1330257.32 g28338 5.00E-94 Human mRNA for cytoskeletal gamma-actin. 452 407023.1 g5689375 2.00E-91 tudor repeat associator with PCTAIRE 2 453 3117184CB1 g4050085 0 Human S164 gene, partial cds; PS1 and hypothetical protein genes, complete cds; and S171 gene, partial cds. 454 3117184CD1 g4050085 0 Human S164 gene, partial cds; PS1 and hypothetical protein genes, complete cds; and S171 gene, partial cds. 455 3105671CB1 g4008148 0 Human alpha-fetoprotein (AFP) mRNA, complete cds. 456 3105671CD1 g4008148 0 Human alpha-fetoprotein (AFP) mRNA, complete cds. 457 2051966CB1 g178856 0 Human apolipoprotein H mRNA, complete 458 2051966CD1 g178856 0 Human apolipoprotein H mRNA, complete 459 1969731CB1 g2344811 0 Human mRNA for Drg1 protein. 460 1969731CD1 g2344811 0 Human mRNA for Drg1 protein. 461 2171401CB1 g7021225 0 Human ERO1-like protein (ERO1-L) mRNA, complete cds. 462 2171401CD1 g7021225 0 Human ERO1-like protein (ERO1-L) mRNA, complete cds. 463 1326983.14 g7243144 0 Human mRNA for KIAA1382 protein, partial 464 339106.1 465 331666.1 466 1422432CB1 g36177 0 Human mRNA for calcium-binding protein 467 1422432CD1 g36177 0 Human mRNA for calcium-binding protein 468 409895.2 g36177 0 Human mRNA for calcium-binding protein 469 245136.9 g1480194 2.00E-23 Sob protein 470 2600262CB1 g896282 0 Human methionine adenosyltransferase alpha subunit gene fragment. 471 2600262CD1 g896282 0 Human methionine adenosyltransferase alpha subunit gene fragment. 472 70246.1 473 1086183.1 g4894364 8.00E-59 zinc finger protein 3 474 900070.12 g6599211 0 Human mRNA: cDNA DKFZp434E1515(from clone DKFZp434E1515). 475 231182.1 g1030904 0 Human CpG island DNA genomic Mse1 fragment, clone 119c10, reverse read 476 12417.1 477 237754.1 478 1256053CB1 g1917006 0 Human Fritz mRNA, complete cds. 479 1256053CD1 g1917006 0 Human Fritz mRNA, complete cds. 480 238391.3 481 201945.4 g6136944 0 Human mRNA for peptide methionine sulfoxide reductase (msrA gene). 482 235725.21 g2772828 0 Human TFAR19 mRNA, complete cds. 483 406031.5 g5006252 0 Human HGC6.4 mRNA, complete cds. 484 998941.1 g6684533 0 Human zinc finger transcription factor TRPS1 mRNA, complete cds. 485 243985.1 g7020286 0 Human cDNA FLJ20291 fis, clone HEP04788. 486 481779.1 g7020539 0 Human cDNA FLJ20438 fis, clone KAT04696, highly similar to HXC9_MOUSE HOMEOBOX PROTEIN HOX-C9. 487 982633.1 488 2120743CB1 489 2120743CD1 490 26914.1 491 199121.14 g6630617 0 Human mRNA for KIAA0021 protein, partial 492 1960207CB1 g337504 0 Human ribosomal protein S24 mRNA. 493 1960207CD1 g337504 0 Human ribosomal protein S24 mRNA. 494 391185.13 g5823553 0 Human cyclin L ania-6a mRNA, complete 495 206866.1 g1066121 0 Human hepatocyte nuclear factor-3 alpha (HNF-3 alpha) mRNA, complete cds. 496 1330257.51 g28338 0 Human mRNA for cytoskeletal gamma-actin. 497 983942.1 g5734709 3.00E-08 Contains PF | 100069 Eukaryotic protein kinase domain. 498 223416.15 g1171563 0 Human mRNA for metabotropic glutamate receptor type 3. 499 5876.1 500 303545.3 501 331571.1 502 2246292CB1 g7959306 0 Human mRNA for KIAA1520 protein, partial 503 2246292CD1 g7959306 0 Human mRNA for KIAA1520 protein, partial 504 411449.1 g5295993 0 Human SDHD gene for small subunit of cytochrome b of succinate dehydrogenase, complete cds. 505 409853.3 g4884218 0 Human mRNA; cDNA DKFZp564A072 (from clone DKFZp564A072). 506 6301537CB1 g2224718 0 Human mRNA for KIAA0389 gene, complete 507 6301537CD1 g2224718 0 Human mRNA for KIAA0389 gene, complete 508 1398801.9 g4884131 0 Human mRNA: cDNA DKFZp586F1019 (from clone DKFZp586F1019); partial cds. 509 1398801.5 g4884131 0 Human mRNA:cDNA DKFZp586F1019 (from clone DKFZp586F1019): partial cds. 510 14538.1 511 14007.1 512 239996.2 513 238403.2 g7959188 0 Human mRNA for KIAA1464 protein, partial 514 234681.2 g7416940 0 Human M5-14 mRNA, complete cds. 515 228678.1 516 233218.22 g291921 0 Human complement factor B mRNA, 517 233218.18 g452937 0 Human complement factor B mRNA, 518 6320.1 g34648 0 Human gene for class II invariant gamma- chain (exon 2-8). 519 15433.1 520 1600311CB1 g2708819 0 Human cytochrome oxidase subunit VIIa-H precursor (COX7AH) gene, nuclear gene encoding mitochondrial protein, complete 521 1600311CD1 g2708819 0 Human cytochrome oxidase subunit VIIa-H precursor (COX7AH) gene, nuclear gene encoding mitochondrial protein, complete 522 335999.1 g4218356 5.00E-44 Human chromosome 18 CpG island DNA, genomic Mse1 fragment, clone 18CGI1H14, 523 197523.6 g1480476 0 Human branched chain alpha-ketoacid dehydrogenase E1 beta subunit mRNA, complete cds. 524 12833.1 525 1080598.1 g7019944 0 Human cDNA FLJ20079 fis, clone COL03057. 526 2239738CB1 g5809681 0 Human carboxypeptidase M precursor, mRNA, partial cds. 527 2239738CD1 g5809681 0 Human carboxypeptidase M precursor, mRNA, partial cds. 528 87074.1 529 12039.1 530 1730175CB1 g2078517 0 Human neogenin mRNA, complete cds. 531 1730175CD1 g2078517 0 Human neogenin mRNA, complete cds. 532 6825202CB1 g2997736 0 Human cytochrome P450 mRNA, complete 533 6825202CD1 g2997736 0 Human cytochrome P450 mRNA, complete 534 25613.1 g3483886 0 Human full length insert cDNA clone ZE09G12. 535 3027821CB1 g6457339 0 Human E2IG3 (E2IG3) mRNA, complete cds. 536 3027821CD1 g6457339 0 Human E2IG3 (E2IG3) mRNA, complete cds. 537 480736.41 g6457339 0 Human E2IG3 (E2IG3) mRNA, complete cds. 538 236943.1 539 76636.1 540 76644.1 541 76699.1 542 238140.1 543 19080.2 g4500250 0 Human mRNA; cDNA DKFZp586F0922 (from clone DKFZp586F0922). 544 274444.1 545 279625.1 546 1330220.16 g3287488 0 Human Hsp89-alpha-delta-N mRNA, 547 99792.1 548 5147.1 g2665892 2.00E-33 kidney injury molecule-1 549 272599.1 550 238396.1 551 23904.1 g7717259 0 Human chromosome 21 segment HS21C010. 552 274712.1 g7243020 0 Human mRNA for KIAA1320 protein, partial 553 979567.11 g4704323 0 Human mRNA for ATPasell, complete cds. 554 234121.1 g7022325 1.00E-23 unnamed protein product 555 252493.15 g6453548 0 Human mRNA; cDNA DKFZp434J0828 (from clone DKFZp434J0828). 556 899766.1 557 247423.13 g5689540 0 Human mRNA for KIAA1102 protein, partial 558 334234.2 559 205672.1 560 1327024.5 g2564321 0 Human mRNA for KIAA0287 gene, parnal cds. 561 2925789CB1 g598573 3.00E-96 Human HepG2 3′ region cDNA, clone 562 2925789CD1 g598573 3.00E-96 Human HepG2 3′ region cDNA, clone 563 335613.1 564 207646.1 565 1720847CB1 g4218425 6.00E-11 Human pex3 gene joined cds, promoter and exon 1). 566 1720847CD1 g4218425 6.00E-11 Human pex3 gene (joined cds, promoter and exon 1). 567 2313349CB1 g1945364 0 Human copper transport protein HAH1 (HAH1) mRNA, complete cds. 568 2313349CD1 g1945364 0 Human copper transport protein HAH1 (HAH1) mRNA, complete cds. 569 107939.2 g4902677 0 Novel Human gene mapping to chomosome 13, similar to rat RhoGAP. 570 11540.1 571 78831.1 572 207778.1 573 296811.1 g7020093 0 Human cDNA FLJ20171 fis, clone COL09761. 574 333776.1 575 1859458CB1 g30292 0 Human mRNA for CTP synthetase (EC 6.3.4.2). 576 1859458CD1 g30292 0 Human mRNA for CTP synthetase (EC 6.3.4.2). 577 110960CB1 g4589543 0 Human mRNA for KIAA0590 protein, partial 578 110960CD1 g4589543 0 Human mRNA for KIAA0950 protein, partial 579 238602.2 g5262473 0 Human mRNA; cDNA DKFZp564J142 (from clone DKFZp564J142). 580 363007.1 581 3478236CB1 g179039 0 Human amphiregulin (AR) mRNA, complete cds, clones lambda-AR1 and lambda-AR2. 582 3478236CD1 g179039 0 Human amphiregulin (AR) mRNA, complete cds, clones lambda-AR1 and lambda-AR2. 583 2466714CB1 g3387950 0 Human clone 24674 mRNA sequence. 584 2466714CD1 g3387950 0 Human clone 24674 mRNA sequence. 585 4208.1 586 903475.2 g7292499 0.0001 CG15021 gene product 587 246037.28 g927070 0 Human thyroid receptor interactor (TRIP7) mRNA, 3′ end of cds. 588 337183.1 589 2651836CB1 g7021191 0 Human cDNA FLJ10005 fis, clone HEMBA1000156. 590 2651836CD1 g7021191 0 HumancDNAFLJ10005 fis. clone HEMBA1000156. 591 80339.1 592 480968.13 g4240302 0 Human mRNA for KIAA0907 protein, 593 337448.1 g5912019 0 Human mRNA; cDNA DKFZp434HO735 (from clone DKFZp434H0735); partial cds. 594 5360.1 595 998599.8 g2226003 2.00E-38 Human Tigger1 transposable element, complete consensus sequence. 596 332821.13 g6457581 0 Human epsilon-tubulin mRNA, complete cds. 597 344186.9 g4959227 0 Human regulator of G-protein signaling 7 (RGS7) mRNA, complete cds. 598 344186.12 g4959229 0 Human regulator of G-protein signaling 7b (RGS7) mRNA. parthal cds. 599 212489.1 600 80711.1 601 80787.1 602 334352.1 603 208376.1 604 7820.1 605 81447.1 606 81821.1 607 81869.1 608 210011.1 g7959150 0 Human mRNA for KIAA1446 protein, partial 609 480336.3 g2088550 0 Human hereditary haemochromatosis region. histone 2A-like protein gene, hereditary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds. 610 1024610.45 g7294995 5.00E-34 CG4942 gene product 611 82013.1 g7768717 8.00E-11 Human genomic DNA, chromosome 21q, section 60/105. 612 212155.1 g241541 0 cellular retinoic acid-binding protein (Human, skin, mRNA, 735 nt). 613 22632.1 g7144645 0 Human glutaredoxin-2 (GRX2) mRNA, complete cds. 614 2789525CB1 g3005586 0 Human Ser/Arg-related nuclear matrix protein (SRM160) mRNA, complete cds. 615 2789525CD1 g3005586 0 Human Ser/Arg-related nuclear matrix protein (SRM160) mRNA, complete cds. 616 1692213CB1 g5420452 0 Human mRNA for parvulin, complete cds. 617 1692213CD1 g5420452 0 Human mRNA for parvulin, complete cds. 618 15393.1 g7263958 4.00E-35 bA395L14.1 (novel forkhead protein similar to FOXD4 (forkhead box D4, FREAC5)) 619 001089CB1 g36141 0 Human mRNA for ribosomal protein (homologuous to Yeast S24). 620 001089CD1 g36141 0 Human mRNA for ribosomal protein (homologuous to Yeast S24). 621 002484CB1 g1256264 0 Human protein kinase C inhibitor (PKCI-1) mRNA, complete cds. 622 002484CD1 g1256264 0 Human protein kinase C inhibitor (PKCI-1) mRNA, complete cds. 623 669671CB1 g4092057 0 Human proteasome subunit HSPC mRNA, complete cds. 624 669671CD1 g4092057 0 Human proteasome subunit HSPC mRNA, complete cds. 625 1344185CB1 g189273 0 Human neuropeptide Y (NPY) mRNA, complete cds. 626 1344185CD1 g189273 0 Human neuropeptlde Y (NPY) mRNA, complete cds. 627 697785CB1 g187109 0 Human 14 kd lectin mRNA, complete cds. 628 697785CD1 g187109 0 Human 14 kd lectin mRNA, complete cds. 629 336435.2 g30495 0 Human mRNA for dopamine D2 receptor. 630 231558.1 g1032517 5.00E-69 Human CpG island DNA genomic Mse1 fragment, clone 21h9, reverse read 631 247784.3 g6624587 0 dJ570F3.1 (homolog of the rat synaptic ras GTPase-activating protein p135 SynGAP) 632 238322.6 g3005747 0 Human clone 24722 unknown mRNA, partial 633 55978.9 g7023735 0 Human cDNA FLJ1212 fis, clone PLACE1007958, highly similar to Human cAMP- specific phosphodiesterase 8B mRNA. 634 55978.4 g3818571 0 Human cAMP-specific phosphodiesterase 8B (PDE8B) mRNA, partial cds. 635 350977.1 g174931 9.00E-18 Human U5E snRNA sequence. 636 238877.11 g4191326 0 Human ZIS1 mRNA, complete cds. 637 238877.8 g4191326 0 Human ZIS1 mRNA, complete cds. 638 997231.15 g3062805 0 Human hDPM1 mRNA for dolichol-phosphate- mannose synthase, complete cds. 639 997231.16 g3062805 0 Human hDPM1 mRNA for dolichol-phosphate mannose synthase, complete cds. 640 346209.3 g212451 0 nonmuscle myosin heavy chain 641 2515666CB1 g30338 0 Human mRNA for cytochrome P3-450. 642 2515666CD1 g30338 0 Human mRNA for cytochrome P3-450. 643 2742913CB1 g179771 0 Human carbonic anhydrase II mRNA, complete cds. 644 2742913CD1 g179771 0 Human carbonic anhydrase II mRNA, complete cds. 645 336615.1 g2072161 0 Human tubby related protein 1 (TULP1) mRNA, complete cds. 646 406830.43 g7022107 1.00E-57 Human cDNA FLJ10207 fis, clone HEMBA1005475. 647 406830.33 g7022107 4.00E-23 Human cDNA FLJ10207 fis, clone HEMBA1005475. 648 84685.1 649 1045907.4 650 1383803.2 g1031002 0 Human CpG island DNA genomic Mse1 fragment, clone 127a5, reverse read 651 85282.1 652 86326.1 653 337470.1 654 3721108CB1 g641961 0 Human steroid hormone receptor Ner-I mRNA, complete cds. 655 3721108CD1 g641961 0 Human steroid hormone receptor Ner-I mRNA, complete cds. 656 1090929.2 g7328949 0 Human 20-alpha HSD gene for 20 alph- hydroxysteroid dehydrogenase, complete 657 95374.1 658 238639.2 659 33627.28 g5163088 0 Human P38IP (P38IP) mRNA, complete cds. 660 33627.33 g5163088 0 Human P38IP (P38IP) mRNA, complete cds. 661 435361.1 g7020164 0 Human cDNA FLJ20215 fis, clone COLF2016. 662 474552.1 g1575342 0 Human apolipoprotein AI regulatory protein- 1/chicken ovalbumin upstream promoter transcription factor II (TFCOUP2) gene. complete cds. 663 2636759CB1 g6692782 6.00E-44 protein phosphatase 664 2636759CD1 g6692782 6.00E-44 protein phosphatase 665 1083665.4 g887792 0 Human fragile X mental retardation protein 1 homolog FXR1 mRNA, complete cds. 666 240518.21 g6841489 6.00E-58 Human HSPC134 mRNA, complete cds. 667 240518.42 g6841489 0 Human HSPC134 mRNA, complete cds. 668 1322.4 g7023922 0 Human cDNA FLJ11333 fis, clone 669 208282.1 670 345272.5 671 345272.2 g7290850 0 CG1514 gene product 672 997613.1 g36073 4.00E-31 Human gene hY1 encoding a cytoplasmic 673 231840.1 g4808519 0 Human zinc transporter 1 (ZNT1) gene, partial cds. 674 13937.3 g5788108 0 supported by ESTs T61992 (NID:g665235) and W26450 (NID:g1307167) and Genscan 675 253783.6 g7670456 8.00E-95 unnamed protein product 676 20828.1w g472859 0 Human gas1 gene, complete cds. 677 222705.14 678 335906.1 679 1325741.2 g405193 0 Human splicing factor (CC1.4) mRNA, complete cds. 680 2703282CB1 g5712753 0 Human sex comb on midleg-like-1 protein (SCML1) mRNA, complete cds. 681 2703282CD1 g5712753 0 Human sex comb on midleg-like-1 protein (SCML1) mRNA, complete cds. 682 118836.2 g7020691 0 Human cDNA FLJ20525 fis, clone KAT10610. 683 3303.2 g1654324 0 Human chromosome 5 Mad homolog Smad5 mRNA, complete cds. 684 92991.1 685 93603.1 686 1383062.7 g5926699 0 Human genomic DNA, chromosome 6p21.3, HLA Class I region, section 11/20. 687 1383062.8 g5926700 0 Human genomic DNA, chromosome 6p21.3, HLA Class I region, section 12/20. 688 1383794.1 689 406289.1 g5678818 0 Human FRG1 (FRG1) gene, complete cds; 5S ribosomal RNA gene, complete sequence; TUB4q and TIG2 pseudogenes, complete 690 175918.15 g3882250 0 Human mRNA for KIAA0765 protein, partial 691 1068290.1 g6984171 0 Human chromosome 19 zinc finger protein ZNF226 mRNA, complete cds. 692 94873.1 693 403616.1 694 95088.1 695 230402.1 696 95172.1 697 250091.1 g36515 2.00E-13 Human (HeLa) small nuclear U5 A RNA. 698 4113161CB1 g3360429 0 Human clone 23929 mRNA sequence. 699 4113161CD1 g3360429 0 Human clone 23929 mRNA sequence. 700 335375.3 701 95395.1 702 229514.1 703 95573.1 704 230463.1 705 95702.1 706 218090.9 g3387967 0 Human clone 24503 mRNA sequence. 707 96126.1 g1030761 5.00E-41 Human CpG island DNA genomic Mse1 fragment, clone 10e4. forward read 708 1508254CB1 g587201 0 Human HK2 mRNA for hexokinase II. 709 1508254CD1 g587201 0 Human HK2 mRNA for hexokinase II. 710 207452CB1 g2804436 4.00E-53 Similar to mitochondrial carrier protein 711 207452CD1 g2804436 4.00E-53 Similar to mftochondrlal carrier protein 712 290233.1 g598240 5.00E-16 Human intron-encoded U22 small nucleolar RNA (UHG) gene. 713 1096917.11 g35219 0 Human mRNA for p68 protein. 714 208748.4 g3876099 0 similar to dynein heavy chain˜cDNA EST EMBL:D27549 comes from this gene˜cDNA EST EMBL:D34859 comes from this gene 715 407517.2 g4589615 0 Human mRNA for KIAA0986 protein, partial 716 233997.1 717 237067.1 g7768665 1.00E-90 Human genomic DNA, chromosome 21q, section 15/105. 718 330862.6 g2459798 2.00E-40 Human CG1 mRNA, complete cds. 719 330862.8 g2459798 0 Human CG1 mRNA, complete cds. 720 2124957CB1 g8218048 0 dJ187J11.2.6 (novel protein similar to S. pombe and S. cerevisiae predicted proteins (partial isoform 6)) 721 2124957CD1 g8218048 0 dJ187J11.2.6 (novel protein similar to S. pombe and S. cerevisiae predicted proteins (partial isoform 6)) 722 1098722.6 g7021926 0 Human cDNA FLJ10083 fis, clone HEMBA1002084. 723 1099023.1 g340102 2.00E-17 Human U2 small nuclear RNA gene, clone 724 201395.4 g2224626 0 Human mRNA for KIAA0343 gene, complete 725 4295277CB1 g437000 0 Human microtubule-associated protein 1B (MAP1B) gene, complete cds. 726 4295277CD1 g437000 0 Human microtubule-associated protein 1B (MAPIB) gene, complete cds. 727 98533.1 g2898163 4.00E-52 Human microtubule-associated protein tau (tau) gene, exon 0. 728 983684.1 729 983684.2 730 1837317CB1 g28335 0 Human ACTB mRNA for mutant beta-actin (beta′-actin). 731 1837317CD1 g28335 0 Human ACTB mRNA for mutant beta-actin (beta′-actin). 732 2937262CB1 g7020244 0 Human cDNA FLJ20267 fis, clone HEP00925, highly similar to AL049996 Human mRNA; cDNA DKFZp564K112. 733 2937262CD1 g7020244 0 Human cDNA FLJ20267 fis, clone HEP00925, highly similar to AL049996 Human mRNA; cDNA DKFZp564K112. 734 199290.9 g3043595 0 Human mRNA for KIAA0536 protein, partial 735 3151579CB1 g2662348 0 Human mRNA for GCP170, complete cds. 736 3151579CD1 g2662348 0 Human mRNA for GCP170, complete cds. 737 235056.14 g2599359 0 Human RNA hellcase p68 (HUMP68) gene, complete cds. 738 337939.2 g2252495 3.00E-58 Human mRNA for SKAP55 protein. 739 208379.1 740 251631.6 g2088550 0 Human hereditary haemochromatosis region, histone 2A-like protein gene, hereditary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds. 741 2847188CB1 g29933 0 Human mRNA fragment for second calcitonin gene related peptide (CGRP) from medullary thyroid carcinoma (MTC). 742 2847188CD1 g29933 0 Human mRNA fragment for second calcitonin gene related peptide (CGRP) from medullary thyroid carcinoma (MTC). 743 100579.1 744 1327498.1 g32029 0 Human hB23 gene for B23 nucleophosmin. 745 1330212.14 g186799 0 Human ribosomal protein L12mRNA. complete cds. 746 252471.7 g2465728 0 Human apoptosis-related protein TFAR15 (TFAR 15) mRNA, complete cds. 747 252471.4 g2465728 0 Human apoptosis-related protein TFAR15 (TFAR15) mRNA, complete cds. 748 983536.1 749 983536.2 750 1330122.1 g2739093 0 Human sodium/myo-inositol cotransporter (SLC5A3) gene, complete cds. 751 407468.1 752 1330149.46 g5870840 0 Human cyclophilin-related protein mRNA, complete cds. 753 32476.2 g5360124 0 Human NY-REN-58 antigen mRNA, complete 754 1281694CB1 g7020931 0 Human cDNA FLJ20678 fis, clone KAIA4163. 755 1281694CD1 g7020931 0 Human cDNA FLJ20678 fis, clone KAIA4163. 756 1719478CB1 g758109 0 Human mRNA for voltage-activated sodium channel. 757 1719478CD1 g758109 0 Human mRNA for voltage-activated sodium channel. 758 230611.1 g1321847 4.00E-28 Human mRNA for U61 small nuclear RNA. 759 236749.1 g6841361 0 Human HSPC062 mRNA, complete cds. 760 407124.2 g4098993 6.00E-07 polyhomeofic 2 761 104322.1 762 400253.14 g2826476 4.00E-35 IL-17 receptor 763 233595.17 764 978065.5 g7020358 0 Human cDNA FLJ20333 fis, clone HEP11252. 765 403642.1 g6453435 9.00E-90 Human mRNA; cDNA DKFZp586E041 (from clone DKFZp586E041); partial cds. 766 984236.4 g7022881 3.00E-36 unnamed protein product 767 984236.1 g7022881 4.00E-42 unnamed protein product 768 1001589CB1 g1228034 0 Human mRNA for KIAA0191 gene, partial cds. 769 1001589CD1 g1228034 0 Human mRNA for KIAA0191 gene, partial cds. 770 7808.1 g3893101 2.00E-91 CRAG protein 771 403627.38 g6841567 0 Human HSPC174 mRNA, complete cds. 772 106415.1 773 474622.1 g2116983 0 Human mRNA for N-WASP, complete cds. 774 1383009.57 g6979641 0 Human alpha gene sequence. 775 1383009.67 g6979641 0 Human alpha gene sequence. 776 1086355.2 g1905925 0 Human excision and cross link repair protein (ERCC4) gene, complete genomic 777 1086355.1 g5262556 0 Human mRNA; cDNA DKFZp569D2231 (from clone DKFZp569D2231); partial cds. 778 998330.2 g5689519 2.00E-44 KIAA1091 protein 779 1384716.4 g531170 0 Human Csa-19 mRNA complete cds. 780 2790762CB1 g4001815 9.00E-11 putative phosphatidylinositol 3-kinase 781 2790762CD1 g4001815 9.00E-11 putative phosphatidylinositol 3-kinase 782 399607.1 g7022092 0 Human cDNA FLJ10197 fis, clone HEMBA1004795, moderately similar to CDC4- LIKE PROTEIN. 783 256138.1 784 413348.4 g36425 0 Human mRNA for selenoprotein P. 785 332088.2 786 035282CB1 g2580553 0 Human dead box, Y isoform (DBY) mRNA, alternative transcript 2, complete cds. 787 035282CD1 g2580553 0 Human dead box, Y isoform (DBY) mRNA, alternative transcript 2, complete cds. 788 350667.7 g2580553 0 Human dead box, Y Isoform (DBY) mRNA, alternative transcript 2, complete cds. 789 343913.1 g190862 0 Human retinoic acid receptor beta gene, 790 211622.1 791 110049.1 g1212991 0 Human mRNA for titin protein (clone hh1- 792 1806212CB1 g7804449 0 Human mRNA for leucyl tRNA synthetase, complete cds. 793 1806212CD1 g7804449 0 Human mRNA for leucyl tRNA synthetase, complete cds. 794 4436028CB1 g307313 0 Human nucleolysin TIAR mRNA, complete 795 4436028CD1 g307313 0 Human nucleolysin TIAR mRNA, complete 796 406663.3 g7768741 0 Human genomic DNA, chromosome 21q, section 90/105. 797 405689.1 798 110815.1 799 1385527.4 g4033734 0 Human spliceosomal protein SAP 155 mRNA, complete cds. 800 2570.1 801 1100724.1 g498151 0 Human mRNA for KIAA0065 gene, partial cds. 802 3704760CB1 g4165090 0 Human NADH-ubiquinone oxidoreductase PDSW subunit mRNA, complete cds. 803 3704760CD1 g4165090 0 Human NADH-ubiquinone oxidoreductase PDSW subunit mRNA, complete cds. 804 344017.6 g7296669 2.00E-16 CG10979 gene product 805 344017.3 806 2770104CB1 g2653862 0 Human leucocyte Ig-like receptor-2 (LIR-2) mRNA, complete cds. 807 2770104CD1 g2653862 0 Human leucocyte Ig-like receptor-2 (LIR-2)- mRNA, complete cds. 808 349204.1 g37556 2.00E-12 Human U4 small nuclear RNA pseudogene 809 2641740CB1 g1857636 0 Human phosphatidylinositol-4-phosphate 5- kinase type II beta mRNA, complete cds. 810 2641740CD1 g1857636 0 Human phosphatidylinositol-4-phosphate 5- kinase type II beta mRNA, complete cds. 811 211881.1 g340088 7.00E-15 Human small nuclear rna pseudogene (clone pu1-1) and flanks. 812 334749.1 813 407838.1 814 170915CB1 g3747096 0 Human C1q-related factor mRNA, complete 815 170915CD1 g3747096 0 Human C1q-related factor mRNA, complete 816 994387.88 g7684537 1.00E-38 similar to KIAA0855: similar to BAA74878 (PID:g4240199) 817 2454013CB1 g3335133 0 Human unknown mRNA, complete cds. 818 2454013CD1 g3335133 0 Human unknown mRNA, complete cds. 819 427967.6 g2280483 1.00E-84 Human mRNA for KIAA0372 gene, complete 820 427967.4 g2280483 0 Human mRNA for KIAA0372 gene, complete 821 257016.1 822 215158.5 g7295806 2.00E-43 CG12795 gene product 823 522.12 g3523196 0 Human full length insert cDNA clone YX30B07. 824 522.1 g3523196 0 Human full length insert cDNA clone YX30B07. 825 113633.1 826 477387.3 g469478 2.00E-06 SM-20 827 477387.7 g1036447 8.00E-72 Human CpG island DNA genomic Mse1 fragment, clone 96f6, forward read 828 347796.7 829 2656429CB1 g4894379 0 Human Mago homolog mRNA, complete 830 2656429CD1 g4894379 0 Human Mago homolog mRNA, complete 831 3346307CB1 g7020644 0 Human cDNA FLJ20500 fis, clone KAT09159. 832 3346307CD1 g7020644 0 Human cDNA FLJ20500 fis, clone KAT09159. 833 2649071CB1 g127580 0 Human pre-T-cell receptor alpha-type chain precursor, mRNA, complete cds. 834 2649071CD1 g1127580 0 Human pre-T-cell receptor alpha-type chain precursor, mRNA, complete cds. 835 1383086.2 g37546 0 Human mRNA for U2 snRNP-specific A′ 836 1850670CB1 g182606 0 Human factor I (C3b/C4b inactivator) mRNA, complete cds. 837 1850670CD1 g182606 0 Human factor I (C3b/C4b inactivator) mRNA, complete cds. 838 1132386.3 g6708478 0 formin-like protein 839 115052.1 840 1330056CB1 g2114362 0 Human int-6 mRNA, complete cds. 841 1330056CD1 g2114362 0 Human int-6 mRNA, complete cds. 842 199788.2 g38256 0 Simian mRNA for ral protein. 843 27881.1 844 234543.1 g577299 2.00E-59 The ha2022 gene product Is novel. 845 231547.2 g1035915 1.00E-30 Human CpG island DNA genomic Mse1 fragment. clone 86bl 1, reverse read 846 399785.1 847 10498.24 g4240316 0 Human mRNA for KIAA0914 protein, 848 399161.1 g337708 2.00E-37 Human U1 small nuclear RNA gene, clone HSD4, complete cds. 849 241467.1 g2088550 3.00E-90 Human hereditary haemochromatosis region, histone 2A-like protein gene, hereditary hoemochromatosis (HLA-H) gene. RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds. 850 997194.1 g2950207 0 Human mRNA for hair keratin acidic 3-II. 851 17819.1 852 116536.1 853 116549.1 854 17886.1 855 351032.1 g339574 0 Human Gly-tRNA-GCC gene and pseudogene, complete cds. 856 977532.9 g7023746 0 Human cDNA FLJ11219 fis, clone 857 117273.1 858 212438.1 859 212265.7 860 403560.1 g7020022 0 Human cDNA FLJ20127 fis, clone COL06176. 861 1073168.6 g5689450 0 Human mRNA for KIAA1057 protein, partial 862 1073168.8 g5689450 0 Human mRNA for KIAA1057 protein, partial 863 119614.1 864 119625.1 865 119671.1 866 3177.1 867 119974.1 868 120831.1 g3861482 0 Human chromosome 3, olfactory receptor pseudogene cluster 1, complete sequence, and myosin light chain kinase (MLCK) pseudogene, partial sequence. 869 27619.3 g8515844 0 Human hepatocellular carcinoma- associated gene TD26 mRNA. 870 212872.1 g7243234 0 Human mRNA for KIAA1427 protein, partial 871 404952.4 g7020256 0 Human cDNA FLJ20275 fis, clone HEF02372. 872 404952.1 g7020256 0 Human cDNA FLJ20275 fis, clone HEP02372. 873 125014.1 874 348390.2 g36502 0 Human mRNA for enteric smooth muscle gamma-actin. 875 227222.1 876 337696.1 g174945 5.00E-23 Human U4c small nuclear RNA (snRNA). 877 253550.2 g184522 0 Human insulin-like growth factor-binding protein-3 gene, complete cds, clone 878 1326925.1 g6466800 0 Human intestinal mucin 3 (MUC3) gene, 879 127140.1 880 127204.1 g184025 6.00E-13 Human 1,4-alpha-glucan branching enzyme (HGBE) mRNA, complete cds. 881 330925.1 882 403960.1 883 20152.1 g7023908 4.00E-25 unnamed protein product (Homo sapiens) 884 26200.1 885 399474.1 g6630993 0 Human early B-cell transcription factor (EBF) mRNA, partial cds. 886 981037.1 g5114274 0 Human MAB21L2 (MAB21L2) gene, complete 887 130502.1 888 5202390CB1 g4240294 0 Human mRNA for KIAA0903 protein, partial 889 5202390CD1 g4240294 0 Human mRNA for KIAA0903 protein, partial 890 213447.4 g7291182 6.00E-08 CG9732 gene product 891 250439.1 g2102633 1.00E-20 Human DNA for GPI-anchored molecule-like protein, complete cds. 892 2743049CB1 g2253155 0 Human mRNA for Ran_GTP binding protein 5. 893 2743049CD1 g2253155 0 Human mRNA for Ran_GTP binding protein 5. 894 256026.8 g2253155 0 Human mRNA for Ran_GTP binding protein 5. 895 998930.1 g854085 0 Human alpha-s1-casein mRNA. 896 981149.2 897 335420.1 g1911580 0 region centromeric to t(12:17) brokepoint: orf1/unknown 43 amino acid transcript . . . orf3/unknown 50 amino acid transcript (Human, testis, acampomelic campomelic dysplasia and sex reversal patient, Genomic, 3 genes, 3414 nt). 898 1082203.1 g498152 0 ha0946 protein is Kruppel-related. 899 225420.1 g6093245 0 Human mRNA; cDNA DKFZp434B0328 (from clone DKFZp434B0328); partial cds. 900 236298.4 g7768692 0 Human genomic DNA, chromosome 21 q, section 20/105. 901 236298.2 902 982813.1 903 154771.1 g7768657 0 Human PTS gene for6- pyruvoyltetrahydropterin synthose, complete 904 477054.1 g541674 0 Human ADH7 mRNA. 905 2966.1 906 136212.1 g2065210 1.00E-13 Pro-Pol-dUTPase polyprotein 907 977975.1 g7021992 0 Human cDNA FLJ10128 fis, clone HEMBA1002997, weakly similar to CENTROMERIC PROTEIN E. 908 1505038CB1 g536897 0 Human follistatin-related protein precursor mRNA, complete cds. 909 1505038CD1 g536897 0 Human follistatin-related protein precursor mRNA complete cds. 910 262830CB1 g180710 0 Human ciliary neurotrophic factor receptor (CNTFR) mRNA, complete cds. 911 262830CD1 g180710 0 Human ciliary neurotrophic factor receptor (CNTFR) mRNA, complete cds. 912 3607580CB1 g747969 0 Human angiotensin II type 2 receptor gene, complete cds. 913 3607580CD1 g747969 0 Human angiotensin II type 2 receptor gene, complete cds. 914 137742.1 915 1095839.1 g4050043 0 Human RAD17 isoform 4 (RAD17) mRNA, complete cds. 916 205328.1 917 252649.14 g7020522 0 Human cDNA FLJ20429 fis, clone KAT03501. 918 221762.2 g4761786 0 Human full length insert cDNA clone YP86E09. 919 138205.1 920 331566.1 g1710195 0 Human clone 23826 mRNA sequence. 921 1384719.3 g3719220 0 Human vascular endothelial growth factor mRNA, complete cds. 922 1330137.1 g177064 3.00E-79 gorilla gorilla beta-2-microglobulin mRNA (GOGOB2M). 923 409962.1 924 481118.7 g7299388 2.00E-39 CG6621 gene product 925 481118.12 g6434473 2.00E-10 predicted using genefinder; preliminary 926 337528.4 g189300 0 Human neurotrophin-3 (NT-3) gene. 927 3687719CB1 g2829128 0 Human forkhead-related transcription factor FREAC-10 (FKHL18) mRNA, partial cds. 928 3687719CD1 g2829128 0 Human forkhead-related transcription factor FREAC-1 0 (FKHL1 8) mRNA, partial cds. 929 332299.1 930 1530186CB1 g5262490 0 Human mRNA; cDNA DKFZp564D0462 (from clone DKFZp564D0462). 931 1530186CD1 g5262490 0 Human mRNA; cDNA DKFZp564D0462 (from clone DKFZp564D0462). 932 251809.1 g498909 1.00E-81 Human endothelial-monocyte activating polypeptide II mRNA, complete cds. 933 334025.5 934 350134.1 g1032100 9.00E-54 Human CpG island DNA genomic Mse1 fragment. clone 193d10, forward read 935 16124.2 936 140468.1 937 3257507CB1 g178746 0 Human apurinic/apyrimidinic endonuclease (HAP1h) mRNA, complete cds. 938 3257507CD1 g178746 0 Human apurinic/apyrimidinic endonuclease (HAP1h) mRNA, complete cds. 939 1400580.1 g2723316 8.00E-86 Zinc-finger protein 940 481154.3 g7959270 0 Human mRNA for KIAA1505 protein, partial 941 346716.17 g1147782 0 Human myosin-1Xb mRNA, complete cds. 942 346716.21 943 1384720.16 g28338 0 Human mRNA for cytoskeletal gamma-actin. 944 1505790CB1 g1036132 1.00E-75 Human CpG island DNA genomic Mse1 fragment, clone 8d3, forward read 945 1505790CD1 g1036132 1.00E-75 Human CpG island DNA genomic Mse1 fragment, clone 8d3, forward read 946 3876162CB1 g2467376 0 Human mRNA for calmegin, complete cds. 947 3876162CD1 g2467376 0 Human mRNA for calmegin, complete cds. 948 40576.1 949 1040190.14 950 1328310.1 g1834502 0 Human MUC5B gene (partial). 951 34297.1 g7018498 3.00E-23 Human mRNA; cDNA DKFZp564L1878 (from clone DKFZp564L1878); partial cds. 952 145549.2 953 42206.1 954 178799.1 955 214767.1 956 94384.1 957 2852561CB1 g5926733 0 Human mRNA for 4F2 heavy chain, complete 958 2852561CD1 g5926733 0 Human mRNA for 4F2 heavy chain, complete 959 337058.1 960 988704.25 g2435500 0 Human HRS gene, partial cds. 961 988704.26 g1049079 0 Human splicing factor SRp40-1 (SRp40) mRNA, complete cds. 962 401906.2 963 154220.1 964 5371205CB1 g3289972 0 Human DENN mRNA, complete cds. 965 5371205CD1 g3289972 0 Human DENN mRNA, complete cds. 966 147026.1 967 410776.1 g36073 2.00E-12 Human gene hY1 encoding a cytoplasmic 968 335121.1 g5926687 3.00E-80 Human genomic DNA, chromosome 3p21.3, clone:603 to 320, anti-oncogene region, section 3/3. 969 147379.1 970 147403.1 971 1041063.1 g1334853 2.00E-05 BPLF1 reading frame, 1 NXT/S, analogous to VZV RF22 972 1041063.5 973 230912.1 g8099056 0 Human regulator of G-protein signaling 17 (RGS17) mRNA, complete cds. 974 1089708.18 g2224670 0 Human mRNA for KIAA0365 gene, parnal cds. 975 1050390.1 g498151 6.00E-11 Human mRNA for KIAA0065 gene, parHal cds. 976 088957CB1 g763428 0 Human mRNA clone with similarity to L- glycerol-3-phosphate:NAD oxidoreductase and albumin gene sequences. 977 088957CD1 g763428 0 Human mRNA clone with similarity to L- glycerol-3-phosphate:NAD oxidoreductase and albumin gene sequences. 978 220943.21 g31441 0 Human mRNA for integrin beta 1 subunit. 979 28005.14 g35896 0 Human mRNA for retinol binding protein 980 980446.1 981 198827.1 g1017792 0 Human substance P beta-PPT-A mRNA, complete cds. 982 215112.1 g4240476 0 Human short chain L-3-hydroxyacyl-CoA dehydrogenase precursor (HADHSC) gene, nuclear gene encoding mitochondrial protein, complete cds. 983 977929.1 g6690339 1.00E-83 hematopoietic zinc finger protein 984 281447.2 985 346641.3 g684935 0 Human actin-like pepfide mRNA, partial cds. 986 230793.3 g5102577 0 Human mRNA full length insert cDNA clone EUROIMAGE 345330. 987 431288.1 g7021910 5.00E-19 Human cDNA FLJ10073 fis, clone HEMBA1001731. 988 4215034CB1 g1663701 0 Human mRNA for KIAA0243 gene, partial cds. 989 4215034CD1 g1663701 0 Human mRNA for KIAA0243 gene, partial cds. 990 150627.1 991 121731.1 992 259907.1 993 977727.13 994 5915.1 g1737211 0 Human basic transcription factor 2 p44 (bff2p44) gene, partial cds, neuronal apoptosis inhibitory protein (naip) and survival motor neuron protein (smn) genes. 995 8835.1 g7768716 9.00E-10 Human genomic DNA, chromosome 21q, section 59/105. 996 242010.6 g5926690 0 Human genomic DNA, chromosome 6p21.3, HLA Class I region. section 2/20. 997 242684.1 g5678818 0 Human FRG1 (FRG1) gene, complete cds; 5S ribosomal RNA gene, complete sequence: TUB4q and TIG2 pseudogenes, complete 998 335145.1 999 678004CB1 g7417394 0 Human peroxisome proliferative activated receptor delta (PPARD) gene, exon 9 and 1000 678004CD1 g7417394 0 Human peroxisome proliferative activated receptor delta (PPARD) gene, exon 9 and 1001 92922.1 g5669134 9.00E-67 Human constitutive fragile region FRA3B sequence. 1002 411373.7 g7243116 0 Human mRNA for KIAA1368 protein, partial 1003 404715.1 1004 278831.1 1005 343924.8 g2887416 0 Human KIAA0421 mRNA, partial cds. 1006 200977.1 g2792363 0 Human unknown protein IT1 mRNA, partial 1007 181818.3 1008 029251CB1 g393314 0 Human HFREP-1 mRNA for unknown protein, complete cds. 1009 029251CD1 g393314 0 Human HFREP-1 mRNA for unknown protein, complete cds. 1010 335648.1 g36712 0 Human mRNA for tyrosine aminotransferase (TAT) (EC 2.6.1.5). 1011 331108.1 g34330 0 Human mRNA for apolipoprotein B-100. 1012 333840.1 g452443 0 Human glucose-6-phosphatase mRNA, complete cds. 1013 334298.1 1014 344597.2 g4589485 3.00E-91 Human mRNA for KIAA0927 protein, partial 1015 1262593.2 g4914599 0 Human mRNA; cDNA DKFZp564A126 (from clone DKFZp564A126): partial cds. 1016 461375.2 1017 233660.2 g7021005 0 Human cDNA FLJ20727 fis, clone HEP13238. 1018 230179.3 g7295706 2.00E-75 CG15438 gene product 1019 230179.7 g7295706 9.00E-15 CG15438 gene product 1020 296245.1 1021 981208.1 g6650767 9.00E-11 Human pancreas-enriched phospholipase C mRNA, complete cds. 1022 406580.1 g1480103 5.00E-11 TYL 1023 200051.1 g3483384 0 Human full length insert cDNA clone 1024 1197030.1 g1800114 0 Human ribosomal protein L7 antisense mRNA gene, partial sequence. 1025 1197030.1 g35902 0 Human mRNA for ribosomal protein L7. 1026 158859.1 1027 229490.1 1028 4832672CB1 g31988 0 Human H3.3 gene exon 4. 1029 4832672CD1 g31988 0 Human H3.3 gene exon 4. 1030 339638.1 1031 480885.2 g2394309 0 Human homeobox protein MEIS2 (MEIS2) mRNA, partial cds. 1032 342074.1 g5732679 0 Human amino acid transporter B0+ (ATBO+) mRNA, complete cds. 1033 406992.1 g5668544 0 Human mRNA for cystine/glutamate transporter, complete cds. 1034 1852849CB1 g2580571 0 Human ubiquitous TPR motif, X Isoform (UTX) mRNA, alternative transcript 2, complete cds. 1035 1852849CD1 g2580571 0 Human ubiquitous TPR motif, X isoform (UTX) mRNA, alternative transcript 2, complete cds. 1036 1132829.1 g4886454 0 Human mRNA; cDNA DKFZp566G013 (from clone DKFZp566GO13); complete cds. 1037 339800.1 1038 1399492.1 1039 13039.2 g4589583 0 Human mRNA for KIAA0970 protein, 1040 399626.1 1040 365070.3 g3550345 4.00E-34 cellular repressor of E1 A-stimulated genes 1042 365070.1 1043 1383263.1 g37643 8.00E-88 vacuolor proton-ATPase 1044 1383263.14 g1710247 0 Human protein disulfide isomerase-related protein P5 mRNA, partial cds. 1045 406707.2 g7110216 3.00E-19 C-type lectin-like receptor-1 1046 406707.1 1047 1051954.7 g6984171 0 Human chromosome 19 zinc finger protein ZNF226 mRNA, complete cds. 1048 102564.1 g7274891 3.00E-37 Human chromosome Xq28 psHMG17 pseudogene, complete sequence; and melanoma antigen family A1 (MAGEA1) and zinc finger protein 275 (ZNF275) genes, 1049 233312.1 g4406631 1.00E-22 Human clone 25221 mRNA sequence, complete cds. 1050 335568.1 g1401184 0 Human adhesion molecule DNAM-1 mRNA, complete cds. 1051 407739.1 1052 272273.1 g6483295 0 Human CDH9 mRNA for cadherin-9, 1053 399133.9 g6807782 0 Human mRNA; cDNA DKFZp434P086 (from clone DKFZp434P086); partial cds. 1054 246727.11 g337456 0 Human ribonucleoprotein (La) mRNA, 3′ end. 1055 246727.17 g178686 0 Human La protein mRNA, complete cds. 1056 230367.2 1057 1383039.18 g32466 0 Human hsc70 gene for 71 kd heat shock cognate protein. 1058 1383039.17 g7672662 0 Tamarin (Saguinus oedipus) intracellular vitamin D binding protein 1 (IDBP1) mRNA, 1059 27704.2 1060 346900.1 g453469 5.00E-18 Human mRNA for ras-related GTP-binding 1061 249813.1 g5732617 0 Human myosin-1Xa mRNA, complete cds. 1062 411357.1 g189564 0 Human, plasminogen activator inhibitor-1 gene, exons 2 to 9. 1063 68902.1 1064 210133.1 g4186165 0 Human candidate tumor suppressor HIC-1 (HIC-1) gene, complete cds. 1065 430665.1 g1495463 0 Human mRNA for metallothionein isoform 1R. 1066 902525.1 g409069 0 Human mRNA for HBp15/L22, complete cds. 1067 256841.1 g1032232 4.00E-50 Human CpG island DNA genomic Mse1 fragment, clone 1e2, forward read 1068 206344.1 1069 107309.1 1070 1074024.1 1071 233218.7 g2347130 0 Human HLA class III region containing tenascin X (tenascin-X) gene, partial cds; cytochrome P450 21-hydroxylase (CYP21B), complement component C4 (C4B) g11, helicase (SKI2W), RD, complement factor B (Bf), and complement component C2 (C2) 1072 1092387.12 g7328949 0 Human 20-alpha HSD gene for 20 alph- hydroxysterold dehydrogenase, complete 1073 1092387.11 g7328949 0 Human 20-alpha HSD gene for 20 alph- hydroxysteroid dehydrogenase, complete 1074 366463.1 g1710239 7.00E-14 Human clone 23933 mRNA sequence. 1075 304409.1 1076 1382920.38 g31347 0 Human pseudogene for apoferritin H (clone 1077 342365.1 g1228035 2.00E-23 The KIAA0191 gene is expressed ubquitously.; The KIAA0191 protein retains the C2H2 zinc- finger at its N-terminal region. (Homo sapiens) 1078 399210.1 1079 1089210.1 g544761 0 chlordecone reductase {clone HAKRa} (Human, liver, mRNA, 1167 nt). 1080 444619.9 g188712 0 Human (clone 14VS) metallothionein-IG (MT1g) gene, complete cds. 1081 312986.1 1082 462057.1 g36111 0 Human RNA for ros1. 1083 197902.12 g391735 0 Human mRNA for very low density lipoprotein receptor, complete cds. 1084 997394.4 g3851202 0 ZO-3 1085 2481150CB1 g4455124 0 Human Sk/Dkk-1 protein precursor, mRNA, complete cds. 1086 2481150CD1 g4455124 0 Human Sk/Dkk-1 protein precursor, mRNA, complete cds. 1087 8198.1 1088 72297.2 1089 994430.16 g8101070 7.00E-71 Human golgin-like protein (GLP) gene, complete cds. 1090 189036.1 1091 221042.1 g7296756 1.00E-57 CG1172geneproduct 1092 408398.1 1093 985369.1 1094 328796.1 1095 58804.1 1096 3505463CB1 g5640003 0 Human ras-related GTP-binding protein 4b (RAB4B) mRNA, complete cds. 1097 3505463CD1 g5640003 0 Human ras-related GTP-binding protein 4b (RAB4B) mRNA, complete cds. 1098 197159.1 g23421 5.00E-47 Human (D1S228) DNA segment containing (CA) repeat; clone AFM196xb4; single read. 1099 369928.1 1100 413466.6 g1806039 0 Human mRNA for adipophilin. 1101 397295.1 g7768668 1.00E-15 Human genomic DNA, chromosome 21q, section 24/105. 1102 1330139.5 g31099 0 Human mRNA for elongation factor-1-beta. 1103 977951.1 g7020272 0 Human cDNA FLJ20283 fis, clone HEP04088. 1104 347316.1 g7414319 0 Human mRNA for type III sodium channel protein (SCN3A gene). 1105 150288.3 1106 2455.1 g2708709 2.00E-13 Wiskott-Aldrich Syndrome protein homolog 1107 372647.1 1108 137710.1 1109 407644.1 g187266 1.00E-25 Human LYL-1 protein gene, complete cds. 1110 373516.1 g5690368 6.00E-10 Rhesus monkey glucose phosphate isomerase (GPI) gene, partial intron 1111 241762.23 g6330377 0 Human mRNA for KIAA1196 protein, partial 1112 1040914.1 g5689484 4.00E-12 Human mRNA for KIAA1074 protein, 1113 358492.1 1114 243924.12 g35570 1.00E-53 polyA binding protein (AA 1-633) 1115 243924.13 g3876085 0 similar to poly-adenylate binding protein˜cDNA EST EMBL:T01123 comes from this gene˜cDNA EST EMBL:D27926 comes from this gene˜cDNA EST EMBL:D27925 comes from this gene˜cDNA EST EMBL:T00103 comes from this gene˜cDNA EST EMBL:T00104 1116 208075.1 g23915 6.00E-47 Human 7SK RNA gene and flanking regions. 1117 168955.1 1118 428508.1 1119 418070.1 g7021107 0 Human cDNA FLJ20795 fis, clone COL00329. 1120 403994.5 g6708123 4.00E-34 cone potassium-dependent sodium-calcium exchanger 1121 336726.1 1122 337250.1 g4539520 5.00E-38 dA22D12.1 (novel protein similar to Drosophila Kelch (Ring Canal protein, KEL) and a heterogenous set of other types of proteins) 1123 410781.1 g1563890 0 Human fibroblast growth factor homologous factor 4 (FHF-4) mRNA, complete cds. 1124 347759.3 g28338 0 Human mRNA for cytoskeletal gamma-actin. 1125 1252060.4 g7770216 0 Human PRO2675 mRNA, complete cds. 1126 209279.1 g177808 0 Human alpha-1-antichymotrypsin (AACT) mRNA, complete cds. 1127 418391.2 g7242973 2.00E-56 KIAA1309 protein 1128 480630.21 1129 117799.1 1130 235194.15 g7293114 8.00E-11 CG8198 gene product 1131 379400.1 g1575442 6.00E-53 Human small nuclear RNA U6atac, partial sequence. 1132 380433.1 1133 140122.22 g5106993 0 Human HSPC038 protein mRNA, complete 1134 131931.1 g189059 0 Human Na,K-ATPase beta subunit (ATP1B) gene, exons 3 through 6. 1135 381058.1 g1021027 0 Human CpG island DNA genomic Mse1 fragment, clone 181h1, reverse read 1136 403136.1 g35896 3.00E-25 Human mRNA for retinol binding protein 1137 276647.1 g4028582 2.00E-12 Human connective tissue growth factor related protein WISP-2 (WISP2) mRNA, 1138 191631.1 g4028582 6.00E-13 Human connective tissue growth factor related protein WISP-2 (WISP2) mRNA, 1139 887619.26 g5817036 0 Human mRNA; cDNA DKFZp564D0164 (from clone DKFZp564D0164). 1140 980953.1 1141 389859.1 1142 217281.1 g5669134 2.00E-12 Homo sapiens consfitutive fragile region FRA3B sequence. 1143 32428.1

TABLE 2 SEQ ID NO Clone ID Start Stop Frame PFAM Description E-Value   4 1863336CD1 46 80 PEPT PPR repeat 1.70E − 04   7 3170236CD1 37 224 PEPT short chain dehydrogenase 1.50E − 48  10 1460258CD1 728 767 PEPT UBA domain 2.20E − 16  10 1460258CD1 336 367 PEPT Ubiquitin carboxyl-terminal hydrolases family 7.80E − 13  10 1460258CD1 802 860 PEPT Ubiquitin carboxyl-terminal hydrolase family 2 8.70E − 23  10 1460258CD1 211 286 PEPT Zn-finger in ubiquitin-hydrolases and other proteins 2.50E − 33  11 1016903.1 2050 2352 forward 1 Transforming growth factor beta like domain 4.30E − 80  11 1016903.1 1270 1968 forward 1 TGF-beta propeptide 7.50E − 90  15 1720920CD1 55 181 PEPT Laminin G domain 2.00E − 25  19 2114865CD1 46 420 PEPT Serpins (serine protease inhibitors) 1.60E − 216  22 2700132CD1 27 91 PEPT FHA domain 4.30E − 21  27 414171.33 1108 1779 forward 1 MAGE family 6.70E − 25  28 230895.1 73 627 forward 1 Glycosyl transferases 1.00E − 45  28 230895.1 994 1371 forward 1 Similarity to lectin domain of ricin beta-chain, 1.40E − 38 3 copies.  30 346663.6 156 704 forward 3 Connexin 1.20E − 50  30 346663.6 289 828 forward 1 Connexin 1.10E − 11  33 995839.2 99 248 forward 3 Metallothionein 6.80E − 08  35 2517374CD1 38 183 PEPT Lipocalin / cytosolic fatty-acid binding 2.10E − 33 protein family  37 1255456CD1 37 142 PEPT Cystatin domain 6.60E − 42  41 533825CD1 178 262 PEPT PDZ domain (Also known as DHR or GLGF). 9.30E − 15  45 1382869.18 504 716 forward 3 RNA recognition motif. (a.k.a. RRM, RBD, or 8.90E − 21 RNP domain)  46 1382869.1 158 370 forward 2 RNA recognition motif. (a.k.a. RRM, RBD, or 7.00E − 19 RNP domain)  48 215990.2 949 1854 forward 1 Inositol polyphosphate phosphatase family, 9.80E − 166 catalytic domain  48 215990.2 2440 2862 forward 1 RhoGAP domain 1.00E − 52  49 428335.59 977 1096 forward 2 Thioredoxin 1.00E − 07  51 1561192CD1 90 206 PEPT Regulator of G protein signaling domain 5.20E − 56  52 1330151.46 284 1333 forward 2 Fructose-bisphosphate aldolase class-1 7.60E − 270  53 1330151.49 724 1734 forward 1 Fructose-bisphosphate aldolase class-1 2.30 E − 258  61 37502.4 1751 1978 forward 2 Disintegrin 9.00E − 17  61 37502.4 713 1063 forward 2 Reprolysin family propeptide 3.00E − 18  61 37502.4 1115 1708 forward 2 Reprolysin (M12B) family zinc metalloprotease 2.60E − 90  64 085596CD1 17 126 PEPT Cystatin domain 3.10E − 25  67 3393396CD1 83 129 PEPT Myb-like DNA-binding domain 4.80E − 22  70 1382924.42 176 457 forward 2 ribosomal L5P family C-terminus 5.80E − 45  72 1256895CD1 23 253 PEPT Prion protein 6.30E − 203  74 291267.1 486 746 forward 3 Lectin C-type domain 1.30E − 5  76 3125723CD1 281 327 PEPT ‘chromo’ (CHRromatin Organization MOdifier) 1.80E − 14 domain  76 3125723CD1 821 905 PEPT Helicases conserved C-terminal domain 1.90E − 24  76 3125723CD1 487 768 PEPT SNF2 and others N-terminal domain 1.20E − 138  85 088564CD1 24 89 PEPT Small cytokines (intecrine/chemokine), 2.50E − 10 Interleukin-8 like  89 24081.12 1250 318 forward 2 Zinc finger, C2H2 type 1.60E − 06  91 1383290.2 317 673 forward 2 Ribosomal protein L6e 4.50E − 10  91 1383290.2 247 588 forward 1 Ribosomal protein L6e 5.80E − 08  93 290344.1 1101 1286 forward 3 Spectrin repeat 1.80E − 06  93 290344.1 596 829 forward 2 Spectrin repeat 2.30E − 04  93 290344.1 1335 1424 forward 3 WW domain 5.40E − 08  93 290344.1 2085 2222 forward 3 Zinc finger present in dystrophin, CBP/p300 1.80E − 10  99 272843.14 1212 1364 forward 3 Helix-loop-helix DNA-binding domain 4.90E − 10  100 234729.3 810 1106 forward 3 C2 domain 4.70E − 10  100 234729.3 4300 4551 forward 1 C2 domain 5.10E − 08  114 1382924.38 880 1077 forward 1 IBR domain 7.70E − 23  114 1382924.38 4011 4430 forward 3 Ubiquitin-conjugating enzyme 1.30E − 57  114 1382924.38 679 822 forward 1 Zinc finger, C3HC4 type (RING finger) 1.10E − 05  116 4349106CD1 4 66 PEPT KRAB box 2.40E − 41  118 197587.3 910 1299 forward 1 Fibroblast growth factor 2.10E − 40  119 403872.1 748 1218 forward 1 PAP2 superfamily 1.80E − 09  127 3230770CD1 771 935 PEPT Ligand-binding domain of nuclear hormone 1.10E − 37 receptor  127 3230770CD1 601 676 PEPT Zinc finger, C4 type (two domains) 2.30E − 46  131 408751.3 194 1204 forward 2 Dihydroorotase-like 1.20E − 12  131 408751.3 456 1355 forward 3 Dihydroorotase-like 6.60E − 08  138 246336.2 568 699 forward 1 Prenyltransferase and squalene oxidase 9.20E − 15  138 246336.2 449 544 forward 2 Prenyltransferase and squalene oxidase 3.10E − 11  139 246336.18 931 1065 forward 1 Prenyltransferase and squalene oxidase 5.40E − 17  141 253855.2 570 1919 forward 3 AMP-binding enzyme 2.20E − 10  142 337187.1 2027 2116 forward 2 Squash family of serine protease inhibitors 1.70E − 04  144 932244CD1 218 282 PEPT Immunoglobulin domain 4.50E − 07  147 399488.4 205 1155 forward 1 FMN-dependent dehydrogenase 2.10E − 162  150 237622.11 16 399 forward 1 Uncharacterized protein family UPF0023 5.40E − 04  151 237622.6 221 943 forward 2 Uncharacterized protein family UPF0023 1.90E − 101  155 334116.1 858 1004 forward 3 PHD-finger 9.80E − 16  158 407612.1 250 1524 forward 1 7 transmembrane receptor (rhodopsin family) 3.00E − 88  161 1004517CD1 291 390 PEPT Cyclic nucleotide-binding domain 2.20E − 32  161 1004517CD 7 44 PEPT Regulatory subunit of type II PKA R-subunit 2.30E − 17  162 199601.12 1 411 forward 1 LIF / OSM family 3.40E − 54  163 232946.1 242 1204 forward 2 Zinc-binding dehydrogenases 1.50E − 55  165 988491CD1 3 127 PEPT Ribosomal protein S8e 9.90E − 88  168 1674368CD1 168 209 PEPT Fibronectin type II domain 8.90E − 34  168 1674368CD1 975 1079 PEPT Lectin C-type domain 3.40E − 43  168 1674368CD1 22 142 PEPT Similarity to lectin domain of ricin beta-chain, 4.50E − 46 3 copies.  170 464689.54 586 774 forward 1 Cystatin domain 6.90E − 21  171 222181.1 453 1208 forward 3 7 transmembrane receptor (rhodopsin family) 9.10E − 94  175 1079625.3 1188 1256 forward 3 Zinc finger, C2H2 type 2.50E − 08  177 1275616CD1 1 115 PEPT 60s Acidic ribosomal protein 3.00E − 41  178 228046.5 1093 1161 forward 1 Zinc finger, C2H2 type 3.40E − 05  179 1225513.1 55 240 forward 1 Metallothionein 2.20E − 17  181 232849.13 1602 1856 forward 3 RNA recognition motif. (a.k.a. RRM, RBD, or 3.80E − 04 RNP domain)  183 411148.3 2057 2173 forward 2 WD domain, G-beta repeat 6.50E − 13  184 444619.13 66 248 forward 3 Metallothionein 1.90E − 24  190 1098877.1 557 829 forward 2 Ribosomal protein S11 3.40E − 51  190 1098877.1 481 549 forward 1 Ribosomal protein S11 1.40E − 09  191 251867.2 540 671 forward 3 Ets-domain 7.20E − 29  198 1571349CD1 81 135 PEPT Helix-turn-helix 6.50E − 13  200 40322.1 165 725 forward 3 Ras family 1.00E − 95  201 205542.2 745 816 forward 1 Leucine Rich Repeat 4.00E − 04  201 205542.2 355 453 forward 1 Leucine rich repeat N-terminal domain 1.50E − 07  203 1867417CD1 34 598 PEPT DNA topoisomerase II (N-terminal region) 0.00E + 00  203 1867417CD1 713 1183 PEPT DNA gyrase/topoisomerase IV, subunit A 1.60E − 191  210 232386.18 1184 1288 forward 2 MYND finger 1.30E − 06  212 2598244CD1 30 59 PEPT Eukaryotic protein kinase domain 5.40E − 07  214 2173757CD1 385 596 PEPT DEAD/DEAH box helicase 1.30E − 74  214 2173757CD1 633 714 PEPT Helicases conserved C-terminal domain 3.00E − 29  216 1405844CD1 9 234 PEPT Transmembrane 4 family 1.50E − 130  220 1099294.6 456 632 forward 3 KOW motif 8.20E − 23  223 241234.1 516 653 forward 3 Ribosomal protein L5 2.00E − 07  223 241234.1 663 980 forward 3 Ribosomal L5P family C-terminus 3.20E − 28  226 138709.5 220 414 forward 1 DnaJ domain 2.10E − 40  226 138709.5 844 1212 forward 1 DnaJ C terminal region 1.20E − 10  227 998926.1 494 595 forward 2 TPR Domain 5.40E − 07  229 1448817CD1 30 89 PEPT Insulin-like growth factor binding proteins 2.20E − 23  229 1448817CD1 176 251 PEPT Thyroglobulin type-1 repeat 5.50E − 40  231 245136.4 1416 1484 forward 3 Zinc finger, C2H2 type 9.60E − 06  231 245136.4 1273 1341 forward 1 Zinc finger, C2H2 type 8.20E − 05  241 997080.1 99 1604 forward 3 UDP-glucoronosyl and UDP-glucosyl 1.50E − 285  242 243369.1 11 253 forward 2 Hexokinase 9.00E − 18  244 322303.15 982 1188 forward 1 Immunoglobulin domain 1.50E − 08  244 322303.15 2600 3577 forward 2 Eukaryotic protein kinase domain 2.80E − 70  245 232935.2 2003 2257 forward 2 Fibronectin type III domain 1.80E − 12  245 232935.2 881 1066 forward 2 Immunoglobulin domain 3.80E − 13  247 1445507CD1 617 806 PEPT ATPases associated with various cellular 2.80E − 91 activities (AAA)  249 444648.12 366 548 forward 3 Metallothionein 1.20E − 24  252 1518310CD1 1 213 PEPT Connexin 5.80E − 163  264 229176.4 170 322 forward 2 Phosphoglucose isomerase 3.10E − 17  264 229176.4 540 608 forward 3 Phosphoglucose isomerase 4.50E − 04  265 229176.5 1606 2439 forward 1 Phosphoglucose isomerase 2.20E − 199  267 124600CD1 6 189 PEPT short chain dehydrogenase 2.60E − 72  272 238660.5 4353 4673 forward 3 CUB domain 2.70E − 38  272 238660.5 1317 1610 forward 3 Scavenger receptor cysteine-rich domain 1.00E − 42  272 238660.5 539 832 forward 2 Scavenger receptor cysteine-rich domain 3.20E − 42  272 238660.5 4707 5474 forward 3 Zona pellucida-like domain 9.90E − 70  275 370489.47 87 452 forward 3 Granulocyte-macrophage colony-stimulating 1.10E − 79  276 197185.2 1 450 forward 1 Cytochrome c/c1 heme lyase 1.20E − 09  278 1822864CD1 310 346 PEPT EGF-like domain 1.00E − 06  278 1822864CD1 83 258 PEPT von Willebrand factor type A domain 5.60E − 55  282 000506CD1 343 406 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 6.70E − 18 RNP domain)  283 407263.1 920 1126 forward 2 HMG (high mobility group) box 8.00E − 20  285 1630551CD1 90 315 PEPT Cytochrome C1 family 6.00E − 171  287 2558815CD1 45 511 PEPT Aldehyde dehydrogenase family 3.50E − 216  289 92230.2 259 429 forward 1 Homeobox domain 1.10E − 29  293 2426210CD1 6 234 PEPT short chain dehydrogenase 2.50E − 50  296 064987CD1 475 559 PEPT Hr1 repeat motif 1.30E − 21  296 064987CD1 1151 1234 PEPT PH domain 2.20E − 06  296 064987CD1 92 354 PEPT Eukaryotic protein kinase domain 1.30E − 74  306 898877.6 2344 2481 forward 1 Myb-like DNA-binding domain 3.30E − 13  309 2619838CD1 861 894 PEPT TPR Domain 1.50E − 07  310 369213.42 283 360 forward 1 Transmembrane 4 family 1.10E − 09  312 3557818CD1 444 546 PEPT PH domain 1.10E − 19  312 3557818CD1 777 963 PEPT RasGEF domain 3.00E − 68  312 3557818CD1 595 650 PEPT Guanine nucleotide exchange factor for Ras- 4.40E − 18 like GTPases; N-terminal motif  312 3557818CD1 204 389 PEPT RhoGEF domain 5.40E − 12  314 001622CD1 156 472 PEPT Eukaryotic protein kinase domain 3.50E − 59  324 1723834CD1 290 808 PEPT MCM2/3/5 family 2.40E − 298  326 2551987CD1 23 262 PEPT 3′ exoribonuclease family 1.30E − 75  328 407451.3 215 445 forward 2 Immunoglobulin domain 7.40E − 07  329 1382931.2 956 1291 forward 2 60s Acidic ribosomal protein 2.40E − 36  329 1382931.2 353 661 forward 2 Ribosomal protein L10 3.30E − 48  330 1382931.39 802 882 forward 1 60s Acidic ribosomal protein 1.60E − 11  330 1382931.39 602 817 forward 2 60s Acidic ribosomal protein 1.30E − 10  330 1382931.39 152 400 forward 2 Ribosomal protein L10 3.30E − 48  334 401532.3 34 465 forward 1 ABC transporter 1.20E − 05  335 401532.2 1067 1882 forward 2 ABC transporter transmembrane region. 4.40E − 44  335 401532.2 4082 4633 forward 2 ABC transporter 3.40E − 46  340 442308.1 294 464 forward 3 Homeobox domain 2.70E − 27  344 344166.2 954 1109 forward 3 Transglutaminase-like superfamily 2.50E − 12  345 1129157.1 472 930 forward 1 F5/8 type C domain 1.20E − 42  345 1129157.1 1012 2133 forward 1 Zinc carboxypeptidase 6.30E − 20  347 1804734CD1 35 246 PEPT Major Intrinsic protein 4.40E − 58  348 43646.7 781 984 forward 1 Annexin 4.90E − 22  349 43646.1 126 329 forward 3 Annexin 6.20E − 21  353 415378.3 144 536 forward 3 Reeler domain 7.50E − 77  353 415378.3 1841 1984 forward 2 Thrombospondin type 1 domain 3.10E − 23  358 1825508CD1 32 138 PEPT Cystatin domain 2.60E − 39  361 1095192.1 58 804 forward 1 Ion transport protein 1.00E − 88  361 1095192.1 1195 1257 forward 1 IQ calmodulin-binding motif 8.80E − 04  363 1383286.12 616 801 forward 1 Sushi domain (SCR repeat) 2.00E − 16  366 337156.2 361 1512 forward 1 POT family 8.30E − 156  369 2125081CD1 486 799 PEPT CNH domain 4.60E − 130  369 2125081CD1 15 272 PEPT Eukaryotic protein kinase domain 1.70E − 75  370 1400574.1 64 132 forward 1 Zinc finger, C2H2 type 4.40E − 07  370 1400574.1 357 425 forward 3 Zinc finger, C2H2 type 1.60E − 06  370 1400574.1 542 610 forward 2 Zinc finger, C2H2 type 3.20E − 05  373 2631218CD1 106 175 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 2.40E − 14 RNP domain)  375 3688791CD1 9 178 PEPT Cyclophilin type peptidyl-prolyl cis-trans 1.00E − 102  377 3283554CD1 22 451 PEPT Sulfatase 4.20E − 111  379 4960375CD1 113 183 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 6.00E − 14 RNP domain)  382 973308.1 522 671 forward 3 KH domain 1.50E − 15  383 238026.4 45 293 forward 3 Cadherin domain 2.10E − 10  385 1094829.54 1957 2151 forward 1 bZIP transcription factor 2.90E − 19  386 899602.1 1356 1586 forward 3 Src homology domain 2 1.20E − 15  387 107569.15 458 1018 forward 2 ADP-ribosylation factor family 1.30E − 05  387 107569.15 530 1111 forward 2 Ras family 1.60E − 86  390 2705321CD1 15 364 PEPT Fructose-bisphosphate aldolase class-I 1.60E − 251  392 903491.4 286 459 forward 1 LIM domain containing proteins 8.30E − 20  401 3676741CD1 498 566 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 2.40E − 04 RNP domain)  404 1640555CD1 232 292 PEPT Immunoglobulin domain 6.70E − 12  409 199584.1 348 485 forward 3 KH domain 4.00E − 04  415 351432.23 185 889 forward 2 HCO3- transporter family 4.10E − 131  415 351432.23 966 1145 forward 3 HCO3- transporter family 2.40E − 32  417 1252096CD1 23 93 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 3.30E − 22 RNP domain)  419 2545475CD1 26 488 PEPT Monocarboxylate transporter 4.00E − 159  428 222278.1 392 514 forward 2 Thrombospondin type 1 domain 9.80E − 06  430 1273292CD1 29 430 PEPT Aminotransferases class-1 8.60E − 196  443 168861CD1 109 165 PEPT Homeobox domain 3.20E − 28  447 2026270CD1 1 130 PEPT Parathyroid hormone family 3.10E − 82  449 522433CD1 211 308 PEPT Transforming growth factor beta like domain 6.80E − 19  454 3117184CD1 89 159 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 1.90E − 09 RNP domain)  456 3105671CD1 220 394 PEPT Serum albumin family 1.20E − 77  458 2051966CD1 84 137 PEPT Sushi domain (SCR repeat) 4.40E − 17  463 1326983.14 590 1783 forward 2 Transmembrane amino acid transporter 1.10E − 19  467 1422432CD1 53 81 PEPT EF hand 1.80E − 04  467 1422432CD1 4 47 PEPT S-100/ICaBP type calcium binding domain 2.70E − 21  468 409895.2 1198 1284 forward 1 EF hand 1.80E − 04  469 245136.9 874 942 forward 1 Zinc finger, C2H2 type 9.70E − 07  471 2600262CD1 17 388 PEPT S-adenosylmethionine synthetase 0.00E + 00  473 1086183.1 308 478 forward 2 KRAB box 1.50E − 15  473 1086183.1 833 901 forward 2 Zinc finger, C2H2 type 1.10E − 06  474 900070.12 739 1032 forward 1 PH domain 6.90E − 22  479 1256053CD1 35 148 PEPT Fz domain 1.30E − 65  479 1256053CD1 189 295 PEPT NTR/C345C module 2.10E − 27  481 201945.4 390 869 forward 3 Peptide methionine sulfoxide reductase 8.10E − 103  482 235725.21 187 501 forward 1 Protein of unknown function DUF122 1.30E − 64  486 481779.1 116 286 forward 2 Homeobox domain 3.20E − 32  491 199121.14 920 1150 forward 2 Disintegrin 4.90E − 24  491 199121.14 2 241 forward 2 Reprolysin family propeptide 1.10E − 13  491 199121.14 287 871 forward 2 Reprolysin (M12B) family zinc metalloprotease 6.50E − 107  493 1960207CD1 23 105 PEPT Ribosomal protein S24e 2.40E − 54  495 206866.1 102 338 forward 3 Fork head domain 3.40E − 53  495 206866.1 50 109 forward 2 Fork head domain 1.30E − 07  496 1330257.51 70 1197 forward 1 Actin 9.00E − 287  503 2246292CD1 188 450 PEPT ABC transporter transmembrane region. 6.00E − 41  503 2246292CD1 489 673 PEPT ABC transporter 8.80E − 54  507 6301537CD1 59 759 PEPT Myosin head (motor domain) 0.00E + 00  516 233218.22 35 571 forward 2 Trypsin 8.50E − 25  517 233218.18 656 823 forward 2 Sushi domain (SCR repeat) 7.90E − 13  517 233218.18 1790 2605 forward 2 Trypsin 9.20E − 48  517 233218.18 1157 1753 forward 2 von Willebrand factor type A domain 4.10E − 63  521 1600311CD1 3 78 PEPT Cytochrome c oxidase subunit VIIa 1.10E − 55  525 1080598.1 277 453 forward 1 KRAB box 1.40E − 17  525 1080598.1 1081 1149 forward 1 Zinc finger, C2H2 type 2.30E − 06  527 2239738CD1 140 424 PEPT Zinc carboxypeptidase 2.00E − 111  531 1730175CD1 539 621 PEPT Fibronectin type III domain 4.10E − 22  531 1730175CD1 263 322 PEPT Immunoglobulin domain 9.10E − 12  533 6825202CD1 52 519 PEPT Cytochrome P450 1.50E − 142  536 3027821CD1 130 405 PEPT GTPase of unknown function 5.40E − 48  537 480736.41 107 979 forward 2 GTPase of unknown function 4.70E − 05  546 1330220.16 214 2697 forward 1 Hsp90 protein 0.00E − 00  546 1330220.16 984 1118 forward 3 Hsp90 protein 2.50E − 23  548 5147.1 109 354 forward 1 Immunoglobulin domain 9.60E − 06  552 274712.1 532 1455 forward 1 HECT-domain (ubiquitin-transferase). 1.10E − 115  557 247423.13 3016 3207 forward 1 LIM domain containing proteins 2.10E − 04  560 1327024.5 111 392 forward 3 SCAN domain 2.80E − 11  560 1327024.5 2889 2957 forward 3 Zinc finger, C2H2 type 3.00E − 06  562 2925789CD1 90 154 PEPT DHHC zinc finger domain 2.30E − 25  569 107939.2 162 572 forward 3 RhoGAP domain 1.90E − 18  569 107939.2 816 1424 forward 3 START domain 3.70E − 39  573 296811.1 1297 1518 forward 1 RNA recognition motif. (a.k.a. RRM, RBD, or 1.60E − 04 RNP domain)  576 1859458CD1 309 546 PEPT Glutamine amidotransferase class-1 8.90E − 64  578 110960CD1 124 315 PEPT Uncharacterized protein family UPF0005 5.30E − 52  584 2466714CD1 67 446 PEPT Transmembrane amino acid transporter 2.10E − 42  587 246037.28 148 438 forward 1 HMG14 and HMG17 2.60E − 19  590 2651836CD1 386 457 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 7.00E − 11 RNP domain)  590 2651836CD1 22 56 PEPT SAP domain 4.80E − 12  596 332821.13 39 488 forward 3 Tubulin/FtsZ family 1.50E − 26  596 332821.13 496 606 forward 1 Tubulin/FtsZ family 1.00E − 05  597 344186.9 62 136 forward 2 Regulator of G protein signaling domain 2.40E − 08  598 344186.12 256 441 forward 1 GGL domain 8.50E − 29  598 344186.12 490 837 forward 1 Regulator of G protein signaling domain 4.50E − 54  612 212155.1 77 481 forward 2 Lipocalin / cytosolic fatty-acid binding 8.70E − 30 protein family  615 2789525CD1 45 118 PEPT PWI domain 2.60E − 41  617 1692213CD1 35 129 PEPT PPIC-type PPIASE domain. 8.90E − 20  620 001089CD1 5 130 PEPT Ribosomal protein S8 6.00E − 58  622 002484CD1 17 118 PEPT HIT family 9.00E − 59  624 669671CD1 31 177 PEPT Proteasome A-type and B-type 3.30E − 51  626 1344185CD1 29 64 PEPT Pancreatic hormone peptides 2.30E − 22  628 697785CD1 22 126 PEPT Vertebrate galactoside-binding lectins 2.90E − 65  629 336435.2 488 1615 forward 2 7 transmembrane receptor (rhodopsin family) 2.10E − 105  632 238322.6 433 1047 forward 1 Sema domain 2.60E − 69  632 238322.6 1191 1565 forward 3 Sema domain 6.10E − 23  633 55978.9 177 329 forward 3 3′5′-cyclic nucleotide phosphodiesterase 7.00E − 09  634 55978.4 841 1038 forward 1 PAS domain 3.40E − 05  634 55978.4 1876 2595 forward 1 3′5′-cyclic nucleotide phosphodiesferase 1.00E − 74  636 238877.11 443 532 forward 2 Zn-finger in Ran binding protein and others. 1.60E − 04  637 238877.8 126 215 forward 3 Zn-finger in Ran binding protein and others. 1.60E − 04  638 997231.15 99 584 forward 3 Glycosyl transferases 1.40E − 11  639 997231.16 100 615 forward 1 Glycosyl transferases 3.20E − 23  640 346209.3 852 914 forward 3 IQ calmodulin-binding motif 6.70E − 05  640 346209.3 246 806 forward 3 Myosin head (motor domain) 7.20E − 92  640 346209.3 1710 4286 forward 3 Myosin toil 2.00E − 181  642 2515666CD1 42 499 PEPT Cytochrome P450 2.00E − 159  644 2742913CD1 5 259 PEPT Eukaryotic-type carbonic anhydrase 3.90E − 193  645 336615.1 86 874 forward 2 Tub family 3.00E − 195  655 3721108CD1 273 432 PEPT Ligand-binding domain of nuclear hormone 2.70E − 48 receptor  655 3721108CD1 85 162 PEPT Zinc finger, C4 type (two domains) 9.60E − 35  664 2636759CD1 54 200 PEPT Dual specificity phosphatase, catalytic 6.90E − 20  668 1322.4 1105 1560 forward 1 RhoGAP domain 8.20E − 28  671 345272.2 1714 2052 forward 1 PX domain 4.30E − 15  671 345272.2 172 672 forward 1 Domain associated with PX domains 1.40E − 06  673 231840.1 24 758 forward 3 Cation efflux family 1.80E − 44  675 253783.6 5 214 forward 2 RNA recognition motif. (a.k.a. RRM, RBD, or 6.40E − 21 RNP domain)  679 1325741.2 2201 2395 forward 2 RNA recognition motif. (a.k.a. RRM, RBD, or 4.00E − 06 RNP domain)  681 2703282CD1 135 201 PEPT SAM domain (Sterile alpha motif) 1.10E − 04  682 118836.2 161 277 forward 2 Bacterial mutT protein 1.70E − 06  683 3303.2 372 1658 forward 3 Dwarfin 3.20E − 249  690 175918.15 2703 2918 forward 3 RNA recognition motif. (a.k.a. RRM, RBD, or 7.00E − 09 RNP domain)  691 1068290.1 359 544 forward 2 KRAB box 3.80E − 27  691 1068290.1 2439 2507 forward 3 Zinc finger, C2H2 type 5.00E − 08  691 1068290.1 1511 1579 forward 2 Zinc finger, C2H2 type 3.70E − 05  709 1508254CD1 16 463 PEPT Hexokinase 0.00E + 00  711 207452CD1 14 310 PEPT Mitochondrial carrier proteins 4.50E − 67  724 201395.4 2434 2694 forward 1 Fibronectin type III domain 3.10E − 18  724 201395.4 2173 2349 forward 1 Immunoglobulin domain 4.10E − 10  726 4295277CD1 1929 1945 PEPT Neuraxin and MAP 1B proteins 1.20E − 08  731 1837317CD1 1 375 PEPT Actin 1.90E − 286  733 2937262CD1 127 211 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 5.80E − 16 RNP domain)  734 199290.9 2261 3211 forward 2 Eukaryotic protein kinase domain 2.50E − 41  742 2847188CD1 80 121 PEPT Calcitonin / CGRP / IAPP family 7.30E − 26  745 1330212.14 147 542 forward 3 Ribosomal protein L11 4.90E − 64  750 1330122.1 13473 14789 forward 3 Sodium:solute symporter family 4.40E − 256  757 1719478CD1 1177 1445 PEPT Ion transport protein 2.00E − 100  769 1001589CD1 972 1065 PEPT Nucleotidyltransferase domain 4.40E − 11  770 7808.1 1559 1750 forward 2 DENN (AEX-3) domain 4.80E − 30  770 7808.1 1366 1593 forward 1 DENN (AEX-3) domain 7.10E − 21  773 474622.1 918 1100 forward 3 P21-Rho-binding domain 1.50E − 25  773 474622.1 411 725 forward 3 WH1 domain 2.30E − 29  773 474622.1 1608 1661 forward 3 Wiskott Aldrich syndrome homology region 2 5.20E − 06  775 1383009.67 2659 3000 forward 1 60s Acidic ribosomal protein 3.30E − 49  777 1086355.1 105 173 forward 3 Zinc finger, C2H2 type 1.10E − 04  779 1384716.4 315 941 forward 3 L1P family of ribosomal proteins 1.60E − 101  779 1384716.4 986 1150 forward 2 Ribosomal protein L3 5.60E − 31  787 035282CD1 191 416 PEPT DEAD/DEAH box helicase 3.20E − 70  787 035282CD1 453 534 PEPT Helicases conserved C-terminal domain 6.40E − 36  788 350667.7 548 697 forward 2 DEAD/DEAH box helicase 1.50E − 18  793 1806212CD1 707 744 PEPT tRNA synthetases class I (C) 9.60E − 4  795 4436028CD1 99 170 PEPT RNA recognition motif. (a.k.a. RRM, RBD, or 7.30E − 26 RNP domain)  804 344017.6 1930 1998 forward 1 Zinc finger, C2H2 type 4.00E − 04  807 2770104CD1 86 144 PEPT Immunoglobulin domain 5.60E − 07  810 2641740CD1 119 415 PEPT Phosphatidylinositol-4-phosphate 5-Kinase 2.90E − 150  815 170915CD1 131 255 PEPT C1q domain 4.80E − 29  815 170915CD1 65 123 PEPT Collagen triple helix repeat (20 copies) 2.20E − 04  820 427967.4 2859 2960 forward 3 TPR Domain 1.50E − 07  822 215158.5 1243 1377 forward 1 AN1-like Zinc finger 9.10E − 04  837 1850670CD1 257 295 PEPT Low-density lipoprotein receptor domain 1.90E − 14  837 1850670CD1 117 215 PEPT Scavenger receptor cysteine-rich domain 1.90E − 33  837 1850670CD1 340 569 PEPT Trypsin 5.30E − 87  841 1330056CD1 328 408 PEPT PCI domain 7.70E − 25  842 199788.2 234 806 forward 3 Ras family 3.80E − 94  850 997194.1 216 1151 forward 3 Intermediate filament proteins 8.20E − 139  861 1073168.6 505 780 forward 1 Ubiquitin carboxyl-terminal hydrolase family 2 2.70E − 21  862 1073168.8 239 334 forward 2 Ubiquitin carboxyl-terminal hydrolases family 4.70E − 08  862 1073168.8 1022 1297 forward 2 Ubiquitin carboxyl-terminal hydrolase family 2 2.70E − 21  871 404952.4 557 727 forward 2 SH3 domain 2.20E − 14  872 404952.1 132 410 forward 3 Fes/CIP4 homology domain 5.50E − 04  872 404952.1 1457 1627 forward 2 SH3 domain 2.50E − 16  874 348390.2 108 449 forward 3 Actin 9.40E − 62  877 253550.2 627 845 forward 3 Thyroglobulin type-1 repeat 1.50E − 32  885 399474.1 733 984 forward 1 IPT/TIG domain 3.50E − 19  889 5202390CD1 288 393 PEPT Calponin homology (CH) domain 2.40E − 17  895 998930.1 353 577 forward 2 Caseins 7.00E − 04  898 1082203.1 961 1029 forward 1 Zinc finger, C2H2 type 2.30E − 08  899 225420.1 2179 2319 forward 1 Phorbol esters/diacylglycerol binding domain 5.60E − 04 (C1 domain)  907 977975.1 603 701 forward 3 Ank repeat 2.40E − 08  909 1505038CD1 54 98 PEPT Kazal-type serine protease Inhibitor domain 7.20E − 12  911 262830CD1 204 291 PEPT Fibronectin type III domain 2.90E − 09  911 262830CD1 39 91 PEPT Immunoglobulin domain 1.10E − 07  913 3607580CD1 61 318 PEPT 7 transmembrane receptor (rhodopsin family) 5.40E − 100  917 252649.14 225 911 forward 3 Ras family 3.00E − 30  921 1384719.3 1221 1457 forward 3 Platelet-derived growth factor (PDGF) 2.50E − 53  924 481118.7 1097 1198 forward 2 TPR Domain 6.90E − 05  926 337528.4 611 964 forward 2 Nerve growth factor family 1.10E − 62  928 3687719CD1 18 113 PEPT Fork head domain 2.50E − 64  931 1530186CD1 152 412 PEPT 7 transmembrane receptor (Secretin family) 1.30E − 59  931 1530186CD1 90 143 PEPT Latrophilin/CL-1-like GPS domain 2.10E − 16  938 3257507CD1 62 317 PEPT AP endonuclease family 1 7.20E − 134  939 1400580.1 416 484 forward 2 Zinc finger, C2H2 type 3.00E − 06  941 346716.17 4829 4975 forward 2 Phorbol esters/diacylglycerol binding domain 1.60E − 07 (C1 domain)  941 346716.17 442 2022 forward 1 Myosin head (motor domain) 9.10E − 202  941 346716.17 2396 2761 forward 2 Myosin head (motor domain) 2.60E − 37  941 346716.17 43 342 forward 1 Ras association (RalGDS/AF-6) domain 1.20E − 33  941 346716.17 5069 5518 forward 2 RhoGAP domain 2.60E − 49  943 1384720.16 1060 1533 forward 1 Actin 1.40E − 88  943 1384720.16 1475 1513 forward 2 Actin 4.10E − 05  945 1505790CD1 138 194 PEPT Homeobox domain 8.60E − 30  947 3876162CD1 60 429 PEPT Calreticulin family 1.90E − 220  958 2852561CD1 112 491 PEPT Alpha amylase 1.70E − 04  960 988704.25 257 448 forward 2 RNA recognition motif. (a.k.a. RRM, RBD, or 6.30E − 20 RNP domain)  961 988704.26 185 376 forward 2 RNA recognition motif. (a.k.a. RRM, RBD, or 6.30E − 20 RNP domain)  965 5371205CD1 254 402 PEPT DENN (AEX-3) domain 6.90E − 86  974 1089708.18 3154 3279 forward 1 G-patch domain 7.90E − 10  974 1089708.18 2622 2786 forward 3 Surp module 1.80E − 20  977 088957CD1 28 202 PEPT Serum albumin family 1.20E − 89  978 220943.21 225 1517 forward 3 Integrins, beta chain 0.00E + 00  985 346641.3 313 1212 forward 1 Actin 6.50E − 40  985 346641.3 126 221 forward 3 Actin 2.40E − 04  996 242010.6 8 1336 forward 2 Hsp70 protein 7.20E − 47  996 242010.6 19 1254 forward 1 Hsp70 protein 2.10E − 04 1000 678004CD1 251 410 PEPT Ligand-binding domain of nuclear hormone 3.70E − 33 receptor 1000 678004CD1 72 146 PEPT Zinc finger, C4 type (two domains) 7.60E − 47 1002 411373.7 437 1744 forward 2 Sema domain 9.50E − 211 1005 343924.8 2678 2776 forward 2 FATC domain 5.50E − 09 1009 029251CD1 79 305 PEPT Fibrinogen beta and gamma chains, C- 1.60E − 103 terminal globular domain 1010 335648.1 208 1416 forward 1 Aminotransferases class-I 1.70E − 138 1011 331108.1 70 1728 forward 1 Lipoprotein amino terminal region 1.10E − 187 1015 1262593.2 467 568 forward 2 TPR Domain 3.30E − 11 1017 233660.2 514 756 forward 1 Ubiquitin carboxyl-terminal hydrolase family 2 7.60E − 25 1023 200051.1 2 646 forward 2 MAGE family 3.90E − 09 1024 1197030.1 987 1145 forward 3 Ribosomal protein L30p/L7e 2.30E − 28 1025 1197030.1 420 578 forward 3 Ribosomal protein L30p/L7e 2.30E − 28 1029 4832672CD1 17 135 PEPT Core histone H2A/H2B/H3/H4 1.40E − 29 1032 342074.1 3 287 forward 3 Sodium:neurotransmitter symporter family 1.60E − 46 1035 1852849CD1 130 163 PEPT TPR Domain 2.60E − 05 1039 13039.2 2886 3119 forward 3 Fibronectin type III domain 3.00E − 09 1044 1383263.14 581 916 forward 2 Thioredoxin 4.00E − 55 1047 1051954.7 1747 1815 forward 1 Zinc finger, C2H2 type 2.60E − 07 1050 335568.1 638 877 forward 2 Immunoglobulin domain 6.70E − 05 1052 272273.1 1 384 forward 1 Cadherin cytoplasmic region 2.00E − 64 1053 399133.9 567 1196 forward 3 Eukaryotic protein kinase domain 6.20E − 15 1055 246727.17 469 678 forward 1 RNA recognition motif. (a.k.a. RRM, RBD, or 1.00E − 13 RNP domain) 1058 1383039.17 13 828 forward 1 Hsp70 protein 3.20E − 11 1064 210133.1 836 904 forward 2 Zinc finger, C2H2 type 4.80E − 07 1065 430665.1 78 257 forward 3 Metallothionein 4.10E − 22 1066 902525.1 597 908 forward 3 Ribosomal L22e protein family 7.10E − 35 1071 233218.7 22 561 forward 1 von Willebrand factor type A domain 2.00E − 04 1072 1092387.12 374 439 forward 2 Aldo/keto reductase family 8.80E − 08 1076 1382920.38 253 723 forward 1 Ferritins 9.80E − 116 1079 1089210.1 61 903 forward 1 Aldo/keto reductase family 6.10E − 172 1080 444619.9 649 804 forward 1 Metallothionein 2.60E − 12 1082 462057.1 1074 1322 forward 3 PDZ domain (Also known as DHR or GLGF). 8.00E − 14 1083 197902.12 1079 1183 forward 2 EGF-like domain 7.80E − 05 1083 197902.12 710 826 forward 2 Low-density lipoprotein receptor domain 4.90E − 19 1083 197902.12 1703 1831 forward 2 Low-density lipoprotein receptor repeat class 4.30E − 17 1084 997394.4 2006 2311 forward 2 Guanylate kinase 1.30E − 05 1084 997394.4 1295 1537 forward 2 PDZ domain (Also known as DHR or GLGF). 2.30E − 19 1091 221042.1 1094 1330 forward 2 Ubiquitin family 1.40E − 08 1097 3505463CD1 4 172 PEPT ADP-ribosylation factor family 2.60E − 05 1097 3505463CD1 10 213 PEPT Ras family 1.40E − 89 1102 1330139.5 775 1035 forward 1 EF-1 guanine nucleotide exchange domain 2.20E − 56 1103 977951.1 1817 2035 forward 2 Prolyl oligopeptidase family 1.60E − 10 1104 347316.1 3514 4311 forward 1 Ion transport protein 1.40E − 97 1104 347316.1 516 1385 forward 3 Ion transport protein 3.20E − 58 1114 243924.12 117 326 forward 3 RNA recognition motif. (a.k.a. RRM, RBD, or 5.00E − 24 RNP domain) 1115 243924.13 635 847 forward 2 RNA recognition motif. (a.k.a. RRM, RBD, or 3.50E − 27 RNP domain) 1120 403994.5 213 599 forward 3 Sodium/calcium exchanger protein 1.60E − 23 1122 337250.1 71 211 forward 2 Kelch motif 3.70E − 18 1123 410781.1 211 600 forward 1 Fibroblast growth factor 2.70E − 43 1124 347759.3 3 407 forward 3 Actin 9.80E − 98 1125 1252060.4 308 850 forward 2 Serum albumin family 1.00E − 33 1126 209279.1 3236 4360 forward 2 Serpins (serine protease inhibitors) 2.90E − 217 1126 209279.1 2193 2333 forward 3 Serpins (serine protease inhibitors) 4.70E − 19 1127 418391.2 322 654 forward 1 BTB/POZ domain 6.10E − 12 1127 418391.2 1423 1566 forward 1 Kelch motif 5.30E − 55

TABLE 3 SEQ ID NO Template ID Clone ID Start Stop   1 230040.1 13504 1011 1342   2 175138.1 21957 1 274   3 1863336CB1 41247 1507 1670   5 343861.16 41479 781 1092   6 3170236CB1 89691 80 237   8 259805.54 96752 614 762   9 1460258CB1 120110 1740 2693  11 1016903.1 126877 2444 3200  12 65385.7 128891 2517 2815  13 3714.1 129775 45 460  14 1720920CB1 136073 2692 3093  16 256009.48 139949 607 1194  17 1055233.1 143765 1 206  18 2114865CB1 167081 239 685  20 1383740.1 168848 365 1279  21 2700132CB1 172023 6933 7334  23 231621.1 195943 70 756  24 216485.1 198719 1105 1598  25 406004.2 198959 1 388  26 1399930.1 220378 1066 1687  27 414171.33 223436 −6 510  28 230895.1 262712 −1 1625  29 22827.1 269310 66 424  30 346663.6 275757 1 579  31 96422.1 278100 −1 558  32 405833.1 278939 332 699  33 995839.2 279898 41 352  34 2517374CB1 293477 392 837  36 1255456CB1 301206 742 825  38 3084.1 305751 1 421  39 302123.12 309006 −6 285  40 533825CB1 322933 90 343  42 220845.2 339737 1 584  43 985475.8 346017 850 1309  44 198309.7 371201 132 401  45 1382869.18 380006 1104 1482  46 1382869.1 380006 1375 1774  47 352049.1 380041 0 393  48 215990.2 389558 4639 5188  49 428335.59 400654 1529 2081  50 1561192CB1 408442 1005 1251  52 1330151.46 409209 859 1181  53 1330151.49 409209 1278 1917  54 404028.1 417432 86 618  55 996427.2 419492 801 2458  56 21971.1 428897 132 838  57 215205.1 434751 1 337  58 400650.3 435549 954 1283  59 344524.1 435610 2868 3547  60 196709.1 439415 26 770  61 37502.4 451090 5285 6112  62 235687.5 459372 177 614  63 085596CB1 481402 1413 1876  65 234811.3 489820 773 1600  66 3393396CB1 494905 166 2601  68 978439.4 495808 1632 4489  69 11390.1 496946 1 242  70 1382924.42 508943 1 536  71 1256895CB1 509758 1211 2418  73 11115.1 509839 1 530  74 291267.1 517374 2520 3328  75 3125723CB1 523797 3368 3846  77 980593.1 526319 1 422  78 980593.6 526319 484 1061  79 410739.1 531505 1 714  80 405773.2 531842 493 1490  81 210871.1 538427 1 428  82 20265.2 548114 1 172  83 39840.1 554654 435 1066  84 088564CB1 560115 341 785  86 28889.1 562585 216 433  87 410611.1 566093 1 476  88 212533.1 569348 792 1393  89 24081.12 592085 1381 1834  90 983961.1 597555 526 850  91 1383290.2 608725 1290 1682  92 337221.11 615776 1501 2328  93 290344.1 617587 3430 3905  94 290344.3 617587 72 655  95 222714.1 619447 1 340  96 2230.1 620879 31 424  97 34424.1 621216 627 944  98 153237.1 621543 1 772  99 272843.14 622565 4919 5454  100 234729.3 626254 482 1134  101 349647.1 626471 23 595  102 236457.1 630375 364 1203  103 230193.1 641039 2371 3152  104 213429.1 641510 102 930  105 5124.22 646463 290 740  106 88974.2 654246 87 598  107 903909.1 660142 1298 2133  108 196981.1 664625 331 898  109 337888.3 668460 1357 1872  110 795.1 671717 32 507  111 3070147CB1 678955 138 472  113 20525.1 686993 1 418  114 1382924.38 689296 1 407  115 4349106CB1 693783 356 1042  117 247185.1 699113 178 527  118 197587.3 739461 2482 2899  119 403872.1 746910 1943 2406  120 900993.1 748477 130 553  121 228511.1 755223 5386 5782  122 406975.2 757370 366 806  123 200171.17 757514 110 501  124 291155.1 761282 371 646  125 1383047.1 777716 130 433  126 3230770CB1 819036 3058 3489  128 481453.1 830408 1 845  129 216141.1 835756 1 445  130 158318.1 854872 51 501  131 408751.3 859218 990 1600  132 998310.1 865145 1 263  133 1097471.1 868678 595 1061  134 983843.2 869702 1 527  135 983843.1 869702 410 521  136 985607.8 870396 4108 4955  137 152298.2 872017 84 834  138 246336.2 891072 338 781  139 246336.18 891072 1016 1301  140 405126.1 893224 1 330  141 253855.2 898741 4545 5026  142 337187.1 916103 2235 2623  143 932244CB1 932244 563 1212  145 160952.1 951433 1 541  146 13343.1 955538 483 864  147 399488.4 960496 385 695  148 399488.5 960496 347 723  149 28048.1 960604 1 103  150 237622.11 963331 1 319  151 237622.6 963331 1122 1603  152 26612.1 964939 1 611  153 413806.9 997480 760 1111  154 162569.1 998615 1 498  155 334116.1 1001486 3673 4838  156 396837.1 1004382 1073 1529  157 406507.1 1209413 267 787  158 407612.1 1210839 3166 3865  159 399501.1 1211357 666 1043  160 1004517CB1 1214989 2645 3017  162 199601.12 1219506 1048 1557  163 232946.1 1235345 4929 5565  164 988491CB1 1235535 256 704  166 199882.12 1236305 1 336  167 1674368CB1 1241484 3525 3926  169 115268.8 1251065 137 581  170 464689.54 1259841 150 1047  171 222181.1 1266985 2454 3205  172 2951538CB1 1268277 57 655  174 1087445.1 1269921 1006 1486  175 1079625.3 1274378 1889 2503  176 1275616CB1 1275616 33 577  178 228046.5 1284155 5543 6165  179 1225513.1 1299246 11 304  180 203438.2 1303862 1 335  181 232849.13 1305249 709 2219  182 19598.1 1306062 108 493  183 411148.3 1306222 4315 4784  184 444619.13 1308729 −2 363  185 1383714.1 1310337 1 328  186 1273641CB1 1315663 699 1247  188 403717.1 1316801 174 946  189 332165.8 1317428 743 1342  190 1098877.1 1319021 393 520  191 251867.2 1320685 73 731  192 5597.1 1323327 134 586  193 235356.1 1323616 1429 1883  194 47593.1 1326255 1 794  195 995887.12 1328741 1022 1726  196 245687.1 1329625 2596 2872  197 1571349CB1 1331853 8 414  199 336735.1 1337924 193 1125  200 40322.1 1342744 33 1267  201 205542.2 1350683 3976 4510  202 1867417CB1 1357231 3074 3751  204 402521.1 1364694 1 402  205 219537.2 1365045 1 254  206 219537.1 1365645 33 487  207 1041138.7 1366040 953 1310  208 49272.1 1370137 1 381  209 221433.21 1377668 295 984  210 232386.18 1383138 1336 1927  211 2598244CB1 1398105 2385 2998  213 2173757CB1 1401312 1953 2582  215 1405844CB1 1405844 72 1165  217 1143377.5 1407125 300 991  218 235147.1 1415119 3245 3728  219 235147.2 1415119 1096 1448  220 1099294.6 1416978 36 785  221 330927.1 1418276 410 940  222 50695.1 1425150 1 506  223 241234.1 1437552 15 1037  224 282397.77 1441245 2551 6114  225 984009.2 1446475 68 808  226 138709.5 1447306 1263 2152  227 998926.1 1448572 2563 3107  228 1448817CB1 1449819 578 1477  230 332521.1 1457424 911 1464  231 245136.4 1459743 1513 1946  232 237485.3 1469028 20 638  233 350851.2 1478855 39 248  234 403794.3 1482166 284 598  235 227489.1 1487428 1087 1568  236 268110.1 1495730 1 299  237 268244.1 1495907 1 592  238 268253.1 1495947 6 177  239 270049.1 1496011 58 414  240 997142.1 1496066 428 976  241 997080.1 1500810 882 2910  242 243369.1 1501410 −6 273  243 379571.7 1501809 4670 5149  244 322303.15 1503162 3816 4344  245 232935.2 1506930 4559 5005  246 1445507CB1 1507302 2107 2804  248 69812.3 1511262 408 899  249 444648.12 1513566 1 691  250 25194.1 1515346 32 446  251 1518310CB1 1518310 1692 2154  253 241335.1 1520151 1453 1948  254 22651.1 1521272 252 754  255 25911.1 1547122 1945 2318  256 336470.1 1552522 1 266  257 978673.2 1559844 1781 2315  258 54242.1 1560380 132 681  259 1823159CB1 1560906 2628 3425  261 20602.1 1569904 15 244  262 1090531.28 1570534 1233 1653  263 399872.1 1571861 172 958  264 229176.4 1573840 320 691  265 229176.5 1573840 2542 2833  266 124600CB1 1578941 38 611  268 994387.65 1594179 2066 2480  269 201462.7 1596220 1 736  270 991497.1 1597837 19 834  271 347444.1 1600180 882 1548  272 238660.5 1604437 5456 5898  273 404601.1 1604650 1200 1721  274 1329936.3 1607203 1397 1747  275 370489.47 1609387 16 779  276 197185.2 1610828 1 477  277 1822864CB1 1611445 875 1602  279 2258794CB1 1611629 3054 3250  281 000506CB1 1614014 433 709  283 407263.1 1616048 372 852  284 1630551CB1 1619292 281 1147  286 2558815CB1 1630990 1846 2385  288 347411.1 1635877 1 627  289 92230.2 1636015 510 788  290 333989.1 1636594 130 807  291 333542.1 1637145 2020 2253  292 24262210CB1 1638756 500 992  294 476760.12 1651008 162 541  295 064987CB1 1652328 1913 2435  297 8450.1 1661892 1 291  298 197652.3 1662632 706 1521  299 248203.2 1662870 51 1084  300 2023351CB1 1667220 571 3240  302 228610.1 1670407 57 1117  303 92268.1 1679595 3215 3666  304 16566.1 1679683 39 264  305 1329120.1 1683583 1 452  306 898877.6 1684617 8435 8991  307 29490.1 1696552 1 501  308 2619838CB1 1697719 4334 5099  310 369213.42 1697855 534 969  311 3557818CB1 1700074 4590 5332  313 001622CB1 1700287 895 1741  315 223407.4 1706751 1061 1472  316 899334.1 1707037 3258 3537  317 237299.13 1709709 1 744  318 1149046.1 1715374 412 1220  319 404011.3 1716458 10 360  320 3768043CB1 1721320 2415 2852  322 39946.19 1721320 2312 2679  323 1723834CB1 1723834 2901 3240  325 2551987CB1 1728013 15 453  327 232772.13 1728013 649 890  328 407451.3 1730026 1482 1824  329 1382931.2 1732792 1486 1872  330 1382931.39 1732792 663 940  331 411059.1 1735702 146 697  332 474862.8 1737512 203 623  333 402366.1 1740179 566 1125  334 401532.3 1740474 1 509  335 401532.2 1740474 4392 4890  336 407896.4 1740788 1098 1629  337 982625.1 1740975 0 356  338 59947.1 1741288 470 1447  339 902471.11 1753283 1 420  340 442308.1 1756875 1 375  341 193755.1 1781411 2504 3043  342 60957.1 1786554 1 597  343 5124.23 1798594 36 297  344 344166.2 1799078 1684 2153  345 1129157.1 1802939 2433 2800  346 1804734CB1 1804553 607 1274  348 43646.7 1805836 572 1073  349 43646.1 1805836 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1988774 2579 2941  428 222278.1 1995136 1945 2319  429 1273292CB1 1995520 2007 2428  431 67855.1 1995767 1 757  432 27185.1 1998317 1 492  433 240057.2 2005266 22 724  434 17090.1 2006043 60 379  435 17021.2 2007730 1 416  436 235682.5 2008331 1 531  437 399329.3 2009252 160 600  438 68862.1 2013251 1 362  439 8603.3 2013955 1 362  440 337647.1 2018315 181 927  441 200268.3 2018808 1584 2089  442 168861CB1 2019910 506 1002  444 334738.1 2021989 1 482  445 410042.1 2025128 526 1313  446 2026270CB1 2026270 532 800  448 522433CB1 2042056 854 1234  450 234987.1 2044184 1 427  451 1330257.32 2046717 1 372  452 407023.1 2047312 476 700  453 3117184CB1 2047730 401 806  455 3105671CB1 2051568 1812 2328  457 2051966CB1 2051966 45 1182  459 1969731CB1 2055569 700 2976  461 2171401CB1 2055814 854 1639  463 1326983.14 2055867 4036 4756  464 339106.1 2057265 1 393  465 331666.1 2057513 407 995  466 1422432CB1 2060823 397 842  468 409895.2 2060823 1224 1458  231 245136.4 2061171 1448 1936  469 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2176212 2637 3047  508 1398801.9 2188005 414 894  509 1398801.5 2188005 1216 1408  510 14538.1 2189061 2 713  511 14007.1 2189237 1 327  512 239996.2 2195427 1 463  513 238403.2 2196870 676 1536  514 234681.2 2203570 1661 2186  515 228678.1 2215282 714 1428  516 233218.22 2216323 80 495  517 233218.18 2216323 2475 2663  518 6320.1 2222155 1 318  519 15433.1 2226309 1 370  520 1600311CB1 2227273 239 714  522 335999.1 2230608 426 1042  523 197523.6 2233219 898 1610  524 12833.1 2234266 1 239  525 1080598.1 2239236 925 1457  526 2239738CB1 2239738 1264 1909  528 87074.1 2246915 2235 2649  529 12039.1 2252501 1 270  530 1730175CB1 2252884 4816 5307  532 6825202CB1 2252906 344 1406  534 25613.1 2253102 2 526  535 3027821CB1 2253868 1053 1602  537 480736.41 2253868 1406 1769  538 236943.1 2260285 844 1253  539 76636.1 2266959 471 892  540 76644.1 2267466 355 721  541 76699.1 2268803 464 724  542 238140.1 2268923 15 233  543 19080.2 2269058 79 645  544 274444.1 2271648 1 483  545 279625.1 2273619 1 450  546 1330220.16 2273944 2433 3329  547 99792.1 2276895 1 708  548 5147.1 2277161 819 1283  549 272599.1 2278772 1 278  550 238396.1 2284694 434 1572  551 23904.1 2285181 113 960  552 274712.1 2285521 2235 2625  553 979567.11 2285721 6236 6729  554 234121.1 2286360 2237 2903  555 252493.15 2287426 3518 3961  556 899766.1 2287703 801 1255  557 247423.13 2287724 4420 4929  558 334234.2 2291665 1379 1798  559 205672.1 2293494 845 1666  560 1327024.5 2293496 7545 7927  561 2925789CB1 2294968 1387 2123  563 335613.1 2302785 1523 1926  564 207646.1 2302810 1 711  565 1720847CB1 2311213 241 930  567 2313349CB1 2313349 17 460  569 107939.2 2313581 2837 3302  570 11540.1 2314164 1 200  571 78831.1 2322243 371 601  572 207778.1 2325802 469 1185  573 296811.1 2327230 3077 3889  574 333776.1 2343348 126 201  575 1859458CB1 2343836 42 2003  577 110960CB1 2345426 94 980  579 238602.2 2346851 776 1266  580 363007.1 2347684 799 960  581 3478236CB1 2350594 72 623  583 2466714CB1 2358261 513 1431  585 4208.1 2364257 38 551  586 903475.2 2370756 1504 2029  587 246037.28 2372040 378 906  588 337183.1 2381040 403 1291  589 2651836CB1 2382190 1308 1775  591 80339.1 2383242 1 677  592 480968.13 2394616 861 1423  593 337448.1 2394990 650 957  594 5360.1 2395112 1 785  595 998599.8 2399169 −8 488  596 332821.13 2399665 208 669  597 344186.9 2403438 1 395  598 344186.12 2403438 1066 1651  599 212489.1 2404746 948 1461  600 80711.1 2405487 25 363  601 80787.1 2407620 1 521  602 334352.1 2408333 963 1521  603 208376.1 2410066 1 563  604 7820.1 2415118 0 190  605 81447.1 2420388 1 96  606 81821.1 2427327 1 311  607 81869.1 2428314 1 789  608 210011.1 2430165 1021 1368  609 480336.3 2430750 1 422  610 1024610.45 2444137 1139 1532  611 82013.1 2444740 1 703  612 212155.1 2445967 22 690  613 22632.1 2447829 393 830  614 2789525CB1 2453558 105 560  616 1692213CB1 2458526 13 435  618 15393.1 2459765 193 608  619 001089CB1 2469891 18 499  621 002484CB1 2471835 74 733  623 669671CB1 2482388 109 780  625 1344185CB1 2494284 1043 1581  627 697785CB1 2495131 21 332  629 336435.2 2497692 2047 2744  630 231558.1 2499418 342 1145  631 247784.3 2499905 116 1213  632 238322.6 2499976 2893 3642  633 55978.9 2500872 1 392  634 55978.4 2500872 2704 3145  635 350977.1 2506425 695 786  636 238877.11 2506973 244 579  637 238877.8 2506973 −31 277  638 997231.15 2507552 1 520  639 997231.16 2507552 3 954  640 346209.3 2511277 4753 5180  641 2515666CB1 2515666 1 2321  643 2742913CB1 2516950 75 1693  645 336615.1 2520894 1088 1325  646 406830.43 2529162 639 986  647 406830.33 2529162 1 296  648 84685.1 2532033 8 309  649 1045907.4 2539933 1 375  650 1383803.2 2544622 312 611  651 85282.1 2545486 83 487  652 86326.1 2571644 749 1212  473 1086183.1 2579218 498 730  653 337470.1 2579572 1 1030  654 3721108CB1 2581075 976 1973  656 1090929.2 2607834 1080 1623  657 95374.1 2611889 63 777  658 238639.2 2619275 26 735  659 33627.28 2619954 −37 288  660 33627.33 2619954 2260 2712  661 435361.1 2623304 916 1175  662 474552.1 2631261 1 448  663 2636759CB1 2636759 1 1130  665 1083665.4 2655279 241 1075  666 240518.21 2660756 1 333  667 240518.42 2660756 534 1026  668 1322.4 2663164 1069 3206  669 208282.1 2667438 117 1205  670 345272.5 2669337 1 330  671 345272.2 2669337 988 1436  672 997613.1 2669871 494 615  673 231840.1 2675433 394 1319  674 13937.3 2687356 19 613  675 253783.6 2695371 1 851  676 20828.1 2697275 89 264  677 222705.14 2698777 −23 515  678 335906.1 2702786 1 369  679 1325741.2 2703122 1671 2046  680 2703282CB1 2703282 846 1314  682 118836.2 2705256 3522 4024  683 3303.2 2706669 4269 4611  684 92991.1 2707635 1 141  685 93603.1 2724032 1 75  686 1383062.7 2725369 17 291  687 1383062.8 2725369 10 563  688 1383794.1 2726759 34 528  689 406289.1 2734007 −219 298  690 175918.15 2742315 5879 6351  691 1068290.1 2747179 850 1090  692 94873.1 2750849 1 395  693 403616.1 2751922 276 947  694 95088.1 2753065 1 618  695 230402.1 2753371 85 489  696 95172.1 2753963 1 802  697 250091.1 2755836 2 448  698 4113161CB1 2756333 1591 2131  700 335375.3 2756587 255 864  701 95395.1 2756747 1 570  702 229514.1 2756910 702 1294  703 95573.1 2759015 1 298  704 230463.1 2760615 528 1215  705 95702.1 2761527 1 360  706 218090.9 2767579 391 1543  707 96126.1 2769732 1 282  708 1508254CB1 2769888 1163 1589  710 207452CB1 2778441 70 1588  712 290233.1 2780013 1 272  713 1096917.11 2786442 1 506  714 208748.4 2794808 1913 2437  715 407517.2 2794866 4244 4978  716 233997.1 2797740 2639 3722  717 237067.1 2803833 67 624  718 330862.6 2806983 1 321  719 330862.8 2806983 1121 1754  720 2124957CB1 2811404 58 1860  722 1098722.6 2817244 1879 2470  723 1099023.1 2818476 174 554  724 201395.4 2822027 4780 5689  725 4295277CB1 2823478 7665 8240  727 98533.1 2823767 1 445  728 983684.1 2828647 318 804  729 983684.2 2828647 1 500  730 1837317CB1 2830240 820 1070  732 2937262CB1 2831351 57 523  734 199290.9 2833342 1 736  735 3151579CB1 2836470 3737 4135  737 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1383009.57 2946292 24 555  775 1383009.67 2946292 216 809  776 1086355.2 2947188 11 416  777 1086355.1 2947188 80 667  778 998330.2 2948678 50 489  779 1384716.4 2954059 308 969  780 2790762CB1 2956444 435 994  782 399607.1 2956670 170 772  783 256138.1 2956869 −12 497  784 413348.4 2959255 1704 2129  785 332088.2 2972013 154 630  786 035282CB1 3001212 3 361  788 350667.7 3001212 381 782  789 343913.1 3001817 1 488  790 211622.1 3003980 1 701  791 110049.1 3016137 229 707  792 1806212CB1 3029474 765 1735  794 4436028CB1 3031022 782 1446  796 406663.3 3031872 142 736  797 405689.1 3034889 1 765  798 110815.1 3035780 1 215  799 1385527.4 3042227 2878 3410  800 2570.1 3045419 29 153  801 1100724.1 3045790 514 738  802 3704760CB1 3047143 36 595  804 344017.6 3049285 1605 2183  805 344017.3 3049285 1027 1623  806 2770104CB1 3057267 316 615  808 349204.1 3057272 1 934  114 1382924.38 3068429 553 964  809 2641740CB1 3068809 53 358  811 211881.1 3068978 1 548  812 334749.1 3069190 74 634  813 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116549.1 3188967 1 465  854 17886.1 3190654 1 210  855 351032.1 3191030 238 844  856 977532.9 3200811 862 1536  857 117273.1 3206352 1 336  858 212438.1 3220149 606 830  859 212265.7 3221109 101 597  860 403560.1 3229449 129 810  861 1073168.6 3230318 386 656  862 1073168.8 3230318 3577 3819  863 119614.1 3253462 1 295  864 119625.1 3253556 135 356  865 119671.1 3253978 1 404  866 3177.1 3254430 260 1532  867 119974.1 3255873 1 295  868 120831.1 3278632 483 958  869 27619.3 3284411 474 1316  870 212872.1 3332232 31 507  871 404952.4 3334476 32 551  872 404952.1 3334476 3392 3982  873 125014.1 3369213 35 308  874 348390.2 3381870 50 205  875 227222.1 3390535 −123 301  876 337696.1 3391835 1 117  877 253550.2 3397390 345 737  878 1326925.1 3408804 528 829  879 127140.1 3408939 1 725  880 127204.1 3409540 1 310  881 330925.1 3410101 303 845  882 403960.1 3411051 166 1032  883 20152.1 3421730 376 722  884 26200.1 3426776 1 388  885 399474.1 3434166 2739 3904  886 981037.1 3449615 468 1309  887 130502.1 3451296 1 799  888 5202390CB1 3451645 98 697  890 213447.4 3456829 142 484  891 250439.1 3474091 1 418  892 2743049CB1 3478570 500 934  894 256026.8 3478570 309 692  895 998930.1 3479268 16 990  896 981149.2 3481841 14 523  897 335420.1 3495173 1712 2684  898 1082203.1 3497137 524 1471  899 225420.1 3497231 1442 2116  900 236298.4 3508345 1448 1916  901 236298.2 3508345 572 928  902 982813.1 3522739 329 1013  903 154771.1 3528232 147 441  904 477054.1 3566383 553 1267  905 2966.1 3569151 86 376  906 136212.1 3571607 1 558  907 977975.1 3595618 118 1885  908 1505038CB1 3606046 2 1186  910 262830CB1 3606947 1 1737  912 3607580CB1 3607580 2034 2829  914 137742.1 3614283 1 304  915 1095839.1 3616233 2977 3842  916 205328.1 3621521 1 729  917 252649.14 3629043 −383 263  918 221762.2 3633707 2 455  919 138205.1 3639747 131 487  920 331566.1 3659618 3517 3954  921 1384719.3 3679667 3030 3522  922 1330137.1 3681722 1 237  923 409962.1 3686411 1 477  924 481118.7 3686603 926 1412  925 481118.12 3686603 1276 1869  926 337528.4 3687607 −49 1310  927 3687719CB1 3687719 328 1256  929 332299.1 3714088 1 836  930 1530186CB1 3715059 3278 4655  932 251809.1 3721985 1 285  933 334025.5 3724351 85 469  934 350134.1 3729593 1 701  935 16124.2 3732960 31 391  936 140468.1 3736815 1 500  937 3257507CB1 3747901 271 1392  939 1400580.1 3770530 356 633  940 481154.3 3778404 653 1655  941 346716.17 3792988 6197 6701  942 346716.21 3792988 413 1063  943 1384720.16 3818422 1 287  944 1505790CB1 3821432 1 1226  946 3876162CB1 3875135 803 1647  948 40576.1 3876612 575 1254  949 1040190.14 3880722 1024 1467  950 1328310.1 3890145 229 314  951 34297.1 3915205 1 707  952 145549.2 3926757 1 377  954 178799.1 3960194 1 782  955 214767.1 3967255 1 370  956 94384.1 3973687 −8 564  957 2852561CB1 3973887 19 1854  959 337058.1 3974247 1770 2672  960 988704.25 3975209 2143 2589  961 988704.26 3975209 714 1164  962 401906.2 3979665 1 412  963 154220.1 3980695 87 385  964 5371205CB1 3983862 3165 3636  966 147026.1 3999352 1 397  967 410776.1 4000614 311 794  968 335121.1 4002388 78 369  969 147379.1 4003219 1 115  970 147403.1 4003460 34 1028  971 1041063.1 4018288 108 506  972 1041063.5 4018288 108 506  973 230912.1 4021009 1 518  974 1089708.18 4070403 448 1006  975 1050390.1 4077648 1 486  976 088957CB1 4087621 1147 1611  978 220943.21 4089291 2931 3683  979 28005.14 4089755 356 833  980 980446.1 4091186 1 801  981 198827.1 4092112 90 1147  982 215112.1 4110976 1 522  983 977929.1 4112181 1192 1685  984 281447.2 4181663 38 609  985 346641.3 4195203 1047 1409  986 230793.3 4203937 1005 2173  987 431288.1 4208369 639 879  988 4215034CB1 4215034 3479 4183  990 150627.1 4221092 1 717  991 121731.1 4222957 0 512  992 259907.1 4223315 1 132  993 977727.13 4223734 0 558  994 5915.1 4228236 1 649  995 8835.1 4232507 122 372  996 242010.6 4246966 405 590  997 242684.1 4247396 29 461  998 335145.1 4247951 1099 1460  999 678004CB1 4248767 1260 1738 1001 92922.1 4249090 1 131 1002 411373.7 4251117 209 1047 1003 404715.1 4252768 1 526 1004 278831.1 4252872 1 456 1005 343924.8 4253663 2628 3110 1006 200977.1 4253809 277 690 1007 181818.3 4266051 1801 2186 1008 029251CB1 4284270 24 622 1010 335648.1 4284384 33 430 1011 331108.1 4286760 2385 2748 1012 333840.1 4287327 1166 1659 1013 334298.1 4288091 1 463 1014 344597.2 4289063 1 259 1015 1262593.2 4289557 1156 1510 1016 461375.2 4291619 1142 1613 1017 233660.2 4292488 1 386 1018 230179.3 4297813 586 897 1019 230179.7 4297813 1135 1582 1020 296245.1 4298848 93 557 1021 981208.1 4307290 1525 1964 1022 406580.1 4312603 2441 3006 1023 200051.1 4312860 1567 2036 1024 1197030.1 4334474 749 1144 1025 1197030.1 4334474 546 971 1026 158859.1 4339883 52 390 1027 229490.1 4340307 166 859 1028 4832672CB1 4373333 40 438  943 1384720.16 4377432 477 601 1030 339638.1 4402555 1 687 1031 480885.2 4403805 190 2066 1032 342074.1 4408943 1 487 1033 406992.1 4413637 1 922 1034 1852849CB1 4423361 2390 2951 1036 1132829.1 4464538 119 561 1037 339800.1 4505265 1 651 1038 1399492.1 4508879 444 1335 1039 13039.2 4535971 2706 3916 1040 399626.1 4543123 1 829 1041 365070.3 4549259 393 841 1042 365070.1 4549259 123 698 1043 1383263.1 4554722 6 353 1044 1383263.14 4554722 2248 2655 1045 406707.2 4587665 1 505 1046 406707.1 4587665 557 675 1047 1051954.7 4590473 171 649 1048 102564.1 4606503 1 413 1049 233312.1 4611240 385 1008 1050 335568.1 4630674 1115 1414 1051 407739.1 4631069 239 419 1052 272273.1 4695453 142 875 1053 399133.9 4698018 3030 3665 1054 246727.11 4715924 272 642 1055 246727.17 4715924 1249 1618 1056 230367.2 4717363 1173 1604 1057 1383039.18 4721130 71 536 1058 1383039.17 4721130 912 1136 1059 27704.2 4738532 1 391 1060 346900.1 4741591 1 562 1061 249813.1 4759669 61 446 1062 411357.1 4792726 3 277 1063 68902.1 4822285 315 898 1064 210133.1 4855265 1669 2303 1065 430665.1 4858420 5 242 1066 902525.1 4860060 280 977 1067 256841.1 4863677 209 785 1068 206344.1 4872725 270 937 1069 107309.1 4883207 509 1011 1070 1074024.1 4884214 445 726 1071 233218.7 4886605 302 976 1011 331108.1 4894508 13145 13506 1072 1092387.12 4896168 1 556 1073 1092387.11 4896168 5 542 1074 366463.1 4912315 212 563 1075 304409.1 4970829 1 381 1076 1382920.38 4978708 49 565 1077 342365.1 5004556 334 589 1078 399210.1 5024212 −10 568 1079 1089210.1 5033671 34 1152 1080 444619.9 5038177 590 959 1081 312986.1 5038604 1 254 1082 462057.1 5044351 688 1106 1083 197902.12 5045593 85 502 1084 997394.4 5046235 866 1306 1085 2481150CB1 5047895 318 738 1087 8198.1 5076842 390 898 1088 72297.2 5089438 192 797 1089 994430.16 5091002 1 521 1090 189036.1 5094042 −58 368 1091 221042.1 5098879 765 2032 1092 408398.1 5101167 544 921 1093 985369.1 5102731 360 1154 1094 328796.1 5102951 1 450 1095 58804.1 5106915 119 715 1096 3505463CB1 5109437 237 522 1098 197159.1 5115293 1 439 1099 369928.1 5138591 1 878 1100 413466.6 5166479 677 1170 1101 397295.1 5186846 1 559 1102 1330139.5 5198045 305 1096  959 337058.1 5206821 1308 2649 1103 977951.1 5207486 1481 2760 1104 347316.1 5208013 4639 5036 1105 150288.3 5262558 1 443 1106 2455.1 5266015 668 1133 1107 372647.1 5266376 81 792 1108 137710.1 5275515 1 659 1109 407644.1 5275693 3222 3571 1110 373516.1 5280239 827 1226 1111 241762.23 5281739 1190 1501 1112 1040914.1 5285915 28 521 1113 358492.1 5291215 369 1080 1114 243924.12 5291518 4 399 1115 243924.13 5291518 1027 1513 1116 208075.1 5293028 417 737 1117 168955.1 5321996 −29 710  804 344017.6 5322365 721 1243 1118 428508.1 5323022 1 783 1119 418070.1 5325802 717 1342 1120 403994.5 5326338 328 974 1121 336726.1 5326983 348 766 1122 337250.1 5372104 1 498 1123 410781.1 5374705 1296 1705 1124 347759.3 5397446 551 814 1125 1252060.4 5398701 133 216 1126 209279.1 5399371 2089 4658 1127 418391.2 5405691 1373 1729 1128 480630.21 5424122 1 293 1129 117799.1 5426158 432 777 1130 235194.15 5427710 357 682 1131 379400.1 5501676 −2 301  560 1327024.5 5506170 393 898 1132 380433.1 5507406 83 281 1133 140122.22 5508135 1819 2042 1134 131931.1 5509134 1 367 1135 381058.1 5512044 201 717 1136 403136.1 5521873 −1 162 1137 276647.1 5541828 1 434 1138 191631.1 5543385 1 303 1139 887619.26 5573549 536 1160 1140 980953.1 5690026 131 481 1141 389859.1 5700537 −8 283 1142 217281.1 5859590 1 396 1143 32428.1 5867032 106 523

TABLE 4 SEQ ID NO Template ID Start Stop Frame Hit Type 1 230040.1 482 553 forward 2 SP 1 230040.1 68 166 forward 2 SP 5 343861.16 1950 2036 forward 3 TM 5 343861.16 284 346 forward 2 TM 5 343861.16 2081 2131 forward 2 TM 5 343861.16 2193 2249 forward 3 TM 5 343861.16 940 993 forward 1 SP 5 343861.16 284 340 forward 2 TM 5 343861.16 952 999 forward 1 TM 5 343861.16 934 1014 forward 1 TM 5 343861.16 940 1005 forward 1 TM 5 343861.16 952 1014 forward 1 TM 5 343861.16 940 1014 forward 1 TM 5 343861.16 940 1011 forward 1 SP 5 343861.16 940 1020 forward 1 SP 5 343861.16 940 996 forward 1 TM 5 343861.16 940 999 forward 1 SP 5 343861.16 940 1008 forward 1 SP 7 3170236CD1 1 21 SP 7 3170236CD1 1 23 SP 7 3170236CD1 1 19 TM 7 3170236CD1 1 17 SP 7 3170236CD1 1 19 SP 8 259805.54 157 225 forward 1 TM 8 259805.54 318 368 forward 3 TM 8 259805.54 356 412 forward 2 TM 11 1016903.1 2165 2242 forward 2 TM 11 1016903.1 1180 1233 forward 1 SP 11 1016903.1 1180 1254 forward 1 SP 11 1016903.1 1180 1272 forward 1 SP 11 1016903.1 1180 1248 forward 1 SP 12 65385.7 2972 3034 forward 2 TM 12 65385.7 1615 1689 forward 1 TM 12 65385.7 1609 1659 forward 1 TM 15 1720920CD1 2220 2246 TM 15 1720920CD1 2229 2246 SP 15 1720920CD1 5 29 SP 15 1720920CD1 2221 2245 TM 15 1720920CD1 2229 2247 TM 15 1720920CD1 2229 2245 TM 15 1720920CD1 2222 2244 SP 15 1720920CD1 2222 2248 SP 15 1720920CD1 2222 2237 SP 15 1720920CD1 2222 2245 SP 15 1720920CD1 2222 2241 SP 15 1720920CD1 1 30 SP 19 2114865CD1 1 25 SP 19 2114865CD1 4 18 SP 19 2114865CD1 1 18 SP 19 2114865CD1 1 20 SP 19 2114865CD1 1 23 SP 20 1383740.1 330 383 forward 3 TM 20 1383740.1 354 413 forward 3 SP 20 1383740.1 354 407 forward 3 SP 20 1383740.1 304 408 forward 1 SP 20 1383740.1 336 389 forward 3 TM 24 216485.1 1088 1156 forward 2 TM 26 1399930.1 1652 1711 forward 2 SP 26 1399930.1 1652 1705 forward 2 SP 26 1399930.1 1625 1702 forward 2 TM 26 1399930.1 618 680 forward 3 TM 26 1399930.1 1263 1331 forward 3 TM 26 1399930.1 946 1011 forward 1 SP 26 1399930.1 579 629 forward 3 TM 26 1399930.1 1637 1699 forward 2 TM 26 1399930.1 1619 1693 forward 2 TM 26 1399930.1 1057 1116 forward 1 SP 26 1399930.1 1652 1702 forward 2 TM 26 1399930.1 1454 1513 forward 2 TM 26 1399930.1 1665 1724 forward 3 TM 26 1399930.1 1460 1513 forward 2 TM 27 414171.33 2618 2701 forward 2 SP 27 414171.33 2618 2689 forward 2 SP 27 414171.33 2129 2203 forward 2 SP 27 414171.33 2623 2682 forward 1 TM 27 414171.33 1160 1279 forward 2 SP 27 414171.33 2631 2687 forward 3 TM 27 414171.33 2630 2689 forward 2 TM 27 414171.33 2618 2677 forward 2 SP 28 230895.1 740 820 forward 2 SP 28 230895.1 647 700 forward 2 TM 28 230895.1 749 814 forward 2 SP 28 230895.1 749 820 forward 2 SP 30 346663.6 237 287 forward 3 TM 30 346663.6 225 287 forward 3 TM 30 346663.6 225 290 forward 3 SP 30 346663.6 225 281 forward 3 SP 31 96422.1 151 228 forward 1 SP 31 96422.1 255 308 forward 3 TM 33 995839.2 140 202 forward 2 SP 35 2517374CD1 1 34 SP 35 2517374CD1 1 21 SP 35 2517374CD1 1 24 SP 35 2517374CD1 1 25 SP 35 2517374CD1 1 18 SP 37 1255456CD1 1 18 SP 37 1255456CD1 5 20 SP 37 1255456CD1 1 20 SP 37 1255456CD1 1 22 SP 37 1255456CD1 1 26 SP 37 1255456CD1 1 24 SP 38 3084.1 13 69 forward 1 SP 41 533825CD1 1 18 SP 41 533825CD1 1 15 SP 43 985475.8 1409 1471 forward 2 SP 45 1382869.18 1352 1405 forward 2 SP 45 1382869.18 1352 1417 forward 2 SP 45 1382869.18 1352 1411 forward 2 SP 45 1382869.18 1352 1423 forward 2 SP 46 1382869.1 1549 1602 forward 1 SP 46 1382869.1 1157 1216 forward 2 TM 46 1382869.1 1549 1614 forward 1 SP 46 1382869.1 1549 1608 forward 1 SP 46 1382869.1 1172 1231 forward 2 SP 46 1382869.1 1549 1620 forward 1 SP 48 215990.2 3227 3301 forward 2 SP 48 215990.2 4238 4306 forward 2 SP 48 215990.2 2866 2949 forward 1 SP 48 215990.2 2015 2071 forward 2 SP 48 215990.2 2015 2077 forward 2 SP 48 215990.2 2120 2173 forward 2 SP 48 215990.2 3507 3563 forward 3 TM 48 215990.2 2120 2182 forward 2 SP 48 215990.2 2015 2083 forward 2 SP 49 428335.59 1518 1577 forward 3 SP 54 404028.1 159 239 forward 3 TM 55 996427.2 99 149 forward 3 TM 55 996427.2 2224 2274 forward 1 TM 56 21971.1 161 220 forward 2 SP 58 400650.3 259 324 forward 1 SP 59 344524.1 2422 2481 forward 1 TM 59 344524.1 2563 2616 forward 1 SP 59 344524.1 1737 1799 forward 3 SP 59 344524.1 1737 1790 forward 3 SP 59 344524.1 1957 2007 forward 1 TM 59 344524.1 3170 3238 forward 2 SP 59 344524.1 2900 2971 forward 2 TM 59 344524.1 3508 3570 forward 1 TM 59 344524.1 1363 1449 forward 1 SP 59 344524.1 2563 2613 forward 1 SP 60 196709.1 366 434 forward 3 TM 60 196709.1 381 458 forward 3 TM 60 196709.1 378 440 forward 3 TM 60 196709.1 378 434 forward 3 TM 61 37502.4 3618 3692 forward 3 SP 61 37502.4 5525 5587 forward 2 TM 61 37502.4 1908 1964 forward 3 SP 61 37502.4 1143 1205 forward 3 SP 61 37502.4 2606 2674 forward 2 TM 61 37502.4 6032 6088 forward 2 TM 61 37502.4 5759 5809 forward 2 SP 61 37502.4 338 400 forward 2 SP 61 37502.4 5516 5587 forward 2 TM 61 37502.4 5551 5604 forward 1 SP 61 37502.4 1735 1815 forward 1 SP 61 37502.4 5045 5155 forward 2 SP 61 37502.4 3627 3677 forward 3 TM 61 37502.4 353 400 forward 2 SP 61 37502.4 335 421 forward 2 SP 61 37502.4 329 403 forward 2 SP 64 085596CD1 1 22 SP 64 085596CD1 1 21 SP 64 085596CD1 1 16 SP 64 085596CD1 1 24 SP 64 085596CD1 1 18 SP 68 978439.4 2571 2636 forward 3 SP 68 978439.4 4666 4713 forward 1 TM 68 978439.4 1008 1067 forward 3 TM 68 978439.4 5694 5756 forward 3 TM 68 978439.4 2318 2386 forward 2 TM 68 978439.4 1102 1158 forward 1 SP 68 978439.4 3745 3798 forward 1 TM 68 978439.4 3730 3789 forward 1 SP 68 978439.4 1117 1173 forward 1 TM 68 978439.4 4360 4416 forward 1 TM 72 1256895CD1 234 251 TM 72 1256895CD1 109 126 SP 72 1256895CD1 1 22 SP 72 1256895CD1 1 20 SP 72 1256895CD1 232 253 SP 74 291267.1 833 898 forward 2 SP 74 291267.1 2145 2198 forward 3 SP 74 291267.1 2172 2246 forward 3 TM 74 291267.1 219 272 forward 3 TM 74 291267.1 210 266 forward 3 TM 74 291267.1 833 895 forward 2 SP 74 291267.1 207 275 forward 3 TM 74 291267.1 2160 2219 forward 3 TM 74 291267.1 210 272 forward 3 TM 74 291267.1 2148 2219 forward 3 TM 74 291267.1 833 880 forward 2 SP 74 291267.1 201 275 forward 3 TM 78 980593.6 663 734 forward 3 TM 78 980593.6 944 1021 forward 2 TM 80 405773.2 1842 1943 forward 3 SP 82 20265.2 64 117 forward 1 TM 85 088564CD1 1 26 SP 85 088564CD1 1 26 SP 85 088564CD1 1 22 SP 88 212533.1 885 935 forward 3 TM 88 212533.1 864 938 forward 3 SP 88 212533.1 864 953 forward 3 SP 88 212533.1 897 959 forward 3 TM 90 983961.1 336 386 forward 3 TM 90 983961.1 330 389 forward 3 TM 91 1383290.2 1197 1259 forward 3 SP 91 1383290.2 826 879 forward 1 TM 91 1383290.2 1239 1301 forward 3 TM 92 337221.11 1631 1717 forward 2 SP 93 290344.1 3833 3904 forward 2 TM 93 290344.1 1972 2025 forward 1 SP 93 290344.1 1307 1384 forward 2 SP 94 290344.3 623 685 forward 2 TM 97 34424.1 221 289 forward 2 SP 99 272843.14 1899 1961 forward 3 SP 99 272843.14 4232 4303 forward 2 SP 99 272843.14 1276 1371 forward 1 SP 99 272843.14 1899 1955 forward 3 TM 99 272843.14 6588 6674 forward 3 SP 99 272843.14 1881 1961 forward 3 SP 99 272843.14 1899 1961 forward 3 TM 99 272843.14 4462 4548 forward 1 SP 99 272843.14 6648 6719 forward 3 SP 99 272843.14 1701 1763 forward 3 SP 99 272843.14 4232 4285 forward 2 SP 99 272843.14 2761 2844 forward 1 SP 99 272843.14 1701 1772 forward 3 SP 99 272843.14 5008 5064 forward 1 TM 99 272843.14 4232 4294 forward 2 SP 99 272843.14 1899 1958 forward 3 TM 99 272843.14 1908 1958 forward 3 TM 99 272843.14 5008 5070 forward 1 TM 99 272843.14 1701 1772 forward 3 SP 99 272843.14 1701 1781 forward 3 SP 99 272843.14 5008 5061 forward 1 TM 99 272843.14 4232 4285 forward 2 SP 100 234729.3 547 606 forward 1 SP 100 234729.3 6397 6456 forward 1 TM 100 234729.3 5821 5898 forward 1 SP 100 234729.3 5866 5913 forward 1 SP 100 234729.3 6351 6407 forward 3 TM 100 234729.3 5857 5916 forward 1 SP 100 234729.3 5866 5922 forward 1 SP 100 234729.3 5848 5916 forward 1 SP 100 234729.3 5848 5913 forward 1 TM 100 234729.3 5860 5913 forward 1 TM 100 234729.3 5848 5910 forward 1 TM 100 234729.3 5830 5919 forward 1 TM 100 234729.3 5821 5910 forward 1 SP 100 234729.3 5860 5919 forward 1 TM 100 234729.3 5845 5916 forward 1 TM 101 349647.1 340 396 forward 1 TM 103 230193.1 1108 1164 forward 1 SP 103 230193.1 572 628 forward 2 TM 103 230193.1 1264 1311 forward 1 TM 104 213429.1 45 107 forward 3 TM 107 903909.1 879 932 forward 3 SP 108 196981.1 841 906 forward 1 SP 108 196981.1 720 785 forward 3 SP 108 196981.1 744 797 forward 3 TM 108 196981.1 720 791 forward 3 TM 108 196981.1 369 419 forward 3 SP 108 196981.1 457 513 forward 1 TM 108 196981.1 738 800 forward 3 TM 108 196981.1 451 507 forward 1 TM 108 196981.1 741 797 forward 3 TM 109 337888.3 1814 1870 forward 2 TM 109 337888.3 1089 1166 forward 3 TM 109 337888.3 1310 1384 forward 2 SP 109 337888.3 1659 1712 forward 3 TM 109 337888.3 1818 1886 forward 3 SP 109 337888.3 1650 1706 forward 3 TM 113 20525.1 167 244 forward 2 SP 113 20525.1 167 226 forward 2 SP 114 1382924.38 2550 2597 forward 3 SP 114 1382924.38 3280 3339 forward 1 TM 114 1382924.38 2550 2624 forward 3 SP 114 1382924.38 2550 2603 forward 3 TM 114 1382924.38 4067 4120 forward 2 TM 114 1382924.38 4228 4290 forward 1 SP 114 1382924.38 2550 2615 forward 3 SP 114 1382924.38 1552 1617 forward 1 TM 114 1382924.38 4228 4290 forward 1 TM 114 1382924.38 4207 4284 forward 1 TM 114 1382924.38 1402 1485 forward 1 TM 114 1382924.38 4067 4123 forward 2 TM 117 247185.1 436 486 forward 1 TM 117 247185.1 448 531 forward 1 TM 118 197587.3 2277 2342 forward 3 SP 118 197587.3 2277 2333 forward 3 SP 118 197587.3 1819 1893 forward 1 TM 118 197587.3 2277 2354 forward 3 SP 118 197587.3 2198 2248 forward 2 TM 118 197587.3 3424 3477 forward 1 TM 118 197587.3 2277 2354 forward 3 SP 119 403872.1 1153 1215 forward 1 TM 119 403872.1 418 480 forward 1 TM 119 403872.1 2105 2176 forward 2 TM 119 403872.1 598 651 forward 1 TM 119 403872.1 1517 1570 forward 2 SP 119 403872.1 1517 1579 forward 2 SP 119 403872.1 1514 1570 forward 2 TM 119 403872.1 415 486 forward 1 TM 119 403872.1 418 489 forward 1 TM 120 900993.1 47 109 forward 2 TM 120 900993.1 299 352 forward 2 TM 120 900993.1 296 352 forward 2 TM 120 900993.1 661 729 forward 1 SP 120 900993.1 661 723 forward 1 SP 120 900993.1 296 358 forward 2 TM 120 900993.1 605 658 forward 2 TM 120 900993.1 646 702 forward 1 TM 120 900993.1 661 717 forward 1 SP 121 228511.1 1098 1163 forward 3 SP 121 228511.1 3939 3992 forward 3 TM 121 228511.1 3996 4046 forward 3 TM 121 228511.1 3958 4014 forward 1 TM 121 228511.1 4589 4666 forward 2 TM 121 228511.1 3713 3769 forward 2 TM 121 228511.1 3993 4049 forward 3 TM 121 228511.1 1803 1886 forward 3 TM 121 228511.1 3700 3759 forward 1 TM 124 291155.1 540 596 forward 3 SP 125 1383047.1 1994 2056 forward 2 SP 125 1383047.1 343 405 forward 1 TM 125 1383047.1 1988 2047 forward 2 TM 125 1383047.1 521 592 forward 2 TM 125 1383047.1 1994 2044 forward 2 TM 129 216141.1 45 110 forward 3 TM 129 216141.1 8 79 forward 2 TM 129 216141.1 122 190 forward 2 SP 129 216141.1 26 85 forward 2 TM 129 216141.1 13 72 forward 1 TM 129 216141.1 10 81 forward 1 TM 131 408751.3 2411 2467 forward 2 TM 131 408751.3 2012 2092 forward 2 SP 132 998310.1 187 252 forward 1 SP 133 1097471.1 216 293 forward 3 SP 134 983843.2 175 237 forward 1 TM 135 983843.1 236 310 forward 2 TM 136 985607.8 3006 3059 forward 3 TM 136 985607.8 2955 3011 forward 3 TM 136 985607.8 4295 4363 forward 2 SP 136 985607.8 4313 4363 forward 2 TM 136 985607.8 4277 4348 forward 2 SP 136 985607.8 2970 3023 forward 3 SP 136 985607.8 4843 4902 forward 1 TM 136 985607.8 4295 4381 forward 2 SP 137 152298.2 364 420 forward 1 SP 137 152298.2 355 405 forward 1 TM 137 152298.2 346 420 forward 1 SP 137 152298.2 355 420 forward 1 SP 137 152298.2 339 398 forward 3 SP 137 152298.2 365 418 forward 2 TM 137 152298.2 339 422 forward 3 SP 137 152298.2 339 392 forward 3 TM 137 152298.2 339 395 forward 3 SP 137 152298.2 339 410 forward 3 SP 137 152298.2 339 407 forward 3 SP 138 246336.2 823 894 forward 1 SP 138 246336.2 1327 1377 forward 1 TM 139 246336.18 449 508 forward 2 TM 139 246336.18 1334 1390 forward 2 TM 139 246336.18 1245 1295 forward 3 TM 139 246336.18 1325 1387 forward 2 TM 139 246336.18 437 493 forward 2 SP 141 253855.2 3745 3798 forward 1 TM 141 253855.2 997 1047 forward 1 SP 141 253855.2 3698 3757 forward 2 SP 141 253855.2 3725 3787 forward 2 TM 141 253855.2 4597 4665 forward 1 SP 141 253855.2 2880 2954 forward 3 TM 141 253855.2 4597 4656 forward 1 SP 141 253855.2 4585 4641 forward 1 TM 141 253855.2 3716 3775 forward 2 TM 142 337187.1 951 1004 forward 3 TM 142 337187.1 421 489 forward 1 SP 142 337187.1 421 504 forward 1 SP 144 932244CD1 302 320 SP 144 932244CD1 302 316 SP 144 932244CD1 302 323 SP 144 932244CD1 1 18 SP 144 932244CD1 302 324 TM 144 932244CD1 302 323 TM 144 932244CD1 1 21 SP 144 932244CD1 302 322 SP 144 932244CD1 305 321 TM 144 932244CD1 305 323 TM 144 932244CD1 302 322 TM 144 932244CD1 1 19 SP 146 13343.1 414 461 forward 3 SP 146 13343.1 414 479 forward 3 SP 147 399488.4 689 751 forward 2 SP 147 399488.4 974 1039 forward 2 SP 147 399488.4 1370 1426 forward 2 SP 147 399488.4 1370 1414 forward 2 SP 147 399488.4 689 763 forward 2 SP 151 237622.6 1548 1625 forward 3 TM 151 237622.6 1071 1121 forward 3 TM 154 162569.1 353 427 forward 2 TM 155 334116.1 4159 4218 forward 1 SP 155 334116.1 3289 3342 forward 1 TM 155 334116.1 3574 3630 forward 1 TM 155 334116.1 4189 4245 forward 1 TM 155 334116.1 4213 4266 forward 1 SP 155 334116.1 4008 4055 forward 3 TM 155 334116.1 4159 4233 forward 1 SP 155 334116.1 4159 4227 forward 1 SP 156 396837.1 1169 1213 forward 2 SP 156 396837.1 1497 1568 forward 3 SP 157 406507.1 50 112 forward 2 SP 157 406507.1 98 175 forward 2 TM 158 407612.1 1381 1443 forward 1 TM 158 407612.1 316 390 forward 1 TM 158 407612.1 3107 3157 forward 2 TM 158 407612.1 403 462 forward 1 SP 158 407612.1 199 273 forward 1 SP 158 407612.1 458 535 forward 2 SP 158 407612.1 403 474 forward 1 SP 158 407612.1 199 261 forward 1 SP 158 407612.1 403 474 forward 1 SP 158 407612.1 458 547 forward 2 SP 158 407612.1 229 282 forward 1 TM 158 407612.1 199 288 forward 1 SP 158 407612.1 2126 2215 forward 2 SP 158 407612.1 3520 3597 forward 1 SP 158 407612.1 3207 3269 forward 3 TM 158 407612.1 3375 3437 forward 3 SP 158 407612.1 214 276 forward 1 TM 158 407612.1 1381 1437 forward 1 TM 158 407612.1 217 285 forward 1 TM 158 407612.1 199 264 forward 1 SP 159 399501.1 926 970 forward 2 SP 159 399501.1 840 893 forward 3 TM 159 399501.1 831 893 forward 3 TM 162 199601.12 1493 1543 forward 2 TM 162 199601.12 1481 1552 forward 2 TM 162 199601.12 1481 1537 forward 2 TM 163 232946.1 4459 4518 forward 1 SP 163 232946.1 4459 4527 forward 1 SP 163 232946.1 5418 5477 forward 3 TM 163 232946.1 5072 5122 forward 2 TM 163 232946.1 5130 5186 forward 3 TM 163 232946.1 720 803 forward 3 SP 163 232946.1 1361 1429 forward 2 SP 163 232946.1 5190 5255 forward 3 SP 163 232946.1 5193 5255 forward 3 TM 163 232946.1 4467 4535 forward 3 TM 163 232946.1 4459 4512 forward 1 SP 163 232946.1 5208 5264 forward 3 TM 163 232946.1 5069 5131 forward 2 TM 163 232946.1 4440 4520 forward 3 SP 163 232946.1 453 512 forward 3 SP 163 232946.1 5190 5261 forward 3 SP 163 232946.1 5078 5146 forward 2 TM 163 232946.1 720 767 forward 3 SP 163 232946.1 4476 4532 forward 3 TM 163 232946.1 5157 5231 forward 3 TM 163 232946.1 1361 1414 forward 2 SP 163 232946.1 5214 5273 forward 3 TM 163 232946.1 5199 5282 forward 3 TM 163 232946.1 1361 1408 forward 2 SP 168 1674368CD1 1 17 SP 168 1674368CD1 1392 1410 TM 168 1674368CD1 1388 1409 TM 168 1674368CD1 1379 1407 SP 168 1674368CD1 1385 1408 TM 168 1674368CD1 1 18 SP 170 464689.54 442 528 forward 1 SP 171 222181.1 835 930 forward 1 SP 171 222181.1 835 912 forward 1 SP 171 222181.1 1044 1106 forward 3 TM 171 222181.1 763 819 forward 1 SP 171 222181.1 3075 3134 forward 3 SP 171 222181.1 870 944 forward 3 TM 171 222181.1 835 900 forward 1 SP 171 222181.1 405 473 forward 3 TM 171 222181.1 882 941 forward 3 TM 171 222181.1 900 968 forward 3 TM 171 222181.1 891 944 forward 3 TM 171 222181.1 885 947 forward 3 TM 174 1087445.1 1137 1214 forward 3 TM 174 1087445.1 645 701 forward 3 TM 175 1079625.3 2543 2596 forward 2 SP 178 228046.5 172 258 forward 1 TM 178 228046.5 1472 1564 forward 2 SP 178 228046.5 872 934 forward 2 SP 179 1225513.1 58 108 forward 1 SP 179 1225513.1 58 123 forward 1 SP 179 1225513.1 58 120 forward 1 SP 179 1225513.1 58 111 forward 1 SP 181 232849.13 1528 1575 forward 1 SP 181 232849.13 337 402 forward 1 SP 181 232849.13 1663 1713 forward 1 SP 181 232849.13 1516 1584 forward 1 SP 181 232849.13 1531 1590 forward 1 SP 181 232849.13 1663 1719 forward 1 SP 181 232849.13 1657 1719 forward 1 SP 181 232849.13 1525 1581 forward 1 TM 181 232849.13 1657 1722 forward 1 SP 182 19598.1 59 127 forward 2 SP 182 19598.1 59 133 forward 2 SP 183 411148.3 3134 3193 forward 2 TM 183 411148.3 3122 3181 forward 2 SP 183 411148.3 315 389 forward 3 TM 183 411148.3 327 386 forward 3 TM 183 411148.3 5461 5505 forward 1 SP 183 411148.3 3119 3193 forward 2 SP 183 411148.3 2939 3013 forward 2 SP 183 411148.3 3107 3193 forward 2 SP 183 411148.3 5449 5511 forward 1 SP 183 411148.3 1734 1817 forward 3 SP 183 411148.3 5449 5514 forward 1 SP 183 411148.3 5449 5505 forward 1 SP 187 1273641CD1 107 123 TM 187 1273641CD1 136 161 SP 187 1273641CD1 105 124 TM 187 1273641CD1 1 24 SP 187 1273641CD1 136 161 SP 187 1273641CD1 136 158 SP 189 332165.8 168 251 forward 3 TM 189 332165.8 1384 1449 forward 1 TM 189 332165.8 1171 1242 forward 1 TM 189 332165.8 1348 1434 forward 1 SP 189 332165.8 1107 1160 forward 3 TM 193 235356.1 372 428 forward 3 SP 193 235356.1 1735 1812 forward 1 SP 194 47593.1 252 314 forward 3 TM 196 245687.1 411 494 forward 3 SP 196 245687.1 423 494 forward 3 SP 201 205542.2 2071 2115 forward 1 SP 201 205542.2 2428 2496 forward 1 SP 201 205542.2 2378 2434 forward 2 SP 201 205542.2 4072 4131 forward 1 TM 201 205542.2 3904 3972 forward 1 SP 201 205542.2 4407 4469 forward 3 TM 201 205542.2 2378 2449 forward 2 SP 201 205542.2 262 345 forward 1 SP 201 205542.2 2174 2254 forward 2 SP 201 205542.2 4051 4104 forward 1 TM 201 205542.2 2041 2103 forward 1 TM 201 205542.2 2437 2496 forward 1 SP 201 205542.2 4008 4061 forward 3 TM 201 205542.2 2293 2367 forward 1 SP 201 205542.2 2284 2349 forward 1 SP 201 205542.2 2428 2487 forward 1 TM 201 205542.2 4410 4478 forward 3 TM 201 205542.2 2378 2443 forward 2 SP 201 205542.2 2428 2496 forward 1 TM 201 205542.2 2293 2349 forward 1 SP 201 205542.2 2378 2476 forward 2 SP 201 205542.2 2302 2349 forward 1 SP 201 205542.2 4069 4131 forward 1 TM 201 205542.2 2437 2490 forward 1 SP 201 205542.2 262 327 forward 1 SP 201 205542.2 262 324 forward 1 SP 201 205542.2 262 333 forward 1 SP 206 219537.1 376 426 forward 1 TM 207 1041138.7 504 566 forward 3 TM 207 1041138.7 688 741 forward 1 TM 207 1041138.7 2591 2650 forward 2 TM 207 1041138.7 2805 2888 forward 3 SP 207 1041138.7 498 569 forward 3 TM 210 232386.18 2705 2761 forward 2 TM 210 232386.18 2583 2636 forward 3 TM 210 232386.18 2693 2764 forward 2 TM 216 1405844CD1 208 225 TM 216 1405844CD1 57 79 TM 216 1405844CD1 86 106 TM 216 1405844CD1 17 35 TM 216 1405844CD1 52 69 TM 216 1405844CD1 62 88 TM 216 1405844CD1 12 28 SP 216 1405844CD1 12 35 SP 216 1405844CD1 12 36 SP 216 1405844CD1 54 74 TM 216 1405844CD1 17 37 TM 216 1405844CD1 84 100 SP 216 1405844CD1 51 72 TM 216 1405844CD1 12 41 SP 216 1405844CD1 84 106 SP 216 1405844CD1 206 225 TM 216 1405844CD1 10 37 TM 216 1405844CD1 58 77 TM 216 1405844CD1 90 109 TM 216 1405844CD1 12 30 SP 216 1405844CD1 206 227 TM 216 1405844CD1 10 35 TM 216 1405844CD1 84 101 TM 216 1405844CD1 84 102 SP 216 1405844CD1 67 103 SP 216 1405844CD1 87 109 TM 216 1405844CD1 205 226 TM 216 1405844CD1 205 229 TM 216 1405844CD1 84 106 SP 216 1405844CD1 84 103 SP 216 1405844CD1 10 32 TM 216 1405844CD1 85 108 TM 217 1143377.5 106 162 forward 1 SP 217 1143377.5 309 371 forward 3 SP 218 235147.1 950 1039 forward 2 SP 218 235147.1 1040 1129 forward 2 SP 218 235147.1 1113 1157 forward 3 SP 218 235147.1 194 268 forward 2 SP 218 235147.1 4307 4366 forward 2 TM 218 235147.1 3935 3991 forward 2 SP 218 235147.1 2687 2749 forward 2 TM 218 235147.1 2152 2220 forward 1 TM 218 235147.1 3940 3990 forward 1 TM 218 235147.1 1174 1233 forward 1 SP 218 235147.1 2614 2664 forward 1 TM 218 235147.1 2164 2223 forward 1 TM 218 235147.1 106 168 forward 1 SP 218 235147.1 1414 1458 forward 1 SP 218 235147.1 2164 2226 forward 1 TM 218 235147.1 3982 4041 forward 1 SP 218 235147.1 3943 4005 forward 1 TM 218 235147.1 2696 2767 forward 2 TM 218 235147.1 3513 3566 forward 3 TM 218 235147.1 719 778 forward 2 TM 218 235147.1 3937 4008 forward 1 TM 218 235147.1 3947 4030 forward 2 TM 218 235147.1 3510 3569 forward 3 TM 218 235147.1 3927 3986 forward 3 TM 218 235147.1 3967 4026 forward 1 TM 218 235147.1 3944 4003 forward 2 TM 219 235147.2 951 1040 forward 3 SP 219 235147.2 195 269 forward 3 SP 219 235147.2 1435 1494 forward 1 TM 219 235147.2 720 779 forward 3 TM 219 235147.2 107 169 forward 2 SP 219 235147.2 1490 1549 forward 2 SP 219 235147.2 1475 1534 forward 2 TM 219 235147.2 1452 1511 forward 3 TM 220 1099294.6 898 951 forward 1 SP 220 1099294.6 842 943 forward 2 SP 221 330927.1 57 128 forward 3 TM 221 330927.1 205 258 forward 1 SP 221 330927.1 205 255 forward 1 SP 222 50695.1 348 410 forward 3 TM 222 50695.1 145 198 forward 1 TM 222 50695.1 109 195 forward 1 TM 224 282397.77 5909 5977 forward 2 TM 224 282397.77 3675 3779 forward 3 SP 224 282397.77 6071 6130 forward 2 TM 224 282397.77 5904 5957 forward 3 TM 224 282397.77 4241 4297 forward 2 SP 224 282397.77 6071 6130 forward 2 SP 224 282397.77 2671 2733 forward 1 SP 224 282397.77 4214 4297 forward 2 SP 225 984009.2 376 429 forward 1 TM 225 984009.2 113 169 forward 2 SP 225 984009.2 113 169 forward 2 SP 226 138709.5 1902 1964 forward 3 TM 226 138709.5 1926 2006 forward 3 TM 226 138709.5 2257 2319 forward 1 TM 226 138709.5 1468 1533 forward 1 TM 226 138709.5 2292 2348 forward 3 TM 226 138709.5 1848 1916 forward 3 SP 226 138709.5 1435 1485 forward 1 TM 226 138709.5 2295 2345 forward 3 TM 226 138709.5 1435 1509 forward 1 TM 226 138709.5 1438 1494 forward 1 TM 227 998926.1 2659 2727 forward 1 SP 227 998926.1 2656 2745 forward 1 SP 227 998926.1 2680 2739 forward 1 TM 227 998926.1 2659 2736 forward 1 SP 227 998926.1 2621 2692 forward 2 TM 229 1448817CD1 9 26 TM 229 1448817CD1 7 24 SP 229 1448817CD1 1 31 SP 229 1448817CD1 1 24 SP 229 1448817CD1 1 25 SP 230 332521.1 130 201 forward 1 TM 230 332521.1 934 1011 forward 1 SP 230 332521.1 943 1011 forward 1 SP 230 332521.1 172 231 forward 1 TM 231 245136.4 1783 1857 forward 1 SP 231 245136.4 1792 1857 forward 1 SP 231 245136.4 1809 1862 forward 3 TM 231 245136.4 1804 1863 forward 1 SP 231 245136.4 1765 1827 forward 1 TM 231 245136.4 1804 1857 forward 1 SP 231 245136.4 1804 1851 forward 1 SP 231 245136.4 1795 1851 forward 1 TM 240 997142.1 35 91 forward 2 TM 241 997080.1 1473 1550 forward 3 TM 241 997080.1 2741 2791 forward 2 TM 241 997080.1 2726 2791 forward 2 SP 241 997080.1 1668 1724 forward 3 TM 241 997080.1 1503 1565 forward 3 TM 241 997080.1 501 554 forward 3 SP 241 997080.1 2747 2809 forward 2 TM 241 997080.1 300 362 forward 3 TM 241 997080.1 2704 2766 forward 1 SP 241 997080.1 1677 1730 forward 3 TM 241 997080.1 30 92 forward 3 SP 241 997080.1 30 104 forward 3 SP 241 997080.1 30 86 forward 3 SP 241 997080.1 2729 2785 forward 2 TM 241 997080.1 30 98 forward 3 SP 243 379571.7 7078 7146 forward 1 TM 243 379571.7 4435 4491 forward 1 SP 243 379571.7 6162 6218 forward 3 SP 243 379571.7 6668 6724 forward 2 SP 243 379571.7 4435 4494 forward 1 SP 243 379571.7 1747 1830 forward 1 SP 243 379571.7 6665 6733 forward 2 SP 243 379571.7 6304 6360 forward 1 SP 243 379571.7 5842 5901 forward 1 SP 243 379571.7 4435 4500 forward 1 SP 243 379571.7 6665 6727 forward 2 SP 243 379571.7 6665 6736 forward 2 SP 244 322303.15 250 312 forward 1 SP 244 322303.15 1364 1432 forward 2 SP 244 322303.15 2655 2720 forward 3 SP 244 322303.15 7555 7605 forward 1 TM 244 322303.15 2655 2711 forward 3 SP 244 322303.15 271 324 forward 1 SP 244 322303.15 250 315 forward 1 SP 244 322303.15 250 330 forward 1 SP 244 322303.15 7564 7650 forward 1 TM 244 322303.15 250 324 forward 1 SP 245 232935.2 2351 2431 forward 2 TM 245 232935.2 5338 5400 forward 1 TM 245 232935.2 3408 3464 forward 3 TM 245 232935.2 3706 3768 forward 1 SP 245 232935.2 3711 3770 forward 3 TM 245 232935.2 423 503 forward 3 SP 245 232935.2 5597 5665 forward 2 SP 245 232935.2 2351 2404 forward 2 TM 245 232935.2 2336 2407 forward 2 TM 245 232935.2 3706 3759 forward 1 SP 245 232935.2 2351 2413 forward 2 TM 245 232935.2 2333 2389 forward 2 TM 245 232935.2 2318 2386 forward 2 TM 248 69812.3 3587 3661 forward 2 SP 248 69812.3 3576 3626 forward 3 SP 248 69812.3 3576 3638 forward 3 SP 252 1518310CD1 23 39 TM 253 241335.1 658 753 forward 1 SP 253 241335.1 1674 1754 forward 3 TM 253 241335.1 684 752 forward 3 TM 253 241335.1 702 773 forward 3 TM 253 241335.1 711 773 forward 3 TM 253 241335.1 711 764 forward 3 TM 253 241335.1 702 758 forward 3 TM 255 25911.1 1226 1291 forward 2 SP 257 978673.2 1043 1099 forward 2 TM 257 978673.2 1019 1084 forward 2 SP 257 978673.2 956 1015 forward 2 TM 257 978673.2 965 1027 forward 2 TM 257 978673.2 161 250 forward 2 SP 257 978673.2 950 1018 forward 2 TM 257 978673.2 1007 1084 forward 2 SP 261 20602.1 138 191 forward 3 TM 263 399872.1 632 694 forward 2 TM 265 229176.5 898 951 forward 1 TM 265 229176.5 1377 1421 forward 3 SP 265 229176.5 1277 1321 forward 2 SP 268 994387.65 4021 4080 forward 1 TM 268 994387.65 6137 6193 forward 2 SP 268 994387.65 2583 2654 forward 3 TM 268 994387.65 5220 5270 forward 3 TM 268 994387.65 2634 2684 forward 3 TM 268 994387.65 6137 6184 forward 2 SP 268 994387.65 4229 4276 forward 2 TM 268 994387.65 4069 4140 forward 1 SP 268 994387.65 2592 2654 forward 3 TM 268 994387.65 2589 2645 forward 3 TM 268 994387.65 2568 2621 forward 3 TM 268 994387.65 5193 5279 forward 3 TM 268 994387.65 6131 6214 forward 2 TM 268 994387.65 6125 6178 forward 2 TM 268 994387.65 4018 4068 forward 1 TM 268 994387.65 6137 6196 forward 2 SP 268 994387.65 4069 4149 forward 1 SP 268 994387.65 2583 2651 forward 3 TM 268 994387.65 6143 6214 forward 2 TM 268 994387.65 6125 6181 forward 2 TM 269 201462.7 383 436 forward 2 TM 270 991497.1 667 741 forward 1 SP 270 991497.1 146 226 forward 2 SP 270 991497.1 146 211 forward 2 SP 271 347444.1 1011 1067 forward 3 TM 271 347444.1 1008 1061 forward 3 TM 271 347444.1 1005 1070 forward 3 SP 271 347444.1 997 1056 forward 1 TM 271 347444.1 992 1066 forward 2 SP 271 347444.1 1299 1367 forward 3 SP 271 347444.1 1010 1069 forward 2 TM 271 347444.1 1000 1089 forward 1 TM 271 347444.1 1194 1250 forward 3 TM 272 238660.5 5330 5401 forward 2 SP 272 238660.5 4546 4629 forward 1 SP 273 404601.11 1473 1535 forward 3 TM 273 404601.11 1346 1417 forward 2 TM 274 1329936.3 929 1006 forward 2 TM 274 1329936.3 1065 1118 forward 3 TM 274 1329936.3 1058 1123 forward 2 SP 274 1329936.3 444 503 forward 3 TM 274 1329936.3 564 632 forward 3 SP 274 1329936.3 932 1000 forward 2 TM 274 1329936.3 938 997 forward 2 TM 274 1329936.3 564 623 forward 3 TM 274 1329936.3 564 608 forward 3 SP 274 1329936.3 564 617 forward 3 SP 274 1329936.3 789 845 forward 3 TM 274 1329936.3 561 641 forward 3 TM 274 1329936.3 432 500 forward 3 TM 274 1329936.3 780 863 forward 3 TM 275 370489.47 865 933 forward 1 SP 275 370489.47 857 910 forward 2 TM 275 370489.47 891 968 forward 3 TM 275 370489.47 840 893 forward 3 TM 275 370489.47 805 864 forward 1 SP 278 1822864CD1 8 28 SP 278 1822864CD1 6 27 SP 278 1822864CD1 1 25 SP 278 1822864CD1 1 27 SP 283 407263.1 2916 2987 forward 3 TM 283 407263.1 2895 2969 forward 3 TM 283 407263.1 2896 2949 forward 1 TM 283 407263.1 2925 2984 forward 3 TM 283 407263.1 2896 2955 forward 1 TM 285 1630551CD1 60 84 SP 285 1630551CD1 288 304 TM 289 92230.2 487 564 forward 1 SP 291 333542.1 1124 1195 forward 2 TM 291 333542.1 1143 1214 forward 3 SP 294 476760.12 490 561 forward 1 SP 298 197652.3 1450 1503 forward 1 SP 298 197652.3 735 791 forward 3 TM 299 248203.2 740 793 forward 2 TM 299 248203.2 888 956 forward 3 SP 299 248203.2 713 781 forward 2 TM 299 248203.2 728 790 forward 2 TM 299 248203.2 734 799 forward 2 TM 301 2023351CD1 1 20 SP 301 2023351CD1 1 19 SP 303 92268.1 263 352 forward 2 SP 303 92268.1 262 351 forward 1 SP 303 92268.1 2411 2485 forward 2 SP 303 92268.1 1652 1732 forward 2 SP 303 92268.1 2393 2485 forward 2 SP 306 898877.6 325 387 forward 1 TM 306 898877.6 245 298 forward 2 SP 307 29490.1 363 416 forward 3 TM 310 369213.42 50 115 forward 2 SP 310 369213.42 181 282 forward 1 SP 310 369213.42 289 348 forward 1 TM 310 369213.42 35 91 forward 2 SP 310 369213.42 289 351 forward 1 TM 310 369213.42 1185 1238 forward 3 SP 310 369213.42 74 157 forward 2 SP 310 369213.42 277 342 forward 1 TM 310 369213.42 277 351 forward 1 TM 315 223407.4 1873 1956 forward 1 SP 315 223407.4 1866 1919 forward 3 TM 316 899334.1 3907 3963 forward 1 TM 316 899334.1 2540 2593 forward 2 TM 316 899334.1 3901 3966 forward 1 SP 316 899334.1 2555 2605 forward 2 SP 316 899334.1 1418 1486 forward 2 SP 316 899334.1 2525 2590 forward 2 SP 316 899334.1 1009 1083 forward 1 SP 316 899334.1 2090 2149 forward 2 SP 316 899334.1 1418 1492 forward 2 SP 316 899334.1 2090 2161 forward 2 SP 316 899334.1 3922 3993 forward 1 TM 316 899334.1 3940 4002 forward 1 TM 316 899334.1 2555 2611 forward 2 SP 316 899334.1 1009 1092 forward 1 SP 316 899334.1 3901 3981 forward 1 TM 318 1149046.1 1534 1596 forward 1 TM 318 1149046.1 1558 1626 forward 1 TM 318 1149046.1 1598 1669 forward 2 TM 318 1149046.1 1531 1581 forward 1 TM 318 1149046.1 1598 1663 forward 2 SP 318 1149046.1 2495 2572 forward 2 TM 318 1149046.1 1534 1593 forward 1 TM 318 1149046.1 1583 1639 forward 2 TM 319 404011.3 210 296 forward 3 SP 321 3768043CD1 37 58 TM 321 3768043CD1 45 63 TM 322 39946.19 2706 2768 forward 3 TM 322 39946.19 1959 2033 forward 3 SP 322 39946.19 1974 2021 forward 3 SP 322 39946.19 140 214 forward 2 SP 322 39946.19 1944 2033 forward 3 SP 322 39946.19 1974 2027 forward 3 SP 322 39946.19 1974 2033 forward 3 SP 327 232772.13 820 900 forward 1 TM 327 232772.13 361 423 forward 1 SP 327 232772.13 64 123 forward 1 SP 327 232772.13 64 120 forward 1 TM 327 232772.13 77 133 forward 2 TM 327 232772.13 84 143 forward 3 TM 328 407451.3 905 967 forward 2 TM 328 407451.3 140 187 forward 2 SP 328 407451.3 899 955 forward 2 TM 329 1382931.2 1143 1226 forward 3 SP 330 1382931.39 780 854 forward 3 SP 330 1382931.39 747 830 forward 3 SP 333 402366.1 843 917 forward 3 SP 334 401532.3 151 213 forward 1 SP 334 401532.3 151 219 forward 1 SP 334 401532.3 151 243 forward 1 SP 335 401532.2 5624 5683 forward 2 TM 335 401532.2 305 367 forward 2 TM 335 401532.2 4317 4379 forward 3 SP 335 401532.2 5236 5295 forward 1 TM 335 401532.2 5626 5688 forward 1 TM 335 401532.2 5642 5695 forward 2 TM 335 401532.2 5245 5316 forward 1 TM 335 401532.2 5501 5566 forward 2 TM 335 401532.2 1478 1540 forward 2 TM 335 401532.2 1178 1234 forward 2 TM 335 401532.2 5239 5292 forward 1 TM 335 401532.2 3740 3796 forward 2 TM 335 401532.2 5586 5642 forward 3 SP 335 401532.2 5586 5636 forward 3 SP 335 401532.2 497 550 forward 2 TM 335 401532.2 5592 5669 forward 3 TM 335 401532.2 185 238 forward 2 TM 335 401532.2 5586 5657 forward 3 SP 335 401532.2 5586 5657 forward 3 SP 335 401532.2 5248 5328 forward 1 TM 335 401532.2 5586 5645 forward 3 SP 335 401532.2 1427 1489 forward 2 SP 335 401532.2 5599 5652 forward 1 TM 335 401532.2 1421 1492 forward 2 SP 335 401532.2 1421 1504 forward 2 SP 335 401532.2 3455 3538 forward 2 TM 335 401532.2 3440 3490 forward 2 TM 335 401532.2 4317 4385 forward 3 SP 335 401532.2 5617 5673 forward 1 TM 335 401532.2 3014 3076 forward 2 TM 335 401532.2 5595 5645 forward 3 TM 335 401532.2 3017 3073 forward 2 TM 335 401532.2 1421 1489 forward 2 SP 335 401532.2 5586 5645 forward 3 TM 335 401532.2 4989 5057 forward 3 TM 335 401532.2 4317 4400 forward 3 SP 335 401532.2 3455 3511 forward 2 TM 335 401532.2 5550 5624 forward 3 TM 335 401532.2 2999 3073 forward 2 TM 336 407896.4 1564 1629 forward 1 SP 337 982625.1 361 426 forward 1 SP 338 59947.1 979 1026 forward 1 TM 338 59947.1 971 1021 forward 2 TM 338 59947.1 967 1026 forward 1 TM 338 59947.1 975 1028 forward 3 TM 338 59947.1 966 1031 forward 3 TM 338 59947.1 972 1028 forward 3 TM 339 902471.11 1140 1232 forward 3 TM 339 902471.11 1117 1170 forward 1 TM 341 193755.1 788 856 forward 2 SP 341 193755.1 788 859 forward 2 SP 341 193755.1 590 640 forward 2 TM 341 193755.1 3327 3380 forward 3 TM 341 193755.1 2643 2711 forward 3 TM 341 193755.1 2658 2720 forward 3 TM 341 193755.1 2652 2705 forward 3 TM 341 193755.1 1497 1571 forward 3 SP 341 193755.1 3087 3146 forward 3 TM 341 193755.1 3308 3394 forward 2 TM 341 193755.1 1926 2009 forward 3 SP 341 193755.1 3301 3363 forward 1 TM 341 193755.1 3535 3591 forward 1 SP 341 193755.1 3313 3363 forward 1 TM 341 193755.1 3307 3387 forward 1 TM 341 193755.1 3310 3378 forward 1 TM 341 193755.1 2634 2711 forward 3 TM 341 193755.1 3310 3369 forward 1 TM 341 193755.1 2658 2717 forward 3 TM 345 1129157.1 88 135 forward 1 SP 345 1129157.1 61 132 forward 1 SP 345 1129157.1 61 123 forward 1 SP 345 1129157.1 61 135 forward 1 SP 345 1129157.1 61 141 forward 1 SP 347 1804734CD1 231 251 TM 347 1804734CD1 41 60 TM 348 43646.7 2035 2094 forward 1 TM 348 43646.7 1615 1674 forward 1 TM 349 43646.1 1322 1381 forward 2 TM 349 43646.1 899 982 forward 2 TM 353 415378.3 2504 2569 forward 2 TM 353 415378.3 2884 2949 forward 1 SP 353 415378.3 2501 2584 forward 2 SP 353 415378.3 4000 4050 forward 1 TM 353 415378.3 26 109 forward 2 SP 354 25685.3 177 245 forward 3 SP 354 25685.3 177 233 forward 3 SP 354 25685.3 177 239 forward 3 SP 355 400427.1 1815 1871 forward 3 TM 355 400427.1 1830 1874 forward 3 TM 356 198008.8 2348 2419 forward 2 SP 356 198008.8 4479 4538 forward 3 SP 356 198008.8 857 907 forward 2 TM 356 198008.8 1164 1232 forward 3 SP 356 198008.8 3308 3379 forward 2 SP 356 198008.8 2348 2401 forward 2 SP 356 198008.8 626 703 forward 2 SP 356 198008.8 5292 5348 forward 3 SP 356 198008.8 317 403 forward 2 SP 358 1825508CD1 5 21 SP 358 1825508CD1 2 20 SP 358 1825508CD1 1 27 SP 358 1825508CD1 1 23 SP 358 1825508CD1 5 24 SP 358 1825508CD1 1 25 SP 360 980807.1 230 292 forward 2 SP 360 980807.1 254 331 forward 2 SP 361 1095192.1 175 228 forward 1 TM 361 1095192.1 346 399 forward 1 TM 361 1095192.1 1784 1846 forward 2 TM 361 1095192.1 1867 1929 forward 1 TM 361 1095192.1 730 783 forward 1 TM 361 1095192.1 2355 2405 forward 3 TM 361 1095192.1 457 510 forward 1 TM 361 1095192.1 259 315 forward 1 TM 361 1095192.1 76 135 forward 1 TM 361 1095192.1 421 492 forward 1 TM 361 1095192.1 451 528 forward 1 TM 361 1095192.1 439 519 forward 1 SP 361 1095192.1 224 277 forward 2 TM 361 1095192.1 442 504 forward 1 SP 361 1095192.1 736 795 forward 1 TM 361 1095192.1 224 292 forward 2 TM 361 1095192.1 466 534 forward 1 TM 361 1095192.1 244 306 forward 1 TM 361 1095192.1 175 231 forward 1 TM 361 1095192.1 439 504 forward 1 SP 361 1095192.1 244 312 forward 1 TM 361 1095192.1 253 309 forward 1 TM 361 1095192.1 733 804 forward 1 TM 361 1095192.1 439 513 forward 1 SP 361 1095192.1 466 525 forward 1 TM 362 167559.1 572 640 forward 2 SP 362 167559.1 1724 1783 forward 2 TM 362 167559.1 1728 1784 forward 3 SP 362 167559.1 572 661 forward 2 SP 363 1383286.12 1121 1186 forward 2 SP 363 1383286.12 3008 3064 forward 2 TM 363 1383286.12 1126 1203 forward 1 TM 363 1383286.12 926 985 forward 2 SP 363 1383286.12 1123 1185 forward 1 TM 363 1383286.12 1123 1185 forward 1 TM 363 1383286.12 1117 1176 forward 1 TM 363 1383286.12 1123 1176 forward 1 TM 365 53059.11 1597 1665 forward 1 SP 366 337156.2 676 741 forward 1 TM 366 337156.2 685 741 forward 1 TM 366 337156.2 1168 1221 forward 1 SP 366 337156.2 202 258 forward 1 TM 366 337156.2 1951 2016 forward 1 SP 366 337156.2 1993 2043 forward 1 TM 366 337156.2 2053 2121 forward 1 TM 366 337156.2 3056 3118 forward 2 TM 366 337156.2 1168 1212 forward 1 SP 366 337156.2 2050 2103 forward 1 TM 366 337156.2 2823 2885 forward 3 TM 366 337156.2 2053 2115 forward 1 TM 366 337156.2 2062 2121 forward 1 TM 371 994430.15 1255 1305 forward 1 TM 377 3283554CD1 1 18 SP 377 3283554CD1 1 22 SP 377 3283554CD1 1 20 SP 380 222956.22 824 886 forward 2 TM 380 222956.22 680 754 forward 2 SP 380 222956.22 707 769 forward 2 TM 381 222956.24 1087 1143 forward 1 SP 381 222956.24 1075 1143 forward 1 SP 381 222956.24 1069 1143 forward 1 SP 382 973308.1 1471 1536 forward 1 SP 382 973308.1 1140 1262 forward 3 SP 382 973308.1 1489 1542 forward 1 TM 382 973308.1 1486 1545 forward 1 TM 383 238026.4 771 815 forward 3 SP 383 238026.4 765 851 forward 3 SP 383 238026.4 765 827 forward 3 SP 383 238026.4 765 836 forward 3 TM 383 238026.4 759 812 forward 3 TM 383 238026.4 765 839 forward 3 SP 383 238026.4 789 845 forward 3 TM 383 238026.4 759 842 forward 3 TM 383 238026.4 771 836 forward 3 TM 383 238026.4 765 827 forward 3 SP 383 238026.4 771 827 forward 3 SP 384 1094829.52 168 236 forward 3 SP 384 1094829.52 1067 1156 forward 2 SP 384 1094829.52 456 539 forward 3 SP 385 1094829.54 1004 1072 forward 2 SP 385 1094829.54 1802 1891 forward 2 SP 385 1094829.54 1292 1375 forward 2 SP 386 899802.1 1032 1115 forward 3 TM 386 899802.1 808 882 forward 1 SP 386 899802.1 808 873 forward 1 SP 386 899802.1 808 870 forward 1 SP 387 107569.15 2382 2435 forward 3 TM 387 107569.15 3577 3630 forward 1 TM 387 107569.15 2380 2457 forward 1 TM 387 107569.15 2365 2433 forward 1 TM 387 107569.15 3212 3292 forward 2 TM 387 107569.15 3542 3610 forward 2 TM 387 107569.15 3512 3574 forward 2 TM 387 107569.15 3242 3295 forward 2 TM 387 107569.15 2501 2557 forward 2 TM 387 107569.15 3224 3289 forward 2 SP 387 107569.15 3609 3692 forward 3 TM 387 107569.15 3615 3674 forward 3 TM 387 107569.15 1334 1408 forward 2 TM 387 107569.15 1384 1440 forward 1 TM 387 107569.15 3562 3636 forward 1 TM 387 107569.15 3592 3651 forward 1 TM 387 107569.15 3233 3292 forward 2 TM 391 383863.2 3825 3884 forward 3 TM 391 383863.2 1622 1672 forward 2 TM 391 383863.2 1595 1651 forward 2 SP 391 383863.2 1163 1216 forward 2 SP 391 383863.2 4404 4472 forward 3 TM 391 383863.2 1595 1666 forward 2 SP 391 383863.2 1307 1360 forward 2 TM 391 383863.2 1595 1654 forward 2 SP 391 383863.2 1595 1663 forward 2 SP 391 383863.2 3846 3899 forward 3 TM 392 903491.4 551 604 forward 2 SP 392 903491.4 1371 1421 forward 3 TM 392 903491.4 1239 1295 forward 3 TM 392 903491.4 1355 1411 forward 2 TM 392 903491.4 789 845 forward 3 TM 392 903491.4 1816 1878 forward 1 SP 392 903491.4 1334 1405 forward 2 TM 392 903491.4 1365 1421 forward 3 TM 392 903491.4 1342 1419 forward 1 SP 395 65367.1 559 615 forward 1 SP 395 65367.1 477 533 forward 3 TM 395 65367.1 491 565 forward 2 TM 398 233513.2 1980 2048 forward 3 SP 401 3676741CD1 45 66 SP 402 346636.6 399 470 forward 3 SP 404 1640555CD1 1 31 SP 409 199584.1 1507 1563 forward 1 TM 409 199584.1 2776 2835 forward 1 SP 409 199584.1 1069 1143 forward 1 TM 409 199584.1 1201 1245 forward 1 SP 409 199584.1 1498 1557 forward 1 SP 409 199584.1 2915 2992 forward 2 TM 409 199584.1 1069 1125 forward 1 SP 409 199584.1 1063 1146 forward 1 TM 410 401736.1 385 462 forward 1 TM 412 167854.1 679 732 forward 1 SP 415 351432.23 1425 1499 forward 3 TM 415 351432.23 689 751 forward 2 TM 415 351432.23 990 1061 forward 3 TM 415 351432.23 1422 1475 forward 3 SP 415 351432.23 1476 1526 forward 3 TM 415 351432.23 396 479 forward 3 SP 415 351432.23 1410 1466 forward 3 TM 415 351432.23 1410 1460 forward 3 SP 415 351432.23 1035 1091 forward 3 TM 415 351432.23 566 625 forward 2 SP 415 351432.23 566 637 forward 2 SP 415 351432.23 569 616 forward 2 TM 415 351432.23 1410 1487 forward 3 SP 415 351432.23 1410 1487 forward 3 SP 415 351432.23 1410 1472 forward 3 SP 415 351432.23 1410 1475 forward 3 SP 415 351432.23 575 631 forward 2 TM 415 351432.23 566 631 forward 2 SP 419 2545475CD1 179 195 SP 419 2545475CD1 263 287 TM 419 2545475CD1 387 405 TM 419 2545475CD1 176 195 TM 419 2545475CD1 87 105 TM 419 2545475CD1 421 438 TM 419 2545475CD1 425 443 TM 422 220134.6 2434 2484 forward 1 TM 422 220134.6 2684 2737 forward 2 TM 422 220134.6 1417 1473 forward 1 TM 422 220134.6 2687 2749 forward 2 TM 422 220134.6 1605 1679 forward 3 SP 422 220134.6 2699 2758 forward 2 SP 422 220134.6 2699 2752 forward 2 SP 422 220134.6 2444 2527 forward 2 TM 422 220134.6 2699 2764 forward 2 SP 422 220134.6 2709 2771 forward 3 TM 422 220134.6 2699 2752 forward 2 SP 423 220134.5 847 900 forward 1 TM 423 220134.5 850 912 forward 1 TM 423 220134.5 862 921 forward 1 SP 423 220134.5 862 915 forward 1 SP 423 220134.5 872 934 forward 2 TM 423 220134.5 607 690 forward 1 TM 423 220134.5 862 927 forward 1 SP 423 220134.5 862 915 forward 1 SP 424 202164.1 215 268 forward 2 TM 424 202164.1 2996 3046 forward 2 SP 424 202164.1 1976 2035 forward 2 TM 424 202164.1 1286 1342 forward 2 SP 424 202164.1 2990 3076 forward 2 TM 424 202164.1 1975 2034 forward 1 TM 424 202164.1 236 298 forward 2 SP 424 202164.1 2393 2440 forward 2 TM 424 202164.1 236 289 forward 2 SP 425 406846.4 752 817 forward 2 TM 425 406846.4 510 572 forward 3 TM 425 406846.4 831 881 forward 3 TM 425 406846.4 628 681 forward 1 TM 425 406846.4 780 842 forward 3 TM 425 406846.4 646 711 forward 1 SP 425 406846.4 429 515 forward 3 TM 425 406846.4 498 560 forward 3 TM 425 406846.4 607 669 forward 1 SP 425 406846.4 411 473 forward 3 TM 425 406846.4 498 551 forward 3 TM 430 1273292CD1 1 22 SP 431 67855.1 190 258 forward 1 SP 431 67855.1 41 97 forward 2 SP 431 67855.1 190 240 forward 1 SP 431 67855.1 294 359 forward 3 SP 431 67855.1 41 109 forward 2 SP 432 27185.1 461 532 forward 2 TM 435 17021.2 40 102 forward 1 TM 435 17021.2 31 84 forward 1 TM 435 17021.2 31 96 forward 1 TM 440 337647.1 477 533 forward 3 TM 441 200268.3 250 303 forward 1 TM 441 200268.3 1214 1264 forward 2 SP 441 200268.3 970 1026 forward 1 SP 441 200268.3 958 1029 forward 1 SP 441 200268.3 1214 1288 forward 2 SP 441 200268.3 1214 1267 forward 2 SP 441 200268.3 1214 1282 forward 2 SP 441 200268.3 1854 1931 forward 3 SP 441 200268.3 1214 1267 forward 2 TM 441 200268.3 958 1026 forward 1 SP 444 334738.1 55 141 forward 1 SP 445 410042.1 2854 2910 forward 1 TM 447 2026270CD1 1 24 SP 447 2026270CD1 1 25 SP 449 522433CD1 14 31 SP 449 522433CD1 14 33 SP 449 522433CD1 6 31 SP 449 522433CD1 1 29 SP 456 3105671CD1 1 18 SP 456 3105671CD1 1 20 SP 458 2051966CD1 1 22 SP 458 2051966CD1 1 19 SP 462 2171401CD1 1 21 SP 462 2171401CD1 1 23 SP 463 1326983.14 598 666 forward 1 TM 463 1326983.14 927 983 forward 3 TM 463 1326983.14 1751 1813 forward 2 SP 463 1326983.14 117 203 forward 3 TM 463 1326983.14 4034 4078 forward 2 SP 463 1326983.14 1340 1399 forward 2 TM 463 1326983.14 1751 1807 forward 2 SP 463 1326983.14 1325 1387 forward 2 SP 463 1326983.14 1769 1837 forward 2 TM 463 1326983.14 1325 1399 forward 2 SP 463 1326983.14 143 202 forward 2 TM 463 1326983.14 4228 4290 forward 1 TM 463 1326983.14 1598 1675 forward 2 TM 463 1326983.14 1325 1378 forward 2 SP 463 1326983.14 1769 1831 forward 2 TM 463 1326983.14 1463 1525 forward 2 TM 463 1326983.14 1751 1816 forward 2 SP 463 1326983.14 1022 1081 forward 2 TM 463 1326983.14 1436 1504 forward 2 TM 463 1326983.14 1325 1390 forward 2 SP 463 1326983.14 1457 1534 forward 2 TM 463 1326983.14 1460 1522 forward 2 TM 463 1326983.14 1475 1528 forward 2 TM 463 1326983.14 118 195 forward 1 TM 463 1326983.14 1751 1825 forward 2 SP 465 331666.1 976 1029 forward 1 TM 465 331666.1 153 239 forward 3 SP 468 409895.2 384 437 forward 3 SP 469 245136.9 1343 1417 forward 2 SP 469 245136.9 1352 1417 forward 2 SP 469 245136.9 1369 1422 forward 1 TM 469 245136.9 1364 1423 forward 2 SP 469 245136.9 1325 1387 forward 2 TM 469 245136.9 1364 1417 forward 2 SP 469 245136.9 1364 1411 forward 2 SP 469 245136.9 1355 1411 forward 2 TM 474 900070.12 1702 1749 forward 1 TM 474 900070.12 2271 2324 forward 3 SP 475 231182.1 944 997 forward 2 TM 479 1256053CD1 9 23 SP 479 1256053CD1 9 27 SP 479 1256053CD1 9 29 SP 479 1256053CD1 9 30 SP 479 1256053CD1 9 32 SP 479 1256053CD1 1 32 SP 480 238391.3 44 97 forward 2 TM 480 238391.3 954 1040 forward 3 SP 480 238391.3 194 262 forward 2 TM 480 238391.3 255 341 forward 3 SP 480 238391.3 302 370 forward 2 SP 480 238391.3 185 244 forward 2 SP 480 238391.3 188 259 forward 2 TM 480 238391.3 200 256 forward 2 TM 480 238391.3 287 358 forward 2 TM 480 238391.3 287 361 forward 2 SP 480 238391.3 287 370 forward 2 SP 480 238391.3 302 358 forward 2 TM 480 238391.3 161 223 forward 2 TM 481 201945.4 1104 1169 forward 3 SP 484 998941.1 2607 2663 forward 3 TM 484 998941.1 2947 3027 forward 1 TM 484 998941.1 2261 2335 forward 2 TM 484 998941.1 947 1006 forward 2 SP 484 998941.1 1776 1826 forward 3 TM 484 998941.1 1277 1333 forward 2 SP 484 998941.1 1131 1187 forward 3 SP 484 998941.1 2334 2402 forward 3 TM 484 998941.1 1277 1336 forward 2 SP 484 998941.1 3745 3807 forward 1 TM 484 998941.1 3473 3538 forward 2 TM 484 998941.1 3757 3810 forward 1 TM 484 998941.1 3316 3378 forward 1 TM 484 998941.1 2485 2544 forward 1 TM 484 998941.1 3319 3381 forward 1 TM 484 998941.1 2276 2332 forward 2 TM 484 998941.1 2476 2544 forward 1 TM 484 998941.1 3313 3363 forward 1 TM 484 998941.1 4277 4333 forward 2 SP 484 998941.1 3301 3375 forward 1 TM 484 998941.1 2337 2396 forward 3 TM 484 998941.1 3757 3816 forward 1 TM 484 998941.1 2334 2396 forward 3 TM 484 998941.1 3319 3375 forward 1 TM 485 243985.1 1887 1961 forward 3 SP 485 243985.1 1202 1270 forward 2 SP 486 481779.1 650 706 forward 2 TM 489 2120743CD1 60 78 SP 489 2120743CD1 36 54 TM 489 2120743CD1 125 142 TM 489 2120743CD1 87 112 SP 489 2120743CD1 189 219 SP 489 2120743CD1 381 398 TM 489 2120743CD1 344 374 SP 489 2120743CD1 295 323 TM 489 2120743CD1 292 312 TM 489 2120743CD1 290 307 TM 489 2120743CD1 196 215 SP 489 2120743CD1 198 214 TM 489 2120743CD1 87 113 SP 489 2120743CD1 172 190 SP 489 2120743CD1 301 319 TM 489 2120743CD1 349 371 SP 489 2120743CD1 172 188 SP 489 2120743CD1 196 220 SP 489 2120743CD1 63 80 TM 489 2120743CD1 177 192 TM 489 2120743CD1 196 218 SP 489 2120743CD1 63 83 TM 489 2120743CD1 298 320 TM 489 2120743CD1 61 83 TM 489 2120743CD1 64 83 TM 489 2120743CD1 62 84 TM 491 199121.14 645 719 forward 3 SP 491 199121.14 1877 1927 forward 2 TM 491 199121.14 1853 1921 forward 2 SP 491 199121.14 1859 1930 forward 2 TM 491 199121.14 453 515 forward 3 SP 491 199121.14 3446 3505 forward 2 TM 491 199121.14 1874 1942 forward 2 TM 491 199121.14 1877 1939 forward 2 TM 491 199121.14 9 59 forward 3 SP 491 199121.14 1877 1936 forward 2 TM 495 206866.1 2463 2516 forward 3 TM 495 206866.1 1095 1148 forward 3 SP 495 206866.1 1960 2040 forward 1 TM 495 206866.1 1971 2042 forward 3 TM 495 206866.1 1857 1904 forward 3 TM 495 206866.1 1857 1916 forward 3 TM 495 206866.1 1860 1934 forward 3 TM 495 206866.1 1966 2025 forward 1 TM 496 1330257.51 2028 2096 forward 3 SP 497 983942.1 1005 1103 forward 3 SP 500 303545.3 284 346 forward 2 SP 500 303545.3 239 322 forward 2 TM 500 303545.3 284 349 forward 2 SP 500 303545.3 284 355 forward 2 SP 503 2246292CD1 82 98 TM 503 2246292CD1 76 97 SP 503 2246292CD1 222 247 SP 503 2246292CD1 328 347 TM 503 2246292CD1 1 21 SP 503 2246292CD1 1 23 SP 503 2246292CD1 185 204 TM 503 2246292CD1 222 240 SP 503 2246292CD1 222 244 SP 503 2246292CD1 222 242 SP 503 2246292CD1 85 104 TM 504 411449.1 2699 2770 forward 2 SP 504 411449.1 2695 2751 forward 1 TM 504 411449.1 1337 1390 forward 2 TM 504 411449.1 2995 3051 forward 1 TM 504 411449.1 1344 1406 forward 3 SP 504 411449.1 2756 2824 forward 2 SP 504 411449.1 2764 2838 forward 1 SP 504 411449.1 2729 2803 forward 2 TM 504 411449.1 3049 3129 forward 1 TM 504 411449.1 2717 2770 forward 2 SP 504 411449.1 2753 2842 forward 2 SP 504 411449.1 2771 2827 forward 2 TM 504 411449.1 3052 3105 forward 1 TM 504 411449.1 2768 2821 forward 2 TM 504 411449.1 2765 2827 forward 2 SP 504 411449.1 2764 2832 forward 1 SP 504 411449.1 2999 3055 forward 2 TM 504 411449.1 3055 3111 forward 1 TM 504 411449.1 3028 3099 forward 1 TM 504 411449.1 2731 2802 forward 1 TM 505 409853.3 1299 1379 forward 3 TM 505 409853.3 1040 1105 forward 2 SP 505 409853.3 2537 2605 forward 2 SP 505 409853.3 1048 1104 forward 1 TM 505 409853.3 2537 2596 forward 2 SP 505 409853.3 1040 1087 forward 2 SP 505 409853.3 1037 1096 forward 2 TM 505 409853.3 1040 1096 forward 2 SP 505 409853.3 2546 2602 forward 2 TM 505 409853.3 1040 1102 forward 2 SP 505 409853.3 2515 2562 forward 1 SP 510 14538.1 341 388 forward 2 SP 512 239996.2 251 322 forward 2 TM 513 238403.2 628 717 forward 1 SP 513 238403.2 585 683 forward 3 SP 513 238403.2 2251 2310 forward 1 TM 513 238403.2 628 690 forward 1 SP 514 234681.2 203 292 forward 2 SP 514 234681.2 762 821 forward 3 TM 514 234681.2 1918 1974 forward 1 SP 514 234681.2 1243 1317 forward 1 TM 514 234681.2 203 277 forward 2 SP 514 234681.2 1184 1252 forward 2 TM 514 234681.2 1221 1301 forward 3 TM 515 228678.1 610 663 forward 1 TM 517 233218.18 720 785 forward 3 SP 517 233218.18 356 433 forward 2 SP 517 233218.18 356 421 forward 2 SP 517 233218.18 356 418 forward 2 SP 517 233218.18 720 779 forward 3 SP 517 233218.18 356 430 forward 2 SP 518 6320.1 289 360 forward 1 SP 518 6320.1 194 268 forward 2 SP 519 15433.1 91 174 forward 1 TM 521 1600311CD1 51 68 TM 522 335999.1 243 314 forward 3 SP 522 335999.1 258 326 forward 3 SP 522 335999.1 219 296 forward 3 TM 522 335999.1 233 307 forward 2 TM 522 335999.1 252 308 forward 3 TM 522 335999.1 251 304 forward 2 TM 522 335999.1 242 304 forward 2 TM 522 335999.1 255 308 forward 3 TM 523 197523.6 422 487 forward 2 SP 523 197523.6 64 123 forward 1 SP 523 197523.6 434 508 forward 2 TM 523 197523.6 97 150 forward 1 TM 523 197523.6 434 496 forward 2 TM 527 2239738CD1 1 19 SP 527 2239738CD1 1 24 SP 527 2239738CD1 1 17 SP 528 87074.1 1324 1377 forward 1 TM 528 87074.1 2545 2601 forward 1 TM 528 87074.1 1334 1390 forward 2 TM 528 87074.1 2520 2594 forward 3 TM 528 87074.1 1309 1380 forward 1 TM 528 87074.1 1230 1283 forward 3 TM 528 87074.1 1303 1371 forward 1 TM 528 87074.1 2639 2710 forward 2 TM 528 87074.1 1315 1371 forward 1 TM 528 87074.1 2541 2600 forward 3 TM 531 1730175CD1 1104 1119 SP 531 1730175CD1 1102 1129 TM 531 1730175CD1 1 30 SP 531 1730175CD1 1107 1129 TM 531 1730175CD1 1104 1124 TM 531 1730175CD1 1104 1121 TM 531 1730175CD1 1104 1123 TM 531 1730175CD1 1104 1126 TM 533 6825202CD1 478 496 SP 533 6825202CD1 16 36 SP 533 6825202CD1 15 36 SP 533 6825202CD1 12 36 SP 533 6825202CD1 1 36 SP 537 480736.41 1612 1683 forward 1 TM 538 236943.1 855 908 forward 3 TM 539 76636.1 215 280 forward 2 SP 540 76644.1 218 289 forward 2 TM 540 76644.1 351 404 forward 3 TM 540 76644.1 197 283 forward 2 TM 541 76699.1 533 586 forward 2 SP 541 76699.1 533 595 forward 2 SP 541 76699.1 533 583 forward 2 SP 541 76699.1 537 593 forward 3 TM 541 76699.1 533 589 forward 2 TM 543 19080.2 913 975 forward 1 SP 543 19080.2 910 966 forward 1 TM 544 274444.1 114 182 forward 3 SP 544 274444.1 138 233 forward 3 SP 546 1330220.16 970 1053 forward 1 SP 546 1330220.16 2624 2677 forward 2 SP 546 1330220.16 2603 2662 forward 2 TM 546 1330220.16 557 610 forward 2 TM 546 1330220.16 4702 4788 forward 1 SP 546 1330220.16 976 1029 forward 1 TM 546 1330220.16 2618 2677 forward 2 SP 546 1330220.16 970 1053 forward 1 SP 546 1330220.16 3609 3677 forward 3 SP 546 1330220.16 551 607 forward 2 TM 547 99792.1 657 710 forward 3 TM 550 238396.1 1136 1213 forward 2 TM 550 238396.1 1172 1225 forward 2 TM 550 238396.1 936 998 forward 3 SP 551 23904.1 392 463 forward 2 TM 551 23904.1 431 493 forward 2 TM 551 23904.1 150 203 forward 3 TM 551 23904.1 773 847 forward 2 TM 551 23904.1 156 212 forward 3 TM 551 23904.1 782 841 forward 2 TM 552 274712.1 1985 2044 forward 2 TM 552 274712.1 2883 2966 forward 3 TM 552 274712.1 1942 2004 forward 1 TM 552 274712.1 1589 1645 forward 2 TM 552 274712.1 2925 2978 forward 3 TM 552 274712.1 2907 2969 forward 3 TM 552 274712.1 2655 2729 forward 3 TM 552 274712.1 590 655 forward 2 SP 552 274712.1 2661 2717 forward 3 TM 552 274712.1 2895 2951 forward 3 TM 552 274712.1 2907 2978 forward 3 TM 553 979567.11 4850 4918 forward 2 TM 553 979567.11 3137 3199 forward 2 TM 553 979567.11 3113 3190 forward 2 TM 553 979567.11 284 352 forward 2 TM 553 979567.11 1279 1341 forward 1 SP 553 979567.11 7904 7972 forward 2 TM 553 979567.11 7829 7894 forward 2 TM 553 979567.11 7606 7659 forward 1 TM 553 979567.11 7826 7891 forward 2 TM 553 979567.11 871 933 forward 1 SP 553 979567.11 885 938 forward 3 TM 553 979567.11 3116 3181 forward 2 SP 553 979567.11 873 932 forward 3 TM 553 979567.11 7832 7888 forward 2 TM 554 234121.1 151 213 forward 1 SP 554 234121.1 2421 2477 forward 3 TM 554 234121.1 2772 2858 forward 3 SP 554 234121.1 2194 2277 forward 1 TM 554 234121.1 2203 2250 forward 1 SP 554 234121.1 1651 1716 forward 1 TM 554 234121.1 2203 2268 forward 1 SP 554 234121.1 2203 2259 forward 1 SP 554 234121.1 2216 2278 forward 2 TM 554 234121.1 2197 2265 forward 1 TM 554 234121.1 2203 2289 forward 1 SP 554 234121.1 2490 2543 forward 3 TM 554 234121.1 2203 2259 forward 1 TM 554 234121.1 2203 2256 forward 1 TM 555 252493.15 902 958 forward 2 TM 555 252493.15 498 554 forward 3 TM 555 252493.15 498 551 forward 3 SP 555 252493.15 3336 3398 forward 3 SP 555 252493.15 3867 3917 forward 3 TM 555 252493.15 1988 2068 forward 2 TM 555 252493.15 906 989 forward 3 TM 555 252493.15 2000 2062 forward 2 TM 555 252493.15 498 545 forward 3 SP 555 252493.15 900 953 forward 3 TM 555 252493.15 1988 2044 forward 2 TM 555 252493.15 498 560 forward 3 SP 555 252493.15 903 977 forward 3 TM 555 252493.15 909 968 forward 3 TM 557 247423.13 2513 2593 forward 2 SP 557 247423.13 3395 3460 forward 2 SP 557 247423.13 3389 3451 forward 2 TM 557 247423.13 4523 4588 forward 2 SP 557 247423.13 4333 4419 forward 1 SP 557 247423.13 5100 5168 forward 3 TM 557 247423.13 4523 4576 forward 2 SP 557 247423.13 659 730 forward 2 SP 557 247423.13 3371 3457 forward 2 TM 557 247423.13 3395 3448 forward 2 SP 557 247423.13 5106 5168 forward 3 TM 557 247423.13 3389 3451 forward 2 TM 557 247423.13 3395 3442 forward 2 SP 557 247423.13 3395 3454 forward 2 SP 557 247423.13 3386 3451 forward 2 TM 557 247423.13 2513 2587 forward 2 SP 557 247423.13 3383 3433 forward 2 TM 557 247423.13 3395 3454 forward 2 TM 558 334234.2 926 1009 forward 2 SP 558 334234.2 1558 1614 forward 1 TM 559 205672.1 1836 1919 forward 3 TM 559 205672.1 1857 1910 forward 3 TM 559 205672.1 1848 1910 forward 3 TM 559 205672.1 1869 1943 forward 3 TM 560 1327024.5 4567 4620 forward 1 SP 560 1327024.5 7801 7860 forward 1 TM 560 1327024.5 7359 7409 forward 3 TM 560 1327024.5 2893 2949 forward 1 SP 560 1327024.5 5923 5979 forward 1 TM 560 1327024.5 7792 7842 forward 1 TM 560 1327024.5 8235 8288 forward 3 TM 560 1327024.5 8289 8333 forward 3 TM 560 1327024.5 6775 6834 forward 1 SP 560 1327024.5 3580 3669 forward 1 SP 560 1327024.5 6775 6846 forward 1 SP 560 1327024.5 7135 7191 forward 1 TM 560 1327024.5 6739 6855 forward 1 SP 560 1327024.5 73 156 forward 1 SP 560 1327024.5 8223 8303 forward 3 TM 560 1327024.5 8232 8303 forward 3 TM 560 1327024.5 8274 8336 forward 3 TM 560 1327024.5 8241 8300 forward 3 TM 562 2925789CD1 22 41 TM 562 2925789CD1 185 215 SP 562 2925789CD1 141 158 SP 562 2925789CD1 142 166 TM 562 2925789CD1 206 224 TM 562 2925789CD1 205 226 TM 562 2925789CD1 145 170 TM 563 335613.1 724 780 forward 1 TM 564 207646.1 315 377 forward 3 TM 564 207646.1 19 69 forward 1 TM 564 207646.1 282 353 forward 3 SP 564 207646.1 294 350 forward 3 TM 564 207646.1 294 368 forward 3 TM 564 207646.1 300 368 forward 3 TM 566 1720847CD1 22 47 SP 566 1720847CD1 22 42 SP 569 107939.2 2634 2705 forward 3 SP 569 107939.2 2936 2992 forward 2 TM 569 107939.2 2942 2992 forward 2 TM 569 107939.2 3776 3847 forward 2 TM 569 107939.2 2939 3004 forward 2 SP 572 207778.1 145 198 forward 1 SP 572 207778.1 589 660 forward 1 SP 572 207778.1 152 214 forward 2 TM 573 296811.1 320 391 forward 2 SP 573 296811.1 308 391 forward 2 SP 573 296811.1 3141 3197 forward 3 TM 573 296811.1 3424 3486 forward 1 SP 573 296811.1 3163 3222 forward 1 TM 573 296811.1 2136 2216 forward 3 SP 573 296811.1 3142 3213 forward 1 TM 573 296811.1 1680 1775 forward 3 SP 574 333776.1 115 168 forward 1 TM 578 110960CD1 185 213 SP 578 110960CD1 108 126 TM 578 110960CD1 102 127 TM 578 110960CD1 105 125 TM 578 110960CD1 289 314 TM 578 110960CD1 106 121 TM 578 110960CD1 225 250 TM 578 110960CD1 232 255 SP 578 110960CD1 162 180 SP 578 110960CD1 232 258 SP 578 110960CD1 226 244 TM 578 110960CD1 197 214 TM 578 110960CD1 184 210 TM 579 238602.2 57 128 forward 3 SP 579 238602.2 613 666 forward 1 TM 579 238602.2 1073 1129 forward 2 TM 579 238602.2 1205 1261 forward 2 TM 579 238602.2 1082 1126 forward 2 SP 579 238602.2 599 679 forward 2 TM 579 238602.2 634 693 forward 1 TM 579 238602.2 479 556 forward 2 TM 579 238602.2 482 532 forward 2 TM 579 238602.2 649 726 forward 1 TM 580 363007.1 669 755 forward 3 TM 580 363007.1 240 290 forward 3 TM 580 363007.1 246 308 forward 3 TM 582 3478236CD1 1 21 SP 582 3478236CD1 1 26 SP 582 3478236CD1 1 26 SP 582 3478236CD1 191 217 SP 584 2466714CD1 328 347 TM 584 2466714CD1 281 303 SP 584 2466714CD1 70 98 SP 584 2466714CD1 322 342 TM 584 2466714CD1 78 97 TM 584 2466714CD1 330 347 TM 584 2466714CD1 200 216 TM 584 2466714CD1 330 349 SP 584 2466714CD1 357 385 SP 584 2466714CD1 433 453 TM 584 2466714CD1 365 388 TM 584 2466714CD1 197 217 TM 584 2466714CD1 169 191 TM 584 2466714CD1 70 94 SP 584 2466714CD1 47 69 TM 584 2466714CD1 70 92 SP 584 2466714CD1 68 88 TM 584 2466714CD1 433 451 TM 584 2466714CD1 371 387 TM 584 2466714CD1 70 90 SP 584 2466714CD1 366 387 TM 584 2466714CD1 197 216 TM 584 2466714CD1 432 454 TM 587 246037.28 886 948 forward 1 TM 587 246037.28 895 951 forward 1 TM 587 246037.28 901 951 forward 1 TM 588 337183.1 1091 1144 forward 2 TM 588 337183.1 215 262 forward 2 TM 592 480968.13 3001 3057 forward 1 TM 592 480968.13 3187 3249 forward 1 TM 592 480968.13 3056 3115 forward 2 SP 592 480968.13 1131 1190 forward 3 SP 592 480968.13 3809 3892 forward 2 TM 592 480968.13 2791 2850 forward 1 SP 592 480968.13 1336 1392 forward 1 SP 592 480968.13 2791 2859 forward 1 SP 592 480968.13 4086 4139 forward 3 TM 592 480968.13 2990 3046 forward 2 TM 592 480968.13 1333 1392 forward 1 SP 592 480968.13 1315 1392 forward 1 SP 592 480968.13 1131 1205 forward 3 SP 592 480968.13 1321 1392 forward 1 SP 592 480968.13 2987 3049 forward 2 TM 592 480968.13 1327 1392 forward 1 SP 595 998599.8 318 389 forward 3 TM 595 998599.8 327 383 forward 3 SP 595 998599.8 309 368 forward 3 TM 595 998599.8 312 365 forward 3 TM 598 344186.12 1508 1570 forward 2 TM 598 344186.12 1214 1273 forward 2 SP 598 344186.12 1296 1352 forward 3 TM 598 344186.12 1217 1276 forward 2 TM 598 344186.12 1217 1273 forward 2 SP 598 344186.12 1208 1273 forward 2 SP 603 208376.1 73 129 forward 1 TM 608 210011.1 1246 1317 forward 1 SP 608 210011.1 1246 1317 forward 1 SP 608 210011.1 1246 1332 forward 1 SP 609 480336.3 557 610 forward 2 SP 610 1024610.45 701 781 forward 2 SP 610 1024610.45 701 775 forward 2 SP 610 1024610.45 701 760 forward 2 TM 613 22632.1 664 711 forward 1 TM 626 1344185CD1 13 28 SP 626 1344185CD1 12 29 TM 626 1344185CD1 1 23 SP 626 1344185CD1 1 26 SP 626 1344185CD1 1 28 SP 629 336435.2 926 979 forward 2 TM 629 336435.2 440 511 forward 2 TM 629 336435.2 1460 1531 forward 2 TM 629 336435.2 554 613 forward 2 TM 629 336435.2 806 862 forward 2 TM 629 336435.2 551 613 forward 2 TM 629 336435.2 926 985 forward 2 TM 629 336435.2 2363 2437 forward 2 SP 629 336435.2 458 517 forward 2 TM 629 336435.2 1460 1516 forward 2 TM 629 336435.2 2363 2443 forward 2 SP 630 231558.1 449 514 forward 2 SP 631 247784.3 596 667 forward 2 SP 631 247784.3 596 688 forward 2 SP 632 238322.6 1615 1671 forward 1 SP 632 238322.6 1606 1671 forward 1 SP 632 238322.6 1597 1671 forward 1 SP 632 238322.6 1837 1884 forward 1 SP 632 238322.6 1408 1467 forward 1 SP 632 238322.6 1908 1979 forward 3 SP 632 238322.6 947 1024 forward 2 SP 632 238322.6 1822 1911 forward 1 SP 632 238322.6 1600 1686 forward 1 SP 632 238322.6 1837 1911 forward 1 SP 632 238322.6 1837 1896 forward 1 SP 632 238322.6 262 324 forward 1 SP 632 238322.6 1837 1890 forward 1 SP 632 238322.6 274 318 forward 1 SP 632 238322.6 1837 1902 forward 1 SP 632 238322.6 274 327 forward 1 SP 632 238322.6 253 324 forward 1 SP 632 238322.6 244 324 forward 1 SP 632 238322.6 253 324 forward 1 SP 634 55978.4 4343 4414 forward 2 TM 634 55978.4 3257 3316 forward 2 SP 634 55978.4 2042 2101 forward 2 SP 636 238877.11 1777 1833 forward 1 TM 636 238877.11 2635 2712 forward 1 TM 636 238877.11 2439 2495 forward 3 TM 636 238877.11 2788 2841 forward 1 TM 637 238877.8 1007 1078 forward 2 TM 637 238877.8 1004 1060 forward 2 TM 637 238877.8 661 738 forward 1 TM 637 238877.8 1019 1075 forward 2 TM 639 997231.16 938 1009 forward 2 TM 640 346209.3 5004 5093 forward 3 SP 640 346209.3 4848 4901 forward 3 TM 642 2515666CD1 1 19 SP 642 2515666CD1 1 30 SP 642 2515666CD1 14 32 TM 642 2515666CD1 1 22 SP 646 406830.43 758 814 forward 2 TM 649 1045907.4 469 561 forward 1 SP 651 85282.1 381 449 forward 3 TM 652 86326.1 1194 1256 forward 3 TM 652 86326.1 645 722 forward 3 SP 652 86326.1 1330 1389 forward 1 TM 652 86326.1 1225 1284 forward 1 TM 657 95374.1 342 398 forward 3 TM 657 95374.1 335 394 forward 2 TM 659 33627.28 3423 3476 forward 3 TM 659 33627.28 2305 2400 forward 1 SP 659 33627.28 3090 3167 forward 3 SP 659 33627.28 3090 3149 forward 3 SP 659 33627.28 2249 2332 forward 2 SP 659 33627.28 1180 1239 forward 1 TM 659 33627.28 2252 2308 forward 2 TM 659 33627.28 1983 2033 forward 3 TM 659 33627.28 2273 2329 forward 2 TM 659 33627.28 2249 2323 forward 2 SP 659 33627.28 2243 2311 forward 2 SP 660 33627.33 2638 2691 forward 1 TM 660 33627.33 2972 3025 forward 2 TM 660 33627.33 2960 3016 forward 2 TM 660 33627.33 2951 3013 forward 2 TM 660 33627.33 2942 3013 forward 2 TM 661 435361.1 1447 1503 forward 1 TM 661 435361.1 1847 1906 forward 2 TM 661 435361.1 1862 1930 forward 2 TM 664 2636759CD1 150 174 SP 665 1083665.4 353 409 forward 2 TM 665 1083665.4 2 52 forward 2 TM 665 1083665.4 9 89 forward 3 TM 667 240518.42 540 599 forward 3 TM 667 240518.42 1678 1788 forward 1 SP 667 240518.42 1741 1788 forward 1 SP 668 1322.4 3555 3608 forward 3 TM 668 1322.4 3495 3548 forward 3 TM 668 1322.4 3496 3552 forward 1 TM 668 1322.4 3647 3718 forward 2 SP 668 1322.4 3454 3528 forward 1 TM 668 1322.4 3475 3528 forward 1 TM 668 1322.4 3030 3089 forward 3 TM 668 1322.4 3641 3733 forward 2 TM 668 1322.4 3647 3706 forward 2 SP 668 1322.4 2627 2704 forward 2 TM 668 1322.4 3534 3608 forward 3 TM 669 208282.1 642 704 forward 3 TM 669 208282.1 705 758 forward 3 TM 669 208282.1 1072 1128 forward 1 TM 671 345272.2 707 781 forward 2 SP 674 13937.3 1988 2041 forward 2 TM 674 13937.3 257 328 forward 2 SP 674 13937.3 263 352 forward 2 SP 674 13937.3 263 328 forward 2 SP 679 1325741.2 804 866 forward 3 SP 679 1325741.2 1463 1537 forward 2 SP 679 1325741.2 804 860 forward 3 SP 682 118836.2 5963 6019 forward 2 TM 682 118836.2 3927 4010 forward 3 TM 682 118836.2 5969 6019 forward 2 TM 682 118836.2 2930 3019 forward 2 SP 682 118836.2 4483 4575 forward 1 SP 682 118836.2 3957 4016 forward 3 SP 682 118836.2 1107 1160 forward 3 TM 683 3303.2 1741 1803 forward 1 TM 683 3303.2 1853 1903 forward 2 TM 683 3303.2 6808 6858 forward 1 TM 683 3303.2 2326 2388 forward 1 TM 683 3303.2 2748 2804 forward 3 TM 683 3303.2 6646 6696 forward 1 TM 683 3303.2 3786 3857 forward 3 TM 683 3303.2 3777 3854 forward 3 TM 683 3303.2 6814 6870 forward 1 TM 683 3303.2 3779 3835 forward 2 TM 683 3303.2 2571 2627 forward 3 TM 683 3303.2 6790 6852 forward 1 TM 683 3303.2 6784 6846 forward 1 SP 683 3303.2 3780 3836 forward 3 SP 683 3303.2 3780 3845 forward 3 SP 683 3303.2 2751 2804 forward 3 TM 683 3303.2 5390 5452 forward 2 TM 683 3303.2 5408 5473 forward 2 TM 683 3303.2 868 957 forward 1 SP 683 3303.2 2745 2807 forward 3 TM 683 3303.2 3780 3824 forward 3 SP 683 3303.2 5405 5461 forward 2 TM 683 3303.2 5396 5470 forward 2 TM 683 3303.2 5405 5461 forward 2 TM 686 1383062.7 165 245 forward 3 SP 687 1383062.8 139 219 forward 1 SP 688 1383794.1 154 225 forward 1 SP 688 1383794.1 154 240 forward 1 SP 689 406289.1 521 577 forward 2 TM 690 175918.15 1678 1722 forward 1 SP 690 175918.15 2620 2697 forward 1 SP 690 175918.15 5448 5504 forward 3 TM 690 175918.15 5772 5837 forward 3 TM 690 175918.15 5665 5718 forward 1 TM 690 175918.15 5186 5242 forward 2 TM 690 175918.15 5787 5849 forward 3 TM 690 175918.15 5656 5727 forward 1 TM 690 175918.15 5784 5837 forward 3 TM 690 175918.15 1678 1734 forward 1 SP 690 175918.15 5751 5822 forward 3 TM 690 175918.15 5772 5828 forward 3 TM 691 1068290.1 2534 2596 forward 2 SP 692 94873.1 191 253 forward 2 SP 693 403616.1 193 261 forward 1 SP 693 403616.1 190 243 forward 1 TM 693 403616.1 178 240 forward 1 TM 693 403616.1 175 237 forward 1 TM 694 95088.1 448 516 forward 1 TM 694 95088.1 369 419 forward 3 TM 694 95088.1 387 464 forward 3 TM 694 95088.1 369 425 forward 3 TM 695 230402.1 314 376 forward 2 TM 696 95172.1 591 644 forward 3 TM 696 95172.1 220 282 forward 1 TM 700 335375.3 815 868 forward 2 TM 700 335375.3 545 607 forward 2 SP 700 335375.3 224 271 forward 2 SP 702 229514.1 153 209 forward 3 TM 702 229514.1 173 229 forward 2 TM 702 229514.1 1219 1287 forward 1 SP 702 229514.1 182 232 forward 2 TM 702 229514.1 1219 1272 forward 1 SP 702 229514.1 1228 1287 forward 1 TM 703 95573.1 154 210 forward 1 TM 704 230463.1 65 127 forward 2 TM 704 230463.1 47 118 forward 2 TM 704 230463.1 89 145 forward 2 TM 704 230463.1 1134 1196 forward 3 TM 706 218090.9 368 433 forward 2 SP 706 218090.9 1025 1087 forward 2 SP 714 208748.4 845 904 forward 2 TM 715 407517.2 5120 5206 forward 2 TM 715 407517.2 5378 5446 forward 2 SP 715 407517.2 2353 2442 forward 1 SP 715 407517.2 1007 1057 forward 2 TM 715 407517.2 1153 1215 forward 1 SP 716 233997.1 3468 3536 forward 3 TM 716 233997.1 2169 2228 forward 3 SP 716 233997.1 2791 2856 forward 1 SP 716 233997.1 2791 2868 forward 1 SP 716 233997.1 2791 2877 forward 1 SP 718 330862.6 209 292 forward 2 TM 718 330862.6 68 136 forward 2 SP 718 330862.6 68 127 forward 2 SP 718 330862.6 70 141 forward 1 TM 719 330862.8 1275 1328 forward 3 TM 719 330862.8 984 1058 forward 3 SP 719 330862.8 984 1058 forward 3 SP 722 1098722.6 1625 1702 forward 2 TM 722 1098722.6 1534 1587 forward 1 SP 722 1098722.6 1534 1599 forward 1 SP 722 1098722.6 381 464 forward 3 TM 722 1098722.6 1534 1599 forward 1 SP 724 201395.4 3659 3757 forward 2 SP 724 201395.4 586 657 forward 1 SP 724 201395.4 2381 2440 forward 2 SP 724 201395.4 3718 3783 forward 1 SP 724 201395.4 3667 3774 forward 1 SP 724 201395.4 3694 3762 forward 1 TM 724 201395.4 4462 4509 forward 1 SP 724 201395.4 3700 3768 forward 1 TM 724 201395.4 3718 3765 forward 1 TM 724 201395.4 2339 2452 forward 2 SP 724 201395.4 2381 2452 forward 2 SP 724 201395.4 3703 3765 forward 1 TM 724 201395.4 3703 3759 forward 1 TM 728 983684.1 214 300 forward 1 TM 729 983684.2 422 481 forward 2 TM 734 199290.9 6174 6224 forward 3 TM 734 199290.9 4201 4260 forward 1 TM 734 199290.9 4999 5055 forward 1 TM 734 199290.9 6159 6227 forward 3 SP 734 199290.9 3961 4029 forward 1 SP 734 199290.9 3988 4050 forward 1 TM 734 199290.9 6591 6671 forward 3 TM 734 199290.9 3588 3653 forward 3 SP 734 199290.9 5689 5754 forward 1 SP 734 199290.9 3988 4047 forward 1 TM 734 199290.9 5051 5107 forward 2 TM 734 199290.9 6174 6230 forward 3 TM 734 199290.9 4198 4254 forward 1 TM 734 199290.9 3961 4023 forward 1 SP 734 199290.9 6588 6647 forward 3 TM 734 199290.9 6603 6647 forward 3 SP 734 199290.9 5665 5721 forward 1 TM 734 199290.9 5225 5275 forward 2 TM 734 199290.9 6585 6632 forward 3 TM 734 199290.9 4996 5058 forward 1 TM 734 199290.9 2115 2171 forward 3 SP 734 199290.9 4189 4260 forward 1 TM 734 199290.9 2115 2165 forward 3 SP 734 199290.9 4996 5052 forward 1 TM 734 199290.9 6159 6242 forward 3 SP 734 199290.9 6159 6233 forward 3 SP 734 199290.9 2103 2153 forward 3 TM 734 199290.9 6159 6221 forward 3 SP 739 208379.1 2649 2711 forward 3 TM 739 208379.1 2637 2711 forward 3 TM 739 208379.1 2135 2191 forward 2 SP 739 208379.1 2674 2733 forward 1 TM 739 208379.1 2070 2129 forward 3 TM 740 251631.6 230 298 forward 2 TM 742 2847188CD1 1 26 SP 742 2847188CD1 1 22 SP 742 2847188CD1 1 25 SP 743 100579.1 28 81 forward 1 TM 744 1327498.1 32 85 forward 2 SP 745 1330212.14 532 588 forward 1 TM 747 252471.4 1129 1182 forward 1 TM 750 1330122.1 24310 24369 forward 1 TM 750 1330122.1 22842 22904 forward 3 TM 750 1330122.1 13584 13646 forward 3 SP 750 1330122.1 16815 16868 forward 3 TM 750 1330122.1 10236 10295 forward 3 TM 750 1330122.1 19685 19768 forward 2 TM 750 1330122.1 15520 15579 forward 1 SP 750 1330122.1 9440 9526 forward 2 TM 750 1330122.1 11175 11228 forward 3 TM 750 1330122.1 14682 14738 forward 3 TM 750 1330122.1 10273 10344 forward 1 TM 750 1330122.1 15657 15740 forward 3 SP 750 1330122.1 23238 23306 forward 3 SP 750 1330122.1 17349 17402 forward 3 TM 750 1330122.1 24203 24259 forward 2 TM 750 1330122.1 14151 14210 forward 3 TM 750 1330122.1 10221 10289 forward 3 TM 750 1330122.1 15189 15266 forward 3 SP 750 1330122.1 2488 2538 forward 1 SP 750 1330122.1 13004 13060 forward 2 SP 750 1330122.1 18699 18758 forward 3 TM 750 1330122.1 3822 3899 forward 3 TM 750 1330122.1 2503 2565 forward 1 TM 750 1330122.1 16212 16265 forward 3 TM 750 1330122.1 18862 18942 forward 1 TM 750 1330122.1 20473 20535 forward 1 TM 750 1330122.1 24050 24112 forward 2 SP 750 1330122.1 2518 2595 forward 1 TM 750 1330122.1 23387 23461 forward 2 SP 750 1330122.1 3687 3743 forward 3 TM 750 1330122.1 15012 15089 forward 3 TM 750 1330122.1 24197 24244 forward 2 TM 750 1330122.1 15654 15710 forward 3 TM 750 1330122.1 12709 12765 forward 1 TM 750 1330122.1 5349 5417 forward 3 TM 750 1330122.1 7305 7358 forward 3 SP 750 1330122.1 23050 23130 forward 1 TM 750 1330122.1 16220 16282 forward 2 TM 750 1330122.1 21438 21485 forward 3 TM 750 1330122.1 15189 15245 forward 3 SP 750 1330122.1 24313 24366 forward 1 TM 750 1330122.1 14619 14705 forward 3 TM 750 1330122.1 7403 7462 forward 2 TM 750 1330122.1 344 394 forward 2 TM 750 1330122.1 10270 10326 forward 1 TM 750 1330122.1 24050 24121 forward 2 SP 750 1330122.1 15345 15395 forward 3 SP 750 1330122.1 24213 24272 forward 3 TM 750 1330122.1 2488 2547 forward 1 SP 750 1330122.1 14607 14663 forward 3 TM 750 1330122.1 13004 13066 forward 2 SP 750 1330122.1 14604 14672 forward 3 TM 750 1330122.1 9895 9945 forward 1 TM 750 1330122.1 17343 17399 forward 3 TM 750 1330122.1 8867 8932 forward 2 SP 750 1330122.1 15345 15413 forward 3 TM 750 1330122.1 5030 5092 forward 2 TM 750 1330122.1 2509 2574 forward 1 TM 750 1330122.1 15360 15419 forward 3 TM 750 1330122.1 16215 16271 forward 3 TM 750 1330122.1 5364 5417 forward 3 TM 750 1330122.1 13004 13075 forward 2 SP 750 1330122.1 21435 21494 forward 3 TM 750 1330122.1 21049 21099 forward 1 TM 750 1330122.1 3645 3719 forward 3 TM 750 1330122.1 18589 18651 forward 1 TM 750 1330122.1 7305 7373 forward 3 SP 750 1330122.1 2488 2544 forward 1 SP 750 1330122.1 846 899 forward 3 SP 750 1330122.1 15654 15716 forward 3 TM 750 1330122.1 10239 10292 forward 3 TM 750 1330122.1 2488 2559 forward 1 SP 750 1330122.1 14688 14744 forward 3 TM 750 1330122.1 2500 2556 forward 1 TM 750 1330122.1 13004 13069 forward 2 SP 750 1330122.1 14610 14672 forward 3 TM 750 1330122.1 7393 7455 forward 1 TM 750 1330122.1 20476 20532 forward 1 TM 750 1330122.1 2488 2556 forward 1 SP 751 407468.1 484 546 forward 1 TM 751 407468.1 481 552 forward 1 TM 752 1330149.46 632 682 forward 2 TM 752 1330149.46 1117 1167 forward 1 TM 752 1330149.46 4076 4144 forward 2 TM 752 1330149.46 1698 1769 forward 3 TM 752 1330149.46 2484 2564 forward 3 SP 752 1330149.46 2363 2461 forward 2 SP 752 1330149.46 1105 1164 forward 1 TM 752 1330149.46 4088 4150 forward 2 TM 752 1330149.46 4088 4144 forward 2 TM 753 32476.2 123 188 forward 3 SP 753 32476.2 123 185 forward 3 SP 753 32476.2 144 203 forward 3 TM 757 1719478CD1 1298 1318 TM 757 1719478CD1 1214 1237 TM 757 1719478CD1 1734 1760 TM 757 1719478CD1 1305 1328 SP 757 1719478CD1 249 266 SP 757 1719478CD1 1535 1552 TM 757 1719478CD1 383 403 TM 757 1719478CD1 932 949 TM 757 1719478CD1 843 868 TM 757 1719478CD1 767 786 TM 757 1719478CD1 1423 1446 TM 757 1719478CD1 1633 1650 TM 757 1719478CD1 1425 1445 TM 757 1719478CD1 941 958 SP 757 1719478CD1 1311 1333 SP 757 1719478CD1 1248 1264 TM 757 1719478CD1 1567 1585 TM 757 1719478CD1 1424 1441 TM 757 1719478CD1 939 961 TM 757 1719478CD1 187 204 TM 757 1719478CD1 855 872 TM 757 1719478CD1 1311 1331 SP 757 1719478CD1 1621 1644 TM 757 1719478CD1 1631 1656 TM 757 1719478CD1 938 958 SP 757 1719478CD1 939 961 SP 757 1719478CD1 1182 1199 TM 757 1719478CD1 1627 1653 SP 757 1719478CD1 249 269 SP 757 1719478CD1 850 870 TM 757 1719478CD1 1307 1324 TM 757 1719478CD1 1628 1648 SP 757 1719478CD1 843 865 TM 757 1719478CD1 1727 1745 TM 757 1719478CD1 1636 1658 TM 757 1719478CD1 1311 1328 SP 757 1719478CD1 379 394 TM 757 1719478CD1 1562 1582 TM 757 1719478CD1 936 956 TM 757 1719478CD1 1539 1557 TM 757 1719478CD1 932 952 TM 757 1719478CD1 1627 1648 SP 757 1719478CD1 1313 1332 TM 757 1719478CD1 1427 1446 TM 757 1719478CD1 939 960 TM 757 1719478CD1 211 228 TM 757 1719478CD1 939 962 SP 757 1719478CD1 1562 1584 TM 757 1719478CD1 1566 1583 TM 757 1719478CD1 384 405 TM 757 1719478CD1 939 967 SP 757 1719478CD1 380 407 TM 757 1719478CD1 379 398 TM 757 1719478CD1 1725 1748 TM 757 1719478CD1 1627 1651 SP 757 1719478CD1 248 266 TM 757 1719478CD1 1636 1655 TM 757 1719478CD1 858 876 TM 757 1719478CD1 1422 1445 TM 757 1719478CD1 378 401 TM 759 236749.1 197 265 forward 2 SP 759 236749.1 1415 1471 forward 2 TM 759 236749.1 1531 1587 forward 1 TM 759 236749.1 224 283 forward 2 TM 759 236749.1 218 265 forward 2 SP 759 236749.1 1492 1548 forward 1 SP 759 236749.1 197 271 forward 2 SP 759 236749.1 221 286 forward 2 TM 759 236749.1 1269 1352 forward 3 TM 759 236749.1 221 280 forward 2 TM 759 236749.1 197 289 forward 2 SP 760 407124.2 1245 1307 forward 3 TM 760 407124.2 1272 1325 forward 3 TM 760 407124.2 1245 1304 forward 3 TM 760 407124.2 1257 1328 forward 3 TM 760 407124.2 1111 1185 forward 1 TM 762 400253.14 1107 1160 forward 3 SP 762 400253.14 1089 1163 forward 3 SP 762 400253.14 1104 1166 forward 3 SP 762 400253.14 1110 1172 forward 3 TM 762 400253.14 1086 1166 forward 3 SP 762 400253.14 1101 1166 forward 3 SP 762 400253.14 222 287 forward 3 SP 762 400253.14 1116 1178 forward 3 TM 762 400253.14 222 302 forward 3 SP 762 400253.14 1110 1172 forward 3 TM 762 400253.14 222 293 forward 3 SP 762 400253.14 222 284 forward 3 SP 764 978065.5 912 971 forward 3 TM 766 984236.4 912 968 forward 3 SP 766 984236.4 1037 1093 forward 2 TM 766 984236.4 1415 1477 forward 2 TM 766 984236.4 391 480 forward 1 SP 766 984236.4 996 1079 forward 3 SP 766 984236.4 1037 1090 forward 2 TM 770 7808.1 1295 1357 forward 2 SP 770 7808.1 1310 1360 forward 2 TM 770 7808.1 1295 1348 forward 2 SP 770 7808.1 1262 1336 forward 2 TM 770 7808.1 2888 2953 forward 2 TM 770 7808.1 3155 3217 forward 2 TM 770 7808.1 3050 3106 forward 2 TM 770 7808.1 3050 3109 forward 2 SP 770 7808.1 1295 1372 forward 2 SP 770 7808.1 3152 3205 forward 2 TM 770 7808.1 3050 3103 forward 2 SP 770 7808.1 3050 3118 forward 2 SP 771 403627.38 140 196 forward 2 TM 771 403627.38 120 197 forward 3 SP 771 403627.38 560 619 forward 2 TM 771 403627.38 638 706 forward 2 SP 771 403627.38 747 833 forward 3 SP 771 403627.38 766 819 forward 1 SP 771 403627.38 954 1022 forward 3 TM 771 403627.38 128 187 forward 2 SP 771 403627.38 638 697 forward 2 SP 773 474622.1 3087 3134 forward 3 TM 773 474622.1 610 681 forward 1 TM 773 474622.1 1939 1998 forward 1 TM 773 474622.1 613 675 forward 1 TM 773 474622.1 2424 2489 forward 3 TM 773 474622.1 1838 1900 forward 2 TM 773 474622.1 604 657 forward 1 TM 773 474622.1 1941 2000 forward 3 TM 773 474622.1 1829 1903 forward 2 TM 773 474622.1 601 678 forward 1 TM 773 474622.1 1917 1982 forward 3 SP 775 1383009.67 10 96 forward 1 SP 779 1384716.4 798 845 forward 3 SP 779 1384716.4 445 531 forward 1 SP 783 256138.1 312 368 forward 3 TM 783 256138.1 289 342 forward 1 TM 784 413348.4 99 173 forward 3 SP 784 413348.4 2300 2374 forward 2 SP 784 413348.4 811 864 forward 1 SP 784 413348.4 526 585 forward 1 SP 784 413348.4 511 570 forward 1 TM 784 413348.4 1742 1825 forward 2 TM 784 413348.4 1625 1678 forward 2 TM 784 413348.4 1475 1534 forward 2 TM 784 413348.4 111 179 forward 3 SP 784 413348.4 117 164 forward 3 SP 784 413348.4 1615 1668 forward 1 TM 784 413348.4 814 879 forward 1 SP 784 413348.4 511 585 forward 1 SP 784 413348.4 814 861 forward 1 SP 784 413348.4 117 179 forward 3 SP 784 413348.4 117 173 forward 3 SP 785 332088.2 49 108 forward 1 TM 787 035282CD1 219 248 SP 788 350667.7 543 632 forward 3 SP 788 350667.7 713 802 forward 2 SP 790 211622.1 59 121 forward 2 TM 790 211622.1 235 288 forward 1 TM 790 211622.1 208 276 forward 1 TM 790 211622.1 199 285 forward 1 TM 790 211622.1 581 637 forward 2 TM 790 211622.1 11 58 forward 2 TM 790 211622.1 563 625 forward 2 TM 790 211622.1 581 658 forward 2 TM 790 211622.1 581 631 forward 2 TM 791 110049.1 158 217 forward 2 SP 791 110049.1 143 214 forward 2 SP 797 405689.1 171 218 forward 3 SP 797 405689.1 5 76 forward 2 SP 797 405689.1 174 227 forward 3 SP 797 405689.1 171 230 forward 3 SP 797 405689.1 153 227 forward 3 SP 797 405689.1 144 227 forward 3 SP 797 405689.1 162 227 forward 3 SP 798 110815.1 120 197 forward 3 TM 799 1385527.4 3910 3969 forward 1 TM 799 1385527.4 3115 3174 forward 1 SP 799 1385527.4 1890 1982 forward 3 SP 799 1385527.4 3115 3171 forward 1 SP 799 1385527.4 1795 1887 forward 1 SP 799 1385527.4 3115 3189 forward 1 SP 799 1385527.4 2119 2220 forward 1 SP 799 1385527.4 3929 3985 forward 2 TM 801 1100724.1 501 569 forward 3 SP 804 344017.6 1628 1681 forward 2 TM 804 344017.6 275 319 forward 2 SP 804 344017.6 707 772 forward 2 SP 804 344017.6 506 565 forward 2 SP 805 344017.3 556 618 forward 1 TM 805 344017.3 872 928 forward 2 TM 805 344017.3 1414 1491 forward 1 TM 805 344017.3 743 787 forward 2 TM 805 344017.3 765 821 forward 3 TM 805 344017.3 743 802 forward 2 TM 805 344017.3 1417 1491 forward 1 TM 807 2770104CD1 277 297 TM 807 2770104CD1 280 301 SP 807 2770104CD1 280 300 SP 807 2770104CD1 45 60 SP 807 2770104CD1 275 295 TM 808 349204.1 595 684 forward 1 SP 811 211881.1 651 731 forward 3 TM 811 211881.1 663 719 forward 3 TM 812 334749.1 307 366 forward 1 TM 812 334749.1 307 360 forward 1 TM 812 334749.1 288 359 forward 3 TM 815 170915CD1 1 18 SP 815 170915CD1 1 16 SP 818 2454013CD1 245 265 TM 818 2454013CD1 251 266 SP 818 2454013CD1 234 254 TM 818 2454013CD1 1 27 SP 819 427967.6 529 600 forward 1 TM 819 427967.6 431 502 forward 2 TM 819 427967.6 417 476 forward 3 SP 819 427967.6 516 596 forward 3 TM 819 427967.6 428 478 forward 2 TM 820 427967.4 3838 3900 forward 1 TM 820 427967.4 2755 2820 forward 1 TM 820 427967.4 2776 2844 forward 1 SP 820 427967.4 2395 2478 forward 1 TM 821 257016.1 153 209 forward 3 TM 821 257016.1 158 214 forward 2 TM 821 257016.1 158 223 forward 2 SP 821 257016.1 158 229 forward 2 SP 826 477387.3 133 207 forward 1 TM 826 477387.3 151 210 forward 1 TM 827 477387.7 605 658 forward 2 TM 827 477387.7 1150 1221 forward 1 TM 827 477387.7 1060 1122 forward 1 TM 827 477387.7 1165 1224 forward 1 TM 827 477387.7 1144 1227 forward 1 SP 827 477387.7 1144 1200 forward 1 SP 827 477387.7 1144 1212 forward 1 SP 827 477387.7 1144 1206 forward 1 SP 827 477387.7 1144 1215 forward 1 SP 828 347796.7 2548 2631 forward 1 TM 828 347796.7 2676 2741 forward 3 TM 828 347796.7 3600 3671 forward 3 TM 828 347796.7 3618 3668 forward 3 TM 828 347796.7 2691 2762 forward 3 TM 828 347796.7 2494 2544 forward 1 TM 828 347796.7 3663 3719 forward 3 TM 828 347796.7 2679 2735 forward 3 TM 834 2649071CD1 1 23 SP 834 2649071CD1 148 163 TM 834 2649071CD1 1 16 SP 834 2649071CD1 1 18 SP 834 2649071CD1 1 20 SP 834 2649071CD1 1 23 SP 837 1850670CD1 1 23 SP 837 1850670CD1 1 18 SP 838 1132386.3 761 829 forward 2 SP 838 1132386.3 231 302 forward 3 SP 842 199788.2 2388 2432 forward 3 SP 842 199788.2 2700 2762 forward 3 TM 842 199788.2 2388 2444 forward 3 TM 843 27881.1 570 632 forward 3 TM 843 27881.1 83 130 forward 2 TM 843 27881.1 83 148 forward 2 SP 844 234543.1 393 455 forward 3 TM 844 234543.1 235 294 forward 1 SP 844 234543.1 381 455 forward 3 TM 844 234543.1 380 451 forward 2 SP 844 234543.1 390 443 forward 3 TM 844 234543.1 3205 3282 forward 1 TM 844 234543.1 3020 3091 forward 2 TM 844 234543.1 389 442 forward 2 TM 844 234543.1 380 445 forward 2 SP 844 234543.1 375 446 forward 3 TM 844 234543.1 388 447 forward 1 TM 844 234543.1 380 451 forward 2 TM 844 234543.1 381 440 forward 3 TM 844 234543.1 380 436 forward 2 TM 847 10498.24 4316 4369 forward 2 SP 847 10498.24 351 404 forward 3 TM 847 10498.24 3895 3957 forward 1 SP 847 10498.24 3895 3951 forward 1 SP 848 399161.1 449 517 forward 2 SP 850 997194.1 1493 1579 forward 2 SP 856 977532.9 2193 2240 forward 3 TM 856 977532.9 2103 2165 forward 3 TM 856 977532.9 3328 3384 forward 1 TM 856 977532.9 959 1039 forward 2 SP 856 977532.9 968 1024 forward 2 SP 856 977532.9 968 1027 forward 2 SP 856 977532.9 2683 2742 forward 1 TM 856 977532.9 2695 2742 forward 1 TM 856 977532.9 2060 2122 forward 2 TM 856 977532.9 1515 1574 forward 3 TM 856 977532.9 2060 2119 forward 2 TM 856 977532.9 968 1039 forward 2 SP 856 977532.9 959 1030 forward 2 SP 856 977532.9 2072 2137 forward 2 TM 861 1073168.6 1042 1101 forward 1 SP 862 1073168.8 2643 2732 forward 3 SP 862 1073168.8 1655 1714 forward 2 SP 862 1073168.8 5065 5127 forward 1 TM 862 1073168.8 5080 5139 forward 1 SP 862 1073168.8 4483 4575 forward 1 SP 862 1073168.8 4265 4336 forward 2 TM 862 1073168.8 4283 4339 forward 2 TM 862 1073168.8 2378 2449 forward 2 SP 862 1073168.8 5068 5121 forward 1 TM 864 119625.1 31 102 forward 1 TM 864 119625.1 1 54 forward 1 TM 864 119625.1 31 90 forward 1 TM 865 119671.1 270 320 forward 3 SP 866 3177.1 118 189 forward 1 TM 866 3177.1 1046 1114 forward 2 TM 866 3177.1 1037 1099 forward 2 TM 866 3177.1 1033 1080 forward 1 TM 866 3177.1 1051 1110 forward 1 TM 866 3177.1 1046 1117 forward 2 TM 866 3177.1 1039 1110 forward 1 TM 866 3177.1 1039 1101 forward 1 TM 866 3177.1 1055 1108 forward 2 TM 868 120831.1 732 797 forward 3 SP 868 120831.1 368 454 forward 2 TM 868 120831.1 233 286 forward 2 SP 868 120831.1 732 785 forward 3 SP 869 27619.3 101 175 forward 2 SP 869 27619.3 462 530 forward 3 SP 869 27619.3 210 281 forward 3 SP 869 27619.3 101 190 forward 2 SP 870 212872.1 462 527 forward 3 SP 870 212872.1 462 521 forward 3 SP 872 404952.1 2266 2325 forward 1 SP 872 404952.1 316 390 forward 1 SP 872 404952.1 3055 3129 forward 1 SP 872 404952.1 3036 3092 forward 3 TM 872 404952.1 3891 3968 forward 3 TM 872 404952.1 3067 3129 forward 1 SP 872 404952.1 3070 3141 forward 1 TM 872 404952.1 1547 1597 forward 2 SP 872 404952.1 3293 3373 forward 2 TM 872 404952.1 3702 3758 forward 3 TM 872 404952.1 2944 2994 forward 1 TM 872 404952.1 3891 3938 forward 3 TM 872 404952.1 3085 3129 forward 1 SP 872 404952.1 2284 2346 forward 1 TM 872 404952.1 3097 3159 forward 1 TM 872 404952.1 3076 3129 forward 1 SP 872 404952.1 3124 3180 forward 1 TM 872 404952.1 3025 3129 forward 1 SP 872 404952.1 3091 3165 forward 1 TM 872 404952.1 3073 3147 forward 1 TM 872 404952.1 3097 3153 forward 1 TM 875 227222.1 32 100 forward 2 SP 875 227222.1 177 254 forward 3 TM 877 253550.2 412 471 forward 1 SP 878 1326925.1 527 589 forward 2 TM 878 1326925.1 890 955 forward 2 TM 881 330925.1 584 652 forward 2 SP 881 330925.1 735 809 forward 3 SP 885 399474.1 3772 3816 forward 1 SP 885 399474.1 3772 3840 forward 1 SP 885 399474.1 3029 3100 forward 2 TM 885 399474.1 3035 3091 forward 2 TM 885 399474.1 641 706 forward 2 SP 885 399474.1 814 879 forward 1 TM 885 399474.1 3414 3485 forward 3 TM 885 399474.1 3772 3828 forward 1 SP 885 399474.1 3772 3834 forward 1 SP 885 399474.1 3438 3500 forward 3 SP 885 399474.1 2347 2415 forward 1 SP 885 399474.1 3043 3102 forward 1 TM 885 399474.1 2022 2072 forward 3 TM 885 399474.1 647 700 forward 2 SP 885 399474.1 2347 2409 forward 1 SP 885 399474.1 3049 3102 forward 1 TM 885 399474.1 3420 3473 forward 3 TM 885 399474.1 3423 3488 forward 3 TM 885 399474.1 3046 3123 forward 1 TM 885 399474.1 641 703 forward 2 SP 885 399474.1 2347 2421 forward 1 SP 885 399474.1 2347 2403 forward 1 SP 887 130502.1 497 565 forward 2 SP 887 130502.1 512 568 forward 2 TM 887 130502.1 506 559 forward 2 SP 887 130502.1 512 562 forward 2 TM 894 256026.8 301 360 forward 1 TM 894 256026.8 344 424 forward 2 TM 895 998930.1 42 128 forward 3 SP 895 998930.1 44 94 forward 2 TM 895 998930.1 234 293 forward 3 SP 895 998930.1 50 103 forward 2 SP 895 998930.1 50 109 forward 2 SP 895 998930.1 50 94 forward 2 SP 896 981149.2 60 137 forward 3 TM 899 225420.1 237 347 forward 3 SP 899 225420.1 3434 3505 forward 2 TM 899 225420.1 3393 3458 forward 3 TM 899 225420.1 3393 3464 forward 3 TM 899 225420.1 3714 3767 forward 3 SP 899 225420.1 876 956 forward 3 SP 899 225420.1 3383 3439 forward 2 SP 899 225420.1 3383 3448 forward 2 SP 899 225420.1 3714 3773 forward 3 SP 899 225420.1 3734 3787 forward 2 TM 899 225420.1 3532 3603 forward 1 TM 899 225420.1 3428 3487 forward 2 TM 899 225420.1 3393 3449 forward 3 TM 899 225420.1 3714 3779 forward 3 SP 900 236298.4 731 811 forward 2 TM 900 236298.4 872 934 forward 2 TM 900 236298.4 869 916 forward 2 TM 900 236298.4 1266 1316 forward 3 TM 900 236298.4 1481 1531 forward 2 TM 900 236298.4 1843 1899 forward 1 TM 900 236298.4 860 916 forward 2 TM 901 236298.2 1060 1119 forward 1 TM 901 236298.2 1147 1197 forward 1 TM 904 477054.1 591 650 forward 3 TM 905 2966.1 148 222 forward 1 SP 905 2966.1 148 201 forward 1 TM 905 2966.1 172 243 forward 1 TM 906 136212.1 29 106 forward 2 TM 906 136212.1 280 351 forward 1 SP 906 136212.1 280 357 forward 1 SP 907 977975.1 5142 5195 forward 3 TM 907 977975.1 4335 4421 forward 3 SP 907 977975.1 4344 4406 forward 3 TM 907 977975.1 4507 4566 forward 1 TM 907 977975.1 4368 4418 forward 3 TM 909 1505038CD1 1 22 SP 909 1505038CD1 1 18 SP 909 1505038CD1 1 16 SP 909 1505038CD1 1 20 SP 911 262830CD1 1 18 SP 911 262830CD1 1 22 SP 911 262830CD1 1 24 SP 913 3607580CD1 116 135 TM 913 3607580CD1 213 232 TM 913 3607580CD1 50 69 TM 913 3607580CD1 257 276 SP 913 3607580CD1 274 294 TM 913 3607580CD1 49 66 TM 913 3607580CD1 79 103 TM 913 3607580CD1 49 70 TM 913 3607580CD1 52 72 TM 913 3607580CD1 49 72 TM 914 137742.1 109 171 forward 1 TM 914 137742.1 88 159 forward 1 TM 914 137742.1 94 165 forward 1 TM 914 137742.1 115 165 forward 1 TM 914 137742.1 103 165 forward 1 TM 915 1095839.1 3222 3278 forward 3 TM 915 1095839.1 331 390 forward 1 SP 915 1095839.1 1407 1484 forward 3 TM 915 1095839.1 322 390 forward 1 SP 915 1095839.1 322 378 forward 1 SP 915 1095839.1 322 396 forward 1 SP 916 205328.1 101 163 forward 2 TM 920 331566.1 2204 2272 forward 2 TM 920 331566.1 5188 5250 forward 1 TM 920 331566.1 590 646 forward 2 TM 920 331566.1 5252 5329 forward 2 SP 920 331566.1 2240 2302 forward 2 SP 920 331566.1 1293 1346 forward 3 TM 920 331566.1 3118 3180 forward 1 SP 920 331566.1 1135 1197 forward 1 TM 920 331566.1 3094 3162 forward 1 TM 920 331566.1 5258 5308 forward 2 TM 920 331566.1 5132 5188 forward 2 TM 920 331566.1 5252 5311 forward 2 TM 920 331566.1 1791 1862 forward 3 TM 920 331566.1 5252 5317 forward 2 SP 920 331566.1 2219 2272 forward 2 TM 920 331566.1 2213 2272 forward 2 TM 920 331566.1 407 466 forward 2 SP 920 331566.1 407 451 forward 2 SP 920 331566.1 407 460 forward 2 SP 921 1384719.3 2975 3046 forward 2 TM 921 1384719.3 3241 3312 forward 1 TM 921 1384719.3 1086 1154 forward 3 SP 921 1384719.3 2613 2702 forward 3 SP 921 1384719.3 3351 3422 forward 3 TM 921 1384719.3 3214 3273 forward 1 TM 921 1384719.3 1086 1148 forward 3 SP 921 1384719.3 2999 3052 forward 2 SP 921 1384719.3 2637 2696 forward 3 TM 921 1384719.3 3336 3410 forward 3 TM 921 1384719.3 2014 2088 forward 1 TM 921 1384719.3 2999 3046 forward 2 SP 921 1384719.3 180 233 forward 3 TM 921 1384719.3 3204 3263 forward 3 TM 921 1384719.3 2978 3055 forward 2 TM 921 1384719.3 3348 3410 forward 3 TM 921 1384719.3 1086 1157 forward 3 SP 921 1384719.3 3366 3419 forward 3 TM 921 1384719.3 3360 3419 forward 3 TM 924 481118.7 2287 2343 forward 1 SP 925 481118.12 2152 2205 forward 1 SP 925 481118.12 2158 2205 forward 1 SP 925 481118.12 2588 2659 forward 2 TM 925 481118.12 2146 2196 forward 1 TM 925 481118.12 2275 2337 forward 1 TM 926 337528.4 1011 1097 forward 3 TM 926 337528.4 210 290 forward 3 TM 926 337528.4 213 266 forward 3 SP 929 332299.1 582 647 forward 3 TM 929 332299.1 686 766 forward 2 TM 929 332299.1 698 757 forward 2 TM 931 1530186CD1 313 336 TM 931 1530186CD1 317 342 TM 931 1530186CD1 158 181 TM 931 1530186CD1 222 240 TM 931 1530186CD1 261 281 TM 931 1530186CD1 193 210 SP 931 1530186CD1 193 213 SP 931 1530186CD1 193 214 SP 931 1530186CD1 318 336 TM 933 334025.5 303 371 forward 3 TM 939 1400580.1 901 951 forward 1 TM 939 1400580.1 898 960 forward 1 TM 939 1400580.1 901 957 forward 1 TM 939 1400580.1 901 969 forward 1 TM 940 481154.3 2641 2703 forward 1 SP 940 481154.3 2620 2703 forward 1 SP 941 346716.17 270 365 forward 3 SP 942 346716.21 815 895 forward 2 SP 943 1384720.16 649 708 forward 1 TM 943 1384720.16 2320 2376 forward 1 TM 943 1384720.16 664 756 forward 1 SP 943 1384720.16 2533 2604 forward 1 SP 943 1384720.16 646 705 forward 1 TM 947 3876162CD1 1 28 SP 947 3876162CD1 1 19 SP 947 3876162CD1 1 19 SP 947 3876162CD1 463 487 SP 947 3876162CD1 470 487 TM 948 40576.1 364 447 forward 1 TM 948 40576.1 342 425 forward 3 SP 948 40576.1 342 401 forward 3 SP 948 40576.1 407 457 forward 2 SP 948 40576.1 151 210 forward 1 TM 948 40576.1 407 463 forward 2 TM 948 40576.1 407 478 forward 2 SP 948 40576.1 407 463 forward 2 SP 948 40576.1 1320 1394 forward 3 TM 948 40576.1 407 466 forward 2 SP 948 40576.1 407 472 forward 2 SP 953 42206.1 68 124 forward 2 SP 953 42206.1 47 106 forward 2 TM 954 178799.1 695 751 forward 2 TM 956 94384.1 359 418 forward 2 TM 958 2852561CD1 78 98 SP 958 2852561CD1 77 99 SP 958 2852561CD1 84 104 TM 958 2852561CD1 79 106 SP 958 2852561CD1 75 99 SP 958 2852561CD1 84 105 TM 959 337058.1 1685 1735 forward 2 TM 960 988704.25 2022 2081 forward 3 TM 960 988704.25 998 1051 forward 2 TM 960 988704.25 1196 1252 forward 2 TM 960 988704.25 1802 1864 forward 2 SP 960 988704.25 1196 1261 forward 2 TM 960 988704.25 1181 1234 forward 2 SP 960 988704.25 2805 2861 forward 3 TM 960 988704.25 1793 1858 forward 2 TM 960 988704.25 1004 1069 forward 2 TM 960 988704.25 2032 2103 forward 1 TM 960 988704.25 1995 2063 forward 3 SP 960 988704.25 1784 1858 forward 2 TM 960 988704.25 1796 1849 forward 2 TM 960 988704.25 1793 1849 forward 2 TM 961 988704.26 1233 1289 forward 3 TM 962 401906.2 42 131 forward 3 SP 965 5371205CD1 349 363 SP 966 147026.1 219 269 forward 3 TM 966 147026.1 234 305 forward 3 TM 966 147026.1 88 147 forward 1 SP 966 147026.1 88 156 forward 1 SP 966 147026.1 249 308 forward 3 TM 966 147026.1 109 162 forward 1 SP 967 410776.1 582 638 forward 3 SP 968 335121.1 34 105 forward 1 TM 970 147403.1 949 1005 forward 1 TM 970 147403.1 624 689 forward 3 SP 970 147403.1 624 698 forward 3 SP 970 147403.1 443 490 forward 2 TM 972 1041063.5 408 461 forward 3 TM 972 1041063.5 372 458 forward 3 TM 973 230912.1 240 305 forward 3 SP 973 230912.1 237 308 forward 3 SP 973 230912.1 243 305 forward 3 SP 973 230912.1 243 299 forward 3 SP 973 230912.1 213 305 forward 3 SP 974 1089708.18 4654 4728 forward 1 TM 974 1089708.18 3604 3657 forward 1 TM 974 1089708.18 3601 3669 forward 1 TM 974 1089708.18 3598 3657 forward 1 TM 974 1089708.18 5653 5739 forward 1 SP 974 1089708.18 4708 4764 forward 1 TM 977 088957CD1 1 16 SP 977 088957CD1 1 20 SP 977 088957CD1 1 18 SP 978 220943.21 3318 3389 forward 3 TM 978 220943.21 3314 3373 forward 2 TM 978 220943.21 3299 3358 forward 2 SP 978 220943.21 3299 3355 forward 2 SP 978 220943.21 2316 2390 forward 3 TM 978 220943.21 3299 3364 forward 2 SP 978 220943.21 2343 2396 forward 3 TM 978 220943.21 3319 3375 forward 1 TM 978 220943.21 2340 2396 forward 3 TM 978 220943.21 3313 3384 forward 1 TM 978 220943.21 2313 2396 forward 3 TM 978 220943.21 2310 2378 forward 3 TM 980 980446.1 380 454 forward 2 TM 980 980446.1 61 120 forward 1 TM 980 980446.1 374 436 forward 2 SP 980 980446.1 374 424 forward 2 SP 980 980446.1 49 135 forward 1 TM 980 980446.1 374 427 forward 2 SP 980 980446.1 287 346 forward 2 TM 980 980446.1 371 427 forward 2 TM 980 980446.1 371 424 forward 2 TM 980 980446.1 374 436 forward 2 SP 980 980446.1 272 343 forward 2 TM 981 198827.1 243 314 forward 3 SP 981 198827.1 243 302 forward 3 SP 981 198827.1 243 287 forward 3 SP 981 198827.1 243 311 forward 3 SP 981 198827.1 243 299 forward 3 SP 982 215112.1 434 490 forward 2 TM 983 977929.1 2216 2287 forward 2 TM 983 977929.1 1284 1346 forward 3 SP 983 977929.1 2405 2452 forward 2 TM 983 977929.1 1284 1355 forward 3 SP 983 977929.1 1284 1337 forward 3 SP 983 977929.1 1284 1349 forward 3 SP 983 977929.1 2399 2455 forward 2 TM 983 977929.1 1284 1379 forward 3 SP 983 977929.1 2390 2461 forward 2 TM 984 281447.2 260 316 forward 2 TM 985 346641.3 1501 1575 forward 1 SP 985 346641.3 1553 1615 forward 2 TM 985 346641.3 1507 1587 forward 1 TM 985 346641.3 1501 1560 forward 1 SP 985 346641.3 1501 1590 forward 1 SP 985 346641.3 1546 1608 forward 1 TM 985 346641.3 1537 1590 forward 1 TM 985 346641.3 1537 1605 forward 1 TM 985 346641.3 1528 1584 forward 1 TM 986 230793.3 1921 1977 forward 1 TM 986 230793.3 231 305 forward 3 SP 986 230793.3 1897 1965 forward 1 TM 986 230793.3 1955 2011 forward 2 TM 986 230793.3 1900 1980 forward 1 TM 986 230793.3 231 299 forward 3 SP 986 230793.3 883 945 forward 1 TM 986 230793.3 1909 1980 forward 1 TM 986 230793.3 1414 1470 forward 1 TM 986 230793.3 1912 1974 forward 1 TM 989 4215034CD1 127 146 TM 989 4215034CD1 122 137 TM 989 4215034CD1 122 146 SP 995 8835.1 277 360 forward 1 SP 996 242010.6 1613 1666 forward 2 TM 996 242010.6 1427 1480 forward 2 SP 998 335145.1 1824 1892 forward 3 TM 998 335145.1 1818 1877 forward 3 TM 998 335145.1 1857 1937 forward 3 TM 998 335145.1 1824 1886 forward 3 TM 998 335145.1 1845 1895 forward 3 TM 1002 411373.7 2216 2275 forward 2 TM 1002 411373.7 281 343 forward 2 SP 1002 411373.7 1206 1268 forward 3 SP 1002 411373.7 2207 2275 forward 2 TM 1002 411373.7 281 334 forward 2 SP 1003 404715.1 775 840 forward 1 SP 1003 404715.1 772 846 forward 1 SP 1003 404715.1 772 852 forward 1 SP 1003 404715.1 792 851 forward 3 SP 1004 278831.1 201 272 forward 3 TM 1004 278831.1 225 281 forward 3 SP 1004 278831.1 240 305 forward 3 SP 1004 278831.1 219 281 forward 3 TM 1004 278831.1 231 284 forward 3 TM 1004 278831.1 225 302 forward 3 TM 1004 278831.1 228 287 forward 3 TM 1006 200977.1 1686 1733 forward 3 TM 1006 200977.1 239 310 forward 2 TM 1006 200977.1 2212 2262 forward 1 TM 1006 200977.1 149 202 forward 2 TM 1009 029251CD1 1 22 SP 1010 335648.1 2607 2663 forward 3 TM 1010 335648.1 2551 2619 forward 1 TM 1010 335648.1 2162 2224 forward 2 TM 1010 335648.1 2572 2655 forward 1 TM 1010 335648.1 2581 2634 forward 1 TM 1010 335648.1 2156 2218 forward 2 TM 1010 335648.1 2640 2702 forward 3 TM 1010 335648.1 2593 2652 forward 1 TM 1010 335648.1 2156 2212 forward 2 SP 1010 335648.1 1262 1330 forward 2 SP 1011 331108.1 9992 10054 forward 2 SP 1011 331108.1 101 169 forward 2 SP 1011 331108.1 13181 13234 forward 2 TM 1011 331108.1 6866 6922 forward 2 TM 1012 333840.1 1902 1991 forward 3 SP 1012 333840.1 704 760 forward 2 TM 1012 333840.1 573 644 forward 3 SP 1012 333840.1 1932 1982 forward 3 SP 1012 333840.1 704 757 forward 2 TM 1012 333840.1 573 644 forward 3 SP 1012 333840.1 1932 1985 forward 3 SP 1012 333840.1 1932 1991 forward 3 SP 1012 333840.1 1932 2000 forward 3 SP 1013 334298.1 669 734 forward 3 SP 1013 334298.1 63 149 forward 3 TM 1013 334298.1 57 116 forward 3 SP 1013 334298.1 57 122 forward 3 TM 1013 334298.1 27 89 forward 3 TM 1013 334298.1 3 65 forward 3 TM 1013 334298.1 156 215 forward 3 TM 1013 334298.1 21 95 forward 3 TM 1013 334298.1 69 128 forward 3 TM 1015 1262593.2 2388 2435 forward 3 SP 1015 1262593.2 2390 2446 forward 2 TM 1015 1262593.2 1320 1370 forward 3 TM 1015 1262593.2 2373 2435 forward 3 TM 1015 1262593.2 2388 2441 forward 3 SP 1015 1262593.2 2379 2426 forward 3 TM 1015 1262593.2 946 1008 forward 1 TM 1015 1262593.2 2373 2426 forward 3 TM 1016 461375.2 3926 4042 forward 2 SP 1016 461375.2 3971 4027 forward 2 TM 1016 461375.2 3822 3881 forward 3 SP 1016 461375.2 689 784 forward 2 SP 1016 461375.2 4209 4265 forward 3 TM 1016 461375.2 4179 4241 forward 3 TM 1016 461375.2 3956 4027 forward 2 TM 1016 461375.2 689 754 forward 2 SP 1017 233660.2 1841 1888 forward 2 TM 1017 233660.2 4505 4564 forward 2 SP 1017 233660.2 5275 5331 forward 1 TM 1017 233660.2 1985 2050 forward 2 SP 1017 233660.2 1994 2044 forward 2 SP 1017 233660.2 2621 2707 forward 2 TM 1017 233660.2 1985 2044 forward 2 SP 1017 233660.2 5230 5316 forward 1 SP 1017 233660.2 1913 1996 forward 2 TM 1017 233660.2 527 586 forward 2 SP 1017 233660.2 527 601 forward 2 SP 1017 233660.2 536 589 forward 2 TM 1017 233660.2 2912 2962 forward 2 TM 1017 233660.2 539 595 forward 2 TM 1017 233660.2 527 595 forward 2 SP 1018 230179.3 2267 2359 forward 2 SP 1018 230179.3 1423 1491 forward 1 SP 1018 230179.3 1179 1268 forward 3 SP 1018 230179.3 1194 1268 forward 3 SP 1018 230179.3 1423 1485 forward 1 SP 1018 230179.3 1925 1987 forward 2 SP 1019 230179.7 402 494 forward 3 SP 1019 230179.7 162 230 forward 3 SP 1019 230179.7 162 224 forward 3 SP 1021 981208.1 669 716 forward 3 SP 1021 981208.1 2276 2332 forward 2 TM 1021 981208.1 1456 1518 forward 1 TM 1021 981208.1 2159 2218 forward 2 TM 1022 406580.1 2597 2647 forward 2 SP 1023 200051.1 1907 1966 forward 2 SP 1023 200051.1 1907 1960 forward 2 SP 1023 200051.1 578 631 forward 2 SP 1023 200051.1 1796 1873 forward 2 TM 1023 200051.1 1796 1855 forward 2 TM 1024 1197030.1 1222 1305 forward 1 SP 1024 1197030.1 594 644 forward 3 TM 1024 1197030.1 603 665 forward 3 TM 1024 1197030.1 585 641 forward 3 TM 1025 1197030.1 1013 1069 forward 2 SP 1025 1197030.1 658 741 forward 1 SP 1025 1197030.1 998 1066 forward 2 SP 1030 339638.1 55 129 forward 1 SP 1030 339638.1 273 323 forward 3 TM 1030 339638.1 105 176 forward 3 SP 1032 342074.1 147 215 forward 3 TM 1032 342074.1 165 224 forward 3 TM 1032 342074.1 60 128 forward 3 SP 1033 406992.1 163 219 forward 1 TM 1033 406992.1 529 591 forward 1 TM 1033 406992.1 709 768 forward 1 TM 1033 406992.1 538 594 forward 1 TM 1033 406992.1 310 366 forward 1 TM 1033 406992.1 443 505 forward 2 SP 1033 406992.1 436 528 forward 1 SP 1033 406992.1 443 511 forward 2 SP 1033 406992.1 616 693 forward 1 SP 1033 406992.1 166 237 forward 1 TM 1035 1852849CD1 1 19 SP 1035 1852849CD1 1 17 SP 1038 1399492.1 1280 1354 forward 2 SP 1039 13039.2 3822 3890 forward 3 TM 1039 13039.2 610 672 forward 1 TM 1039 13039.2 4688 4759 forward 2 TM 1039 13039.2 4362 4418 forward 3 TM 1039 13039.2 3828 3890 forward 3 TM 1039 13039.2 5778 5837 forward 3 TM 1039 13039.2 5216 5278 forward 2 SP 1039 13039.2 3917 3976 forward 2 TM 1039 13039.2 5772 5834 forward 3 TM 1039 13039.2 4084 4158 forward 1 SP 1039 13039.2 3828 3878 forward 3 TM 1039 13039.2 4084 4149 forward 1 SP 1039 13039.2 3834 3902 forward 3 TM 1039 13039.2 5216 5269 forward 2 SP 1039 13039.2 3837 3911 forward 3 TM 1039 13039.2 3837 3893 forward 3 TM 1039 13039.2 5766 5819 forward 3 TM 1040 399626.1 539 613 forward 2 TM 1040 399626.1 340 393 forward 1 TM 1040 399626.1 521 577 forward 2 TM 1041 365070.3 1252 1323 forward 1 SP 1041 365070.3 70 135 forward 1 SP 1041 365070.3 82 135 forward 1 SP 1041 365070.3 1267 1323 forward 1 SP 1041 365070.3 43 135 forward 1 SP 1044 1383263.14 624 683 forward 3 SP 1044 1383263.14 107 172 forward 2 SP 1044 1383263.14 1698 1757 forward 3 TM 1044 1383263.14 107 160 forward 2 TM 1044 1383263.14 83 163 forward 2 SP 1044 1383263.14 1353 1424 forward 3 SP 1044 1383263.14 107 178 forward 2 SP 1044 1383263.14 1696 1755 forward 1 TM 1044 1383263.14 113 172 forward 2 TM 1044 1383263.14 107 163 forward 2 SP 1045 406707.2 423 491 forward 3 SP 1045 406707.2 375 434 forward 3 TM 1046 406707.1 277 345 forward 1 SP 1046 406707.1 230 289 forward 2 SP 1046 406707.1 230 292 forward 2 SP 1046 406707.1 229 288 forward 1 TM 1050 335568.1 959 1039 forward 2 TM 1050 335568.1 209 268 forward 2 SP 1050 335568.1 1937 1999 forward 2 SP 1050 335568.1 209 262 forward 2 SP 1050 335568.1 977 1030 forward 2 TM 1050 335568.1 956 1030 forward 2 TM 1050 335568.1 977 1033 forward 2 TM 1050 335568.1 956 1027 forward 2 TM 1050 335568.1 974 1036 forward 2 TM 1052 272273.1 851 910 forward 2 TM 1053 399133.9 2698 2766 forward 1 SP 1053 399133.9 2698 2757 forward 1 SP 1053 399133.9 3717 3779 forward 3 TM 1053 399133.9 714 803 forward 3 SP 1054 246727.11 209 262 forward 2 TM 1055 246727.17 2454 2537 forward 3 SP 1056 230367.2 533 598 forward 2 SP 1056 230367.2 155 217 forward 2 TM 1056 230367.2 533 592 forward 2 SP 1056 230367.2 2070 2126 forward 3 TM 1056 230367.2 1341 1412 forward 3 SP 1057 1383039.18 335 394 forward 2 SP 1059 27704.2 6 77 forward 3 TM 1060 346900.1 122 196 forward 2 TM 1060 346900.1 158 211 forward 2 SP 1060 346900.1 6 62 forward 3 TM 1060 346900.1 146 196 forward 2 TM 1060 346900.1 140 196 forward 2 TM 1062 411357.1 611 676 forward 2 SP 1062 411357.1 115 177 forward 1 SP 1064 210133.1 1788 1847 forward 3 SP 1068 206344.1 694 744 forward 1 TM 1072 1092387.12 810 881 forward 3 SP 1072 1092387.12 763 825 forward 1 SP 1073 1092387.11 770 829 forward 2 SP 1073 1092387.11 788 841 forward 2 TM 1073 1092387.11 931 993 forward 1 TM 1074 366463.1 169 231 forward 1 TM 1079 1089210.1 954 1022 forward 3 SP 1079 1089210.1 915 977 forward 3 TM 1080 444619.9 265 339 forward 1 SP 1081 312986.1 272 346 forward 2 TM 1082 462057.1 3021 3074 forward 3 TM 1082 462057.1 3018 3098 forward 3 TM 1082 462057.1 2634 2687 forward 3 TM 1082 462057.1 4415 4471 forward 2 TM 1082 462057.1 4460 4534 forward 2 TM 1082 462057.1 3000 3068 forward 3 SP 1082 462057.1 2994 3056 forward 3 TM 1082 462057.1 2304 2366 forward 3 SP 1082 462057.1 1890 1943 forward 3 SP 1082 462057.1 3045 3104 forward 3 TM 1082 462057.1 3051 3119 forward 3 TM 1082 462057.1 2991 3062 forward 3 TM 1083 197902.12 3358 3411 forward 1 TM 1083 197902.12 2306 2371 forward 2 TM 1083 197902.12 2663 2737 forward 2 TM 1083 197902.12 2 79 forward 2 SP 1083 197902.12 2315 2371 forward 2 TM 1083 197902.12 2 64 forward 2 SP 1083 197902.12 1515 1589 forward 3 SP 1083 197902.12 2675 2734 forward 2 TM 1083 197902.12 2 55 forward 2 SP 1083 197902.12 2 55 forward 2 SP 1083 197902.12 2 70 forward 2 SP 1083 197902.12 2 73 forward 2 SP 1084 997394.4 2190 2273 forward 3 SP 1087 8198.1 200 271 forward 2 TM 1087 8198.1 1530 1592 forward 3 SP 1087 8198.1 1515 1589 forward 3 SP 1089 994430.16 19 84 forward 1 SP 1089 994430.16 40 84 forward 1 SP 1089 994430.16 37 90 forward 1 SP 1089 994430.16 10 66 forward 1 TM 1089 994430.16 1 90 forward 1 SP 1089 994430.16 25 84 forward 1 SP 1091 221042.1 930 1016 forward 3 SP 1092 408398.1 143 196 forward 2 SP 1093 985369.1 1016 1078 forward 2 TM 1093 985369.1 1046 1105 forward 2 TM 1095 58804.1 543 593 forward 3 TM 1098 197159.1 1041 1091 forward 3 TM 1098 197159.1 83 139 forward 2 TM 1098 197159.1 2946 3020 forward 3 SP 1098 197159.1 3156 3218 forward 3 TM 1098 197159.1 2958 3017 forward 3 SP 1099 369928.1 757 819 forward 1 TM 1100 413466.6 398 451 forward 2 TM 1100 413466.6 1811 1885 forward 2 TM 1100 413466.6 1808 1861 forward 2 TM 1100 413466.6 1306 1395 forward 1 SP 1100 413466.6 335 409 forward 2 SP 1100 413466.6 335 421 forward 2 SP 1100 413466.6 1318 1389 forward 1 SP 1101 397295.1 46 102 forward 1 TM 1102 1330139.5 953 1036 forward 2 SP 1103 977951.1 481 549 forward 1 TM 1104 347316.1 1351 1419 forward 1 SP 1104 347316.1 4855 4908 forward 1 TM 1104 347316.1 3980 4036 forward 2 SP 1104 347316.1 3991 4062 forward 1 SP 1104 347316.1 900 953 forward 3 SP 1104 347316.1 1231 1296 forward 1 SP 1104 347316.1 4684 4743 forward 1 TM 1104 347316.1 3970 4032 forward 1 TM 1104 347316.1 2611 2688 forward 1 TM 1104 347316.1 1351 1404 forward 1 SP 1104 347316.1 3718 3789 forward 1 TM 1104 347316.1 4966 5019 forward 1 TM 1104 347316.1 1351 1422 forward 1 SP 1104 347316.1 4342 4404 forward 1 TM 1104 347316.1 4336 4407 forward 1 TM 1104 347316.1 4792 4848 forward 1 TM 1104 347316.1 4669 4737 forward 1 TM 1104 347316.1 2905 2958 forward 1 SP 1104 347316.1 4009 4077 forward 1 SP 1104 347316.1 2260 2322 forward 1 TM 1104 347316.1 4585 4644 forward 1 TM 1104 347316.1 1363 1425 forward 1 TM 1104 347316.1 2386 2442 forward 1 TM 1104 347316.1 2647 2700 forward 1 TM 1104 347316.1 2905 2970 forward 1 SP 1104 347316.1 513 590 forward 3 TM 1104 347316.1 4009 4071 forward 1 SP 1104 347316.1 4930 5001 forward 1 TM 1104 347316.1 2905 2967 forward 1 SP 1104 347316.1 4960 5037 forward 1 TM 1104 347316.1 895 963 forward 1 SP 1104 347316.1 4948 5028 forward 1 SP 1104 347316.1 2632 2694 forward 1 TM 1104 347316.1 900 962 forward 3 SP 1104 347316.1 2899 2964 forward 1 TM 1104 347316.1 3997 4050 forward 1 TM 1104 347316.1 4339 4392 forward 1 TM 1104 347316.1 4951 5013 forward 1 SP 1104 347316.1 2611 2679 forward 1 TM 1104 347316.1 2878 2949 forward 1 TM 1104 347316.1 1351 1398 forward 1 TM 1104 347316.1 2896 2970 forward 1 SP 1104 347316.1 4975 5043 forward 1 TM 1104 347316.1 4009 4062 forward 1 SP 1104 347316.1 4753 4815 forward 1 TM 1104 347316.1 2896 2985 forward 1 SP 1104 347316.1 1366 1431 forward 1 TM 1104 347316.1 1351 1410 forward 1 TM 1104 347316.1 1354 1437 forward 1 TM 1104 347316.1 4948 5013 forward 1 SP 1104 347316.1 4015 4074 forward 1 TM 1104 347316.1 786 839 forward 3 TM 1104 347316.1 4753 4821 forward 1 TM 1104 347316.1 2878 2940 forward 1 TM 1104 347316.1 4348 4407 forward 1 TM 1104 347316.1 4762 4818 forward 1 TM 1104 347316.1 2878 2931 forward 1 TM 1104 347316.1 4948 5022 forward 1 SP 1104 347316.1 897 953 forward 3 TM 1104 347316.1 2890 2952 forward 1 TM 1104 347316.1 4975 5034 forward 1 TM 1104 347316.1 2656 2712 forward 1 TM 1104 347316.1 4333 4404 forward 1 TM 1104 347316.1 1348 1419 forward 1 TM 1105 150288.3 836 901 forward 2 SP 1105 150288.3 337 384 forward 1 SP 1105 150288.3 331 387 forward 1 TM 1105 150288.3 325 378 forward 1 TM 1105 150288.3 319 378 forward 1 TM 1107 372647.1 63 134 forward 3 TM 1107 372647.1 81 143 forward 3 SP 1107 372647.1 66 113 forward 3 TM 1107 372647.1 66 128 forward 3 TM 1108 137710.1 648 710 forward 3 TM 1108 137710.1 654 710 forward 3 TM 1109 407644.1 658 717 forward 1 TM 1109 407644.1 910 984 forward 1 SP 1109 407644.1 631 702 forward 1 SP 1109 407644.1 909 968 forward 3 SP 1109 407644.1 3262 3330 forward 1 SP 1109 407644.1 884 958 forward 2 SP 1109 407644.1 3262 3342 forward 1 SP 1109 407644.1 3235 3312 forward 1 TM 1109 407644.1 3262 3351 forward 1 SP 1110 373516.1 364 435 forward 1 SP 1111 241762.23 1634 1717 forward 2 SP 1112 1040914.1 434 496 forward 2 TM 1112 1040914.1 452 511 forward 2 SP 1113 358492.1 125 205 forward 2 SP 1117 168955.1 615 698 forward 3 TM 1120 403994.5 417 485 forward 3 TM 1120 403994.5 396 464 forward 3 TM 1121 336726.1 666 737 forward 3 TM 1122 337250.1 1179 1241 forward 3 TM 1123 410781.1 1182 1235 forward 3 TM 1126 209279.1 4636 4707 forward 1 SP 1126 209279.1 2203 2274 forward 1 TM 1126 209279.1 2423 2476 forward 2 SP 1126 209279.1 3185 3238 forward 2 SP 1126 209279.1 3185 3253 forward 2 SP 1126 209279.1 2423 2491 forward 2 SP 1126 209279.1 2212 2259 forward 1 TM 1126 209279.1 2804 2878 forward 2 SP 1126 209279.1 2813 2857 forward 2 SP 1126 209279.1 3194 3238 forward 2 SP 1126 209279.1 2432 2476 forward 2 SP 1126 209279.1 2804 2857 forward 2 SP 1126 209279.1 2423 2482 forward 2 SP 1126 209279.1 3185 3244 forward 2 SP 1126 209279.1 2804 2863 forward 2 SP 1126 209279.1 2212 2271 forward 1 TM 1126 209279.1 3185 3253 forward 2 SP 1126 209279.1 2423 2491 forward 2 SP 1126 209279.1 2804 2872 forward 2 SP 1128 480630.21 269 325 forward 2 TM 1133 140122.22 1009 1065 forward 1 TM 1133 140122.22 1802 1852 forward 2 TM 1133 140122.22 2868 2921 forward 3 TM 1133 140122.22 3511 3564 forward 1 TM 1133 140122.22 1766 1822 forward 2 TM 1133 140122.22 2865 2921 forward 3 TM 1133 140122.22 553 633 forward 1 TM 1133 140122.22 3487 3543 forward 1 TM 1134 131931.1 253 303 forward 1 TM 1139 887619.26 728 784 forward 2 TM 1140 980953.1 348 410 forward 3 TM 1140 980953.1 216 275 forward 3 TM 1140 980953.1 337 411 forward 1 TM 1140 980953.1 313 369 forward 1 TM 1140 980953.1 336 401 forward 3 TM 1140 980953.1 306 386 forward 3 TM 1140 980953.1 339 410 forward 3 TM 1140 980953.1 348 401 forward 3 TM 1140 980953.1 339 398 forward 3 TM

TABLE 5 SEQ ID NO Template ID Tissue Distribution   1 230040.1 Embryonic Structures - 41%, Liver - 20%, Nervous System - 11%   2 175138.1 Hemic and Immune System - 60%, Digestive System - 40%   4 1863336CD1   5 343861.16 widely distributed   7 3170236CD1   8 259805.54 Embryonic Structures - 11%, Endocrine System - 10%  10 1460258CD1  11 1016903.1 Musculoskeletal System - 28%, Cardiovascular System - 14%, Respiratory System - 11%  12 65385.7 Sense Organs- 14%, Urinary Tract- 11%  13 3714.1 Male Genitalia - 67%, Nervous System - 33%  15 1720920CD1  16 256009.48 Embryonic Structures - 20%, Liver - 13%, Female Genitalia - 12%  17 1055233.1 Hemic and Immune System - 100%  19 2114865CD1  20 1383740.1 Liver - 50%, Germ Cells - 36%, Hemic and Immune System - 12%  22 2700132CD1  23 231621.1 Unclassified/Mixed - 29%, Urinary Tract - 25%, Exocrine Glands -  24 216485.1 Connective Tissue - 30%, Exocrine Glands - 17%, Urinary Tract - 17%, Hemic and Immune System - 17%  25 406004.2 Urinary Tract- 100%  26 1399930.1 Respiratory System - 18%, Pancreas - 16%, Endocrine System - 16%  27 414171.33 Skin - 19%, Liver- 18%, Nervous System - 12%  28 230895.1 Nervous System - 41%, Respiratory System - 29%, Female Genitalia - 29%  29 22827.1 Urinary Tract - 27%, Musculoskeletal System - 23%, Digestive System - 15%  30 346663.6 Unclassified/Mixed - 62%, Male Genitalia - 15%, Digestive System -  31 96422.1 Male Genitalia - 100%  32 405833.1 Germ Cells - 57%, Male Genitalia - 43%  33 995839.2 Liver - 25%, Musculoskeletal System - 13%, Cardiovascular System - 11%  35 2517374CD1  37 1255456CD1  38 3084.1 Cardiovascular System - 100%  39 302123.12 Hemic and Immune System - 100%  41 533825CD1  42 220845.2 Hemic and Immune System - 100%  43 985475.8 Connective Tissue - 16%  44 198309.7 Liver - 69%, Respiratory System - 23%  45 1382869.18 widely distributed  46 1382869.1 widely distributed  47 352049.1 Liver - 69%, Male Genitalia - 15%  48 215990.2 Embryonic Structures - 10%  49 428335.59 Pancreas - 14%  51 1561192CD1  52 1330151.46 Musculoskeletal System - 12%, Stomatognathic System - 12%  53 1330151.49 Musculoskeletal System - 14%, Stomatognathic System - 12%  54 404028.1 Pancreas - 35%, Exocrine Glands - 15%, Unclassified/Mixed - 15%  55 996427.2 Hemic and Immune System - 18%, Exocrine Glands - 12%  56 21971.1 Urinary Tract - 88%, Respiratory System - 12%  57 215205.1 Endocrine System - 36%, Urinary Tract - 36%, Respiratory System - 27%  58 400650.3 Exocrine Glands - 24%, Unclassified/Mixed - 24%, Connective Tissue - 21%  59 344524.1 Liver - 16%, Exocrine Glands - 11%, Unclassified/Mixed - 11%  60 196709.1 Germ Cells - 28%, Unclassified/Mixed - 22%, Embryonic Structures - 10%  61 37502.4 Sense Organs - 43%, Nervous System - 14%, Connective Tissue -  62 235687.5 Germ Cells - 45%, Skin - 24%, Unclassified/Mixed - 14%  64 085596CD1  65 234811.3 Liver - 24%, Germ Cells - 11%  67 3393396CD1  68 978439.4 Unclassified/Mixed - 13%  69 11390.1 Hemic and Immune System - 100%  70 1382924.42 Pancreas - 21%, Exocrine Glands - 19%, Cardiovascular System -  72 1256895CD1  73 11115.1 Hemic and Immune System - 100%  74 291267.1 Hemic and Immune System - 43%, Skin - 21%  76 3125723CD1  77 980593.1 Embryonic Structures - 13%, Sense Organs - 12%  78 980593.6 Sense Organs - 15%, Unclassified/Mixed - 12%, Embryonic Structures - 10%  79 410739.1 Nervous System - 100%  80 405773.2 Respiratory System - 28%, Liver - 19%, Urinary Tract - 19%  81 210871.1 Digestive System - 67%, Hemic and Immune System - 33%  82 20265.2 Respiratory System - 100%  83 39840.1 Connective Tissue - 55%, Embryonic Structures - 12%, Unclassified/Mixed - 11%  85 088564CD1  86 28889.1 Hemic and Immune System - 47%, Digestive System - 27%, Endocrine System - 27%  87 410611.1 Hemic and Immune System - 100%  88 212533.1 Sense Organs - 58%, Hemic and Immune System - 13%  89 24081.12 Urinary Tract - 23%, Digestive System - 13%  90 983961.1 Skin - 30%, Nervous System - 17%, Exocrine Glands - 17%  91 1383290.2 widely distributed  92 337221.11 Germ Cells - 16%, Pancreas - 11%  93 290344.1 Nervous System - 36%, Embryonic Structures - 23%, Musculoskeletal System - 15%  94 290344.3 Embryonic Structures - 35%, Connective Tissue - 27%, Nervous System - 23%  95 222714.1 Embryonic Structures - 64%, Endocrine System - 29%  96 2230.1 Liver - 47%, Cardiovascular System - 21%, Endocrine System - 21%  97 34424.1 Cardiovascular System - 62%, Endocrine System - 31%  98 153237.1 Endocrine System - 57%, Male Genitalia - 29%, Nervous System -  99 272843.14 Pancreas - 11%  100 234729.3 Embryonic Structures- 14%, Connective Tissue - 10%  101 349647.1 Urinary Tract - 31%, Unclassified/Mixed - 18%, Respiratory System - 11%  102 236457.1 Nervous System - 33%, Endocrine System - 22%, Urinary Tract - 22%, Digestive System - 22%  103 230193.1 Liver - 19%, Nervous System - 15%, Musculoskeletal System - 14%  104 213429.1 Exocrine Glands - 67%, Female Genitalia - 33%  105 5124.22 Exocrine Glands - 43%, Urinary Tract - 4%, Digestive System - 14%  106 88974.2 Respiratory System - 33%, Hemic and Immune System - 33%, Female Genitalia - 22%  107 903909.1 Nervous System - 67%  108 196981.1 Nervous System - 80%, Digestive System - 20%  109 337888.3 Nervous System - 43%, Germ Cells - 32%, Endocrine System - 16%  110 795.1 Nervous System - 100%  112 3070147CD1  113 20525.1 Female Genitalia - 100%  114 1382924.38 widely distributed  116 4349106CD1  117 247185.1 Musculoskeletal System - 40%, Respiratory System - 33%, Male Genitalia - 13%  118 197587.3 Sense Organs - 53%, Nervous System - 12%, Cardiovascular System - 11%  119 403872.1 Nervous System - 30%, Embryonic Structures - 18%, Unclassified/Mixed - 16%  120 900993.1 Urinary Tract - 29%, Female Genitalia - 38%, Male Genitalia - 11%, Exocrine Glands - 11%, Endocrine System - 11%, Hemic and Immune System - 11%  121 228511.1 Unclassified/Mixed - 18%, Germ Cells - 13%, Male Genitalia - 12%  122 406975.2 Urinary Tract - 24%, Respiratory System - 14%, Skin - 11%  123 200171.17 Musculoskeletal System - 29%, Respiratory System - 24%, Endocrine System - 19%  124 291155.1 Urinary Tract - 67%, Nervous System - 33%  125 1383047.1 Unclassified/Mixed - 35%, Sense Organs - 22%  127 3230770CD1  128 481453.1 Male Genitalia - 67%, Nervous System - 33%  129 216141.1 Male Genitalia - 80%, Nervous System - 20%  130 158318.1 Cardiovascular System - 40%, Respiratory System - 30%, Male Genitalia - 20%  131 408751.3 Nervous System - 43%, Sense Organs - 31%  132 998310.1 Nervous System - 100%  133 1097471.1 Unclassified/Mixed - 34%, Nervous System - 13%  134 983843.2 Musculoskeletal System - 55%, Respiratory System - 45%  135 983843.1 Female Genitalia - 44%, Cardiovascular System - 30%, Respiratory System - 19%  136 985607.8 Respiratory System - 12%  137 152298.2 Digestive System - 50%, Respiratory System - 38%, Hemic and Immune System - 13%  138 246336.2 Germ Cells - 24%, Female Genitalia - 17%, Hemic and Immune System - 11%  139 246336.18 Sense Organs - 20%, Unclassified/Mixed - 14%, Stomatognathic System - 12%  140 405126.1 Digestive System - 100%  141 253855.2 Liver - 20%, Embryonic Structures - 10%  142 337187.1 Nervous System - 16%, Skin - 14%, Germ Cells - 13%  144 932244CD1  145 160952.1 Pancreas - 53%, Exocrine Glands - 47%  146 13343.1 Endocrine System - 33%, Urinary Tract - 33%, Nervous System - 17%, Digestive System - 17%  147 399488.4 Urinary Tract - 49%, Liver - 36%  148 399488.5 Urinary Tract - 77%, Liver - 16%  149 28048.1 Exocrine Glands - 100%  150 237622.11 Cardiovascular System - 25%, Exocrine Glands - 25%, Respiratory System - 19%  151 237622.6 widely distributed  152 26612.1 Exocrine Glands - 67%, Endocrine System - 33%  153 413806.9 Unclassified/Mixed - 16%  154 162569.1 Embryonic Structures - 83%, Urinary Tract - 17%  155 334116.1 Germ Cells - 14%, Unclassified/Mixed - 14%, Skin - 11%  156 396837.1 Urinary Tract - 35%, Skin 22%, Embryonic Structures - 14%  157 406507.1 Sense Organs - 68%, Endocrine System - 12%, Exocrine Glands -  158 407612.1 Unclassified/Mixed - 21%, Musculoskeletal System - 13%, Germ Cells - 11%  159 399501.1 Embryonic Structures - 39%, Exocrine Glands - 35%, Endocrine System - 17%  161 1004517CD1  162 199601.12 Hemic and Immune System - 67%  163 232946.1 Skin - 17%  165 988491CD1  166 199882.12 Respiratory System - 75%, Nervous System - 25%  168 1674368CD1  169 115268.8 Endocrine System - 45%, Exocrine Glands - 20%, Respiratory System - 13%, Nervous System - 13%  170 464689.54 Male Genitalia - 18%, Nervous System - 13%  171 222181.1 Unclassified/Mixed - 27%, Nervous System - 21%, Exocrine Glands - 13%  173 2951538CD1  174 1087445.1 Unclassified/Mixed - 18%, Nervous System - 13%, Respiratory System - 10%  175 1079625.3 Germ Cells - 22%, Unclassified/Mixed - 21%, Endocrine System -  177 1275616CD1  178 228046.5 Stomatognathic System - 14%  179 1225513.1 Musculoskeletal System - 21%, Liver - 19%  180 203438.2 Embryonic Structures - 100%  181 232849.13 Connective Tissue - 34%, Embryonic Structures - 13%, Liver - 13%  182 19598.1 Embryonic Structures - 75%, Hemic and Immune System - 25%  183 411148.3 Embryonic Structures - 12%  184 444619.13 Liver - 42%, Endocrine System - 11%  185 1383714.1 Female Genitalia - 50%, Digestive System - 50%  187 1273641CD1  188 403717.1 Unclassified/Mixed - 37%, Embryonic Structures - 20%, Cardiovascular System - 17%  189 332165.8 Unclassified/Mixed - 24%, Germ Cells - 12%, Connective Tissue -  190 1098877.1 Stomatognathic System - 10%  191 251867.2 Embryonic Structures - 51%, Musculoskeletal System - 16%, Endocrine System - 11%, Urinary Tract - 11%  192 5597.1 Stomatognathic System - 96%  193 235356.1 Stomatognathic System - 66%, Liver - 17%  194 47593.1 Stomatognathic System - 100%  195 995887.12 Sense Organs- 25%, Female Genitalia - 14%, Nervous System -  196 245687.1 Sense Organs - 30%, Unclassified/Mixed - 29%, Pancreas - 15%  198 1571349CD1  199 336735.1 Musculoskeletal System - 67%, Digestive System - 22%, Hemic and Immune System - 11%  200 40322.1 Hemic and Immune System - 15%  201 205542.2 Germ Cells - 30%, Female Genitalia - 21%, Sense Organs - 15%  203 1867417CD1  204 402521.1 Nervous System - 100%  205 219537.2 Sense Organs - 96%  206 219537.1 Hemic and Immune System - 50%, Male Genitalia - 33%, Nervous System - 17%  207 1041138.7 widely distributed  208 49272.1 Nervous System - 100%  209 221433.2 Respiratory System - 21%, Endocrine System - 18%, Liver - 18%  210 232386.18 Unclassified/Mixed - 27%, Liver - 15%, Digestive System - 12%  212 2598244CD1  214 2173757CD1  216 1405844CD1  217 1143377.5 Sense Organs - 21%, Connective Tissue - 11%, Nervous System -  218 235147.1 Cardiovascular System - 13%, Connective Tissue - 12%  219 235147.2 Cardiovascular System - 18%, Connective Tissue - 15%, Unclassified/Mixed - 13%  220 1099294.6 Stomatognathic System - 15%  221 330927.1 Unclassified/Mixed - 28%, Male Genitalia - 12%, Exocrine Glands -  222 50695.1 Respiratory System - 100%  223 241234.1 Pancreas - 59%, Hemic and Immune System - 20%, Musculoskeletal System - 13%  224 282397.77 Embryonic Structures - 11%  225 984009.2 Embryonic Structures - 31%, Connective Tissue - 24%  226 138709.5 widely distributed  227 998926.1 Germ Cells - 16%, Urinary Tract - 11%, Digestive System - 10%  229 1448817CD1  230 332521.1 Embryonic Structures - 18%, Unclassified/Mixed - 16%, Musculoskeletal System - 12%  231 245136.4 Female Genitalia - 33%, Male Genitalia - 18%  232 237485.3 Unclassified/Mixed - 31%, Liver - 20%  233 350851.2 Exocrine Glands - 80%, Nervous System - 20%  234 403794.3 Urinary Tract - 44%, Respiratory System - 33%, Nervous System -  235 227489.1 Female Genitalia - 39%, Unclassified/Mixed - 35%, Cardiovascular System - 17%  236 268110.1 Male Genitalia - 100%  237 268244.1 Male Genitalia - 100%  238 268253.1 Male Genitalia - 100%  239 270049.1 Exocrine Glands - 67%, Male Genitalia - 33%  240 997142.1 Unclassified/Mixed - 27%, Musculoskeletal System - 20%, Male Genitalia - 13%, Cardiovascular System - 13%  241 997080.1 Urinary Tract - 49%, Digestive System - 29%, Liver - 13%  242 243369.1 Liver - 60%, Digestive System - 40%  243 379571.7 Unclassified/Mixed - 15%  244 322303.15 Embryonic Structures - 56%, Sense Organs - 12%, Unclassified/Mixed - 11%  245 232935.2 Nervous System - 21%, Endocrine System - 12%, Unclassified/Mixed - 12%  247 1445507CD1  248 69812.3 Urinary Tract - 15%, Respiratory System - 12%  249 444648.12 Liver - 23%, Male Genitalia - 12%  250 25194.1 Pancreas - 38%, Nervous System - 21%, Exocrine Glands - 17%, Hemic and Immune System - 17%  252 1518310CD1  253 241335.1 Connective Tissue 15%, Embryonic Structures - 12%  254 22651.1 Embryonic Structures - 56%, Unclassified/Mixed - 24%, Urinary Tract - 21%  255 25911.1 Exocrine Glands - 34%, Male Genitalia - 15%, Nervous System - 11%, Unclassified/Mixed - 11%  256 336470.1 Embryonic Structures - 39%, Unclassified/Mixed - 35%, Hemic and Immune System - 17%  257 978673.2 Musculoskeletal System - 19%, Urinary Tract - 11%  258 54242.1 Musculoskeletal System - 55%, Hemic and Immune System - 27%, Female Genitalia - 18%  260 1823159CD1  261 20602.1 Female Genitalia - 88%, Hemic and Immune System - 13%  262 1090531.28 Connective Tissue - 32%, Liver 17%, Unclassified/Mixed - 16%  263 399872.1 Embryonic Structures - 41%, Respiratory System 23%, Male Genitalia - 18%  264 229176.4 Nervous System - 46%, Exocrine Glands - 31%, Female Genitalia -  265 229176.5 widely distributed  267 124600CD1  268 994387.65 Female Genitalia - 12%  269 201462.7 Embryonic Structures - 69%, Nervous System - 15%, Digestive System- 15%  270 991497.1 Unclassified/Mixed - 16%, Sense Organs - 11%  271 347444.1 Liver - 31%, Urinary Tract-24%, Female Genitalia - 17%  272 238660.5 Digestive System - 56%, Pancreas - 24%, Respiratory System - 11%  273 404601.11 Unclassified/Mixed - 23%, Musculoskeletal System - 12%  274 1329936.3 Cardiovascular System - 12%, Pancreas - 10%  275 370489.47 Cardiovascular System - 28%, Germ Cells - 25%, Hemic and Immune System - 21%  276 197185.2 Digestive System - 100%  278 1822864CD1  280 2258794CD1  282 000506CD1  283 407263.1 Liver - 26%, Pancreas - 18%, Digestive System - 12%  285 1630551CD1  287 2558815CD1  288 347411.1 Female Genitalia - 50%, Urinary Tract - 40%, Nervous System - 10%  289 92230.2 Male Genitalia - 23%, Connective Tissue - 18%, Urinary Tract - 18%  290 333989.1 Connective Tissue - 21%, Respiratory System - 15%, Nervous System- 15%  291 333542.1 Germ Cells - 22%, Unclassified/Mixed - 22%, Embryonic Structures - 16%  293 2426210CD1  294 476760.12 Endocrine System - 25%, Male Genitalia - 25%, Respiratory System - 19%, Nervous System - 19%  296 064987CD1  297 8450.1 Exocrine Glands - 67%, Male Genitalia - 33%  298 197652.3 Germ Cells - 41%  299 248203.2 Unclassified/Mixed - 10%  301 2023351CD1  302 228610.1 Germ Cells - 36%, Exocrine Glands - 11%, Unclassified/Mixed - 11%  303 92268.1 Skin - 18%, Urinary Tract - 14%, Female Genitalia - 12%  304 16566.1 Digestive System - 80%, Nervous System - 20%  305 1329120.1 Male Genitalia - 67%, Nervous System - 33%  306 898877.6 widely distributed  307 29490.1 Digestive System - 64%, Pancreas - 36%  309 2619838CD1  310 369213.42 Urinary Tract - 25%, Digestive System - 25%, Respiratory System -  312 3557818CD1  314 001622CD1  315 223407.4 Sense Organs - 13%, Nervous System - 12%, Endocrine System -  316 899334.1 Embryonic Structures - 15%  317 237299.13 Skin - 47%, Male Genitalia - 13%, Urinary Tract - 13%  318 1149046.1 widely distributed  319 404011.3 Germ Cells - 73%, Unclassified/Mixed - 24%  321 3768043CD1  322 39946.19 Urinary Tract - 17%  324 1723834CD1  326 2551987CD1  327 232772.13 Germ Cells - 33%, Connective Tissue - 18%, Liver - 11%  328 407451.3 Hemic and Immune System - 30%, Pancreas - 22%, Unclassified/Mixed - 15%  329 1382931.2 Cardiovascular System - 10%  330 1382931.39 Stomatognathic System - 13%  331 411059.1 Male Genitalia - 64%, Digestive System - 36%  332 474862.8 Sense Organs - 41%, Female Genitalia - 13%, Digestive System -  333 402366.1 Skin - 45%, Male Genitalia - 23%, Female Genitalia - 16%  334 401532.3 Male Genitalia - 67%, Nervous System - 33%  335 401532.2 Liver - 38%, Stomatognathic System - 24%  336 407896.4 Nervous System - 55%, Endocrine System - 30%, Female Genitalia - 11%  337 982625.1 Nervous System - 100%  338 59947.1 Embryonic Structures - 75%, Nervous System - 25%  339 902471.11 Connective tissue - 32%, Liver - 14%, Urinary Tract - 13%  340 442308.1 Endocrine System - 72%, Nervous System - 28%  341 193755.1 Germ Cells - 11%  342 60957.1 Nervous System - 100%  343 5124.23 Connective Tissue - 30%, Digestive System - 17%, Unclassified/Mixed- 17%  344 344166.2 Stomatognathic System - 17%, Sense Organs - 12%, Embryonic Structures - 10%  345 1129157.1 Stomatognathic System - 11%  347 1804734CD1  348 43646.7 widely distributed  349 43646.1 Cardiovascular System - 16%, Pancreas - 5%, Skin - 12%  351 4674640CD1  352 25423.3 Male Genitalia - 57%, Nervous System - 29%, Hemic and Immune System - 14%  353 415378.3 Germ Cells - 17%, Embryonic Structures - 14%, Female Genitalia -  354 25685.3 Endocrine System - 35%, Unclassified/Mixed - 31%, Digestive System - 23%  355 400427.1 Liver - 34%, Nervous System - 15%, Digestive System - 15%  356 198008.8 Germ Cells - 22%, Unclassified/Mixed - 14%  358 1825508CD1  359 236957.9 Exocrine Glands - 20%, Hemic and Immune System - 18%, Digestive System - 12%  360 980807.1 Hemic and Immune System - 60%, Nervous System - 40%  361 1095192.1 Nervous System - 54%, Liver - 32%, Respiratory System - 11%  362 167559.1 Nervous System - 37%, Endocrine System - 22%, Unclassified/Mixed - 20%  363 1383286.12 Endocrine System - 11%, Respiratory System - 10%  364 40790.1 Sense Organs - 62%, Embryonic Structures - 23%, Respiratory System - 12%  365 53059.11 Unclassified/Mixed - 18%, Embryonic Structures - 13%, Germ Cells - 11%  366 337156.2 Sense Organs - 30%, Male Genitalia - 19%  367 349630.7 Urinary Tract - 38%, Pancreas - 20%, Germ Cells - 15%  369 212508CD1  370 1400574.1 Unclassified/Mixed - 31%, Nervous System - 15%, Cardiovascular System - 15%  371 994430.15 Pancreas - 18%, Liver - 11%, Germ Cells - 10%  373 2631218CD1  375 3688791CD1  377 3283554CD1  379 4960375CD1  380 222956.22 Female Genitalia - 15%, Exocrine Glands - 15%, Hemic and Immune System - 15%  381 222956.24 Embryonic Structures - 17%, Unclassified/Mixed - 10%  382 973308.1 widely distributed  383 238026.4 Germ Cells - 19%, Connective Tissue - 13%  384 1094829.52 Liver - 11%, Musculoskeletal System - 11%  385 1094829.54 widely distributed  386 899802.1 Skin - 22%, Unclassified/Mixed - 13%, Embryonic Structures - 11%  387 107569.15 Nervous System - 12%  388 236605.2 Male Genitalia - 16%, Skin - 16%, Germ Cells - 15%  390 2705321CD1  391 383863.2 Stomatognathic System - 22%, Connective Tissue - 13%  392 903491.4 Female Genitalia - 15%, Germ Cells - 14%  393 332755.5 Nervous System - 34%, Skin - 12%, Endocrine System - 11%  394 201694.5 Urinary Tract - 15%, Stomatognathic System - 14%, Skin - 10%  395 65367.1 Endocrine System - 67%, Male Genitalia - 33%  396 199140.9 Stomatognathic System - 38%  397 1088542.9 Cardiovascular System - 28%, Female Genitalia - 18%, Urinary Tract - 18%  398 233513.2 Nervous System - 13%, Germ Cells - 13%, Urinary Tract - 11%  399 1330257.53 Sense Organs - 36%  401 3676741CD1  402 346636.6 Nervous System - 82%, Musculoskeletal System - 18%  404 1640555CD1  405 199286.3 Endocrine System - 33%, Male Genitalia - 33%, Respiratory System - 25%  406 199286.2 Germ Cells - 68%, Sense Organs - 12%  407 474200.1 Unclassified/Mixed - 47%, Embryonic Structures - 18%  408 206397.1 Connective Tissue - 78%, Urinary Tract - 22%  409 199584.1 Unclassified/Mixed - 14%  410 401736.1 Unclassified/Mixed - 13%, Skin - 10%  411 1100773.2 Unclassified/Mixed - 27%, Urinary Tract - 17%, Exocrine Glands -  412 167854.1 Exocrine Glands - 67%, Nervous System - 17%, Hemic and Immune System - 17%  414 1693903CD1  415 351432.23 Liver 23%, Skin - 14%, Embryonic Structures - 14%  417 1252096CD1  419 2545475CD1  421 1756951CD1  422 220134.6 Skin - 25%, Liver - 14%  423 220134.5 Male Genitalia - 15%, Urinary Tract - 12%, Liver - 12%  424 202164.1 Exocrine Glands - 16%, Respiratory System - 10%, Endocrine System - 10%  425 406846.4 Unclassified/Mixed - 12%, Embryonic Structures - 11%  427 2716815CD1  428 222278.1 Exocrine Glands - 26%, Embryonic Structures - 10%, Urinary Tract - 12%  430 1273292CD1  431 67855.1 Germ Cells - 70%, Respiratory System - 14%, Exocrine Glands - 11%  432 27185.1 Unclassified/Mixed - 63%, Exocrine Glands - 30%  433 240057.2 Germ Cells - 43%, Unclassified/Mixed - 34%, Male Genitalia - 22%  434 17090. 1 Germ Cells - 65%, Digestive System - 22%  435 17021.2 Germ Cells - 64%, Unclassified/Mixed - 27%  436 235682.5 Male Genitalia - 100%  437 399329.3 Germ Cells - 63%, Unclassified/Mixed - 14%  438 68862.1 Unclassified/Mixed - 80%, Male Genitalia - 20%  439 8603.3 Male Genitalia - 100%  440 337647.1 Respiratory System - 36%, Endocrine System - 29%, Male Genitalia - 14%, Female Genitalia - 14%  441 200268.3 Unclassified/Mixed - 20%, Urinary Tract - 13%, Digestive System -  443 168861CD1  444 334738.1 Skin - 20%, Pancreas - 19%, Unclassified/Mixed - 17%  445 410042.1 Embryonic Structures - 21%, Unclassified/Mixed - 15%, Connective Tissue - 13%  447 2026270CD1  449 522433CD1  450 234987.1 Hemic and Immune System - 80%, Nervous System - 20%  451 1330257.32 Hemic and Immune System - 100%  452 407023.1 Sense Organs - 81%  454 3117184CD1  456 3105671CD1  458 2051966CD1  460 1969731CD1  462 2171401CD1  463 1326983.14 widely distributed  464 339106.1 Respiratory System - 100%  465 331666.1 Germ Cells - 51%, Unclassified/Mixed - 13%  467 1422432CD1  468 409895.2 Digestive System - 18%, Embryonic Structures - 17%, Liver - 16%  469 245136.9 Male Genitalia - 30%, Female Genitalia - 20%  471 2600262CD1  472 70246.1 Respiratory System - 38%, Female Genitalia - 25%, Digestive System - 25%  473 1086183.1 Liver - 25%, Skin - 20%, Hemic and Immune System - 14%  474 900070.12 Embryonic Structures - 14%, Stomatognathic System - 13%  475 231182.1 Unclassified/Mixed - 43%, Pancreas - 16%  476 12417.1 Pancreas-100%  477 237754.1 Germ Cells - 33%, Urinary Tract - 17%  479 1256053CD1  480 238391.3 Respiratory System - 21%, Germ Cells - 18%, Digestive System -  481 201945.4 Urinary Tract - 27%, Unclassified/Mixed - 26%  482 235725.21 widely distributed  483 406031.5 Germ Cells - 35%, Embryonic Structures - 12%, Liver - 12%  484 998941.1 Exocrine Glands - 27%, Connective Tissue - 17%  485 243985.1 Unclassified/Mixed - 21%, Germ Cells - 16%  486 481779.1 Unclassified/Mixed - 37%, Germ Cells - 29%  487 982633.1 Endocrine System - 13%, Embryonic Structures - 13%, Liver - 13%  489 2120743CD1  490 26914.1 Endocrine System - 38%, Connective Tissue - 29%, Exocrine Glands- 17%  491 199121.14 Cardiovascular System - 17%, Connective Tissue - 13%, Respiratory System - 11%  493 1960207CD1  494 391185.13 Sense Organs - 11%  495 206866.1 Male Genitalia - 47%, Exocrine Glands - 21%  496 1330257.51 widely distributed  497 983942.1 Germ Cells - 49%, Nervous System - 45%  498 223416.15 Nervous System - 100%  499 5876.1 Cardiovascular System - 28%, Urinary Tract - 24%, Hemic and Immune System - 24%  500 303545.3 Cardiovascular System - 100%  501 331571.1 Cardiovascular System - 42%, Digestive System - 21%, Respiratory System - 16%, Nervous System - 16%  503 2246292CD1  504 411449.1 Stomatognathic System - 15%  505 409853.3 Male Genitalia - 17%, Cardiovascular System - 11%  507 6301537CD1  508 1398801.9 Unclassified/Mixed - 19%, Skin - 15%, Urinary Tract - 12%  509 1398801.5 Germ Cells - 36%, Unclassified/Mixed - 18%  510 14538.1 Pancreas- 64%, Female Genitalia - 14%, Male Genitalia - 14%  511 14007.1 Male Genitalia - 100%  512 239996.2 Hemic and Immune System - 100%  513 238403.2 Unclassified/Mixed - 16%  514 234681.2 Sense Organs - 11%, Stomatognathic System - 11%, Urinary Tract - 10%  515 228678.1 Unclassified/Mixed - 28%, Exocrine Glands - 14%, Respiratory System - 12%, Liver- 12%  516 233218.22 Liver - 65%, Cardiovascular System - 11%  517 233218.18 Liver - 48%  518 6320.1 Unclassified/Mixed - 42%, Respiratory System - 26%, Exocrine Glands -21%  519 15433.1 Male Genitalia - 58%, Respiratory System - 42%  521 1600311CD1  522 335999.1 Sense Organs - 45%, Urinary Tract - 25%, Nervous System - 11%  523 197523.6 Unclassified/Mixed - 15%, Male Genitalia - 12%, Embryonic Structures - 12%  524 12833.1 Pancreas - 87%  525 1080598.1 Embryonic Structures - 15%, Germ Cells - 14%, Unclassified/Mixed - 14%  527 2239738CD1  528 87074.1 Nervous System - 18%, Embryonic Structures - 13%, Unclassified/Mixed - 12%  529 12039.1 Female Genitalia - 83%, Nervous System - 17%  531 1730175CD1  533 6825202CD1  534 25613.1 Endocrine System - 30%, Female Genitalia - 14%, Skin - 12%  536 3027821CD1  537 480736.41 Unclassified/Mixed - 12%, Skin - 12%  538 236943.1 Cardiovascular System - 28%, Unclassified/Mixed - 28%, Female Genitalia - 24%  539 76636.1 Exocrine Glands - 57%, Female Genitalia - 29%, Nervous System -  540 76644.1 Respiratory System - 42%, Female Genitalia - 42%, Digestive System - 17%  541 76699.1 Nervous System - 50%, Female Genitalia - 50%  542 238140.1 Connective Tissue - 17%, Male Genitalia - 14%, Exocrine Glands -  543 19080.2 Unclassified/Mixed - 26%, Stomatognathic System - 14%  544 274444.1 Respiratory System - 60%, Male Genitalia - 40%  545 279625.1 Male Genitalia - 67%, Female Genitalia - 33%  546 1330220.16 widely distributed  547 99792.1 Male Genitalia - 40%, Female Genitalia - 40%, Hemic and Immune System - 20%  548 5147.1 Unclassified/Mixed - 26%, Germ Cells - 20%, Male Genitalia - 14%  549 272599.1 Hemic and Immune System - 50%, Female Genitalia - 25%, Male Genitalia - 25%  550 238396.1 Sense Organs - 21%, Unclassified/Mixed - 20%, Skin - 16%  551 23904.1 Liver - 38%, Connective Tissue - 29%, Respiratory System - 13%  552 274712.1 Embryonic Structures - 14%, Pancreas - 14%, Nervous System -  553 979567.11 Endocrine System - 14%, Nervous System - 14%  554 234121.1 Nervous System- 19%, Germ Cells- 18%  555 252493.15 widely distributed  556 899766.1 Sense Organs - 29%, Connective Tissue - 27%  557 247423.13 Stomatognathic System - 14%, Sense Organs - 12%  558 334234.2 Nervous System - 70%, Unclassified/Mixed - 13%  559 205672.1 Liver - 33%, Sense Organs - 27%, Unclassified/Mixed - 17%  560 1327024.5 Embryonic Structures - 31%, Endocrine System - 13%  562 2925789CD1  563 335613.1 Sense Organs - 55%  564 207646.1 Exocrine Glands - 67%, Male Genitalia - 33%  566 1720847CD1  568 2313349CD1  569 107939.2 Embryonic Structures - 13%, Unclassified/Mixed - 10%  570 11540.1 Nervous System - 100%  571 78831.1 Respiratory System - 60%, Female Genitalia - 40%  572 207778.1 Pancreas - 50%, Female Genitalia - 28%, Exocrine Glands - 22%  573 296811.1 Germ Cells - 23%, Skin - 12%  574 333776.1 Hemic and Immune System - 67%, Male Genitalia - 33%  576 1859458CD1  578 110960CD1  579 238602.2 widely distributed  580 363007.1 Connective Tissue - 72%, Male Genitalia - 14%, Exocrine Glands -  582 347823CD1  584 2466714CD1  585 4208.1 Endocrine System - 40%, Urinary Tract - 40%, Male Genitalia - 20%  586 903475.2 Nervous System - 25%, Skin 19%, Endocrine System - 18%  587 246037.28 Exocrine Glands - 13%, Respiratory System - 12%  588 337183.1 Liver - 18%, Cardiovascular System - 16%, Digestive System - 16%  590 2651836CD1  591 80339.1 Endocrine System - 100%  592 480968.13 Germ Cells - 15%, Embryonic Structures - 15%  593 337448.1 Unclassified/Mixed - 50%, Germ Cells - 22%, Male Genitalia - 14%  594 5360.1 Hemic and Immune System - 32%, Exocrine Glands - 21% Endocrine System - 21%  595 998599.8 Hemic and Immune System - 100%  596 332821.13 Sense Organs - 37%, Germ Cells - 18%  597 344186.9 Cardiovascular System - 100%  598 344186.12 Nervous System - 69%, Cardiovascular System - 31%  599 212489.1 Germ Cells - 27%, Urinary Tract - 19%, Liver - 19%  600 80711.1 Nervous System - 100%  601 80787.1 Nervous System - 100%  602 334352.1 Nervous System - 31%, Unclassified/Mixed - 30%, Liver - 11%  603 208376.1 Male Genitalia - 67%, Nervous System - 33%  604 7820.1 Unclassified/Mixed - 80%, Nervous System - 20%  605 81447.1 Nervous System - 100%  606 81821.1 Nervous System - 100%  607 81869.1 Nervous System - 100%  608 210011.1 Nervous System - 20%, Pancreas - 19%, Endocrine System - 19%  609 480336.3 Pancreas - 21%, Skin - 16%, Embryonic Structures - 10%, Liver - 10%  610 1024610.45 Endocrine System - 19%, Embryonic Structures - 13%, Urinary Tract - 10%  611 82013.1 Urinary Tract - 67%, Nervous System - 17%, Hemic and Immune System - 17%  612 212155.1 Sense Organs - 38%, Endocrine System - 12%, Nervous System -  613 22632.1 Sense Organs - 22%, Germ Cells - 11%, Male Genitalia - 11%  615 2789525CD1  617 1692213CD1  618 15393.1 Endocrine System - 50%, Nervous System - 50%  620 001089CD1  622 002484CD1  624 669671CD1  626 1344185CD1  628 697785CD1  629 336435.2 Endocrine System - 64%, Respiratory System - 12%  630 231558.1 Endocrine System - 29%, Urinary Tract - 29%, Male Genitalia - 14%, Female Genitalia - 14%, Digestive System - 14%  631 247784.3 Female Genitalia - 21%, Endocrine System - 14%, Nervous System - 14%  632 238322.6 Musculoskeletal System - 27%, Unclassified/Mixed - 11%  633 55978.9 Unclassified/Mixed - 33%, Endocrine System - 12%, Embryonic Structures - 12%, Male Genitalia - 12%, Liver - 12%  634 55978.4 Endocrine System - 15%, Unclassified/Mixed - 13%, Nervous System - 13%, Male Genitalia - 13%  635 350977.1 Pancreas - 14%, Hemic and Immune System - 14%, Cardiovascular System - 13%, Respiratory System - 13%,  636 238877.11 widely distributed  637 238877.8 Sense Organs - 33%  638 997231.15 Musculoskeletal System - 17%, Male Genitalia - 11%, Germ Cells - 10%, Cardiovascular System - 10%  639 997231.16 Germ Cells - 20%  640 346209.3 Digestive System - 24%, Pancreas - 12%  642 2515666CD1  644 2742913CD1  645 336615.1 Sense Organs - 58%, Endocrine System - 14%, Nervous System -  646 406830.43 Germ Cells - 36%  647 406830.33 Digestive System - 100%  648 84685.1 Connective Tissue - 64%, Male Genitalia - 18%, Digestive System -  649 1045907.4 Musculoskeletal System - 67%, Respiratory System - 33%  650 1383803.2 Liver - 26%, Embryonic Structures- 14%, Unclassified/Mixed - 12%  651 85282.1 Female Genitalia - 45%, Respiratory System - 27%, Hemic and Immune System - 27%  652 86326.1 Female Genitalia - 29%, Urinary Tract - 24%, Respiratory System -  653 337470.1 Unclassified/Mixed - 57%, Respiratory System - 14%, Liver - 13%  655 3721108CD1  656 1090929.2 Liver - 28%, Skin - 21%  657 95374.1 Connective Tissue - 47%, Respiratory System - 20%, Hemic and Immune System - 20%  658 238639.2 Female Genitalia - 36%, Urinary Tract - 29%, Hemic and Immune System - 21%  659 33627.28 Connective Tissue - 16%, Liver - 14%, Female Genitalia - 12%  660 33627.33 Germ Cells - 12%  661 435361.1 widely distributed  662 474552.1 Exocrine Glands - 50%, Male Genitalia - 25%, Digestive System -  664 2636759CD1  665 1083665.4 Hemic and Immune System - 18%, Connective Tissue - 18%, Male Genitalia - 18%  666 240518.21 Connective Tissue - 23%, Liver - 15%, Respiratory System - 13%  667 240518.42 widely distributed  668 1322.4 Respiratory System - 12%, Unclassified/Mixed - 12% Stomatognathic System - 11%  669 208282.1 Unclassified/Mixed - 38%, Embryonic Structures - 14%, Connective Tissue - 11%  670 345272.5 Digestive System - 100%  671 345272.2 Unclassified/Mixed - 18%  672 997613.1 Digestive System - 67%, Cardiovascular System - 22%  673 231840.1 Germ Cells - 30%, Liver - 14%  674 13937.3 Connective Tissue - 18%, Hemic and Immune System - 11%  675 253783.6 Male Genitalia - 41%, Nervous System - 26%, Urinary Tract - 18%  676 20828.1 Embryonic Structures - 60%, Male Genitalia - 13%, Female Genitalia - 13%, Digestive System - 13%  677 222705.14 Embryonic Structures - 25%, Connective Tissue - 12%, Female Genitalia - 11%  678 335906.1 Female Genitalia - 56%, Endocrine System - 44%  679 1325741.2 Unclassified/Mixed - 17%, Embryonic Structures - 16%  681 2703282CD1  682 118836.2 Urinary Tract - 12%  683 3303.2 Embryonic Structures - 13%  684 92991.1 Respiratory System - 60%, Nervous System - 20%, Hemic and Immune System - 20%  685 93603.1 Respiratory System - 100%  686 1383062.7 Nervous System - 36%, Skin - 16%, Male Genitalia - 13%  687 1383062.8 Respiratory System - 43%, Nervous System - 29%, Female Genitalia - 29%  688 1383794.1 Female Genitalia - 38%, Endocrine System - 31%, Hemic and Immune System - 31%  689 406289.1 Hemic and Immune System - 59%, Female Genitalia - 29%, Nervous System - 12%  690 175918.15 widely distributed  691 1068290.1 Unclassified/Mixed - 15%, Hemic and Immune System - 13%, Pancreas - 11%, Respiratory System - 11%  692 94873.1 Digestive System - 67%, Hemic and Immune System - 33%  693 403616.1 Embryonic Structures - 39%, Liver - 39%, Hemic and Immune System - 13%  694 95088.1 Hemic and Immune System - 100%  695 230402.1 Embryonic Structures - 30%, Unclassified/Mixed - 27%, Endocrine System - 13%, Urinary Tract - 13%  696 95172.1 Female Genitalia - 67%, Hemic and Immune System - 33%  697 250091.1 Nervous System - 50%, Hemic and Immune System - 50%  699 4113161CD1  700 335375.3 Liver - 67%  701 95395.1 Hemic and Immune System - 100%  702 229514.1 Urinary Tract - 32%, Cardiovascular System - 18%, Endocrine System - 18%  703 95573.1 Hemic and Immune System - 100%  704 230463.1 Cardiovascular System - 26%, Exocrine Glands - 26%, Urinary Tract - 23%  705 95702.1 Nervous System - 100%  706 218090.9 Sense Organs- 16%, Cardiovascular System - 10%  707 96126.1 Connective Tissue - 78%, Digestive System - 22%  709 1508254CD1  711 207452CD1  712 290233.1 Female Genitalia - 100%  713 1096917.11 Exocrine Glands- 67%, Female Genitalia - 17%, Male Genitalia -  714 208748.4 Germ Cells - 23%, Urinary Tract - 13%, Unclassified/Mixed - 11%  715 407517.2 Stomatognathic System - 17%, Urinary Tract - 10%  716 233997.1 Sense Organs- 18%  717 237067.1 Respiratory System - 18%, Unclassified/Mixed - 18%, Male Genitalia - 16%  718 330862.6 Hemic and Immune System - 24%, Exocrine Glands - 16%, Urinary Tract - 16%, Digestive System - 16%, Cardiovascular System - 16%  719 330862.8 Urinary Tract - 12%, Sense Organs - 10%, Germ Cells - 10%  721 2124957CD1  722 1098722.6 Embryonic Structures - 19%, Musculoskeletal System - 10%, Unclassified/Mixed - 10%  723 1099023.1 Unclassified/Mixed - 53%, Respiratory System - 31%, Exocrine Glands - 13%  724 201395.4 Nervous System - 39%, Endocrine System - 15%  726 4295277CD1  727 98533.1 Endocrine System - 100%  728 983684.1 Skin - 52%, Unclassified/Mixed - 30%, Hemic and Immune System -  729 983684.2 Unclassified/Mixed - 93%  731 1837317CD1  733 2937262CD1  734 199290.9 widely distributed  736 3151579CD1  737 235056.14 Nervous System - 50%, Hemic and Immune System - 50%  738 337939.2 Hemic and Immune System - 100%  739 208379.1 Nervous System 52%, Embryonic Structures - 21%, Urinary Tract - 17%  740 251631.6 Exocrine Glands - 29%, Digestive System - 29%, Hemic and Immune System - 29%  742 2847188CD1  743 100579.1 Nervous System - 50%, Hemic and Immune System - 50%  744 1327498.1 Exocrine Glands - 50%, Female Genitalia - 25%, Digestive System -  745 1330212.14 widely distributed  746 252471.7 Respiratory System - 25%, Exocrine Glands - 13%, Urinary Tract - 11%, Connective Tissue - 11%, Female Genitalia - 11%  747 252471.4 Germ Cells - 18%, Unclassified/Mixed - 13%  748 983536.1 Endocrine System - 45%, Female Genitalia - 35%, Male Genitalia -  749 983536.2 Endocrine System - 100%  750 1330122.1 Embryonic Structures - 14%, Sense Organs - 11%  751 407468.1 Germ Cells - 43%, Unclassified/Mixed - 28%, Female Genitalia -  752 1330149.46 Sense Organs - 14%, Hemic and Immune System - 10%  753 32476.2 Unclassified/Mixed - 22%, Cardiovascular System - 17%, Hemic and Immune System - 13%, Female Genitalia - 13%  755 1281694CD1  757 1719478CD1  758 230611.1 Respiratory System - 75%, Hemic and Immune System - 25%  759 236749.1 Hemic and Immune System - 50%, Pancreas - 19%, Digestive System - 17%  760 407124.2 Unclassified/Mixed - 29%, Digestive System - 21%, Male Genitalia -  761 104322.1 Pancreas - 38%, Connective Tissue - 29%, Male Genitalia - 17%  762 400253.14 Urinary Tract - 23%, Hemic and Immune System - 15%, Liver - 13%, Nervous System - 13%  763 233595.17 Sense Organs - 30%  764 978065.5 Germ Cells - 47%, Hemic and Immune System - 11%, Unclassified/Mixed - 10%  765 403642.1 Hemic and Immune System - 100%  766 984236.4 Digestive System - 80%, Nervous System - 10%, Hemic and Immune System - 10%  767 984236.1 Digestive System - 35%, Liver - 26%, Female Genitalia - 15%  769 1001589CD1  770 7808.1 Hemic and Immune System - 21%, Liver - 20%  771 403627.38 Nervous System - 13%, Urinary Tract - 12%, Endocrine System - 11%  772 106415.1 Endocrine System - 100%  773 474622.1 Skin - 15%, Unclassified/Mixed - 10%  774 1383009.57 Endocrine System - 10%  775 1383009.67 widely distributed  776 1086355.2 Urinary Tract - 80%, Nervous System - 20%  777 1086355.1 Germ Cells - 23%, Nervous System - 12%, Endocrine System - 12%  778 998330.2 Urinary Tract - 36%, Respiratory System - 27%, Female Genitalia -  779 1384716.4 Exocrine Glands - 10%  781 2790762CD1  782 399607.1 Endocrine System - 56%, Urinary Tract - 25%, Nervous System - 13%  783 256138.1 Urinary Tract - 67%, Male Genitalia - 33%  784 413348.4 Liver - 15%, Digestive System - 11%  785 332088.2 Cardiovascular System - 67%, Nervous System - 17%, Hemic and Immune System - 17%  787 035282CD1  788 350667.7 Cardiovascular System - 38%, Urinary Tract - 19%, Hemic and Immune System - 19%  789 343913.1 Hemic and Immune System - 100%  790 211622.1 Respiratory System - 60%, Nervous System - 20%, Hemic and Immune System - 20%  791 110049.1 Musculoskeletal System - 76%, Cardiovascular System - 24%  793 1806212CD1  795 4436028CD1  796 406663.3 Hemic and Immune System - 50%, Respiratory System - 21%, Digestive System - 14%, Male Genitalia - 14%  797 405689.1 Liver - 69%, Male Genitalia - 27%  798 110815.1 Hemic and Immune System - 100%  799 1385527.4 Stomatognathic System - 26%  800 2570.1 Sense Organs - 69%, Skin - 19%  801 1100724.1 Germ Cells - 11%, Exocrine Glands - 10%  803 3704760CD1  804 344017.6 Sense Organs - 33%, Liver - 11%, Hemic and Immune System - 10%  805 344017.3 Skin - 22%  807 2770104CD1  808 349204.1 Hemic and Immune System - 67%, Male Genitalia - 22%, Nervous System - 11%  810 2641740CD1  811 211881.1 Female Genitalia - 83%, Hemic and Immune System - 17%  812 334749.1 Connective Tissue - 88%  813 407838.1 Musculoskeletal System - 60%, Respiratory System - 30%, Nervous System - 10%  815 170915CD1  816 994387.88 Nervous System - 100%  818 2454013CD1  819 427967.6 Embryonic Structures - 50%, Exocrine Glands - 44%  820 427967.4 Embryonic Structures - 12%  821 257016.1 Connective Tissue - 50%, Respiratory System - 18%, Endocrine System - 14%, Exocrine Glands - 14%  822 215158.5 Liver - 13%, Nervous System - 12%, Unclassified/Mixed - 11%  823 522.12 Exocrine Glands - 31%, Digestive System - 31%, Female Genitalia - 15%, Nervous System - 15%  824 522.1 Cardiovascular System - 67%, Female Genitalia - 33%  825 113633.1 Digestive System - 50%, Female Genitalia - 25%, Nervous System - 13%, Hemic and Immune System - 13%  826 477387.3 Hemic and Immune System - 60%, Digestive System - 40%  827 477387.7 Stomatognathic System - 19%, Unclassified/Mixed - 17%, Skin -  828 347796.7 Stomatognathic System - 11%  830 2656429CD1  832 3346307CD1  834 2649071CD1  835 1383086.2 Germ Cells - 15%, Exocrine Glands - 14%, Male Genitalia - 11%  837 1850670CD1  838 1132386.3 Urinary Tract - 19%, Nervous System - 18%, Unclassified/Mixed -  839 115052. 1 Cardiovascular System - 100%  841 1330056CD1  842 199788.2 widely distributed  843 27881.1 Exocrine Glands - 53%, Cardiovascular System - 27%, Nervous System - 13%  844 234543.1 Sense Organs - 20%, Germ Cells - 20%, Musculoskeletal System -  845 231547.2 Pancreas - 36%, Female Genitalia - 20%, Exocrine Glands - 16%, Endocrine System - 16%  846 399785.1 Pancreas - 32%, Unclassified/Mixed - 29%, Male Genitalia - 14%, Cardiovascular System - 14%  847 10498.24 Embryonic Structures - 21%  848 399161.1 Nervous System - 40%, Exocrine Glands - 40%, Female Genitalia -  849 241467.1 Germ Cells - 75%, Endocrine System - 13%  850 997194.1 Embryonic Structures - 43%, Connective Tissue - 33%, Cardiovascular System - 19%  851 17819.1 Connective Tissue - 24%, Embryonic Structures - 15%, Cardiovascular System - 14%, Exocrine Glands - 14%  852 116536.1 Cardiovascular System - 36%, Urinary Tract - 36%, Digestive System - 18%  853 116549.1 Liver - 90%, Hemic and Immune System - 10%  854 17886.1 Hemic and Immune System - 100%  855 351032.1 Embryonic Structures - 64%, Hemic and Immune System - 29%  856 977532.9 Sense Organs - 23%, Unclassified/Mixed - 13%  857 117273.1 Male Genitalia - 100%  858 212438.1 Embryonic Structures - 50%, Exocrine Glands - 22%, Female Genitalia - 11%, Digestive System - 11%  859 212265.7 Male Genitalia - 33%, Digestive System - 33%, Nervous System - 17%, Hemic and Immune System - 17%  860 403560.1 Digestive System - 91%  861 1073168.6 Unclassified/Mixed - 32%, Exocrine Glands - 16%, Urinary Tract -  862 1073168.8 widely distributed  863 119614.1 Female Genitalia - 100%  864 119625.1 Female Genitalia - 67%, Hemic and Immune System - 33%  865 119671.1 Female Genitalia - 100%  866 3177.1 Female Genitalia - 15%, Urinary Tract - 13%, Embryonic Structures - 11%, Liver - 11%  867 119974.1 Female Genitalia - 100%  868 120831.1 Endocrine System - 57%, Digestive System - 29%, Hemic and Immune System - 14%  869 27619.3 Liver - 91%  870 212872.1 Nervous System - 37%, Urinary Tract - 26%, Respiratory System - 19%, Female Genitalia - 19%  871 404952.4 Sense Organs - 35%, Liver - 18%  872 404952.1 Germ Cells - 20%  873 125014.1 Connective Tissue - 88%, Hemic and Immune System - 13%  874 348390.2 Digestive System - 44%, Male Genitalia - 21%, Female Genitalia -  875 227222.1 Pancreas - 56%, Cardiovascular System - 25%, Respiratory System - 19%  876 337696.1 Connective Tissue - 50%, Respiratory System - 21%, Digestive System - 14%  877 253550.2 Connective Tissue - 30%, Endocrine System - 14%  878 1326925.1 Liver - 47%, Digestive System - 42%, Male Genitalia - 11%  879 127140.1 Male Genitalia - 100%  880 127204.1 Male Genitalia - 100%  881 330925.1 Germ Cells - 37%, Sense Organs - 18%  882 403960.1 Unclassified/Mixed - 36%, Female Genitalia - 23%, Endocrine System - 18%  883 20152.1 Liver - 19%, Cardiovascular System - 17%, Respiratory System - 17%, Unclassified/Mixed - 17%  884 26200.1 Skin - 54%, Musculoskeletal System - 23%, Exocrine Glands - 15%  885 399474.1 Skin - 17%  886 981037.1 Digestive System - 50%, Pancreas - 25%, Endocrine System - 11%  887 130502.1 Female Genitalia - 100%  889 5202390CD1  890 213447.4 Unclassified/Mixed - 51%, Respiratory System - 13%  891 250439.1 Respiratory System - 100%  893 2743049CD1  894 256026.8 Embryonic Structures - 28%, Liver - 28%, Respiratory System - 25%  895 998930.1 Musculoskeletal System - 68%, Exocrine Glands - 21%, Female Genitalia - 11%  896 981149.2 Connective Tissue - 36%, Urinary Tract - 18%, Nervous System - 13%, Female Genitalia - 13%  897 335420.1 Endocrine System - 69%, Nervous System - 23%  898 1082203.1 Embryonic Structures - 23%, Endocrine System - 11%, Male Genitalia - 11%  899 225420.1 Unclassified/Mixed - 14%, Female Genitalia - 12%, Male Genitalia -  900 236298.4 Germ Cells - 28%  901 236298.2 Endocrine System - 20%, Hemic and Immune System - 17%, Embryonic Structures - 10%, Liver - 10%  902 982813.1 Nervous System - 75%, Digestive System - 25%  903 154771.1 Urinary Tract - 64%, Female Genitalia - 18%, Digestive System -  904 477054.1 Respiratory System - 92%  905 2966.1 Musculoskeletal System - 54%, Cardiovascular System - 33%  906 136212.1 Cardiovascular System - 100%  907 977975.1 Sense Organs- 16%, Stomatognathic System - 12%, Connective Tissue - 11%  909 1505038CD1  911 262830CD1  913 3607580CD1  914 137742.1 Respiratory System - 56%, Male Genitalia - 22%, Female Genitalia -  915 1095839.1 Sense Organs - 16%, Skin - 11%  916 205328.1 Unclassified/Mixed - 41%, Pancreas - 22%, Female Genitalia - 17%  917 252649.14 Urinary Tract- 16%, Digestive System - 11%  918 221762.2 Liver - 50%, Hemic and Immune System - 19%, Cardiovascular System - 12%  919 138205.1 Respiratory System - 60%, Female Genitalia - 40%  920 331566.1 Unclassified/Mixed - 26%, Embryonic Structures - 14%, Stomatognathic System - 12%  921 1384719.3 widely distributed  922 1330137.1 Respiratory System - 100%  923 409962.1 Germ Cells - 65%, Embryonic Structures - 23%, Cardiovascular System - 10%  924 481118.7 Exocrine Glands - 16%, Female Genitalia - 11%, Cardiovascular System - 10%  925 481118.12 Stomatognathic System - 11%  926 337528.4 Pancreas - 17%, Embryonic Structures - 17%, Male Genitalia - 17%, Liver- 17%  928 3687719CD1  929 332299.1 Exocrine Glands - 32%, Embryonic Structures - 24%, Respiratory System - 14%  931 1530186CD1  932 251809.1 Male Genitalia - 100%  933 334025.5 Embryonic Structures - 36%, Cardiovascular System - 16%, Male Genitalia - 16%, Exocrine Glands - 16%  934 350134.1 Cardiovascular System - 67%, Respiratory System - 25%  935 16124.2 Cardiovascular System - 67%, Female Genitalia - 33%  936 140468.1 Cardiovascular System - 100%  938 3257507CD1  939 1400580.1 Musculoskeletal System - 24%, Female Genitalia - 20%, Exocrine Glands - 16%, Urinary Tract - 16%, Digestive System - 16%  940 481154.3 Unclassified/Mixed - 29%, Urinary Tract - 12%, Female Genitalia -  941 346716.17 Unclassified/Mixed - 14%, Female Genitalia - 11%, Liver - 11%  942 346716.21 Cardiovascular System - 22%, Nervous System - 17%, Urinary Tract - 13%, Male Genitalia - 13%  943 1384720.16 Stomatognathic System - 12%  945 1505790CD1  947 3876162CD1  948 40576.1 Sense Organs - 46%, Urinary Tract - 12%, Nervous System - 12%  949 1040190.14 Sense Organs - 36%, Hemic and Immune System - 21%, Embryonic Structures - 19%  950 1328310.1 Liver - 67%, Exocrine Glands - 15%, Respiratory System - 11%  951 34297.1 Nervous System - 100%  952 145549.2 Urinary Tract - 100%  953 42206.1 Liver - 31%, Pancreas - 31%, Cardiovascular System - 14%  954 178799.1 Liver - 30%, Unclassified/Mixed - 27%, Respiratory System - 17%  955 214767.1 Male Genitalia - 100%  956 94384.1 Endocrine System - 40%, Exocrine Glands - 40%, Nervous System - 10%, Hemic and Immune System - 10%  958 2852561CD1  959 337058.1 Respiratory System - 28%, Nervous System - 28%, Endocrine System - 22%  960 988704.25 widely distributed  961 988704.26 Exocrine Glands - 11%  962 401906.2 Respiratory System - 100%  963 154220.1 Respiratory System - 75%, Nervous System - 25%  965 5371205CD1  966 147026.1 Nervous System - 100%  967 410776.1 Hemic and Immune System - 86%, Nervous System - 14%  968 335121.1 Germ Cells - 67%, Exocrine Glands - 10%, Urinary Tract - 10%, Digestive System - 10%  969 147379.1 Nervous System - 100%  970 147403.1 Embryonic Structures - 69%, Nervous System - 23%  971 1041063.1 Liver - 38%, Respiratory System - 33%, Male Genitalia - 17%  972 1041063.5 Pancreas - 32%, Respiratory System - 18%, Exocrine Glands - 14%, Urinary Tract - 14%, Hemic and Immune System - 14%  973 230912.1 Cardiovascular System - 44%, Respiratory System - 33%, Nervous System - 11%, Hemic and Immune System - 11%  974 1089708.18 Nervous System - 11%, Embryonic Structures - 10%  975 1050390.1 Skin - 58%, Pancreas - 38%  977 088957CD1  978 220943.21 Connective Tissue - 12%, Cardiovascular System - 12%  979 28005.14 Liver - 40%, Musculoskeletal System - 14%  980 980446.1 Embryonic Structures - 29%, Male Genitalia - 14%, Nervous System - 14%  981 198827.1 Connective Tissue - 23%, Nervous System - 17%, Exocrine Glands - 11%  982 215112.1 Male Genitalia - 80%, Nervous System - 20%  983 977929.1 Sense Organs - 46%, Male Genitalia - 11%  984 281447.2 Urinary Tract - 67%, Digestive System - 33%  985 346641.3 Unclassified/Mixed - 31%, Connective Tissue - 27%, Exocrine Glands- 15%  986 230793.3 Unclassified/Mixed - 27%, Exocrine Glands - 11%, Hemic and Immune System - 11%  987 431288.1 Respiratory System - 87%, Nervous System - 13%  989 4215034CD1  990 150627.1 Pancreas- 96%  991 121731.1 Pancreas - 86%, Hemic and Immune System - 14%  992 259907.1 Pancreas - 100%  993 977727.13 Pancreas - 66%, Liver - 22%  994 5915.1 Respiratory System - 42%, Urinary Tract - 23%, Hemic and Immune System - 19%  995 8835.1 Nervous System - 57%, Female Genitalia - 29%, Hemic and Immune System - 14%  996 242010.6 Nervous System - 19%, Musculoskeletal System - 15%, Embryonic Structures- 12%  997 242684.1 Exocrine Glands - 31%, Respiratory System - 23%, Hemic and Immune System - 23%  998 335145.1 Nervous System - 33%, Unclassified/Mixed - 18%, Male Genitalia - 1000 678004CD1 1001 92922.1 Nervous System - 100% 1002 411373.7 Embryonic Structures - 48%, Unclassified/Mixed - 17%, Nervous System - 12% 1003 404715.1 Endocrine System - 44%, Nervous System - 22%, Female Genitalia - 22% 1004 278831.1 Respiratory System - 75%, Nervous System - 25% 1005 343924.8 Skin - 15%, Digestive System - 11%, Respiratory System - 11% 1006 200977.1 Stomatognathic System - 31%, Urinary Tract - 13% 1007 181818.3 Connective Tissue - 39%, Hemic and Immune System - 17%, Male Genitalia - 15% 1009 029251CD1 1010 335648.1 Liver - 67%, Exocrine Glands - 20%, Unclassified/Mixed - 12% 1011 331108.1 Liver - 72%, Digestive System - 18% 1012 333840.1 Liver - 68%, Urinary Tract - 24% 1013 334298.1 Liver - 75%, Endocrine System - 11%, Hemic and Immune System - 1014 344597.2 Nervous System - 100% 1015 1262593.2 Embryonic Structures - 33%, Unclassified/Mixed - 13% 1016 461375.2 Embryonic Structures - 16%, Connective Tissue - 13% 1017 233660.2 Germ Cells - 12%, Unclassified/Mixed - 10% 1018 230179.3 Liver - 43%, Endocrine System - 10%, Musculoskeletal System- 10% 1019 230179.7 Liver - 25%, Pancreas - 14%, Germ Cells - 10% 1020 296245.1 Female Genitalia - 67%, Nervous System - 33% 1021 981208.1 Pancreas - 31%, Nervous System 17%, Endocrine System - 15% 1022 406580.1 Germ Cells - 54%, Nervous System - 32% 1023 200051.1 Sense Organs - 38%, Nervous System - 20% 1024 1197030.1 Stomatognathic System - 17% 1025 1197030.1 Musculoskeletal System - 14% 1026 158859.1 Endocrine System - 50%, Nervous System - 38%, Hemic and Immune System - 13% 1027 229490.1 Sense Organs - 55%, Connective Tissue - 15% 1029 4832672CD1 1030 339638.1 Male Genitalia - 44%, Female Genitalia - 22%, Digestive System - 1031 480885.2 Connective Tissue - 14%, Male Genitalia - 13%, Embryonic Structures - 10% 1032 342074.1 Skin - 61%, Respiratory System - 22%, Exocrine Glands - 17% 1033 406992.1 Skin - 48%, Hemic and Immune System - 21%, Exocrine Glands - 14%, Digestive System - 14% 1035 1852849CD1 1036 1132829.1 Cardiovascular System - 10% 1037 339800.1 Nervous System - 100% 1038 1399492.1 Unclassified/Mixed - 29%, Respiratory System - 16% 1039 13039.2 Sense Organs - 19%, Embryonic Structures - 17% 1040 399626.1 Endocrine System - 69%, Male Genitalia - 15%, Nervous System - 1041 365070.3 Nervous System - 54%, Endocrine System - 31%, Female Genitalia - 15% 1042 365070.1 Nervous System - 83%, Female Genitalia - 17% 1043 1383263.1 Embryonic Structures - 55%, Skin - 27% 1044 1383263.14 widely distributed 1045 406707.2 Hemic and Immune System - 100% 1046 406707.1 Germ Cells - 94% 1047 1051954.7 Embryonic Structures - 18%, Female Genitalia - 16%, Endocrine System - 13% 1048 102564.1 Male Genitalia - 40%, Exocrine Glands - 40%, Digestive System - 1049 233312.1 Male Genitalia - 27%, Exocrine Glands - 27%, Respiratory System - 20%, Nervous System - 20% 1050 335568. Hemic and Immune System - 43%, Nervous System - 21%, Respiratory System - 21% 1051 407739.1 Exocrine Glands - 29%, Hemic and Immune System - 29%, Nervous System - 14%, Male Genitalia - 14%, Digestive System - 1052 272273.1 Nervous System - 67%, Digestive System - 33% 1053 399133.9 Exocrine Glands - 14% 1054 246727.11 Embryonic Structures - 18%, Connective Tissue - 14%, Female Genitalia - 14%, Male Genitalia - 14% 1055 246727.17 Sense Organs - 12% 1056 230367.2 Unclassified/Mixed - 18%, Germ Cells - 14%, Exocrine Glands - 13% 1057 1383039.18 Musculoskeletal System - 47%, Hemic and Immune System - 19%, Liver - 17% 1058 1383039.17 Sense Organs - 27% 1059 27704.2 Hemic and Immune System - 100% 1060 346900.1 Digestive System - 57%, Hemic and Immune System - 43% 1061 249813.1 Liver - 18%, Unclassified/Mixed - 17%, Nervous System - 13% 1062 411357.1 Cardiovascular System - 30%, Pancreas - 12%, Respiratory System - 11%, Exocrine Glands - 11%, Unclassified/Mixed - 11% 1063 68902.1 Unclassified/Mixed - 63%, Musculoskeletal System - 12%, Digestive System - 12% 1064 210133.1 Pancreas - 18%, Connective Tissue - 14%, Female Genitalia - 13% 1065 430665.1 Connective Tissue - 24%, Liver - 18%, Cardiovascular System - 16% 1066 902525.1 Endocrine System - 27%, Exocrine Glands - 27%, Respiratory System - 20% 1067 256841.1 Germ Cells - 85% 1068 206344.1 Digestive System - 93% 1069 107309.1 Urinary Tract - 40%, Respiratory System - 30%, Male Genitalia - 1070 1074024.1 Pancreas - 56%, Respiratory System - 31%, Digestive System - 13% 1071 233218.7 Liver - 43%, Skin - 22%, Respiratory System - 13%, Digestive System - 13% 1072 1092387.12 Liver - 67%, Respiratory System - 19%, Hemic and Immune System - 11% 1073 1092387.11 Liver - 26%, Musculoskeletal System - 19%, Respiratory System - 11%, Unclassified/Mixed - 11% 1074 366463.1 Hemic and Immune System - 43%, Digestive System - 29%, Male Genitalia - 29% 1075 304409.1 Urinary Tract - 67%, Male Genitalia - 33% 1076 1382920.38 Hemic and Immune System - 14%, Connective Tissue - 12% 1077 342365.1 Urinary Tract - 54%, Hemic and Immune System - 31%, Male Genitalia - 15% 1078 399210.1 Urinary Tract - 36%, Hemic and Immune System - 27%, Female Genitalia - 18%, Male Genitalia - 1079 1089210.1 Liver - 95% 1080 444619.9 Liver - 31%, Endocrine System - 11% 1081 312986.1 Digestive System - 67%, Hemic and Immune System - 33% 1082 462057.1 Germ Cells - 19%, Skin - 16% 1083 197902.12 Embryonic Structures - 14%, Endocrine System - 13%, Unclassified/Mixed - 13% 1084 997394.4 Stomatognathic System - 28%, Digestive System - 17%, Embryonic Structures - 10% 1086 2481150CD1 1087 8198.1 Embryonic Structures - 20%, Skin - 15%, Musculoskeletal System - 1088 72297.2 Embryonic Structures - 35%, Musculoskeletal System - 23%, Urinary Tract - 15% 1089 994430.16 Female Genitalia - 100% 1090 189036.1 Unclassified/Mixed - 56%, Cardiovascular System - 14% 1091 221042.1 Cardiovascular System - 12%, Male Genitalia - 11% 1092 408398.1 Sense Organs - 90% 1093 985369.1 Germ Cells - 15%, Male Genitalia - 11% 1094 328796.1 Urinary Tract - 44%, Hemic and Immune System - 33%, Male Genitalia - 22% 1095 58804.1 Male Genitalia - 100% 1097 3505463CD1 1098 197159.1 Sense Organs - 11%, Hemic and Immune System - 11% 1099 369928.1 Female Genitalia - 100% 1100 413466.6 Musculoskeletal System - 22%, Female Genitalia - 12% 1101 397295.1 Connective Tissue - 80% 1102 1330139.5 Stomatognathic System - 15%, Cardiovascular System - 11% 1103 977951.1 Hemic and Immune System - 12%, Germ Cells - 10% 1104 347316.1 Nervous System - 50%, Cardiovascular System - 17%, Exocrine Glands- 17% 1105 150288.3 Embryonic Structures - 20%, Unclassified/Mixed - 18%, Male Genitalia - 13% 1106 2455.1 Nervous System - 76% 1107 372647.1 Nervous System - 100% 1108 137710.1 Respiratory System - 33%, Male Genitalia - 22%, Nervous System - 22%, Female Genitalia - 22% 1109 407644.1 Musculoskeletal System - 12%, Connective Tissue - 11%, Stomatognathic System - 11% 1110 373516.1 Musculoskeletal System - 72%, Respiratory System - 17%, Female Genitalia - 11% 1111 241762.23 Embryonic Structures - 34%, Cardiovascular System - 14%, Musculoskeletal System - 11%, Digestive System - 11% 1112 1040914.1 Male Genitalia - 57%, Respiratory System - 43% 1113 358492.1 Liver - 31%, Pancreas - 31%, Endocrine System - 14%, Digestive System - 14% 1114 243924.12 Liver - 90%, Hemic and Immune System - 10% 1115 243924.13 Female Genitalia - 20%, Liver - 17%, Urinary Tract - 17% 1116 208075.1 Hemic and Immune System - 29%, Unclassified/Mixed - 20%, Exocrine Glands - 14% 1117 168955.1 Sense Organs - 36%, Germ Cells - 36%, Connective Tissue - 19% 1118 428508.1 Connective Tissue - 100% 1119 418070.1 Pancreas - 72%, Urinary Tract - 16%, Nervous System - 12% 1120 403994.5 Female Genitalia - 50%, Nervous System - 25%, Hemic and Immune System - 25% 1121 336726.1 Unclassified/Mixed - 41%, Liver - 15%, Exocrine Glands - 13% 1122 336726.1 Germ Cells - 36%, Nervous System - 17%, Cardiovascular System - 11%, Unclassified/Mixed - 11% 1123 410781.1 Respiratory System - 31%, Connective Tissue - 21%, Pancreas - 1124 347759.3 Exocrine Glands - 15% 1125 1252060.4 Liver - 92% 1126 209279.1 Liver - 37%, Sense Organs - 16%, Pancreas - 11% 1127 418391.2 Connective Tissue - 44%, Nervous System - 44%, Female Genitalia - 13% 1128 480630.21 Hemic and Immune System - 33%, Unclassified/Mixed - 30%, Digestive System - 15%, Cardiovascular System - 15% 1129 117799.1 Liver - 51%, Connective Tissue - 20%, Male Genitalia - 11%, Digestive System - 11% 1130 235194.15 Liver - 69%, Hemic and Immune System - 23% 1131 379400.1 Nervous System - 100% 1132 380433.1 Male Genitalia - 29%, Female Genitalia - 29%, Digestive System - 1133 140122.22 Skin - 21%, Musculoskeletal System - 14%, Respiratory System - 13% 1134 131931.1 Urinary Tract - 80%, Nervous System - 20% 1135 381058.1 Unclassified/Mixed - 85%, Male Genitalia - 10% 1136 403136.1 Liver- 100% 1137 276647.1 Respiratory System - 50%, Urinary Tract - 25%, Female Genitalia - 13%, Digestive System - 13% 1138 191631.1 Male Genitalia - 67%, Nervous System - 33% 1139 887619.26 widely distributed 1140 980953.1 Unclassified/Mixed - 41%, Skin - 23%, Connective Tissue - 11% 1141 389859.1 Cardiovascular System - 67%, Nervous System - 33% 1142 217281.1 Musculoskeletal System - 67%, Nervous System - 33% 1143 32428.1 Digestive System - 60%, Endocrine System - 40%

TABLE 6 mean mean mean mean mean mean mean mean mean DE DE DE DE DE DE DE DE DE t/Mife t/Mife t/Mife t/Mife t/Mife t/Mife t/Mife t/Mife t/Mife Ave DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clone ID t/Mife Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr Cluster GEM  560115 −1.45 −2.67 to −0.04 −1.69 −1.90 −0.04 −1.54 −2.11 −0.57 −1.14 −2.67 −1.43 0 HGG 1 1315663 −0.75 −1.49 to −0.25 −0.38 −0.69 −0.95 −0.25 −0.85 −0.97 −0.45 −0.69 −1.49 0 HGG 1 1398105 −0.76 −1.59 to −0.26 −0.63 −0.56 −0.70 −0.26 −0.57 −1.06 −0.51 −0.98 −1.59 0 HGG 1 1607203 −0.78 −1.95 to −0.16 −0.39 −0.60 −0.16 −0.34 −0.94 −0.45 −0.64 −1.95 −1.54 0 HGG 1 1611445 −0.93 −1.58 to −0.41 −0.60 −1.05 −0.41 −0.99 −1.09 −0.65 −0.70 −1.58 −1.26 0 HGG 1 1619292 −0.93 −1.40 to −0.51 −0.74 −0.95 −0.79 −0.51 −0.94 −1.01 −0.89 −1.13 −1.40 0 HGG 1 1651008 −0.71 −1.40 to −0.48 −0.72 −0.74 −0.48 −0.48 −0.54 −0.55 −0.66 −1.40 −0.85 0 HGG 1 1781411 −0.98 −1.60 to −0.63 −1.23 −0.86 −0.65 −0.81 −1.09 −0.63 −0.89 −1.60 −1.08 0 HGG 1 1807155 −0.58 −1.56 to 0.01   −0.57 −1.00 −0.17 −0.13 −1.05 −0.22 −0.01 −1.56 −0.48 0 HGG 1 2026270 −0.67 −1.34 to −0.32 −0.38 −0.51 −0.32 −0.40 −0.86 −0.56 −0.66 −1.34 −0.96 0 HGG 1 2055867 −0.84 −1.99 to −0.29 −0.50 −1.35 −0.32 −0.29 −1.56 −0.34 −0.31 −1.99 −0.88 0 HGG 1 2890141 −0.71 −1.40 to −0.09 −0.63 −0.71 −0.73 −0.19 −0.78 −0.84 −0.09 −1.03 −1.40 0 HGG 1 2769888 −1.29 −1.94 to −0.72 −0.92 −1.50 −1.07 −0.77 −1.73 −1.30 −0.72 −1.94 −1.65 0 HGG 1 3397390 −1.13 −1.50 to −0.73 −1.08 −1.18 −1.01 −0.98 −1.50 −1.27 −0.73 −1.36 −1.09 0 HGG 1 3451645 −0.74 −1.44 to −0.14 −0.69 −0.84 −0.44 −0.36 −0.94 −0.62 −0.14 −1.18 −1.44 0 HGG 1 3715059 −0.75 −1.45 to −0.16 −0.33 −1.02 −0.69 −0.16 −0.92 −0.85 −0.22 −1.45 −1.11 0 HGG 1 4408943 −0.96 −2.01 to −0.16 −0.82 −1.23 −0.16 −0.68 −1.40 −0.40 −0.55 −2.01 −1.43 0 HGG 1 5047895 −1.19 −2.49 to −0.30 −0.32 −1.28 −0.30 −0.50 −1.64 −0.96 −0.82 −2.49 −2.42 0 HGG 1 5208013 −0.76 −1.34 to −0.26 −0.66 −0.82 −0.66 −0.43 −0.80 −0.70 −0.26 −1.16 −1.34 0 HGG 1 1308729 0.86 0.26 to 1.33 0.48 1.16 1.10 0.26 1.04 1.22 0.40 1.33 0.74 1 HGG 1 2430750 0.60 0.16 to 1.52 0.33 0.25 0.16 0.47 0.44 0.34 1.52 0.75 1.11 1 HGG 1 4721130 0.85 0.41 to 1.46 0.49 0.84 1.46 0.49 0.75 1.14 0.41 1.01 1.07 1 HGG 1 4110976 −0.17 −1.56 to 0.12   0.00 0.00 −1.56 −0.03 0.00 0.00 −0.06 0.00 0.12 2 HGG 1  739461 −0.22 −1.98 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 −1.98 0.00 0.00 2 HGG 1  865145 −0.23 −1.57 to 0.10   −1.57 −0.16 −0.05 0.03 −0.27 −0.02 0.10 0.08 −0.16 2 HGG 1 2515666 1.29 0.53 to 2.23 0.56 1.70 1.06 0.62 2.23 1.51 0.53 2.00 1.38 3 HGG 1 4287327 1.26 0.21 to 1.95 0.76 1.84 1.14 0.77 1.80 1.37 0.21 1.95 1.47 3 HGG 1  279898 1.40 0.38 to 2.18 0.79 1.81 1.68 0.50 1.91 1.64 0.38 2.18 1.70 3 HGG 1 1911443 −1.14 −1.70 to −0.33 −0.73 −1.29 −1.24 −0.33 −1.56 −1.70 0 HGG 3 3120209 −1.24 −1.93 to −0.50 −1.93 −1.29 −1.32 −1.51 −0.50 −0.90 0 HGG 3 3135460 −1.04 −1.77 to −0.46 −0.85 −1.47 −0.62 −0.46 −1.77 −1.09 0 HGG 3 3778404 −0.78 −1.44 to −0.21 −0.49 −0.96 −0.70 −0.21 −1.44 −0.87 0 HGG 3 5426158 −0.93 −1.33 to −0.61 −0.81 −0.93 −0.72 −0.61 −1.33 −1.21 0 HGG 3 5427710 −0.94 −1.44 to −0.69 −0.77 −0.69 −1.24 −0.77 −0.76 −1.44 0 HGG 3 5293028 −1.38 −2.18 to 0.49   0.49 −1.52 −1.51 −1.64 −2.18 −1.92 1 HGG 3 4543123 −1.20 −1.90 to 0.27   0.27 −1.31 −1.19 −1.46 −1.90 −1.62 1 HGG 3 5166479 −1.28 −2.37 to −0.14 −1.20 −1.34 −0.14 −1.11 −2.37 −1.51 1 HGG 3

TABLE 7 mean mean mean mean mean mean mean mean mean DE DE DE DE DE DE DE DE DE t/prog t/prog t/prog t/prog t/prog t/prog t/prog t/prog t/prog Ave DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clone ID t/prog Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr Cluster GEM 2311213 1.08 0.76 to 1.61 0.76 1.40 1.31 1.61 1.17 0.93 0.89 0.85 0.81 0 HGG 1 2313349 1.36 1.15 to 1.51 1.15 1.43 1.15 1.38 1.47 1.40 1.51 1.42 1.31 0 HGG 1 3595618 1.21 0.90 to 1.38 0.90 1.37 1.03 1.29 1.26 1.24 1.38 1.25 1.12 0 HGG 1 1342744 1.30 1.01 to 1.42 1.01 1.39 1.14 1.42 1.38 1.31 1.39 1.37 1.32 0 HGG 1  139949 1.05 0.72 to 1.48 1.01 1.11 0.72 1.47 1.24 0.77 1.48 0.73 0.92 0 HGG 1 2403438 1.32 0.93 to 1.66 1.21 1.66 1.54 1.47 1.50 1.28 1.30 0.97 0.93 0 HGG 1 2445967 1.29 1.03 to 1.52 1.03 1.27 1.06 1.37 1.45 1.44 1.52 1.22 1.22 0 HGG 1 1459743 1.18 0.96 to 1.50 1.02 1.22 0.99 1.44 1.50 1.29 1.22 0.96 0.97 0 HGG 1 2494284 1.27 0.68 to 1.75 1.19 0.92 0.68 1.75 1.60 1.61 1.27 1.16 1.29 0 HGG 1 1521272 1.04 0.63 to 1.34 0.63 0.91 0.68 1.34 1.27 1.26 1.23 0.88 1.19 0 HGG 1 3687719 1.37 1.06 to 1.60 1.06 1.34 1.08 1.45 1.46 1.53 1.60 1.41 1.37 0 HGG 1  371201 1.17 0.91 to 1.44 0.91 1.18 1.04 1.44 1.24 1.05 1.10 1.35 1.26 0 HGG 1 3821432 1.17 0.87 to 1.39 0.93 1.08 0.87 1.32 1.39 1.34 1.34 1.15 1.08 0 HGG 1 2516950 1.46 1.18 to 1.65 1.18 1.56 1.42 1.64 1.65 1.52 1.57 1.32 1.29 0 HGG 1 1684617 1.42 0.93 to 1.72 1.65 1.60 1.28 1.68 1.72 1.42 1.31 1.16 0.93 0 HGG 1 4092112 1.09 0.78 to 1.35 0.98 1.11 0.96 1.32 1.35 1.27 1.20 0.82 0.78 0 HGG 1 1756875 1.28 0.88 to 1.51 1.42 1.51 1.42 1.50 1.48 1.18 1.18 0.96 0.88 0 HGG 1 4286760 1.28 1.07 to 1.55 1.07 1.55 1.40 1.25 1.33 1.36 1.17 1.17 1.25 0 HGG 1 2697275 1.18 0.72 to 1.36 0.72 1.36 1.04 1.33 1.27 1.26 1.25 1.18 1.21 0 HGG 1 4978708 1.28 0.91 to 1.39 0.91 1.35 1.14 1.31 1.32 1.39 1.37 1.36 1.34 0 HGG 1 2756333 1.17 0.92 to 1.36 1.12 1.30 1.10 1.36 1.20 1.07 1.13 1.28 0.92 0 HGG 1 5046235 1.25 0.99 to 1.56 1.15 1.22 0.99 1.56 1.21 1.21 1.17 1.21 1.48 0 HGG 1 1956982 1.43 0.85 to 1.77 0.85 1.48 1.70 1.41 1.77 1.69 1.71 1.03 1.24 0 HGG 1  671717 1.25 1.04 to 1.52 1.04 1.52 1.22 1.39 1.37 1.35 1.11 1.13 1.16 0 HGG 1 2778441 1.11 0.79 to 1.38 0.79 1.02 0.84 1.26 1.23 1.29 1.38 1.07 1.09 0 HGG 1  279898 1.52 0.53 to 2.97 0.53 1.66 1.91 0.64 1.73 1.83 0.59 1.79 2.97 0 HGG 1 2823767 1.37 0.96 to 1.73 1.34 1.40 1.25 1.61 1.73 1.46 1.54 1.08 0.96 0 HGG 1 2830240 0.97 0.66 to 1.33 0.66 1.03 1.04 0.96 0.94 1.02 0.78 1.00 1.33 0 HGG 1 2833342 1.25 0.98 to 1.41 0.98 1.37 1.05 1.30 1.41 1.28 1.35 1.27 1.26 0 HGG 1 2120743 1.25 0.83 to 1.58 1.03 1.58 1.32 1.45 1.56 1.37 1.10 0.97 0.83 0 HGG 1  305751 1.33 1.08 to 1.63 1.08 1.33 1.18 1.63 1.48 1.29 1.21 1.40 1.41 0 HGG 1 3391835 1.38 0.57 to 2.26 1.20 1.67 1.65 2.26 1.54 1.65 1.06 0.57 0.84 0 HGG 1 2055814 −0.99 −1.44 to −0.68 −0.78 −1.12 −1.31 −0.72 −1.16 −1.44 −0.68 −0.69 −1.01 1 HGG 1 2055867 −0.82 −1.42 to 0.08   −0.35 −1.03 −1.40 −0.18 −1.40 −1.42 0.08 −0.58 −1.11 1 HGG 1 3126622 −0.99 −1.33 to −0.76 −0.79 −0.96 −1.18 −0.92 −1.11 −1.33 −0.90 −0.76 −0.98 1 HGG 1 2839946 −1.15 −1.47 to −0.84 −1.28 −0.94 −1.17 −1.29 −1.47 −1.44 −1.05 −0.85 −0.84 1 HGG 1 2132607 −1.10 −1.44 to −0.74 −0.89 −0.98 −1.05 −1.28 −1.34 −1.44 −1.13 −0.74 −1.07 1 HGG 1 3397390 −1.13 −1.58 to −0.73 −1.02 −1.11 −1.21 −0.91 −1.43 −1.58 −1.01 −0.73 −1.17 1 HGG 1 2382190 −0.83 −1.33 to 0.00   −0.61 −0.82 −1.00 −0.83 −1.04 −1.33 −0.87 0.00 −0.98 1 HGG 1 2495131 −1.04 −1.42 to −0.58 −1.01 −1.11 −1.27 −0.92 −1.25 −1.42 −0.90 −0.58 −0.90 1 HGG 1 3408804 −1.16 −1.56 to −0.83 −1.56 −1.12 −1.14 −1.20 −1.23 −1.24 −1.03 −1.09 −0.83 1 HGG 1  167081 −1.12 −1.57 to −0.53 −1.05 −1.18 −1.57 −0.53 −1.42 −1.39 −1.03 −0.70 −1.18 1 HGG 1 3451645 −0.91 −1.33 to −0.57 −0.73 −0.83 −1.14 −0.79 −1.10 −1.33 −0.57 −0.75 −0.91 1 HGG 1 1807155 −0.91 −1.40 to −0.54 −0.65 −0.68 −1.08 −0.83 −1.25 −1.40 −0.54 −0.70 −1.08 1 HGG 1  41479 −0.95 −1.35 to −0.64 −0.64 −0.92 −1.07 −0.82 −1.11 −1.35 −0.71 −0.84 −1.08 1 HGG 1 4246966 −1.04 −1.45 to −0.70 −1.06 −0.70 −0.78 −1.10 −1.15 −0.97 −1.11 −1.01 −1.45 1 HGG 1 5045593 −1.02 −1.41 to −0.76 −0.95 −0.92 −1.10 −0.76 −1.19 −1.41 −0.90 −0.85 −1.07 1 HGG 1 2767579 −1.14 −1.40 to −0.91 −0.91 −1.21 −1.33 −1.07 −1.26 −1.40 −1.00 −0.91 −1.19 1 HGG 1 2769888 −1.11 −1.73 to −0.59 −0.91 −1.13 −1.67 −0.67 −1.34 −1.73 −0.59 −0.88 −1.06 1 HGG 1 2047730 −1.15 −1.47 to −0.91 −0.91 −0.94 −1.05 −1.30 −1.47 −1.36 −1.03 −1.03 −1.27 1 HGG 1 2506973 −1.59 −1.92 to −1.28 −1.39 −1.28 −1.43 −1.81 −1.83 −1.92 −1.67 −1.33 −1.68 2 HGG 1 3001212 −1.44 −1.70 to −1.18 −1.28 −1.36 −1.33 −1.60 −1.55 −1.70 −1.40 −1.18 −1.56 2 HGG 1 3975209 −1.27 −1.67 to −1.04 −1.12 −1.11 −1.11 −1.54 −1.27 −1.67 −1.41 −1.04 −1.20 2 HGG 1 1441245 −1.25 −1.50 to −1.09 −1.24 −1.24 −1.12 −1.50 −1.42 −1.23 −1.14 −1.09 −1.27 2 HGG 1 2623304 −1.30 −1.59 to −0.99 −1.25 −1.05 −1.36 −1.42 −1.56 −1.59 −1.17 −0.99 −1.34 2 HGG 1 3679667 −1.39 −1.61 to −1.24 −1.61 −1.43 −1.39 −1.32 −1.50 −1.44 −1.30 −1.24 −1.27 2 HGG 1  891072 −1.30 −1.47 to −1.06 −1.06 −1.26 −1.34 −1.24 −1.45 −1.47 −1.28 −1.24 −1.32 2 HGG 1 1619292 −1.28 −1.50 to −0.89 −0.89 −1.28 −1.45 −1.27 −1.31 −1.48 −1.15 −1.17 −1.50 2 HGG 1 5291518 −1.35 −1.66 to −0.99 −1.27 −1.23 −1.19 −1.50 −1.66 −1.60 −1.44 −0.99 −1.25 2 HGG 1 1740474 −1.35 −1.62 to −1.03 −1.03 −1.20 −1.15 −1.49 −1.52 −1.62 −1.34 −1.33 −1.46 2 HGG 1 1868536 −1.36 −1.65 to −1.15 −1.15 −1.20 −1.27 −1.33 −1.51 −1.65 −1.51 −1.31 −1.32 2 HGG 1 1876456 −1.33 −1.54 to −1.06 −1.06 −1.25 −1.17 −1.54 −1.47 −1.40 −1.44 −1.19 −1.47 2 HGG 1 1890576 −1.62 −1.83 to −1.40 −1.40 −1.54 −1.60 −1.67 −1.56 −1.74 −1.65 −1.83 −1.64 2 HGG 1 1910401 −1.33 −1.57 to −1.13 −1.35 −1.13 −1.22 −1.38 −1.57 −1.52 −1.39 −1.18 −1.23 2 HGG 1 2042056 −1.66 −2.17 to −0.42 −2.14 −1.81 −1.52 −2.17 −1.94 −1.53 −1.93 −1.44 −0.42 2 HGG 1 2061528 −1.34 −1.58 to −1.07 −1.23 −1.38 −1.24 −1.58 −1.49 −1.31 −1.36 −1.07 −1.39 2 HGG 1 4698018 −1.23 −1.38 to −1.06 −1.23 −1.08 −1.06 −1.32 −1.36 −1.38 −1.15 −1.16 −1.36 2 HGG 1 5047895 −1.62 −1.83 to −1.44 −1.77 −1.44 −1.71 −1.51 −1.72 −1.83 −1.53 −1.44 −1.65 2 HGG 1 5509134 1.85 1.29 to 2.19 1.43 2.13 2.09 2.18 2.10 1.95 2.19 1.29 1.32 3 HGG 1  617587 1.59 1.08 to 2.09 1.66 1.74 1.21 2.09 1.96 1.78 1.67 1.10 1.08 3 HGG 1 1320685 1.68 1.30 to 2.04 1.47 1.48 1.30 1.95 1.90 1.85 2.04 1.44 1.69 3 HGG 1 1457424 2.11 1.73 to 2.53 1.73 2.07 1.89 2.20 2.39 2.53 2.29 1.90 1.99 3 HGG 1 3068809 1.97 1.49 to 2.15 1.49 2.15 1.85 2.06 2.04 2.00 2.11 2.08 1.97 3 HGG 1 2110430 1.61 1.22 to 2.09 1.29 1.51 1.22 2.09 1.97 2.00 1.67 1.23 1.56 3 HGG 1 2511277 1.67 1.26 to 1.89 1.26 1.80 1.57 1.62 1.76 1.66 1.76 1.89 1.69 3 HGG 1 2520894 1.93 1.49 to 2.23 2.00 2.17 1.92 2.23 2.16 1.86 1.93 1.66 1.49 3 HGG 1 2956444 1.57 1.22 to 1.77 1.59 1.58 1.51 1.65 1.77 1.56 1.77 1.49 1.22 3 HGG 1 3792988 1.85 1.48 to 2.17 1.97 2.17 1.87 2.06 2.05 1.84 1.59 1.57 1.48 3 HGG 1 3606046 1.52 1.15 to 1.82 1.47 1.75 1.47 1.65 1.82 1.54 1.53 1.35 1.15 3 HGG 1  459372 1.87 1.77 to 2.03 1.77 1.91 1.83 2.03 1.93 1.79 1.85 1.86 1.84 3 HGG 1  548114 1.73 1.51 to 1.90 1.82 1.90 1.51 1.87 1.79 1.55 1.67 1.79 1.64 3 HGG 1 5501676 1.86 0.36 to 2.55 1.85 2.43 2.02 2.15 2.55 2.36 1.97 1.06 0.36 3 HGG 1 3031022 −1.93 −2.59 to −1.43 −1.43 −2.59 −1.92 −1.78 −2.08 −2.29 −1.62 −1.72 −1.94 4 HGG 1 1596220 −1.69 −1.99 to −1.49 −1.49 −1.50 −1.52 −1.99 −1.85 −1.72 −1.68 −1.61 −1.82 4 HGG 1 4408943 −1.85 −2.36 to −1.47 −1.75 −1.47 −1.78 −1.88 −2.22 −2.36 −1.68 −1.58 −1.90 4 HGG 1  560115 −2.08 −2.78 to −1.54 −2.16 −2.10 −1.95 −2.11 −2.78 −2.12 −1.54 −1.85 −2.08 4 HGG 1 2886955 −1.70 −2.00 to −1.42 −1.42 −1.64 −1.63 −1.84 −2.00 −1.92 −1.68 −1.54 −1.63 4 HGG 1 5541828 −1.76 −2.07 to −1.46 −1.51 −1.68 −1.82 −1.95 −2.07 −2.02 −1.56 −1.46 −1.76 4 HGG 1 2912637 −2.08 −2.37 to −1.73 −1.73 −2.16 −2.08 −2.09 −2.26 −2.28 −1.78 −1.98 −2.37 4 HGG 1 4549259 2.93 2.51 to 3.24 2.69 2.86 2.70 3.14 3.24 3.08 3.19 2.51 3.00 5 HGG 1 2755836 2.78 2.03 to 3.33 2.94 2.90 3.33 3.04 2.91 2.84 2.74 2.03 2.25 5 HGG 1 2818476 2.46 1.91 to 2.82 2.53 2.82 2.58 2.78 2.68 2.30 2.50 1.91 2.00 5 HGG 1 1630990 2.35 1.92 to 2.80 2.23 2.80 2.56 2.41 2.53 2.30 2.39 1.92 1.97 5 HGG 1 4287327 2.26 1.90 to 2.48 2.23 2.24 1.90 2.23 2.48 1.93 2.44 2.42 2.45 5 HGG 1 1299246 0.64 0.09 to 1.65 0.32 0.34 0.75 0.09 0.82 0.96 0.21 0.67 1.65 6 HGG 1 4858420 0.74 0.18 to 1.76 0.37 0.55 0.63 0.27 1.06 1.14 0.18 0.75 1.76 6 HGG 1 2847188 0.26 0.00 to 2.37 2.37 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 6 HGG 1 1513566 0.63 0.18 to 1.36 0.40 0.45 0.75 0.18 0.79 0.76 0.25 0.73 1.36 6 HGG 1 1308729 0.71 0.20 to 1.59 0.40 0.38 0.77 0.20 0.97 1.23 0.24 0.63 1.59 6 HGG 1 2233219 −0.31 −1.63 to 0.00   −0.28 0.00 −1.63 −0.14 −0.42 −0.33 0.00 0.00 0.00 7 HGG 1 3001817 −0.17 −1.98 to 0.25   0.00 −1.98 0.25 0.19 0.00 −0.03 0.00 0.00 0.00 7 HGG 1  531842 −0.26 −2.41 to 0.08   −2.41 0.00 0.00 0.08 0.00 −0.01 0.00 0.00 0.00 7 HGG 1  481402 0.06 −1.44 to 0.47   0.24 −1.44 0.23 0.40 0.47 0.47 0.24 −0.15 0.12 7 HGG 1 2499905 1.24 1.10 to 1.51 1.19 1.51 1.16 1.11 1.39 1.11 1.46 1.10 1.12 0 HGG 2 1988540 1.43 1.02 to 1.80 1.44 1.80 1.25 1.64 1.65 1.61 1.28 1.17 1.02 0 HGG 2 2394990 1.26 0.62 to 1.56 0.62 1.36 1.22 1.34 1.56 1.19 1.19 1.46 1.40 0 HGG 2 1337924 0.79 0.32 to 1.42 0.32 1.42 0.75 0.72 0.82 0.62 0.71 0.99 0.79 0 HGG 2 1407125 1.41 1.20 to 1.56 1.39 1.56 1.32 1.36 1.55 1.31 1.47 1.48 1.20 0 HGG 2 1487428 1.23 0.65 to 1.54 0.65 1.37 1.23 1.28 1.24 1.18 1.25 1.54 1.35 0 HGG 2 2018315 1.62 1.44 to 1.85 1.47 1.85 1.65 1.50 1.77 1.44 1.49 1.77 1.60 0 HGG 2 2021989 1.35 1.01 to 1.70 1.19 1.48 1.27 1.32 1.31 1.01 1.40 1.70 1.48 0 HGG 2  960604 1.28 0.70 to 1.60 1.35 1.52 1.60 1.43 1.32 1.46 0.70 1.05 1.06 0 HGG 2 3206352 1.41 1.14 to 1.65 1.34 1.65 1.39 1.43 1.53 1.39 1.14 1.42 1.44 0 HGG 2 1841901 0.95 0.42 to 1.34 0.42 1.34 0.93 0.79 1.05 0.89 0.97 1.17 0.97 0 HGG 2 1926934 1.24 0.00 to 1.81 1.55 0.00 1.79 1.81 1.67 1.56 1.42 0.00 1.34 0 HGG 2 2226309 1.57 0.00 to 2.35 1.74 2.35 2.05 1.54 1.72 1.69 1.55 0.00 1.44 0 HGG 2 2837006 1.40 1.18 to 1.68 1.39 1.68 1.46 1.41 1.46 1.18 1.43 1.19 1.38 0 HGG 2 1303862 1.69 0.00 to 2.48 1.73 0.00 2.12 2.48 2.32 2.42 1.01 1.99 1.17 1 HGG 2 1316801 2.26 1.89 to 2.68 2.48 2.68 2.38 2.37 2.30 1.97 2.15 1.89 2.15 1 HGG 2 1326255 2.56 1.43 to 3.48 2.28 2.47 2.36 3.05 3.43 3.48 2.43 2.12 1.43 1 HGG 2  626471 1.81 1.56 to 2.09 1.69 1.98 1.88 1.78 1.57 1.56 1.90 1.85 2.09 1 HGG 2  660142 2.89 2.51 to 3.20 2.97 3.20 3.02 2.86 2.84 2.51 2.69 2.88 3.02 1 HGG 2 1961617 2.08 1.64 to 2.53 1.90 2.53 2.35 2.02 2.34 2.00 1.64 2.19 1.76 1 HGG 2 2124056 2.22 2.03 to 2.43 2.19 2.25 2.10 2.43 2.43 2.33 2.16 2.03 2.03 1 HGG 2 2234266 2.28 1.94 to 2.68 2.09 2.68 2.34 2.31 2.58 2.26 1.94 2.18 2.14 1 HGG 2 2544622 2.22 1.54 to 2.59 2.15 2.59 2.32 2.48 2.40 2.45 1.54 2.27 1.78 1 HGG 2 1616048 −0.98 −1.39 to −0.45 −1.09 −1.10 −1.21 −0.96 −1.39 −1.23 −0.45 −0.84 −0.60 2 HGG 2 1753283 −1.28 −1.55 to −1.01 −1.29 −1.12 −1.23 −1.47 −1.55 −1.42 −1.01 −1.28 −1.16 2 HGG 2 2469891 −0.93 −1.33 to −0.46 −0.46 −1.05 −0.86 −0.83 −1.25 −1.33 −0.88 −0.85 −0.89 2 HGG 2 2655279 −1.03 −1.33 to −0.78 −0.78 −1.21 −1.16 −0.92 −1.14 −1.33 −0.85 −0.88 −1.00 2 HGG 2 2703122 −1.41 −1.74 to −1.09 −1.09 −1.58 −1.37 −1.27 −1.72 −1.74 −1.26 −1.31 −1.30 2 HGG 2 2794866 −0.98 −1.40 to −0.50 −0.79 −0.96 −0.97 −0.98 −1.10 −1.40 −0.50 −1.03 −1.05 2 HGG 2 3100048 −0.87 −1.35 to 0.03   −0.78 −1.12 −1.35 −0.12 −1.26 −1.35 0.03 −1.03 −0.87 2 HGG 2 2253868 −1.14 −1.44 to −0.87 −1.01 −1.17 −0.87 −1.15 −1.21 −0.99 −1.13 −1.24 −1.44 2 HGG 2 1988774 −1.22 −1.76 to −0.51 −0.75 −1.71 −1.45 −0.75 −1.69 −1.76 −0.51 −1.20 −1.19 2 HGG 2 1981929 0.24 0.00 to 1.84 0.00 0.00 1.84 0.00 0.00 0.00 0.29 0.00 0.00 3 HGG 2 1986919 0.65 0.00 to 1.43 0.85 0.00 0.00 0.73 1.06 0.84 0.91 0.00 0.43 3 HGG 2 1820882 0.26 0.00 to 1.33 1.33 0.00 0.00 0.00 0.00 0.00 0.99 0.00 0.00 3 HGG 2 3876612 0.26 0.00 to 1.46 0.87 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.46 3 HGG 2 2246915 0.83 0.00 to 1.78 1.40 0.00 0.00 0.00 1.31 1.38 1.78 0.00 1.60 3 HGG 2 2579572 0.20 0.00 to 1.45 0.37 0.00 0.00 0.00 0.00 0.00 1.45 0.00 0.00 3 HGG 2 1816768 0.28 0.00 to 1.85 1.85 0.00 0.00 0.00 0.00 0.00 0.71 0.00 0.00 3 HGG 2 0.00 to 0.00 HGG 2 2828647 −0.14 −1.53 to 0.28   0.28 0.00 0.00 0.00 0.00 0.00 −1.53 0.00 0.00 4 HGG 2 3136307 −0.28 −1.45 to 0.23   0.23 −0.29 −0.25 0.16 −0.18 −0.17 −1.45 −0.18 −0.33 4 HGG 2 2918279 −0.21 −2.04 to 0.15   0.15 0.00 0.00 0.00 0.00 0.00 −2.04 0.00 0.00 4 HGG 2 3714088 −0.20 −2.13 to 0.32   0.32 0.00 0.00 0.00 0.00 0.00 −2.13 0.00 0.00 4 HGG 2 1560380 1.25 1.06 to 1.55 1.06 1.44 1.22 1.18 1.22 1.17 1.55 1.32 1.08 0 HGG 3 1786554 1.20 1.03 to 1.36 1.03 1.36 1.21 1.19 1.18 1.17 1.11 1.33 1.24 0 HGG 3 3974247 1.02 0.83 to 1.39 0.83 1.15 0.93 0.95 0.92 0.93 1.00 1.39 1.12 0 HGG 3 2195427 1.28 0.99 to 1.46 1.25 1.28 1.30 1.45 1.44 1.46 1.36 1.02 0.99 0 HGG 3 2343348 1.47 1.21 to 1.61 1.21 1.61 1.48 1.44 1.59 1.46 1.45 1.47 1.48 0 HGG 3 3158828 1.28 1.01 to 1.62 1.17 1.62 1.31 1.26 1.34 1.22 1.01 1.26 1.33 0 HGG 3 2545486 1.53 0.82 to 1.96 0.82 1.96 1.32 1.39 1.54 1.84 1.23 1.80 1.84 0 HGG 3 2972013 1.28 0.96 to 1.46 0.96 1.46 1.23 1.25 1.28 1.33 1.23 1.38 1.40 0 HGG 3 4508879 0.80 −0.08 to 1.53   0.94 1.53 1.13 0.79 0.99 1.12 0.41 0.32 −0.08 0 HGG 3 4912315 1.21 0.98 to 1.41 1.13 1.41 0.98 1.02 1.18 1.34 1.17 1.39 1.27 0 HGG 3 3495173 1.14 0.90 to 1.34 0.90 1.34 1.14 1.05 1.11 1.14 1.11 1.24 1.29 0 HGG 3 3528232 0.99 0.00 to 1.32 0.74 1.22 1.15 1.20 1.32 1.15 1.08 1.03 0.00 0 HGG 3 5293028 1.13 0.54 to 1.36 0.54 1.28 1.04 1.15 1.21 1.16 1.02 1.35 1.36 0 HGG 3 5322365 1.18 1.02 to 1.34 1.02 1.34 1.13 1.19 1.21 1.14 1.04 1.30 1.22 0 HGG 3 5508135 1.40 1.03 to 1.73 1.23 1.73 1.56 1.67 1.57 1.49 1.06 1.26 1.03 0 HGG 3 5512044 1.41 1.16 to 1.68 1.16 1.68 1.37 1.49 1.47 1.34 1.40 1.46 1.30 0 HGG 3  554654 0.91 0.25 to 1.44 1.01 1.23 0.72 1.44 1.23 1.03 0.68 0.62 0.25 0 HGG 3  621543 1.31 1.03 to 1.45 1.03 1.38 1.17 1.35 1.25 1.39 1.44 1.31 1.45 0 HGG 3  664625 1.06 0.00 to 1.42 1.02 1.42 1.24 1.41 1.31 1.19 0.72 1.27 0.00 0 HGG 3  872017 1.40 1.01 to 1.72 1.01 1.59 1.32 1.32 1.35 1.35 1.39 1.57 1.72 0 HGG 3 5166479 −1.50 −1.92 to −0.89 −1.45 −1.80 −1.69 −1.12 −1.69 −1.92 0.89 −1.38 −1.56 1 HGG 3 3778404 −1.57 −1.89 to −1.00 −1.45 −1.88 −1.70 −1.51 −1.89 −1.85 −1.00 −1.32 −1.51 1 HGG 3 3084204 −1.32 −1.56 to −0.92 −1.19 −1.48 −1.28 −1.40 −1.48 −1.56 −0.92 −1.16 −1.42 1 HGG 3 5399371 −1.10 −1.45 to −0.56 −0.87 −1.31 −1.45 −0.56 −1.33 −1.42 −1.00 −0.65 −1.28 1 HGG 3 5427710 −1.76 −2.12 to −1.37 −1.37 −1.99 −1.70 −1.76 −1.83 −2.12 −1.42 −1.77 −1.91 1 HGG 3 3120209 −1.43 −1.88 to −0.83 −1.88 −1.50 −0.83 −1.88 −1.36 −1.02 −1.31 −1.59 −1.48 1 HGG 3 3135460 −1.02 −1.82 to −0.57 −0.68 −1.04 −1.23 −0.80 −1.27 −1.82 −0.57 −0.71 −1.10 1 HGG 3 3125211 −1.10 −1.37 to −0.89 −0.89 −1.15 −1.07 −1.12 −1.19 −1.37 −1.03 −0.92 −1.18 1 HGG 3 5573549 −1.29 −1.59 to −0.99 −1.03 −1.35 −1.20 −1.36 −1.55 −1.59 −0.99 −1.21 −1.30 1 HGG 3 4289557 −1.65 −2.06 to −1.34 −1.37 −1.82 −1.53 −1.59 −1.78 −1.69 −1.34 −1.68 −2.06 1 HGG 3 1911443 −0.84 −1.37 to −0.40 −0.78 −0.79 −1.25 −0.53 −0.87 −1.37 −0.40 −0.71 −0.90 1 HGG 3 5089438 −0.95 −1.40 to −0.42 −1.09 −1.12 −0.86 −1.14 −1.40 −0.98 −0.42 −0.73 −0.81 1 HGG 3 5102731 1.72 1.48 to 1.97 1.48 1.86 1.73 1.73 1.65 1.75 1.97 1.53 1.82 2 HGG 3 3068978 2.29 1.76 to 2.83 1.76 2.55 2.02 2.83 2.65 2.23 2.13 2.25 2.20 2 HGG 3 5266015 2.01 1.72 to 2.21 1.72 2.15 1.92 2.05 2.02 1.92 2.03 2.11 2.21 2 HGG 3 3074113 1.82 1.54 to 2.03 1.54 2.03 1.83 1.85 1.92 1.74 1.90 1.77 1.82 2 HGG 3 3957354 2.12 1.73 to 2.51 2.08 2.51 2.11 2.21 2.09 2.24 1.73 2.10 1.96 2 HGG 3 4253809 1.77 1.58 to 1.88 1.64 1.88 1.58 1.84 1.83 1.68 1.83 1.82 1.81 2 HGG 3 4402555 1.79 1.47 to 2.02 1.47 1.94 1.76 1.70 1.83 1.79 1.66 1.96 2.02 2 HGG 3 3091342 −0.12 −1.54 to 0.29   0.00 0.00 0.00 0.29 0.00 −1.54 0.22 0.00 0.00 3 HGG 3 4822285 0.32 0.00 to 1.39 0.00 0.14 0.03 0.15 0.10 0.31 0.56 1.39 0.23 3 HGG 3 2532033 0.25 0.00 to 1.60 0.00 0.00 0.00 0.65 0.00 0.00 0.00 0.00 1.60 3 HGG 3  699113 0.86 0.00 to 1.75 0.00 0.00 0.00 1.12 1.07 1.63 1.37 0.83 1.75 3 HGG 3 3980695 0.59 0.00 to 1.77 0.00 0.00 0.28 0.44 0.00 0.73 0.93 1.17 1.77 3 HGG 3 3069190 3.54 3.08 to 3.82 3.08 3.61 3.38 3.67 3.61 3.54 3.62 3.55 3.82 4 HGG 3 3172265 3.67 3.21 to 4.02 3.21 4.02 3.61 3.47 3.70 3.59 3.75 3.98 3.68 4 HGG 3  439415 1.14 0.80 to 1.36 0.80 1.36 1.36 1.18 1.33 1.31 0.99 0.88 1.09 0 HGG 4 1365045 1.61 1.43 to 1.98 1.51 1.98 1.54 1.64 1.59 1.58 1.43 1.56 1.66 0 HGG 4 1370137 2.17 1.54 to 2.53 1.54 2.27 1.84 2.26 2.48 2.53 2.08 2.15 2.36 0 HGG 4 2006043 1.22 1.09 to 1.65 1.12 1.65 1.09 1.27 1.30 1.20 1.14 1.13 1.09 0 HGG 4 3191030 1.59 0.71 to 2.32 1.98 2.32 1.71 1.59 1.94 1.78 1.33 0.96 0.71 0 HGG 4 2007730 1.20 0.95 to 1.80 1.38 1.80 1.17 1.03 0.95 1.02 1.01 1.23 1.22 0 HGG 4 2013251 1.87 1.68 to 2.27 1.68 2.27 1.83 1.74 1.96 1.95 1.68 1.72 1.99 0 HGG 4 2350594 1.11 0.63 to 1.34 0.63 1.34 1.31 1.11 1.00 1.12 1.06 1.15 1.24 0 HGG 4 2278772 2.40 2.07 to 2.91 2.53 2.15 2.07 2.74 2.91 2.59 2.29 2.15 2.19 0 HGG 4 1964758 2.06 1.90 to 2.40 2.05 2.40 2.24 2.00 1.97 1.98 1.90 1.93 2.08 0 HGG 4 1965856 1.20 0.92 to 1.47 1.13 1.12 1.35 1.42 1.47 1.26 1.15 0.94 0.92 0 HGG 4  509839 1.38 1.11 to 1.59 1.17 1.55 1.54 1.30 1.59 1.57 1.25 1.11 1.35 0 HGG 4 3188967 0.04 −1.40 to 0.49   0.00 0.00 −1.40 0.33 0.45 0.46 0.49 0.00 0.00 1 HGG 4 3188631 −0.17 −1.91 to 0.41   0.00 0.00 0.00 −1.91 0.41 0.00 0.00 0.00 0.00 1 HGG 4 2013955 0.22 −0.02 to 1.72   1.72 0.00 0.00 0.17 −0.01 0.00 −0.02 −0.02 0.11 1 HGG 4 2847867 −0.10 −1.78 to 0.51   0.00 0.00 0.00 0.51 0.40 0.00 −1.78 0.00 0.00 1 HGG 4 2756910 −0.21 −1.90 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 −1.90 0.00 0.00 1 HGG 4 2159706 0.23 0.00 to 2.03 2.03 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1 HGG 4 3221109 0.29 0.00 to 1.76 1.76 0.00 0.00 0.17 0.24 0.12 0.25 0.00 0.08 1 HGG 4 3255873 0.03 −1.36 to 0.73   0.00 0.00 0.00 0.40 0.26 0.29 −1.36 0.00 0.73 1 HGG 4 3190654 0.07 −0.42 to 1.69   1.69 0.00 −0.04 −0.07 −0.20 −0.15 −0.42 −0.10 −0.11 1 HGG 4  955538 0.28 0.00 to 1.66 1.66 0.00 0.00 0.21 0.23 0.03 0.31 0.00 0.11 1 HGG 4 3220149 0.53 0.00 to 1.36 0.00 0.00 0.00 1.31 1.36 1.29 0.86 0.00 0.00 2 HGG 4 3016137 0.95 0.37 to 1.79 0.96 0.63 0.37 1.79 1.75 1.61 0.64 0.45 0.37 2 HGG 4 3253556 −0.03 −1.48 to 0.42   −1.48 0.00 0.00 0.32 0.42 0.27 0.24 0.00 0.00 2 HGG 4 2753065 0.78 0.00 to 1.46 0.00 0.00 0.66 0.99 1.16 1.46 0.97 0.83 0.98 2 HGG 4 4002388 0.04 −1.52 to 0.35   −1.52 0.00 0.00 0.29 0.34 0.27 0.35 0.28 0.31 2 HGG 4 4077648 0.95 0.34 to 1.38 0.77 0.88 0.34 1.38 1.02 1.12 1.08 0.83 1.10 2 HGG 4 1323327 0.83 0.00 to 1.37 0.77 0.00 0.48 1.10 1.37 1.21 0.86 0.76 0.93 2 HGG 4 2751922 0.91 0.19 to 1.37 0.19 1.37 1.17 0.92 1.03 1.00 0.80 0.81 0.89 2 HGG 4 1448572 0.82 0.37 to 1.44 0.37 1.44 0.84 0.74 0.76 0.84 0.76 0.83 0.77 2 HGG 4 3390535 0.30 0.00 to 1.33 0.57 1.33 0.81 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG 4 1679683 0.25 −0.38 to 2.11   0.00 2.11 0.00 0.43 −0.38 0.00 0.04 0.00 0.04 3 HGG 4  21957 0.47 0.00 to 1.42 1.39 1.42 1.38 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG 4 2277161 0.42 −0.20 to 1.69   −0.20 1.69 0.27 0.49 0.31 0.27 0.44 0.27 0.23 3 HGG 4 4631069 0.37 0.00 to 2.30 0.00 2.30 0.00 0.13 0.05 0.46 0.15 0.00 0.20 3 HGG 4 2325802 0.76 0.00 to 2.62 2.07 2.62 2.14 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG 4 2427327 0.68 0.00 to 2.37 1.76 2.37 1.97 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG 4 2408333 1.16 0.70 to 1.71 0.71 0.70 0.78 1.51 1.71 1.54 1.35 1.01 1.12 4 HGG 4 2581075 2.55 0.56 to 3.53 0.97 0.90 0.56 3.52 3.53 3.36 3.37 3.43 3.27 4 HGG 4 2267466 1.06 0.00 to 1.45 0.67 0.00 0.76 1.31 1.34 1.28 1.45 1.26 1.43 4 HGG 4 2266959 0.96 0.00 to 1.35 0.68 0.00 0.83 1.27 1.19 1.08 1.35 1.07 1.15 4 HGG 4 2106010 1.21 0.00 to 1.52 0.93 0.00 1.25 1.51 1.51 1.52 1.28 1.38 1.50 4 HGG 4  434751 1.10 0.00 to 1.81 0.00 0.00 0.00 1.81 1.63 1.49 1.58 1.71 1.70 4 HGG 4 1600180 1.06 0.00 to 1.50 0.99 0.00 0.74 1.16 1.27 1.50 1.28 1.26 1.34 4 HGG 4 1857850 −1.86 −2.28 to −1.44 −1.69 −1.93 −1.44 −1.86 −2.28 −2.21 −1.85 −1.69 −1.79 5 HGG 4 2786442 −1.34 −1.56 to −1.05 −1.13 −1.56 −1.25 −1.51 −1.44 −1.49 −1.31 −1.05 −1.33 5 HGG 4 3042227 −1.26 −1.72 to −0.93 −1.00 −1.48 −1.24 −1.31 −1.47 −1.72 −1.09 −0.93 −1.11 5 HGG 4 2055569 −0.88 −1.84 to −0.11 −0.62 −1.24 −1.42 −0.36 −1.12 −1.84 −0.11 −0.43 −0.79 5 HGG 4 1449819 −1.36 −2.39 to −0.56 −0.56 −1.81 −2.28 −0.66 −1.59 −2.39 −0.62 −0.89 −1.48 5 HGG 4 1383138 −0.88 −1.36 to −0.44 −0.77 −1.25 −1.03 −0.53 −1.13 −1.36 −0.44 −0.57 −0.81 5 HGG 4

TABLE 8 mean mean mean mean mean mean DE DE DE DE DE DE mean DE mean DE mean DE Ave t/Beclo t/Beclo t/Beclo t/Beclo t/Beclo t/Beclo t/Beclo t/Beclo t/Beclo DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clone ID t/Beclo Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 1 hr Cluster GEM 1004382 1.10 0.91 to 1.45 1.11 0.91 0.91 1.11 1.45 0.96 1.31 1.13 1.01 0 HGG1 2313349 1.45   1 to 1.86 1.40 1.33 1.23 1.51 1.86 1.57 1.61 1.41 1.17 0 HGG1 1236305 0.89 0.69 to 1.32 0.99 0.76 0.74 1.06 1.32 0.89 0.78 0.69 0.77 0 HGG1 1241484 1.37 1.14 to 1.75 1.44 1.29 1.24 1.14 1.75 1.37 1.60 1.31 1.22 0 HGG1 1268277 1.13 0.78 to 1.41 1.14 0.97 0.94 1.10 1.41 1.33 1.41 1.10 0.78 0 HGG1 1275616 0.94 0.54 to 1.35 0.97 0.85 0.73 1.17 1.35 0.99 0.95 0.94 0.54 0 HGG1 1320685 1.65 1.39 to 2.10 1.59 1.46 1.39 1.72 2.10 1.67 1.87 1.57 1.44 0 HGG1 1342744 1.60 1.15 to 2.03 1.38 1.31 1.15 1.83 2.03 1.72 1.96 1.57 1.44 0 HGG1 136073 0.99 0.00 to 1.70 1.03 0.96 0.72 0.00 1.70 1.07 1.18 1.04 1.17 0 HGG1 139949 1.14 0.00 to 1.82 1.12 1.09 0.73 1.26 1.54 1.03 1.82 1.65 0.00 0 HGG1 143765 1.24 0.94 to 1.67 0.99 1.08 0.94 1.28 1.18 1.39 1.67 1.44 1.13 0 HGG1 3595618 1.41 1.09 to 1.75 1.37 1.29 1.09 1.56 1.69 1.35 1.75 1.44 1.16 0 HGG1 2830240 0.98 0.83 to 1.35 0.99 0.96 0.94 0.84 1.35 1.02 0.94 0.83 0.95 0 HGG1 1459743 1.52 1.13 to 2.12 1.35 1.21 1.13 1.67 2.12 1.82 1.61 1.56 1.20 0 HGG1 1521272 1.19 0.83 to 1.93 1.01 0.89 0.83 1.64 1.93 1.15 1.27 1.09 0.92 0 HGG1 1560906 1.27 0.00 to 1.75 1.32 1.29 1.03 1.47 1.75 1.41 1.64 1.48 0.00 0 HGG1 1573840 0.97 0.55 to 1.41 1.01 0.82 0.55 0.95 1.41 0.95 1.21 0.90 0.90 0 HGG1 3497231 1.19 1.06 to 1.37 1.37 1.18 1.09 1.06 1.28 1.27 1.19 1.13 1.09 0 HGG1 2445967 1.38 1.06 to 1.67 1.34 1.24 1.06 1.46 1.67 1.29 1.67 1.40 1.30 0 HGG1 1609387 1.15 0.84 to 1.58 1.06 0.95 0.84 0.91 1.58 1.26 1.53 1.26 0.93 0 HGG1 1610828 1.17 0.97 to 1.47 1.13 1.04 1.02 1.42 1.47 1.13 1.24 1.14 0.97 0 HGG1 3123530 0.77 0.37 to 1.33 0.61 0.52 0.58 0.75 1.33 0.79 1.03 0.96 0.37 0 HGG1 2459765 1.22 0.86 to 1.67 1.18 0.98 0.86 1.42 1.67 1.23 1.52 1.11 0.98 0 HGG1 2778441 1.39 1.04 to 1.84 1.31 1.15 1.04 1.57 1.84 1.45 1.55 1.46 1.14 0 HGG1 671717 1.22 0.00 to 2.11 1.50 1.23 1.35 0.00 2.11 1.49 1.78 1.48 0.00 0 HGG1 5398701 0.82 0.23 to 1.32 0.94 1.32 1.06 0.98 0.23 0.92 0.46 0.81 0.70 0 HGG1 531505 1.15 0.85 to 1.51 1.12 1.02 1.02 1.31 1.24 1.51 1.28 0.99 0.85 0 HGG1 5275693 1.00 0.61 to 1.60 0.97 0.85 0.79 1.19 1.60 1.12 1.06 0.81 0.61 0 HGG1 5098879 1.12 0.55 to 1.79 0.80 0.55 0.60 1.26 1.71 1.09 1.79 1.34 0.92 0 HGG1 5046235 1.18 0.63 to 1.89 0.90 0.86 0.63 1.56 1.89 1.19 1.42 1.18 1.02 0 HGG1 4978708 1.34 1.08 to 1.56 1.56 1.31 1.19 1.38 1.46 1.45 1.39 1.28 1.08 0 HGG1 435610 0.80 0.00 to 3.25 0.38 0.47 0.25 0.00 0.30 0.18 3.25 1.75 0.60 0 HGG1 2494284 1.12 0.82 to 1.58 0.98 0.87 0.86 1.30 1.58 1.01 1.39 1.31 0.82 0 HGG1 2506425 0.88 0.53 to 1.33 0.87 1.12 0.59 1.06 1.33 0.74 0.75 0.53 0.93 0 HGG1 4286760 1.13 0.65 to 1.50 0.88 1.21 1.14 0.84 0.65 1.08 1.42 1.50 1.49 0 HGG1 4087621 0.89 0.42 to 1.33 1.01 1.33 1.06 1.25 0.42 1.13 0.46 0.80 0.54 0 HGG1 4021009 1.15 0.89 to 1.57 1.09 0.91 0.89 1.29 1.57 1.14 1.34 1.13 0.99 0 HGG1 4018288 0.88 0.57 to 1.41 0.81 0.61 0.57 0.70 1.41 0.81 1.37 0.98 0.70 0 HGG1 3108506 1.06 0.52 to 1.43 0.91 0.79 0.86 1.07 1.34 1.40 1.43 1.20 0.52 0 HGG1 1944123 1.17 0.83 to 1.47 1.01 0.93 0.83 1.34 1.47 1.43 1.39 1.17 0.97 0 HGG1 1956982 1.30 0.93 to 1.56 1.40 1.43 0.93 1.04 1.35 1.20 1.44 1.35 1.56 0 HGG1 400654 1.06 0.81 to 1.36 1.18 1.18 1.02 1.21 1.36 1.00 0.90 0.81 0.85 0 HGG1 3821432 1.40 0.81 to 1.94 1.20 1.11 0.81 1.71 1.94 1.36 1.86 1.40 1.19 0 HGG1 371201 1.26 0.94 to 1.64 1.01 1.04 0.94 1.40 1.64 1.31 1.60 1.34 1.04 0 HGG1 3075994 1.04 0.86 to 1.38 1.03 0.89 0.87 0.96 1.38 1.00 1.32 1.10 0.86 0 HGG1 2516950 1.67 1.41 to 2.16 1.71 1.56 1.42 1.81 2.16 1.70 1.79 1.49 1.41 0 HGG1 3687719 1.46 1.00 to 1.92 1.25 1.17 1.00 1.60 1.71 1.39 1.92 1.59 1.50 0 HGG1 3687607 1.03 0.77 to 1.51 0.99 0.89 0.77 1.11 1.51 1.08 1.18 0.96 0.82 0 HGG1 3606947 0.99 0.61 to 1.52 0.86 0.79 0.61 1.28 1.52 1.03 1.18 0.82 0.79 0 HGG1 2120743 1.55 1.34 to 2.03 1.63 1.41 1.34 1.45 2.03 1.49 1.65 1.52 1.42 0 HGG1 2833342 1.43 1.06 to 1.89 1.38 1.24 1.15 1.66 1.89 1.48 1.70 1.34 1.06 0 HGG1 2756333 1.46 0.92 to 2.07 1.19 0.97 1.10 1.87 2.07 1.68 1.75 1.55 0.92 0 HGG1 2148703 0.98 0.74 to 1.32 0.95 0.95 0.95 1.00 1.32 1.02 0.91 0.74 0.95 0 HGG1 2636759 0.81 0.30 to 1.45 0.54 0.30 0.43 0.76 1.43 0.80 1.45 1.01 0.58 0 HGG1 2311213 1.01 0.58 to 1.54 0.66 0.69 0.58 1.54 1.42 0.88 1.47 1.06 0.83 0 HGG1 3681722 −1.17 −1.35 to −1.02 −1.02 −1.10 −1.09 −1.05 −1.18 −1.26 −1.27 −1.19 −1.35 1 HGG1 3973887 −0.91 −1.37 to −0.50 −0.50 −0.73 −0.65 −1.07 −0.95 −0.82 −1.37 −1.17 −0.93 1 HGG1 41479 −1.08 −1.59 to −0.82 −1.17 −0.82 −1.00 −1.05 −1.59 −1.02 −0.89 −0.99 −1.19 1 HGG1 4246966 −1.04 −1.32 to −0.64 −0.64 −0.84 −0.75 −1.32 −1.21 −0.98 −1.16 −1.32 −1.12 1 HGG1 4297813 −1.09 −1.39 to −0.87 −0.87 −0.88 −0.87 −1.39 −1.31 −1.02 −1.14 −1.20 −1.11 1 HGG1 1614014 −0.92 −1.40 to −0.62 −0.92 −0.77 −0.68 −1.32 −1.40 −0.86 −0.93 −0.74 −0.62 1 HGG1 4698018 −1.21 −1.66 to −0.97 −1.07 −1.04 −1.03 −1.47 −1.66 −1.47 −1.05 −0.97 −1.13 1 HGG1 963331 −1.01 −1.35 to −0.82 −0.82 −0.87 −0.87 −1.22 −1.35 −1.06 −1.12 −0.90 −0.90 1 HGG1 1833362 −1.03 −1.76 to −0.67 −1.12 −0.97 −0.99 −1.06 −1.76 −1.12 −0.72 −0.67 −0.90 1 HGG1 1840426 −1.13 −1.50 to −0.95 −0.95 −1.02 −1.10 −0.95 −1.36 −1.15 −1.08 −1.04 −1.50 1 HGG1 1910401 −1.19 −1.64 to −0.97 −0.98 −0.98 −1.04 −1.47 −1.56 −1.64 −0.97 −1.03 −1.06 1 HGG1 2047730 −1.24 −1.86 to −0.65 −1.28 −1.06 −1.28 −1.36 −1.86 −1.50 −0.83 −0.65 −1.31 1 HGG1 2055814 −1.03 −1.33 to −0.69 −0.99 −0.89 −1.16 −0.99 −1.33 −1.27 −0.69 −0.84 −1.13 1 HGG1 2132606 −1.07 −1.33 to −0.79 −0.80 −0.79 −1.18 −0.80 −1.16 −1.06 −1.21 −1.30 −1.33 1 HGG1 2132607 −1.15 −1.77 to −0.83 −1.04 −0.94 −1.01 −1.35 −1.77 −1.40 −0.96 −0.83 −1.00 1 HGG1 2287724 −1.05 −1.34 to −0.69 −0.71 −0.69 −0.93 −1.05 −1.13 −1.04 −1.34 −1.33 −1.22 1 HGG1 2372040 −1.05 −1.52 to −0.74 −0.95 −0.85 −0.97 −1.23 −1.52 −1.14 −0.74 −0.76 −1.28 1 HGG1 2471835 −1.21 −1.57 to −0.76 −0.85 −0.76 −1.00 −1.26 −1.24 −1.11 −1.57 −1.53 −1.53 1 HGG1 2623304 −1.13 −1.54 to −0.65 −1.22 −1.20 −1.27 −0.94 −1.46 −1.54 −0.65 −0.80 −1.13 1 HGG1 2769888 −1.15 −1.71 to −0.50 −0.50 −0.99 −1.45 −0.96 −1.13 −1.71 −0.63 −1.35 −1.60 1 HGG1 2947188 −1.02 −1.48 to −0.77 −1.01 −0.81 −0.77 −1.35 −1.48 −1.06 −1.03 −0.82 −0.86 1 HGG1 3126622 −1.11 −1.73 to −0.87 −1.26 −0.87 −0.89 −1.13 −1.73 −1.08 −1.01 −0.95 −1.05 1 HGG1 3397390 −1.14 −1.40 to −0.87 −0.87 −1.07 −0.99 −1.40 −1.40 −1.26 −0.97 −1.03 −1.31 1 HGG1 1210839 1.05 0.00 to 1.75 1.34 1.16 1.13 1.08 1.75 1.32 0.00 1.63 0.00 2 HGG1 2061171 0.81 0.00 to 1.69 1.04 0.87 0.86 0.00 1.69 1.44 0.00 1.37 0.00 2 HGG1 2697275 1.21 0.00 to 1.80 1.34 1.10 1.20 1.80 1.63 1.44 0.00 1.26 1.15 2 HGG1 3391835 0.92 0.00 to 2.36 1.51 1.64 1.14 0.00 2.36 1.61 0.00 0.00 0.00 2 HGG1 279898 1.06 0.08 to 1.67 0.40 1.15 1.46 0.08 1.46 1.59 0.10 1.63 1.67 2 HGG1 1995520 0.82 0.00 to 1.44 1.22 0.93 0.79 0.00 1.44 0.94 0.00 1.13 0.92 2 HGG1 4092112 0.97 0.00 to 1.84 0.99 1.03 0.83 0.00 1.84 1.22 0.00 1.75 1.05 2 HGG1 2046717 0.98 0.00 to 1.38 1.13 1.06 0.82 1.17 1.38 1.01 0.00 1.19 1.08 2 HGG1 2403438 1.48 0.00 to 2.26 1.88 1.78 1.76 2.15 2.17 2.26 0.00 1.36 0.00 2 HGG1 4554722 1.00 0.00 to 1.81 0.83 0.71 0.66 1.54 1.81 1.47 0.00 1.35 0.65 2 HGG1 1756875 1.02 0.00 to 2.25 1.32 1.22 1.14 1.65 2.25 1.63 0.00 0.00 0.00 2 HGG1 5501676 1.49 0.00 to 3.22 2.72 2.69 2.07 0.00 3.22 2.72 0.00 0.00 0.00 2 HGG1 5509134 1.80 0.00 to 2.56 2.30 2.19 2.07 2.56 2.38 1.95 0.00 1.43 1.30 2 HGG1 3057272 0.83 0.00 to 1.65 0.79 0.85 0.52 1.65 1.47 1.15 0.00 1.08 0.00 2 HGG1 305751 1.25 0.00 to 2.51 1.22 1.24 1.20 2.51 1.97 1.43 0.00 1.66 0.00 2 HGG1 3068809 1.64 0.00 to 2.43 2.15 1.93 1.91 2.23 2.43 2.18 0.00 1.97 0.00 2 HGG1 2511277 1.49 0.00 to 2.22 1.53 1.51 1.37 1.95 2.22 2.05 0.00 1.73 1.04 2 HGG1 1457424 2.31 1.89 to 2.84 2.07 2.16 1.96 2.69 2.84 2.44 2.51 2.24 1.89 3 HGG1 3606046 1.86 1.28 to 2.44 1.69 1.43 1.28 1.89 2.44 2.06 2.43 1.98 1.49 3 HGG1 4287327 2.43 2.16 to 2.96 2.16 2.30 2.18 2.19 2.68 2.30 2.51 2.96 2.62 3 HGG1 1630990 3.17 2.79 to 3.39 3.32 3.21 2.98 3.38 3.39 3.34 3.24 2.79 2.84 3 HGG1 3792988 2.26 1.68 to 2.92 1.97 1.78 1.68 2.20 2.91 2.43 2.92 2.51 1.97 3 HGG1 2755836 3.71 2.86 to 4.47 3.56 3.34 3.27 4.47 4.42 4.32 3.77 2.86 3.37 3 HGG1 2956444 1.95 1.64 to 2.43 1.92 1.77 1.64 1.98 2.43 2.24 2.02 1.85 1.70 3 HGG1 2110430 1.85 1.37 to 2.40 1.65 1.63 1.37 2.22 2.40 1.75 2.09 1.89 1.63 3 HGG1 2823767 1.75 1.34 to 2.35 1.71 1.69 1.34 1.73 2.35 1.71 1.96 1.75 1.49 3 HGG1 459372 1.96 1.68 to 2.27 2.01 1.93 1.78 2.14 2.27 1.97 1.99 1.85 1.68 3 HGG1 2818476 2.12 0.00 to 4.04 2.86 2.85 2.41 3.79 4.04 3.12 0.00 0.00 0.00 3 HGG1 1684617 1.75 1.35 to 2.48 1.58 1.35 1.43 1.66 2.48 1.89 2.18 1.79 1.40 3 HGG1 548114 1.71 0.00 to 2.25 1.89 1.86 1.73 2.13 2.25 1.99 1.75 1.80 0.00 3 HGG1 4549259 3.18 2.53 to 3.89 2.93 2.76 2.53 3.61 3.89 3.28 3.49 3.09 2.98 3 HGG1 2520894 2.32 1.58 to 3.13 1.96 1.83 1.58 2.50 3.13 2.52 2.79 2.48 2.05 3 HGG1 617587 1.74 0.00 to 2.79 1.62 1.48 1.25 2.59 2.79 1.91 2.00 1.99 0.00 3 HGG1 1596220 −1.64 −2.24 to −1.18 −1.75 −1.49 −1.76 −1.70 −2.24 −1.82 −1.25 −1.18 −1.53 4 HGG1 3001212 −1.51 −2.33 to −1.21 −1.61 −1.25 −1.36 −1.84 −2.33 −1.47 −1.23 −1.21 −1.33 4 HGG1 2506973 −1.56 −2.07 to −1.11 −1.56 −1.42 −1.66 −1.77 −2.07 −1.71 −1.27 −1.11 −1.49 4 HGG1 1740474 −1.48 −1.83 to −1.22 −1.39 −1.33 −1.55 −1.79 −1.83 −1.66 −1.31 −1.28 −1.22 4 HGG1 5291518 −1.49 −1.81 to −1.18 −1.27 −1.39 −1.18 −1.73 −1.81 −1.46 −1.48 −1.49 −1.60 4 HGG1 3679667 −1.34 −1.73 to −1.05 −1.05 −1.15 −1.12 −1.48 −1.73 −1.37 −1.31 −1.40 −1.46 4 HGG1 2061528 −1.42 −1.69 to −1.23 −1.33 −1.34 −1.23 −1.47 −1.61 −1.43 −1.39 −1.30 −1.69 4 HGG1 1868536 −1.36 −1.85 to −0.84 −1.27 −1.19 −1.45 −1.52 −1.83 −1.85 −0.84 −1.08 −1.24 4 HGG1 4408943 −1.55 −2.08 to −0.99 −1.52 −1.32 −1.54 −1.74 −2.08 −1.88 −0.99 −1.22 −1.64 4 HGG1 1441245 −1.50 −2.16 to −0.98 −1.17 −1.13 −0.98 −1.96 −2.16 −1.69 −1.57 −1.43 −1.43 4 HGG1 891072 −1.43 −1.83 to −1.13 −1.36 −1.28 −1.54 −1.38 −1.83 −1.70 −1.21 −1.13 −1.47 4 HGG1 3451645 −0.99 −1.49 to −0.32 −0.82 −0.96 −1.32 −0.90 −1.49 −1.38 −0.32 −0.70 −1.07 5 HGG1 1807155 −0.93 −1.52 to −0.29 −0.63 −0.78 −1.06 −0.94 −1.52 −1.47 −0.29 −0.63 −1.03 5 HGG1 2839946 −0.94 −1.36 to −0.49 −0.86 −1.05 −1.11 −1.01 −1.36 −1.18 −0.51 −0.49 −0.90 5 HGG1 2447829 −0.67 −1.43 to 0.00  −0.59 −0.54 −0.75 −0.79 −0.89 −0.87 0.00 −0.19 −1.43 5 HGG1 4253663 −0.70 −1.45 to −0.36 −0.63 −0.64 −0.64 −0.91 −1.45 −0.84 −0.36 −0.41 −0.43 5 HGG1 3686603 −0.85 −1.45 to −0.44 −0.87 −0.85 −0.88 −0.84 −1.45 −0.94 −0.63 −0.44 −0.78 5 HGG1 1697719 −0.69 −1.63 to 0.00  −0.77 −0.62 −0.67 −0.90 −1.63 −0.88 0.00 0.00 −0.72 5 HGG1 4284270 −0.70 −1.40 to −0.38 −0.55 −0.38 −0.61 −0.73 −1.40 −0.97 −0.46 −0.62 −0.59 5 HGG1 1602328 −0.82 −1.49 to −0.33 −0.43 −0.70 −0.94 −0.88 −1.49 −0.98 −0.33 −0.60 −0.99 5 HGG1 2695371 0.51 0.00 to 1.39 0.87 0.71 0.71 0.00 1.39 0.92 0.00 0.00 0.00 6 HGG1 1723834 0.47 0.00 to 1.56 0.87 0.00 0.85 0.00 1.56 0.96 0.00 0.00 0.00 6 HGG1 2836470 −0.18 −2.17 to 0.23  0.19 0.14 0.00 0.00 0.23 0.00 0.00 0.00 −2.17 6 HGG1 1857044 0.61 0.00 to 1.36 0.71 0.67 0.49 0.82 1.36 0.92 0.00 0.00 0.50 6 HGG1 2358261 0.46 0.00 to 1.47 1.47 0.00 1.21 0.00 0.55 0.93 0.00 0.00 0.00 6 HGG1 1636015 0.11 0.00 to 1.34 0.58 0.49 0.46 1.02 1.34 0.73 0.00 0.00 0.00 6 HGG1 1654437 0.47 0.00 to 1.37 0.72 0.67 0.53 0.00 1.37 0.93 0.00 0.00 0.00 6 HGG1 2886955 −1.76 −2.29 to −1.43 −1.43 −1.43 −1.47 −2.08 −2.29 −2.19 −1.46 −1.55 −1.89 7 HGG1 5541828 −2.06 −2.81 to −1.72 −1.93 −1.73 −1.72 −2.26 −2.81 −2.21 −1.88 −1.79 −2.24 7 HGG1 560115 −1.89 −2.73 to −1.09 −1.70 −2.01 −2.10 −1.73 −2.73 −2.35 −1.09 −1.52 −1.81 7 HGG1 2912637 −2.39 −2.74 to −2.13 −2.50 −2.24 −2.13 −2.74 −2.71 −2.29 −2.46 −2.22 −2.21 7 HGG1 3031022 −1.90 −2.21 to −1.56 −1.73 −1.84 −2.02 −1.95 −2.05 −2.21 −1.56 −1.75 −2.00 7 HGG1 2042056 −1.86 −2.23 to −1.48 −1.48 −1.84 −1.58 −2.13 −2.23 −1.90 −2.04 −1.91 −1.61 7 HGG1 3975209 −1.61 −1.85 to −1.12 −1.70 −1.12 −1.38 −1.85 −1.82 −1.49 −1.85 −1.45 −1.79 8 HGG1 5047895 −1.65 −2.03 to −1.39 −1.39 −1.41 −1.56 −1.59 −1.55 −2.03 −1.78 −1.52 −2.02 8 HGG1 1619292 −1.57 −1.86 to −1.20 −1.20 −1.26 −1.38 −1.76 −1.75 −1.67 −1.55 −1.70 −1.86 8 HGG1 1890576 −1.67 −2.18 to −1.30 −1.30 −1.44 −1.39 −1.79 −1.73 −1.68 −2.18 −1.80 −1.68 8 HGG1 1876456 −1.56 −1.99 to −1.25 −1.36 −1.34 −1.25 −1.73 −1.99 −1.45 −1.77 −1.52 −1.60 8 HGG1 2874010 −0.59 −5.68 to 0.17  0.17 0.00 0.09 0.00 −0.02 0.11 0.00 0.00 −5.68 9 HGG1 2252501 0.28 −0.25 to 2.16  2.16 −0.25 0.04 0.00 0.00 0.00 0.00 0 HGG2 2230608 1.23 1.00 to 1.45 1.29 1.13 1.00 1.26 1.45 1.19 1.25 0 HGG2 1323616 1.09 0.86 to 1.43 1.43 1.20 0.86 1.17 1.03 1.06 0.87 0 HGG2 2667438 0.86 0.00 to 1.36 1.29 1.01 1.04 1.36 0.00 1.30 0.00 0 HGG2 1407125 1.55 1.33 to 1.83 1.83 1.71 1.49 1.52 1.62 1.33 1.35 0 HGG2 1487428 0.90 0.00 to 1.53 1.53 1.41 0.89 1.34 0.00 1.10 0.00 0 HGG2 1547122 0.21 0.00 to 1.46 0.00 0.00 1.46 0.00 0.00 0.00 0.00 0 HGG2 2394990 0.98 0.00 to 1.39 1.39 1.34 1.00 1.28 0.00 1.13 0.73 0 HGG2 2110103 0.36 0.00 to 2.52 2.52 0.00 0.03 0.00 0.00 0.00 0.00 0 HGG2 1709709 1.34 0.99 to 1.62 1.48 1.22 0.99 1.31 1.62 1.45 1.31 0 HGG2 2018315 1.33 0.00 to 1.79 1.70 1.45 1.29 1.56 0.00 1.79 1.49 0 HGG2 1911819 1.32 0.85 to 1.83 1.14 0.93 0.85 1.48 1.83 1.71 1.29 0 HGG2 2021989 1.11 0.00 to 1.58 1.58 1.42 1.19 1.22 0.00 1.28 1.10 0 HGG2 2725369 0.84 0.45 to 1.46 0.67 0.67 0.45 1.06 1.46 0.76 0.78 0 HGG2 2797740 0.32 0.00 to 2.06 2.06 0.00 0.15 0.00 0.00 0.00 0.00 0 HGG2 2837006 1.46 1.24 to 1.81 1.57 1.38 1.25 1.24 1.59 1.39 1.81 0 HGG2 3047143 1.10 0.84 to 1.35 1.25 1.13 0.84 1.11 1.35 1.09 0.91 0 HGG2 757514 1.02 0.77 to 1.34 1.11 0.93 0.78 0.77 1.34 1.05 1.16 0 HGG2 870396 1.10 0.77 to 1.33 1.10 0.93 0.77 1.27 1.19 1.33 1.14 0 HGG2 960604 1.23 0.00 to 1.70 1.55 1.48 1.13 1.40 0.00 1.33 1.70 0 HGG2 2086783 −0.88 −1.36 to −0.64 −0.66 −0.64 −0.92 −1.00 −0.74 −0.83 −1.36 1 HGG2 2294968 −0.73 −1.39 to 0.00  −0.92 −1.00 −1.39 −0.90 0.00 −0.91 0.00 1 HGG2 2453558 −1.22 −1.39 to −0.99 −1.39 −1.17 −1.39 −1.07 −0.99 −1.33 −1.17 1 HGG2 2469891 −1.09 −1.48 to −0.69 −0.69 −0.83 −1.15 −1.14 −1.12 −1.22 −1.48 1 HGG2 2703122 −1.41 −1.63 to −1.26 −1.42 −1.43 −1.63 −1.34 −1.30 −1.48 −1.26 1 HGG2 2287703 −0.99 −1.34 to −0.76 −0.76 −0.82 −1.07 −0.98 −0.89 −1.11 −1.34 1 HGG2 2794866 −1.10 −1.36 to −0.86 −1.31 −1.11 −1.36 −0.86 −1.01 −1.18 −0.89 1 HGG2 1616048 −0.87 −1.39 to 0.00  0.00 −1.35 −1.39 −1.12 0.00 −1.20 −1.03 1 HGG2 1662870 −0.76 −1.38 to 0.00  −1.38 −0.89 −1.13 −0.73 0.00 −0.55 −0.64 1 HGG2 1753283 −1.12 −1.60 to 0.00  −1.60 −1.42 −1.60 −0.99 0.00 −1.24 −1.00 1 HGG2 3100048 −0.81 −1.46 to 0.03  −0.17 −1.11 −1.38 0.03 −0.41 −1.14 −1.46 1 HGG2 3421730 −0.88 −1.38 to −0.39 −0.44 −1.00 −1.38 −0.70 −0.39 −1.23 −0.98 1 HGG2 2285181 −0.88 −1.37 to −0.69 −0.72 −0.69 −1.00 −0.74 −0.72 −0.95 −1.37 1 HGG2 1988774 −1.11 −1.64 to −0.60 −0.61 −1.45 −1.64 −0.60 −0.95 −1.33 −1.22 1 HGG2 2095329 −0.99 −1.48 to −0.36 −0.36 −0.83 −1.03 −1.11 −1.02 −1.09 −1.48 1 HGG2 1988540 1.75 1.39 to 2.09 1.95 1.92 1.54 2.09 1.89 1.39 1.51 2 HGG2 1326255 2.69 1.99 to 3.28 3.10 3.28 1.99 2.98 2.58 2.04 2.85 2 HGG2 2124056 2.47 2.09 to 2.66 2.59 2.57 2.41 2.46 2.66 2.09 2.49 2 HGG2 3206352 1.75 1.30 to 2.02 1.75 1.75 1.30 1.73 2.02 1.84 1.86 2 HGG2 660142 2.50 0.00 to 3.47 2.96 2.68 2.73 2.66 0.00 3.01 3.47 3 HGG2 2234266 2.49 0.00 to 3.35 3.35 2.98 2.78 3.07 0.00 2.79 2.44 3 HGG2 2544622 2.72 0.00 to 3.47 3.47 3.26 2.87 3.26 0.00 3.13 3.06 3 HGG2 1316801 1.96 0.00 to 2.68 2.38 2.14 1.91 2.14 0.00 2.48 2.68 3 HGG2 626471 1.40 0.00 to 2.17 2.07 1.93 1.76 1.85 0.00 2.17 0.00 4 HGG2 1303862 2.01 0.00 to 3.09 3.09 2.96 2.27 2.86 0.00 2.88 0.00 4 HGG2 1961617 1.99 0.00 to 2.92 2.85 2.56 2.66 2.90 0.00 2.92 0.00 4 HGG2 2226309 1.28 0.00 to 3.19 3.19 2.90 2.88 0.00 0.00 0.00 0.00 5 HGG2 1926934 0.97 0.00 to 2.39 2.39 2.14 2.25 0.00 0.00 0.00 0.00 5 HGG2 654246 −0.95 −1.42 to 0.00  −0.90 −1.13 −1.42 −0.81 −1.05 −1.37 0.00 0 HGG3 4070403 −1.00 −1.35 to −0.53 −0.88 −0.93 −1.18 −1.07 −1.08 −1.35 −0.53 0 HGG3 4223734 −0.38 −2.70 to 0.12  −2.70 0.00 −0.10 0.00 0.00 0.12 0.00 0 HGG3 1911443 −0.97 −1.94 to −0.41 −0.44 −1.00 −1.60 −0.69 −0.68 −1.94 −0.41 0 HGG3 3778404 −1.61 −2.05 to −0.72 −1.35 −1.59 −2.04 −1.58 −2.05 −1.97 −0.72 0 HGG3 4289557 −1.91 −2.31 to −1.12 −1.64 −1.99 −2.31 −1.90 −2.11 −2.28 −1.12 0 HGG3 4715924 −1.12 −1.43 to −0.96 −0.96 −0.98 −1.27 −1.09 −1.43 −1.17 −0.97 0 HGG3 4894508 −0.93 −1.50 to −0.20 −0.90 −1.15 −1.50 −0.98 −0.70 −1.11 −0.20 0 HGG3 5089438 −1.03 −1.39 to 0.00  −0.91 −1.39 −1.33 −1.25 −1.11 −1.18 0.00 0 HGG3 2908777 −0.32 −2.54 to 0.28  −2.54 0.00 0.28 0.00 0.00 0.00 0.00 0 HGG3 5091002 −1.13 −1.44 to −0.72 −0.72 −1.13 −1.09 −1.16 −1.44 −1.28 −1.07 0 HGG3 5166479 −1.42 −1.97 to −0.94 −0.94 −1.51 −1.97 −1.21 −1.37 −1.76 −1.16 0 HGG3 5309371 −1.07 −1.49 to −0.78 −0.83 −1.33 −1.15 −0.97 −0.78 −1.49 −0.95 0 HGG3 5427710 −1.99 −2.36 to −1.26 −1.94 −2.20 −2.36 −1.96 −1.93 −2.26 −1.26 0 HGG3 4312603 −0.30 −2.12 to 0.00  −2.12 0.00 0.00 0.00 0.00 0.00 0.00 0 HGG3 3084204 −1.51 −1.92 to −0.89 −1.17 −1.55 −1.68 −1.48 −1.92 −1.89 −0.89 0 HGG3 3090808 −0.89 −1.35 to −0.31 −0.76 −0.71 −1.02 −0.85 −1.35 −1.20 −0.31 0 HGG3 3097624 −1.31 −1.61 to −0.87 −0.87 −1.27 −1.45 −1.37 −1.46 −1.61 −1.14 0 HGG3 3120209 −1.53 −2.06 to −0.99 −1.35 −1.47 −0.99 −1.98 −1.68 −1.19 −2.06 0 HGG3 3125211 −1.16 −1.40 to −0.81 −0.99 −1.01 −1.40 −1.31 −1.30 −1.35 −0.81 0 HGG3 3135460 −1.22 −1.96 to −0.45 −0.84 −0.95 −1.96 −1.08 −1.36 −1.91 −0.45 0 HGG3 5573549 −1.46 −1.70 to −1.12 −1.12 −1.16 −1.49 −1.53 −1.70 −1.66 −1.57 0 HGG3 4298848 −0.19 −1.36 to 0.00  0.00 0.00 −1.36 0.00 0.00 0.00 0.00 0 HGG3 1251065 1.32 1.04 to 1.68 1.23 1.22 1.04 1.40 1.68 1.23 1.43 1 HGG3 3974247 1.40 1.12 to 1.90 1.12 1.37 1.15 1.25 1.90 1.60 1.42 1 HGG3 3495173 1.28 1.10 to 1.49 1.39 1.44 1.25 1.10 1.49 1.15 1.13 1 HGG3 4091186 0.94 0.67 to 1.46 1.02 0.92 0.96 0.68 1.46 0.90 0.67 1 HGG3 3960194 1.00 0.00 to 1.45 1.33 1.23 0.84 1.36 1.45 0.83 0.00 1 HGG3 2871076 1.37 0.99 to 2.10 1.05 1.24 0.99 1.45 2.10 1.64 1.08 1 HGG3 2972013 1.51 1.28 to 1.76 1.34 1.50 1.28 1.53 1.76 1.47 1.66 1 HGG3 3034889 1.37 1.10 to 1.79 1.30 1.27 1.10 1.41 1.79 1.22 1.52 1 HGG3 4215334 1.13 0.75 to 1.51 1.08 1.13 0.75 1.04 1.51 1.24 1.17 1 HGG3 3973687 1.23 1.08 to 1.56 1.12 1.14 1.08 1.26 1.56 1.16 1.28 1 HGG3 5266376 1.17 0.74 to 1.61 1.61 1.07 0.92 1.24 1.56 1.03 0.74 1 HGG3 5293028 1.25 0.98 to 1.42 1.34 1.42 1.06 1.40 1.41 1.13 0.98 1 HGG3 5322365 1.48 1.25 to 1.78 1.51 1.42 1.25 1.46 1.78 1.45 1.48 1 HGG3 4855265 1.00 0.82 to 1.45 0.90 1.00 0.82 0.95 1.45 1.04 0.84 1 HGG3 4863677 1.09 0.79 to 1.59 1.04 0.85 0.79 1.05 1.59 1.10 1.25 1 HGG3 554654 1.20 0.71 to 1.75 1.14 1.21 0.71 1.38 1.75 1.34 0.85 1 HGG3 597555 0.96 0.00 to 1.47 1.08 1.03 0.88 1.18 1.47 1.11 0.00 1 HGG3 615776 1.01 0.59 to 1.45 0.81 0.99 0.59 1.00 1.45 1.21 1.00 1 HGG3 668460 1.23 0.85 to 1.72 1.16 1.02 0.85 1.29 1.72 1.17 1.40 1 HGG3 748477 1.49 1.10 to 2.07 1.54 1.22 1.10 1.48 2.07 1.44 1.55 1 HGG3 4402555 2.23 1.94 to 2.75 1.94 2.19 1.96 2.17 2.75 2.23 2.37 2 HGG3 3158828 1.92 1.62 to 2.58 1.71 1.86 1.62 1.86 2.58 2.08 1.72 2 HGG3 5512044 1.89 1.61 to 2.47 1.61 1.74 1.66 1.79 2.47 2.01 1.93 2 HGG3 5102731 1.59 0.00 to 2.16 1.85 1.95 1.69 1.61 2.16 1.85 0.00 2 HGG3 4253809 2.02 1.76 to 2.31 2.19 2.05 1.83 2.08 2.31 1.93 1.76 2 HGG3 5266015 2.38 2.03 to 2.79 2.27 2.24 2.03 2.29 2.79 2.39 2.64 2 HGG3 1786554 1.58 1.42 to 1.89 1.54 1.61 1.50 1.51 1.89 1.42 1.60 2 HGG3 621543 1.65 0.00 to 2.60 1.73 1.74 1.75 1.66 2.60 2.04 0.00 2 HGG3 4912315 1.85 0.00 to 2.39 2.08 2.39 1.93 2.36 2.00 2.16 0.00 2 HGG3 2343348 1.89 1.54 to 2.37 1.87 1.67 1.54 1.84 2.37 1.85 2.07 2 HGG3 2545486 1.48 0.00 to 1.99 1.32 1.95 1.52 1.92 1.99 1.64 0.00 2 HGG3 517374 0.40 0.00 to 1.48 1.33 0.00 1.48 0.00 0.00 0.00 0.00 3 HGG3 2364257 0.37 0.00 to 2.62 0.00 0.00 2.62 0.00 0.00 0.00 0.00 3 HGG3 3068978 0.65 0.00 to 2.31 2.31 0.00 2.26 0.00 0.00 0.00 0.00 3 HGG3 3528232 0.38 0.00 to 1.36 1.32 0.00 1.36 0.00 0.00 0.00 0.00 3 HGG3 4222957 0.26 −0.15 to 1.76  −0.15 1.76 0.12 0.19 −0.11 0.14 −0.11 3 HGG3 4232507 0.41 0.00 to 1.49 1.36 0.00 1.49 0.00 0.00 0.00 0.00 3 HGG3 4508879 0.47 0.00 to 1.43 0.92 0.00 1.43 0.93 0.00 0.00 0.00 3 HGG3 699113 0.65 0.00 to 2.37 2.21 0.00 2.37 0.00 0.00 0.00 0.00 3 HGG3 1560380 0.43 0.00 to 1.59 1.59 0.00 1.43 0.00 0.00 0.00 0.00 3 HGG3 3915205 1.23 0.00 to 5.29 0.46 0.00 0.00 5.29 0.00 2.89 0.00 4 HGG3 872017 1.30 0.00 to 1.93 1.74 1.93 1.66 1.84 0.00 1.90 0.00 4 HGG3 3074113 1.49 0.00 to 2.22 2.15 2.09 1.78 2.22 0.00 2.16 0.00 4 HGG3 5508135 1.19 0.00 to 1.89 1.61 1.89 1.54 1.74 0.00 1.55 0.00 4 HGG3 3957354 2.35 0.00 to 3.55 3.09 3.46 3.21 3.55 0.00 3.13 0.00 4 HGG3 3172265 3.56 3.32 to 3.84 3.84 3.67 3.41 3.59 3.69 3.40 3.32 5 HGG3 3069190 3.98 3.71 to 4.32 4.00 3.97 3.90 3.95 4.32 3.97 3.71 5 HGG3 2370756 0.58 −0.04 to 3.74  0.13 0.00 −0.04 0.11 0.00 0.12 3.74 6 HGG3 2106010 1.52 1.17 to 1.95 1.62 1.36 1.17 1.65 1.95 1.34 0 HGG4 1365045 1.75 1.43 to 2.08 1.83 1.66 1.43 1.84 2.08 1.62 0 HGG4 409209 1.10 0.82 to 1.37 1.24 1.16 0.82 1.08 1.37 0.93 0 HGG4 4077648 0.99 0.62 to 1.40 1.04 0.89 0.62 1.04 1.40 0.94 0 HGG4 1425150 1.03 0.78 to 1.35 1.05 1.01 0.78 0.96 1.35 1.02 0 HGG4 3522739 1.16 0.00 to 1.56 1.43 0.00 0.96 1.56 1.56 1.46 0 HGG4 1730026 1.20 0.92 to 1.39 1.38 1.14 0.92 1.39 1.35 1.05 0 HGG4 3016137 1.28 0.68 to 1.91 0.93 0.99 0.68 1.68 1.91 1.48 0 HGG4 2669871 1.07 0.75 to 1.35 1.35 1.17 1.14 1.14 0.75 0.87 0 HGG4 1913334 1.51 1.30 to 1.79 1.65 1.30 1.31 1.63 1.79 1.41 0 HGG4 1951845 1.01 0.00 to 1.42 1.42 0.00 1.00 1.24 1.33 1.05 0 HGG4 2619275 1.25 1.06 to 1.46 1.44 1.21 1.06 1.23 1.46 1.08 0 HGG4 2430165 1.04 0.00 to 1.99 0.00 0.00 0.74 1.99 1.91 1.58 0 HGG4 1965856 1.51 1.35 to 1.65 1.62 1.51 1.43 1.49 1.65 1.35 0 HGG4 2006043 1.10 0.91 to 1.38 1.20 1.01 0.91 1.12 1.38 0.95 0 HGG4 2007730 1.21 0.98 to 1.37 1.29 1.09 0.98 1.37 1.37 1.14 0 HGG4 2110482 1.59 1.38 to 1.79 1.79 1.48 1.38 1.61 1.75 1.52 0 HGG4 2408333 1.32 1.08 to 1.53 1.53 1.42 1.16 1.38 1.36 1.08 0 HGG4 2062085 1.22 0.96 to 1.40 1.40 1.27 1.16 1.21 1.32 0.96 0 HGG4 434751 1.59 1.28 to 1.82 1.75 1.57 1.46 1.64 1.82 1.28 0 HGG4 509839 1.62 1.32 to 1.82 1.75 1.53 1.32 1.75 1.82 1.56 0 HGG4 5101167 1.18 0.85 to 1.58 1.20 1.00 0.85 1.58 1.34 1.12 0 HGG4 5690026 1.31 1.01 to 1.60 1.55 1.29 1.01 1.24 1.60 1.15 0 HGG4 2410066 1.01 0.00 to 1.73 1.61 0.00 1.29 1.39 1.73 0.00 1 HGG4 2724032 0.68 0.00 to 4.06 0.00 0.00 4.06 0.00 0.00 0.00 1 HGG4 3149570 0.95 0.00 to 1.70 1.52 0.00 1.06 1.42 1.70 0.00 1 HGG4 1329625 0.35 0.00 to 1.40 1.40 0.00 0.71 0.00 0.00 0.00 1 HGG4 2013251 0.25 0.00 to 1.50 0.00 0.00 1.50 0.00 0.00 0.00 1 HGG4 2267466 1.08 0.00 to 1.71 1.65 0.00 1.53 1.56 1.71 0.00 1 HGG4 2405487 0.98 0.00 to 1.68 1.54 0.00 1.17 1.50 1.68 0.00 1 HGG4 3191030 2.47 2.22 to 2.76 2.59 2.22 2.22 2.63 2.76 2.37 2 HGG4 1964758 2.32 2.11 to 2.57 2.57 2.35 2.12 2.26 2.52 2.11 2 HGG4 2581075 3.52 3.23 to 3.92 3.62 3.45 3.27 3.64 3.92 3.23 2 HGG4 1370137 2.71 2.39 to 2.91 2.91 2.60 2.39 2.83 2.85 2.65 2 HGG4 2278772 2.48 2.03 to 2.71 2.71 2.66 2.66 2.37 2.45 2.03 2 HGG4 2786442 −1.53 −1.92 to −1.24 −1.52 −1.30 −1.24 −1.84 −1.92 −1.38 3 HGG4 1857850 −2.14 −2.95 to −1.53 −2.18 −1.77 −2.08 −2.36 −2.95 −1.53 3 HGG4 3042227 −1.72 −2.03 to −1.41 −1.55 −1.41 −1.74 −1.80 −1.81 −2.03 3 HGG4 1953051 −1.33 −1.59 to −0.95 −1.16 −0.95 −1.29 −1.41 −1.59 −1.59 3 HGG4 1449819 −1.30 −2.37 to −0.40 −0.40 −1.33 −2.15 −0.45 −1.10 −2.37 4 HGG4 1383138 −1.06 −1.43 to −0.74 −0.74 −1.04 −1.10 −0.80 −1.25 −1.43 4 HGG4 2055569 −0.96 −1.57 to −0.45 −0.45 −1.10 −1.43 −0.60 −0.59 −1.57 4 HGG4 1876829 −1.00 −1.35 to −0.68 −0.80 −0.68 −0.98 −1.35 −1.07 −1.14 4 HGG4

TABLE 9 mean mean mean mean mean mean mean mean mean DE DE DE DE DE DE DE DE DE t/MAH t/MAH t/MAH t/MAH t/MAH t/MAH t/MAH t/MAH t/MAH Ave DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clone ID t/MAH Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr Cluster GEM 1944123 1.27 0.00 to 1.59 1.15 1.00 1.25 1.34 1.30 1.59 1.34 1.19 1.24 0 HGG1 1210839 1.29 0.90 to 1.58 1.40 0.90 1.19 1.47 1.31 1.58 1.48 1.18 1.07 0 HGG1 1995520 1.09 0.00 to 1.50 0.00 0.85 1.27 1.23 1.35 1.50 1.37 1.28 0.96 0 HGG1 1268277 1.16 0.86 to 1.51 1.20 0.86 1.30 1.34 1.09 1.51 1.20 0.98 0.98 0 HGG1 1995767 1.00 0.61 to 1.38 0.87 0.61 0.84 0.84 1.11 1.38 1.35 0.84 1.14 0 HGG1 129775 0.97 0.56 to 1.46 0.81 0.56 0.79 0.87 1.08 1.46 1.15 0.86 1.14 0 HGG1 4377432 1.13 0.83 to 1.45 1.07 0.84 1.35 1.19 1.15 1.45 1.23 0.83 1.09 0 HGG1 4289063 1.09 0.83 to 1.43 0.99 0.83 1.11 1.19 1.19 1.43 1.19 1.04 0.87 0 HGG1 4286760 1.08 0.64 to 1.50 1.00 1.50 1.25 1.02 1.15 0.77 0.64 1.47 0.93 0 HGG1 2459765 1.23 0.83 to 1.62 1.20 0.83 1.00 1.09 1.39 1.62 1.46 1.27 1.26 0 HGG1 419492 1.07 0.78 to 1.33 0.86 0.78 0.94 1.07 0.99 1.33 1.22 1.21 1.18 0 HGG1 4089755 1.19 0.82 to 1.57 1.19 0.82 1.22 1.18 1.34 1.22 1.20 1.57 1.02 0 HGG1 139949 1.22 0.83 to 1.70 1.08 0.83 0.91 1.30 1.15 1.50 1.70 1.30 1.17 0 HGG1 371201 1.20 0.78 to 1.60 1.05 0.90 1.06 1.30 1.19 1.60 1.53 0.78 1.36 0 HGG1 3057272 0.99 0.69 to 1.52 0.96 0.69 0.80 0.83 0.97 1.07 1.12 0.91 1.52 0 HGG1 3687607 1.05 0.76 to 1.40 0.94 0.76 0.94 1.02 1.09 1.40 1.34 0.93 1.05 0 HGG1 4021009 1.25 1.02 to 1.59 1.21 1.02 1.32 1.33 1.33 1.59 1.38 1.06 1.05 0 HGG1 2891601 1.04 0.69 to 1.51 1.07 0.82 0.91 0.69 1.02 1.17 1.51 1.05 1.15 0 HGG1 3606947 1.05 0.62 to 1.52 0.92 0.62 0.84 0.85 0.99 1.52 1.46 1.11 1.11 0 HGG1 3566383 1.09 0.92 to 1.38 1.38 0.92 0.92 1.05 1.04 1.19 1.19 1.05 1.07 0 HGG1 1573840 0.90 0.52 to 1.37 0.87 0.52 0.73 0.78 0.99 1.25 1.37 0.76 0.85 0 HGG1 4018288 1.10 0.79 to 1.55 1.15 0.79 1.03 1.16 1.13 1.55 1.37 0.83 0.88 0 HGG1 2830240 1.17 0.73 to 1.51 1.00 0.73 1.24 1.17 1.21 1.51 1.27 1.22 1.17 0 HGG1 1609387 1.22 0.87 to 1.69 1.14 0.87 1.21 1.36 1.27 1.69 1.45 1.05 0.91 0 HGG1 1610828 1.25 1.01 to 1.46 1.20 1.06 1.36 1.41 1.24 1.46 1.33 1.17 1.01 0 HGG1 2636759 0.93 0.51 to 1.49 0.80 0.51 0.94 0.90 1.02 1.49 1.27 0.70 0.76 0 HGG1 400654 1.15 0.79 to 1.35 1.19 0.79 1.24 1.10 1.21 1.28 1.35 0.99 1.21 0 HGG1 2148703 1.14 0.71 to 1.42 1.08 0.71 1.27 1.13 1.15 1.42 1.27 1.08 1.14 0 HGG1 3075994 1.24 0.89 to 1.65 1.31 0.89 1.29 1.42 1.25 1.65 1.35 0.99 1.02 0 HGG1 622565 1.20 1.02 to 1.40 1.26 1.09 1.28 1.40 1.16 1.38 1.15 1.02 1.07 0 HGG1 2173002 0.99 0.75 to 1.36 1.07 0.75 0.88 1.02 0.97 1.36 1.09 0.80 0.93 0 HGG1 5521873 1.19 0.79 to 1.56 1.35 0.79 1.14 1.17 1.17 1.25 1.23 1.56 1.05 0 HGG1 5398701 1.09 0.45 to 1.71 1.27 1.19 1.06 0.72 1.16 0.45 1.00 1.71 1.22 0 HGG1 2311213 1.04 0.56 to 1.37 0.98 0.56 0.82 0.84 1.15 1.19 1.37 1.12 1.36 0 HGG1 5098879 1.10 0.67 to 1.69 1.09 0.67 1.03 1.08 1.12 1.69 1.49 0.85 0.90 0 HGG1 1756875 1.27 0.00 to 1.91 0.00 1.07 1.38 1.39 1.39 1.91 1.83 1.28 1.22 0 HGG1 4978708 1.31 0.99 to 1.50 1.38 0.99 1.37 1.42 1.23 1.49 1.50 1.23 1.18 0 HGG1 494905 0.91 0.36 to 1.37 0.80 0.36 0.84 0.87 1.07 1.37 1.20 0.79 0.85 0 HGG1 4554722 1.13 0.81 to 1.36 1.23 0.81 1.17 1.12 1.15 1.36 1.24 1.00 1.09 0 HGG1 1888260 1.18 0.85 to 1.59 1.21 0.85 1.07 1.22 1.25 1.59 1.43 1.10 0.93 0 HGG1 3770530 −0.89 −1.33 to −0.09 −1.16 −0.62 −0.81 −1.33 −0.80 −1.15 −1.25 −0.09 −0.84 1 HGG1 3715059 −0.66 −1.44 to −0.23 −0.23 −0.52 −1.07 −0.39 −0.52 −1.44 −0.28 −0.38 −1.07 1 HGG1 1284155 −1.10 −1.80 to 0.00  −0.65 −1.05 −1.16 −0.86 −1.08 −1.80 −1.80 −1.47 0.00 1 HGG1 2382190 −0.95 −1.38 to 0.00  −1.13 −0.90 −1.38 −1.03 −1.00 −1.33 −0.79 −0.96 0.00 1 HGG1 2831351 −0.87 −1.45 to −0.47 −0.65 −0.55 −0.74 −0.95 −0.91 −1.45 −1.23 −0.47 −0.84 1 HGG1 2927486 −0.90 −1.67 to −0.56 −0.71 −0.60 −1.05 −0.56 −0.69 −1.67 −0.75 −0.76 −1.34 1 HGG1 2864790 −1.00 −1.51 to −0.77 −0.77 −0.96 −1.01 −0.82 −1.00 −1.51 −1.13 −0.87 −0.96 1 HGG1 1398105 −0.68 −1.33 to −0.28 −0.46 −0.60 −0.71 −0.68 −0.55 −1.33 −0.65 −0.28 −0.82 1 HGG1 2811404 −0.92 −1.39 to −0.68 −0.75 −0.70 −0.73 −0.68 −0.83 −1.39 −1.37 −0.87 −0.95 1 HGG1 3616233 −0.86 −1.37 to −0.60 −0.60 −0.65 −0.91 −0.82 −0.90 −1.37 −0.97 −0.66 −0.82 1 HGG1 3497137 −0.88 −1.34 to −0.03 −1.09 −0.74 −0.80 −1.34 −0.80 −1.11 −1.24 −0.03 −0.78 1 HGG1 3230318 −0.88 −1.48 to −0.56 −0.67 −0.56 −0.91 −0.63 −1.00 −1.48 −0.90 −0.57 −1.19 1 HGG1 2663164 −0.86 −1.52 to −0.59 −0.68 −0.62 −0.79 −0.86 −0.70 −1.52 −0.86 −0.59 −1.15 1 HGG1 3200811 −0.77 −1.33 to 0.00  0.00 −0.65 −0.93 −0.75 −1.08 −1.31 −1.33 −0.83 0.00 1 HGG1 1697719 −0.86 −1.43 to 0.00  −1.04 −0.55 −1.01 −1.01 −0.95 −1.43 −1.43 −0.32 0.00 1 HGG1 5208013 −0.99 −1.65 to −0.58 −0.81 −0.58 −0.98 −0.89 −1.02 −1.65 −1.31 −0.68 −1.03 1 HGG1 4590473 −0.96 −1.43 to −0.57 −1.14 −0.57 −0.75 −1.09 −0.84 −1.23 −1.43 −0.70 −0.86 1 HGG1 2890141 −0.95 −1.60 to −0.33 −0.98 −0.73 −1.04 −0.94 −0.78 −1.60 −0.92 −0.33 −1.19 1 HGG1 508943 −0.93 −1.37 to −0.59 −0.84 −1.02 −0.93 −1.37 −0.70 −1.17 −0.91 −0.79 −0.59 1 HGG1 4535971 −1.00 −1.72 to −0.64 −0.81 −0.64 −0.86 −0.65 −1.05 −1.72 −1.18 −0.83 −1.23 1 HGG1 5004556 −0.93 −1.38 to −0.68 −0.68 −0.73 −0.86 −0.84 −0.98 −1.38 −1.14 −0.74 −1.01 1 HGG1 3068429 −0.86 −1.57 to −0.39 −0.39 −0.64 −0.94 −0.80 −0.71 −1.57 −1.03 −0.87 −0.76 1 HGG1 2132606 −1.00 −1.32 to −0.73 −0.82 −0.98 −1.10 −1.32 −1.02 −1.32 −0.93 −0.73 −0.76 1 HGG1 4423361 −0.90 −1.40 to −0.67 −0.77 −0.78 −0.88 −0.67 −0.95 −1.40 −0.92 −0.78 −0.96 1 HGG1 4413637 −0.91 −1.38 to −0.47 −0.67 −0.84 −0.47 −0.67 −1.14 −1.38 −1.36 −1.01 −0.68 1 HGG1 4284270 −0.96 −1.52 to −0.57 −0.85 −0.68 −0.94 −0.94 −0.98 −1.52 −1.23 −0.57 −0.91 1 HGG1 2176212 −0.74 −1.33 to 0.00  −0.28 −0.82 −0.84 −0.86 −0.85 −1.33 −1.10 −0.57 0.00 1 HGG1 2293496 −0.89 −1.41 to −0.49 −0.86 −0.70 −0.95 −0.75 −0.83 −1.41 −0.83 −0.49 −1.19 1 HGG1 4253663 −0.96 −1.37 to −0.63 −0.80 −0.63 −0.92 −0.79 −1.06 −1.37 −1.36 −0.86 −0.82 1 HGG1 3045790 −0.77 −1.33 to −0.33 −0.76 −0.33 −0.62 −0.62 −0.70 −1.26 −1.33 −0.51 −0.77 1 HGG1 3875135 −0.82 −1.35 to −0.46 −0.65 −0.46 −0.66 −0.56 −0.74 −1.35 −1.07 −0.73 −1.16 1 HGG1 1004382 1.32 1.10 to 1.57 1.35 1.10 1.39 1.52 1.32 1.57 1.36 1.18 1.13 2 HGG1 1241484 1.34 1.01 to 1.76 1.26 1.01 1.34 1.52 1.33 1.76 1.53 1.25 1.04 2 HGG1 2511277 1.43 1.04 to 1.60 1.57 1.04 1.14 1.57 1.47 1.51 1.47 1.49 1.60 2 HGG1 2697275 1.36 1.04 to 1.63 1.45 1.04 1.42 1.51 1.31 1.63 1.39 1.23 1.28 2 HGG1 2756333 1.45 1.07 to 1.98 1.42 1.07 1.49 1.43 1.44 1.98 1.68 1.22 1.32 2 HGG1 1342744 1.56 1.08 to 1.99 1.43 1.08 1.42 1.57 1.64 1.99 1.88 1.55 1.49 2 HGG1 2778441 1.65 1.19 to 2.00 1.65 1.19 1.61 1.63 1.67 2.00 1.74 1.68 1.67 2 HGG1 279898 1.43 0.46 to 2.72 0.71 1.39 1.71 0.46 1.55 2.04 0.88 1.41 2.72 2 HGG1 2833342 1.37 1.10 to 1.62 1.29 1.10 1.34 1.34 1.38 1.62 1.55 1.34 1.39 2 HGG1 1459743 1.63 1.15 to 2.18 1.54 1.15 1.46 1.63 1.62 2.18 2.03 1.53 1.50 2 HGG1 305751 1.54 1.03 to 1.90 1.50 1.23 1.54 1.61 1.54 1.86 1.90 1.03 1.66 2 HGG1 3595618 1.39 1.15 to 1.57 1.35 1.15 1.36 1.40 1.42 1.57 1.49 1.35 1.38 2 HGG1 1521272 1.53 1.09 to 2.04 1.41 1.09 1.54 1.50 1.58 2.04 1.75 1.51 1.34 2 HGG1 1560906 1.80 1.39 to 2.19 1.94 1.42 1.95 2.06 1.80 2.19 1.91 1.39 1.56 2 HGG1 3687719 1.67 1.17 to 2.16 1.77 1.17 1.60 1.58 1.60 2.16 1.95 1.70 1.52 2 HGG1 3821432 1.51 1.07 to 1.93 1.39 1.07 1.39 1.39 1.56 1.93 1.89 1.50 1.43 2 HGG1 4092112 1.60 1.24 to 2.02 1.61 1.24 1.44 1.45 1.74 2.02 1.75 1.52 1.61 2 HGG1 5046235 1.55 1.04 to 2.05 1.60 1.04 1.15 1.46 1.56 2.05 2.05 1.29 1.78 2 HGG1 5397446 1.36 1.02 to 1.57 1.34 1.02 1.48 1.28 1.33 1.55 1.49 1.57 1.22 2 HGG1 671717 1.51 1.15 to 2.02 1.38 1.15 1.60 1.66 1.49 2.02 1.70 1.33 1.24 2 HGG1 1956982 1.62 1.14 to 1.78 1.74 1.63 1.71 1.70 1.55 1.78 1.71 1.58 1.14 2 HGG1 2046717 1.52 1.25 to 1.70 1.56 1.31 1.70 1.25 1.54 1.63 1.67 1.61 1.39 2 HGG1 2070126 1.58 1.19 to 1.86 1.64 1.33 1.60 1.74 1.68 1.86 1.73 1.49 1.19 2 HGG1 2120743 1.47 1.06 to 1.82 1.37 1.06 1.54 1.71 1.73 1.82 1.64 1.23 1.17 2 HGG1 2313349 1.59 1.12 to 1.89 1.51 1.12 1.60 1.65 1.59 1.89 1.70 1.56 1.68 2 HGG1 2403438 1.34 0.86 to 1.75 1.57 1.07 1.64 1.75 1.15 1.59 1.48 0.98 0.86 2 HGG1 2445967 1.61 1.36 to 1.90 1.61 1.39 1.69 1.81 1.61 1.90 1.76 1.41 1.36 2 HGG1 2494284 1.69 1.08 to 2.11 1.95 1.08 1.45 1.56 1.95 2.11 1.96 1.67 1.48 2 HGG1 2506425 1.38 0.99 to 1.72 1.42 0.99 1.54 1.10 1.48 1.61 1.72 1.34 1.27 2 HGG1 1910401 −1.42 −1.80 to −1.18 −1.20 −1.31 −1.47 −1.18 −1.61 −1.80 −1.45 −1.46 −1.35 3 HGG1 5047895 −1.71 −2.37 to −1.27 −1.33 −1.71 −1.60 −1.52 −1.95 −2.37 −1.69 −1.92 −1.27 3 HGG1 2042056 −1.56 −1.84 to −1.26 −1.54 −1.43 −1.55 −1.27 −1.80 −1.55 −1.76 −1.84 −1.26 3 HGG1 2047730 −1.56 −2.22 to −1.00 −1.45 −1.00 −1.50 −1.48 −1.52 −2.22 −2.00 −1.17 −1.67 3 HGG1 1441245 −1.48 −2.14 to −1.13 −1.38 −1.16 −1.29 −1.13 −1.47 −1.91 −2.14 −1.61 −1.21 3 HGG1 3975209 −1.63 −2.19 to −1.24 −1.83 −1.29 −1.58 −1.88 −1.42 −1.91 −2.19 −1.24 −1.36 3 HGG1 3679667 −1.53 −1.83 to −1.26 −1.26 −1.27 −1.56 −1.27 −1.70 −1.83 −1.75 −1.59 −1.51 3 HGG1 4698018 −1.37 −1.83 to −0.98 −1.21 −0.98 −1.36 −1.15 −1.45 −1.66 −1.83 −1.29 −1.43 3 HGG1 1868536 −1.66 −2.06 to −1.40 −1.46 −1.59 −1.82 −1.40 −1.61 −2.06 −1.77 −1.44 −1.77 3 HGG1 1876456 −1.51 −1.93 to −1.09 −1.44 −1.23 −1.49 −1.48 −1.60 −1.89 −1.93 −1.09 −1.44 3 HGG1 1619292 −1.52 −1.70 to −1.31 −1.35 −1.38 −1.60 −1.31 −1.67 −1.70 −1.63 −1.67 −1.37 3 HGG1 891072 −1.52 −2.15 to −1.08 −1.29 −1.24 −1.51 −1.50 −1.55 −2.15 −1.75 −1.08 −1.56 3 HGG1 2623304 −1.46 −1.79 to −1.14 −1.14 −1.40 −1.32 −1.21 −1.52 −1.79 −1.65 −1.57 −1.56 3 HGG1 1890576 −1.54 −1.98 to −0.92 −1.26 −1.94 −1.76 −1.43 −1.98 −1.65 −1.39 −1.51 −0.92 3 HGG1 2061528 −1.63 −2.10 to −1.41 −1.57 −1.43 −1.53 −1.41 −1.73 −2.02 −2.10 −1.41 −1.46 3 HGG1 3408804 −1.49 −2.16 to −0.93 −1.19 −1.27 −1.39 −0.93 −1.59 −1.66 −1.70 −2.16 −1.54 3 HGG1 2132607 −1.53 −2.12 to −1.10 −1.20 −1.10 −1.46 −1.37 −1.71 −2.12 −2.12 −1.26 −1.40 3 HGG1 5291518 −1.45 −1.72 to −1.10 −1.20 −1.20 −1.35 −1.10 −1.62 −1.70 −1.68 −1.72 −1.47 3 HGG1 1740474 −1.56 −1.82 to −1.36 −1.57 −1.36 −1.63 −1.46 −1.80 −1.82 −1.60 −1.36 −1.44 3 HGG1 3001212 −1.67 −2.20 to −1.14 −1.69 −1.31 −1.55 −1.90 −1.58 −2.20 −2.08 −1.14 −1.55 3 HGG1 2880819 −1.08 −1.62 to −0.57 −1.11 −0.57 −1.16 −0.98 −1.09 −1.55 −1.62 −0.67 −1.00 4 HGG1 2507552 −1.06 −1.45 to −0.69 −0.94 −0.95 −1.06 −1.02 −1.15 −1.45 −1.40 −0.69 −0.94 4 HGG1 3681722 −1.11 −1.39 to −0.56 −1.04 −1.28 −1.27 −1.35 −1.39 −1.39 −0.98 −0.56 −0.74 4 HGG1 96752 −1.08 −1.44 to −0.44 −1.23 −0.66 −1.14 −1.33 −0.93 −1.27 −1.44 −0.44 −1.30 4 HGG1 963331 −1.03 −1.32 to −0.59 −0.94 −1.00 −1.07 −1.20 −1.14 −1.32 −1.11 −0.59 −0.88 4 HGG1 1652328 −1.19 −1.86 to −0.69 −1.12 −0.78 −1.07 −1.30 −1.02 −1.86 −1.42 −0.69 −1.41 4 HGG1 3686603 −1.10 −1.67 to −0.53 −1.14 −0.72 −0.90 −1.19 −1.12 −1.67 −1.53 −0.53 −1.08 4 HGG1 2055814 −1.19 −1.57 to −0.80 −1.26 −1.15 −1.18 −1.26 −1.30 −1.57 −0.93 −0.80 −1.31 4 HGG1 2947188 −1.09 −1.55 to −0.66 −1.18 −0.78 −0.96 −1.18 −1.11 −1.35 −1.55 −0.66 −1.05 4 HGG1 2780013 −1.09 −1.46 to −0.88 −0.89 −0.88 −1.13 −1.07 −1.11 −1.41 −1.46 −0.89 −0.94 4 HGG1 1833362 −1.31 −1.98 to −0.86 −1.21 −0.86 −1.17 −1.22 −1.30 −1.98 −1.82 −0.94 −1.30 4 HGG1 4884214 −1.09 −1.57 to −0.53 −1.21 −0.59 −1.02 −1.32 −0.96 −1.31 −1.57 −0.53 −1.34 4 HGG1 3721985 −1.05 −1.59 to −0.47 −0.88 −0.94 −1.00 −1.12 −1.04 −1.59 −1.32 −0.47 −1.12 4 HGG1 41479 −1.28 −1.75 to −0.93 −1.37 −1.07 −1.15 −1.61 −1.17 −1.75 −1.29 −0.93 −1.20 4 HGG1 1840426 −1.28 −1.73 to −0.33 −1.43 −1.21 −1.46 −1.34 −1.44 −1.73 −1.19 −0.33 −1.38 4 HGG1 3126622 −1.15 −1.57 to −0.64 −1.20 −1.13 −1.00 −1.40 −1.08 −1.57 −1.35 −0.64 −0.99 4 HGG1 2078880 −1.14 −1.57 to −0.67 −1.25 −1.09 −1.33 −1.04 −1.26 −1.57 −0.97 −0.67 −1.10 4 HGG1 2372040 −1.21 −1.67 to −0.94 −1.12 −0.94 −1.12 −0.94 −1.29 −1.58 −1.67 −1.22 −0.98 4 HGG1 3890145 −1.09 −1.53 to −0.81 −1.08 −0.90 −1.00 −0.81 −0.96 −1.10 −1.21 −1.53 −1.22 5 HGG1 2055867 −1.01 −1.66 to −0.17 −0.38 −1.38 −1.23 −0.35 −1.66 −1.66 −0.17 −0.85 −1.37 5 HGG1 4886605 −1.13 −1.39 to −0.84 −0.84 −1.06 −1.19 −0.92 −1.37 −1.39 −1.19 −1.16 −1.08 5 HGG1 5045593 −1.03 −1.43 to −0.65 −0.69 −1.02 −1.13 −0.65 −1.24 −1.43 −0.73 −1.33 −1.08 5 HGG1 1807155 −1.13 −1.72 to −0.70 −0.87 −0.98 −1.10 −0.70 −1.36 −1.72 −0.95 −1.04 −1.49 5 HGG1 1501410 −1.03 −1.35 to −0.71 −0.75 −0.98 −1.09 −0.71 −1.17 −1.35 −0.92 −1.17 −1.17 5 HGO1 1700287 −1.11 −1.37 to −0.74 −0.74 −1.08 −1.10 −0.82 −1.23 −1.37 −1.05 −1.36 −1.21 5 HGG1 167081 −1.00 −1.61 to −0.53 −0.98 −1.61 −1.08 −1.04 −1.42 −0.81 −0.53 −0.84 −0.72 5 HGG1 2930673 −1.09 −1.76 to −0.65 −0.65 −0.92 −0.95 −0.92 −1.08 −1.76 −1.35 −1.20 −0.99 5 HGG1 2769888 −1.22 −1.62 to −0.56 −0.78 −1.28 −1.48 −0.69 −1.41 −1.62 −0.56 −1.61 −1.59 5 HGG1 2839946 −1.19 −1.68 to −0.85 −0.85 −1.09 −1.36 −1.22 −1.44 −1.68 −0.89 −1.36 −0.86 5 HGG1 3141607 −1.00 −1.46 to −0.74 −0.85 −1.00 −1.13 −0.74 −1.10 −1.46 −0.87 −0.89 −0.96 5 HGG1 3334476 −0.99 −1.39 to −0.77 −0.95 −0.90 −0.94 −0.80 −1.09 −1.39 −0.77 −0.85 −1.22 5 HGG1 3397390 −1.20 −1.62 to −0.66 −0.97 −1.32 −1.29 −0.98 −1.50 −1.62 −0.66 −1.13 −1.34 5 HGG1 3451645 −1.21 −1.76 to −0.93 −1.02 −0.93 −1.21 −1.06 −1.28 −1.76 −1.07 −1.05 −1.54 5 HGG1 2619954 −1.05 −1.57 to −0.70 −0.74 −0.70 −0.95 −0.70 −1.16 −1.57 −1.35 −1.21 −1.05 5 HGG1 2495131 −1.13 −1.60 to −0.55 −1.09 −1.60 −1.40 −1.09 −1.60 −1.16 −0.81 −0.83 −0.55 5 HGG1 2520894 2.40 1.78 to 2.94 2.40 1.78 2.31 2.26 2.46 2.92 2.94 2.34 2.21 6 HGG1 3391835 2.10 1.58 to 2.78 2.16 1.58 1.82 1.72 2.49 2.40 2.78 1.67 2.27 6 HGG1 1320685 2.02 1.59 to 2.47 1.94 1.59 1.86 1.98 2.12 2.47 2.20 1.99 2.01 6 HGG1 2823767 2.15 1.74 to 2.50 2.14 1.74 2.12 2.16 2.18 2.50 2.48 2.05 2.02 6 HGG1 1457424 2.53 2.15 to 2.94 2.31 2.15 2.63 2.66 2.73 2.94 2.62 2.41 2.34 6 HGG1 5509134 2.02 1.81 to 2.28 2.08 1.81 2.28 2.18 2.08 1.97 1.96 1.93 1.88 6 HGG1 548114 1.91 1.53 to 2.16 2.12 1.53 1.72 1.74 1.96 2.06 2.16 2.14 1.72 6 HGG1 3792988 2.25 1.73 to 2.86 2.17 1.73 2.18 2.32 2.29 2.86 2.62 2.03 2.04 6 HGG1 459372 2.07 1.69 to 2.25 2.06 1.83 2.21 2.19 2.24 2.20 2.25 1.69 1.94 6 HGG1 2110430 2.38 1.96 to 3.02 2.22 1.96 2.31 2.40 2.42 3.02 2.63 2.25 2.18 6 HGG1 2956444 2.04 1.62 to 2.46 1.88 1.62 1.99 2.04 2.07 2.46 2.26 2.13 1.89 6 HGG1 1684617 1.88 1.39 to 2.38 1.87 1.39 1.92 2.01 2.00 2.38 2.14 1.59 1.65 6 HGG1 3068809 2.01 1.69 to 2.27 2.07 1.69 2.04 2.12 2.00 2.27 2.14 1.89 1.88 6 HGG1 4287327 2.29 1.91 to 2.83 1.91 1.93 2.07 1.98 2.30 2.75 2.30 2.83 2.56 6 HGG1 2516950 1.86 1.60 to 2.19 1.81 1.60 1.96 2.00 1.90 2.19 1.96 1.67 1.70 6 HGG1 3606046 1.85 1.37 to 2.42 1.65 1.37 1.82 1.86 1.95 2.42 2.27 1.66 1.63 6 HGG1 617587 2.41 1.72 to 2.96 2.44 1.72 2.21 2.19 2.50 2.96 2.88 2.51 2.31 6 HGG1 1299246 0.75 −0.03 to 1.47  0.29 0.59 0.95 −0.03 0.97 1.22 0.47 0.84 1.47 7 HGG1 1308729 0.81 0.04 to 1.58 0.33 0.66 0.94 0.04 0.95 1.28 0.60 0.92 1.58 7 HGG1 2959255 0.21 −0.25 to 1.33  0.04 0.08 0.02 −0.25 0.25 −0.11 0.28 1.33 0.29 7 HGG1 1513566 0.77 0.19 to 1.35 0.43 0.59 0.82 0.19 0.98 1.18 0.53 0.84 1.35 7 HGG1 2358261 0.49 0.00 to 1.63 0.00 1.27 1.63 0.00 0.00 0.00 0.90 0.64 0.00 7 HGG1 2956869 0.91 0.50 to 1.50 0.97 0.80 0.82 0.61 0.98 0.50 1.00 1.50 1.02 7 HGG1 4087621 1.01 0.29 to 1.78 1.18 1.03 0.89 0.63 1.20 0.29 0.89 1.78 1.15 7 HGG1 898741 0.47 0.00 to 1.39 0.00 0.56 0.43 0.61 0.58 0.01 0.65 1.39 0.00 7 HGG1 2051568 0.50 −0.12 to 1.59  0.48 0.49 0.39 −0.06 0.46 −0.12 0.50 1.59 0.78 7 HGG1 2675433 0.59 0.29 to 1.33 0.36 0.51 0.48 0.29 0.77 0.48 0.57 1.33 0.47 7 HGG1 2742315 0.30 0.00 to 1.39 0.00 0.69 0.63 0.00 0.00 0.00 0.00 1.39 0.00 7 HGG1 4858420 0.61 −0.15 to 1.36  0.25 0.41 0.66 −0.15 0.69 1.05 0.48 0.71 1.36 7 HGG1 5038177 0.77 0.11 to 1.38 0.36 0.60 0.84 0.11 0.95 1.20 0.59 0.90 1.38 7 HGG1 2908212 0.46 0.00 to 1.53 0.00 1.17 1.46 0.00 0.00 0.00 0.00 1.53 0.00 7 HGG1 136073 1.04 0.00 to 1.66 0.90 0.81 0.92 1.08 1.35 1.66 1.50 1.11 0.00 8 HGG1 1604437 1.18 0.00 to 2.00 1.52 0.78 1.16 1.18 1.40 1.65 2.00 0.96 0.00 8 HGG1 1723834 0.72 0.00 to 1.65 0.00 0.82 1.57 0.00 0.00 1.65 1.32 1.12 0.00 8 HGG1 2061171 1.17 0.00 to 1.76 1.27 0.96 1.32 1.36 1.34 1.76 1.39 1.12 0.00 8 HGG1 301206 0.67 0.00 to 1.37 0.00 0.73 1.26 0.00 0.00 1.29 1.35 1.37 0.00 8 HGG1 1857044 0.96 0.00 to 1.51 0.91 0.68 1.11 1.10 1.19 1.51 1.30 0.81 0.00 8 HGG1 2695371 0.70 0.00 to 1.56 0.00 0.70 1.11 0.94 0.00 1.56 1.25 0.74 0.00 8 HGG1 1824860 0.77 0.00 to 1.37 0.00 0.46 0.92 0.78 1.01 1.37 1.19 1.17 0.00 8 HGG1 4630674 0.87 0.00 to 1.55 0.00 1.14 1.55 1.41 1.39 1.31 0.00 1.03 0.00 8 HGG1 531505 1.07 0.00 to 1.37 1.21 1.00 1.23 1.37 1.17 1.33 1.11 1.24 0.00 8 HGG1 4408943 −1.93 −2.56 to −1.57 −1.72 −1.57 −1.79 −1.60 −2.01 −2.56 −2.30 −1.99 −1.80 9 HGG1 2886955 −2.01 −2.50 to −1.60 −2.11 −1.60 −2.15 −1.66 −2.17 −2.26 −2.50 −1.83 −1.85 9 HGG1 2506973 −1.86 −2.28 to −1.43 −1.84 −1.43 −1.91 −1.73 −1.89 −2.28 −2.07 −1.65 −1.89 9 HGG1 3031022 −1.97 −2.37 to −1.78 −1.82 −1.80 −2.19 −1.85 −2.07 −2.37 −1.78 −1.79 −2.11 9 HGG1 2912637 −2.30 −2.54 to −2.00 −2.37 −2.23 −2.30 −2.54 −2.47 −2.28 −2.44 −2.08 −2.00 9 HGG1 1596220 −1.95 −2.49 to −1.40 −1.91 −1.40 −1.82 −1.75 −1.92 −2.47 −2.49 −1.94 −1.89 9 HGG1 5541828 −2.26 −3.04 to −1.53 −2.15 −1.53 −2.05 −1.96 −2.23 −3.04 −2.98 −2.05 −2.38 9 HGG1 560115 −2.07 −2.46 to −1.84 −1.84 −2.11 −2.24 −1.88 −2.37 −2.46 −1.87 −1.87 −1.97 9 HGG1 2818476 3.29 2.79 to 3.80 3.05 2.79 3.41 2.82 3.32 3.77 3.80 3.26 3.36 10 HGG1 1630990 3.00 2.56 to 3.39 2.90 2.56 3.19 2.95 3.16 3.25 3.39 2.82 2.83 10 HGG1 2755836 3.57 3.17 to 4.02 3.43 3.17 3.92 3.25 3.68 3.89 4.02 3.43 3.31 10 HGG1 5501676 2.89 2.33 to 3.49 2.53 2.46 3.33 2.56 2.92 3.49 3.43 2.92 2.33 10 HGG1 4549259 3.30 2.73 to 3.86 3.12 2.73 3.29 3.04 3.38 3.86 3.81 3.35 3.14 10 HGG1 0.00 to 0.00 HGG1 1740975 −0.04 −1.53 to 0.37  −1.53 0.21 0.26 0.36 0.00 0.00 0.00 0.37 0.00 11 HGG1 2313581 −0.20 −1.99 to 0.26  −1.99 −0.06 0.26 0.00 0.00 0.00 0.00 0.00 0.00 11 HGG1 1209413 −0.15 −1.60 to 0.60  0.00 0.38 −1.60 0.00 0.00 0.00 0.00 0.60 0.00 0 HGG2 641039 0.29 0.00 to 1.69 0.00 1.69 0.00 0.00 0.00 0.00 0.00 0.97 0.00 0 HGG2 686993 0.36 0.00 to 1.42 0.00 0.81 0.00 0.00 0.00 1.42 0.00 1.02 0.00 0 HGG2 2246915 0.29 0.00 to 1.35 0.00 1.22 0.00 0.00 0.00 0.00 0.00 1.35 0.00 0 HGG2 916103 0.26 0.00 to 1.59 0.00 0.36 0.00 0.00 0.00 0.00 1.59 0.43 0.00 0 HGG2 1998317 −0.15 −1.44 to 0.50  0.00 −0.43 −1.44 0.00 0.00 0.00 0.00 0.50 0.00 0 HGG2 2260285 −0.18 −1.54 to 0.35  0.00 −0.44 −1.54 0.00 0.00 0.00 0.00 0.35 0.00 0 HGG2 2291665 −0.17 −1.38 to 0.20  0.00 −0.34 −1.38 0.00 0.00 0.00 0.00 0.20 0.00 0 HGG2 2302785 −0.19 −1.43 to 0.27  0.00 −0.56 −1.43 0.00 0.00 0.00 0.00 0.27 0.00 0 HGG2 2302810 0.34 −0.05 to 2.62  0.00 −0.05 0.00 0.00 0.00 0.00 0.00 0.48 2.62 0 HGG2 1741288 0.12 −0.44 to 1.72  0.00 −0.41 −0.44 0.04 0.03 −0.04 1.72 0.02 0.19 0 HGG2 2383242 −0.15 −1.58 to 0.43  0.00 −0.23 −1.58 0.00 0.00 0.00 0.00 0.43 0.00 0 HGG2 1909281 0.18 −0.31 to 1.55  0.00 −0.31 0.00 0.00 0.00 0.00 1.55 0.40 0.00 0 HGG2 2395112 0.20 −0.05 to 1.82  0.00 −0.05 0.00 0.00 1.82 0.00 0.00 0.02 0.00 0 HGG2 2761527 0.35 0.00 to 2.16 0.00 0.31 0.00 0.00 0.00 0.00 2.16 0.67 0.00 0 HGG2 1930088 −0.16 −1.47 to 0.11  0.00 −0.06 −1.47 0.00 0.00 0.00 0.00 0.11 0.00 0 HGG2 3035780 −0.30 −3.26 to 0.43  0.00 0.43 −3.26 0.00 0.00 0.00 0.00 0.17 0.00 0 HGG2 2409976 1.19 0.82 to 1.41 1.30 0.82 1.28 1.39 1.07 1.41 0.99 1.22 1.20 1 HGG2 2838627 1.08 0.71 to 1.35 1.01 0.71 1.12 1.30 1.35 1.25 0.86 0.98 1.09 1 HGG2 3047143 1.08 0.57 to 1.35 1.13 0.57 1.12 1.26 1.13 1.24 1.35 0.90 1.06 1 HGG2 2725369 1.20 0.83 to 1.63 1.52 0.83 1.08 1.41 1.42 1.63 0.99 1.08 0.85 1 HGG2 2173973 1.04 0.70 to 1.38 0.97 0.70 1.09 1.17 0.95 1.20 0.94 0.92 1.38 1 HGG2 2499418 0.84 0.39 to 1.37 0.77 0.39 0.85 1.00 0.72 0.97 1.37 0.61 0.91 1 HGG2 755223 1.21 0.86 to 1.63 1.20 0.86 1.14 1.23 1.14 1.41 1.63 1.18 1.09 1 HGG2 757514 1.03 0.54 to 2.33 0.90 0.54 0.83 1.01 0.85 1.21 2.33 0.78 0.88 1 HGG2 859218 0.96 0.40 to 1.61 0.90 0.40 0.88 1.06 1.11 1.15 1.61 0.70 0.86 1 HGG2 870396 1.12 0.95 to 1.34 1.13 0.95 1.20 1.29 1.09 1.13 0.98 0.98 1.34 1 HGG2 2499905 1.11 0.50 to 1.45 1.28 0.95 1.14 1.14 1.21 1.16 0.50 1.11 1.45 1 HGG2 2021989 1.31 0.94 to 1.58 1.42 0.94 1.20 1.25 1.28 1.45 1.58 1.43 1.25 1 HGG2 2025128 0.93 0.30 to 1.39 0.98 0.30 0.83 1.05 1.02 1.11 1.39 0.72 1.00 1 HGG2 1926934 1.28 0.00 to 2.42 0.00 1.58 1.95 0.00 1.85 2.06 0.00 1.66 2.42 2 HGG2 2394990 1.18 0.00 to 1.49 1.35 0.98 1.37 1.28 1.36 1.35 0.00 1.44 1.49 2 HGG2 1487428 1.02 0.00 to 1.49 0.00 1.04 1.38 1.37 1.09 1.33 0.00 1.49 1.45 2 HGG2 1515346 1.15 0.00 to 1.53 1.29 0.90 1.22 1.46 1.38 1.43 0.00 1.15 1.53 2 HGG2 1670407 0.93 0.00 to 1.39 0.00 0.90 1.39 1.35 1.13 1.25 0.00 1.13 1.23 2 HGG2 1986919 0.84 0.00 to 1.55 0.00 0.96 0.98 0.94 1.15 1.03 0.00 1.55 0.98 2 HGG2 2018315 1.41 0.00 to 1.80 1.60 1.06 1.49 1.80 1.70 1.80 0.00 1.49 1.76 2 HGG2 2226309 0.85 0.00 to 2.32 0.00 1.59 2.03 0.00 0.00 0.00 0.00 1.74 2.32 2 HGG2 2057513 0.92 0.00 to 1.39 0.75 0.66 1.15 1.17 1.19 1.39 0.00 1.02 0.98 2 HGG2 869702 0.88 0.00 to 1.48 0.00 0.67 1.10 1.27 1.18 1.16 0.00 1.06 1.48 2 HGG2 3426776 0.81 0.00 to 1.39 0.00 0.53 0.95 1.23 1.29 1.39 0.00 0.88 1.05 2 HGG2 619447 0.81 0.00 to 1.35 0.00 0.59 0.92 1.21 1.13 1.35 0.00 1.01 1.06 2 HGG2 2253868 −0.99 −1.38 to −0.58 −1.13 −0.92 −0.86 −1.16 −1.00 −1.17 −1.38 −0.58 −0.66 3 HGG2 24698991 −0.92 −1.34 to −0.52 −0.90 −1.02 −1.34 −1.20 −1.06 −1.01 −0.65 −0.57 −0.52 3 HGG2 2453558 −1.23 −1.48 to −1.01 −1.36 −1.35 −1.28 −1.13 −1.01 −1.11 −1.48 −1.15 −1.20 3 HGG2 2794866 −1.32 −1.94 to −0.97 −1.28 −0.97 −1.43 −1.34 −1.21 −1.45 −1.94 −0.97 −1.32 3 HGG2 1401312 −1.06 −1.49 to −0.82 −1.09 −0.89 −1.01 −1.22 −0.92 −1.49 −1.25 −0.82 −0.87 3 HGG2 2188005 −0.83 −1.40 to −0.62 −0.75 −0.79 −0.75 −0.62 −0.88 −0.74 −1.40 −0.75 −0.74 3 HGG2 1753283 −1.46 −1.66 to −1.01 −1.66 −1.43 −1.56 −1.49 −1.51 −1.52 −1.56 −1.01 −1.39 3 HGG2 3115505 −0.94 −1.44 to −0.53 −0.83 −1.10 −0.95 −1.00 −0.98 −0.81 −1.44 −0.85 −0.53 3 HGG2 2703122 −1.44 −1.63 to −1.24 −1.63 −1.45 −1.50 −1.42 −1.51 −1.57 −1.37 −1.24 −1.32 3 HGG2 2230608 1.34 0.93 to 1.93 1.21 0.93 1.28 1.44 1.50 1.43 1.93 1.08 1.24 4 HGG2 2837006 1.52 1.13 to 2.04 1.46 1.13 1.56 1.65 1.44 1.67 2.04 1.20 1.56 4 HGG2 1407125 1.61 1.15 to 1.88 1.75 1.15 1.61 1.59 1.64 1.66 1.70 1.88 1.47 4 HGG2 1709709 1.40 0.97 to 1.85 1.32 0.97 1.37 1.60 1.37 1.57 1.85 1.21 1.32 4 HGG2 3206352 1.84 1.41 to 2.23 1.62 1.41 1.76 1.98 2.02 1.97 2.23 1.56 1.98 4 HGG2 1911819 1.64 1.29 to 1.91 1.65 1.30 1.60 1.87 1.57 1.91 1.70 1.29 1.84 4 HGG2 1988540 1.69 1.15 to 1.97 1.95 1.56 1.85 1.73 1.67 1.74 1.15 1.55 1.97 4 HGG2 626471 1.65 0.00 to 2.29 0.00 1.43 1.81 1.95 1.74 1.97 2.29 1.57 2.10 4 HGG2 960604 1.51 0.89 to 2.21 1.50 1.35 1.59 1.54 1.18 1.60 2.21 0.89 1.69 4 HGG2 1326255 3.24 2.13 to 3.68 3.67 3.26 3.40 3.43 2.99 2.93 2.13 3.68 3.62 5 HGG2 2234266 2.05 0.00 to 2.89 0.00 2.30 2.88 2.61 2.68 2.71 0.00 2.38 2.89 5 HGG2 660142 2.87 2.38 to 3.21 2.96 2.38 2.88 2.97 2.70 3.00 3.21 2.54 3.17 5 HGG2 1316801 2.15 0.00 to 2.73 0.00 2.04 2.38 2.57 2.28 2.55 2.73 2.15 2.65 5 HGG2 1303862 2.14 0.00 to 3.23 0.00 2.52 2.80 0.00 2.72 2.34 3.23 3.07 2.57 5 HGG2 2124056 2.68 2.41 to 3.04 3.04 2.41 2.58 2.76 2.63 2.85 2.78 2.58 2.50 5 HGG2 2544622 3.17 2.78 to 3.70 3.04 2.78 3.36 3.05 3.14 3.09 3.70 3.11 3.23 5 HGG2 1961617 2.01 0.00 to 2.69 0.00 1.92 2.29 2.15 2.23 2.29 2.58 1.94 2.69 5 HGG2 3421730 −0.87 −1.34 to −0.26 −0.50 −1.34 −1.16 −0.61 −0.09 −0.88 −0.26 −1.22 −0.97 6 HGG2 1973123 −0.93 −1.37 to 0.00  −1.06 −1.04 −0.99 −1.17 −1.02 −1.37 0.00 −0.75 −0.93 6 HGG2 1988774 −1.09 −1.87 to −0.08 −0.52 −1.87 −1.68 −0.80 −1.46 −1.28 −0.08 −0.93 −1.16 6 HGG2 3084204 −1.53 −1.69 to −1.23 −1.50 −1.66 −1.69 −1.49 −1.64 −1.65 −1.61 −1.35 −1.23 0 HGG3 3090808 −1.13 −1.53 to −0.65 −1.07 −0.84 −1.19 −1.37 −0.96 −1.53 −1.38 −0.65 −1.15 0 HGG3 3097624 −1.24 −1.52 to −0.89 −1.01 −1.52 −1.40 −1.16 −1.51 −1.31 −1.21 −1.10 −0.89 0 HGG3 5427710 −2.13 −2.26 to 1.89  −2.13 −2.26 −2.22 −2.23 −1.96 −2.13 −2.23 −2.12 −1.89 0 HGG3 1911443 −1.04 −1.46 to −0.43 −0.59 −1.41 −1.46 −0.50 −1.05 −1.33 −0.43 −1.31 −1.27 0 HGG3 3120209 −1.51 −2.04 to −0.98 −2.04 −1.51 −1.30 −1.93 −1.38 −1.12 −1.91 −1.42 −0.98 0 HGG3 5399371 −0.97 −1.74 to −0.43 −0.71 −1.74 −1.02 −0.97 −1.38 −0.87 −0.43 −0.97 −0.68 0 HGG3 5166479 −1.47 −2.20 to −0.81 −0.98 −2.20 −1.84 −1.24 −1.87 −1.64 −0.81 −1.59 −1.08 0 HGG3 2698777 −0.99 −1.37 to −0.61 −0.81 −1.13 −1.37 −1.32 −1.02 −1.13 −0.72 −0.61 −0.77 0 HGG3 3135460 −1.37 −1.83 to −0.86 −0.86 −1.67 −1.69 −0.90 −1.37 −1.83 −0.95 −1.44 −1.60 0 HGG3 4715924 −1.06 −1.46 to −0.40 −1.33 −0.88 −1.03 −1.46 −0.98 −1.37 −1.16 −0.40 −0.91 0 HGG3 5089438 −1.34 −1.63 to −0.87 −1.52 −1.63 −1.63 −1.32 −1.36 −1.29 −1.33 −1.12 −0.87 0 HGG3 3170010 −0.46 −1.47 to 0.05  −0.30 −1.47 −0.91 0.00 0.00 −0.68 0.05 −0.87 0.00 0 HGG3 3778404 −1.91 −2.25 to −1.58 −1.86 −2.09 −2.25 −2.06 −1.93 −1.97 −1.80 −1.58 −1.62 0 HGG3 4289557 −1.92 −2.27 to −1.57 −1.95 −2.07 −2.27 −1.84 −1.97 −1.97 −2.01 −1.57 −1.60 0 HGG3 5076842 −0.62 −1.69 to 0.00  −1.33 −1.28 −1.31 0.00 0.00 −1.69 0.00 0.00 0.00 0 HGG3 4894508 −0.99 −1.60 to −0.60 −0.96 −1.60 −1.11 −0.88 −1.12 −0.94 −0.69 −0.98 −0.60 0 HGG3 5573549 −1.44 −1.65 to −1.22 −1.35 −1.46 −1.65 −1.60 −1.41 −1.65 −1.34 −1.27 −1.22 0 HGG3 654246 −1.22 −1.56 to −0.92 −1.16 −1.56 −1.42 −1.25 −1.14 −1.25 −1.09 −1.23 −0.92 0 HGG3 3633707 0.73 0.38 to 1.64 0.64 0.38 0.50 0.61 0.85 0.66 0.81 0.46 1.64 1 HGG3 3960194 1.17 0.77 to 1.45 1.09 0.77 0.94 1.17 1.31 1.35 1.45 1.32 1.15 1 HGG3 3974247 1.32 0.97 to 1.65 1.41 1.04 1.28 1.65 1.46 1.43 1.56 0.97 1.07 1 HGG3 2871076 1.23 0.86 to 1.50 1.35 1.09 1.20 1.50 1.36 1.31 1.40 0.97 0.86 1 HGG3 3034889 1.36 1.01 to 1.54 1.49 1.01 1.35 1.54 1.44 1.50 1.53 1.08 1.31 1 HGG3 3057267 0.67 −0.05 to 2.09  0.31 −0.05 2.09 1.44 0.72 0.48 0.50 0.15 0.36 1 HGG3 4252872 1.13 0.89 to 1.32 1.31 1.07 1.09 1.27 1.07 1.32 1.26 0.93 0.89 1 HGG3 3495173 1.34 1.15 to 1.58 1.39 1.15 1.30 1.58 1.28 1.48 1.46 1.22 1.23 1 HGG3 3957354 1.26 0.00 to 3.28 0.00 2.66 2.97 3.28 0.00 0.00 0.00 2.43 0.00 1 HGG3 4340307 0.63 0.19 to 1.66 0.62 0.19 0.52 0.55 0.49 0.65 1.66 0.39 0.58 1 HGG3 4508879 1.24 0.00 to 1.86 1.20 1.63 1.60 1.25 1.86 1.31 0.00 1.31 0.99 1 HGG3 4863677 1.12 0.78 to 1.38 1.17 0.78 1.11 1.38 1.19 1.33 1.31 0.92 0.94 1 HGG3 517374 1.00 0.00 to 1.71 1.40 1.09 1.29 1.37 0.00 0.00 1.71 1.07 1.10 1 HGG3 5266376 1.26 0.83 to 1.71 1.24 0.89 1.35 1.28 1.21 1.21 1.59 1.71 0.83 1 HGG3 1251065 1.35 0.97 to 1.59 1.45 0.97 1.24 1.54 1.45 1.59 1.40 1.19 1.25 1 HGG3 3621521 0.42 0.00 to 3.44 0.00 0.38 0.00 3.44 0.00 0.00 0.00 0.00 0.00 1 HGG3 664625 1.05 0.00 to 1.59 1.47 1.37 1.42 1.59 0.00 1.54 0.00 0.97 1.08 1 HGO3 668460 1.28 0.77 to 1.54 1.26 0.77 1.24 1.45 1.41 1.54 1.42 1.26 1.12 1 HGG3 893224 1.05 0.68 to 1.35 1.20 0.77 1.10 1.35 1.26 1.24 1.12 0.69 0.68 1 HGG3 2545486 1.57 1.12 to 1.98 1.54 1.24 1.12 1.56 1.90 1.85 1.98 1.60 1.37 2 HGG3 3158828 1.64 1.22 to 1.94 1.56 1.22 1.59 1.90 1.84 1.88 1.94 1.28 1.51 2 HGG3 5266015 2.42 2.09 to 2.68 2.44 2.09 2.35 2.68 2.52 2.64 2.64 2.15 2.28 2 HGG3 4402555 2.20 1.93 to 2.39 2.33 1.93 1.98 2.39 2.33 2.36 2.38 2.07 2.05 2 HGG3 5293028 1.48 1.19 to 1.75 1.53 1.19 1.51 1.49 1.40 1.46 1.75 1.58 1.42 2 HGG3 5322365 1.41 1.09 to 1.69 1.43 1.09 1.36 1.69 1.49 1.59 1.56 1.16 1.33 2 HGG3 2343348 1.87 1.55 to 2.27 1.55 1.61 1.97 1.98 2.27 2.10 1.95 1.69 1.72 2 HGG3 1786554 1.52 1.26 to 1.77 1.60 1.29 1.53 1.77 1.53 1.76 1.62 1.26 1.28 2 HGG3 5508135 1.66 1.29 to 1.91 1.84 1.29 1.69 1.89 1.66 1.91 1.72 1.29 1.68 2 HGG3 5512044 1.78 1.34 to 2.05 1.82 1.50 1.74 2.02 2.05 2.02 1.88 1.34 1.64 2 HGG3 554654 1.70 1.15 to 2.35 1.98 1.76 2.35 1.74 1.83 1.46 1.56 1.15 1.42 2 HGG3 3074113 1.98 1.65 to 2.29 2.00 1.76 1.98 2.21 2.24 2.29 2.01 1.66 1.65 2 HGG3 621543 1.77 1.24 to 2.07 1.68 1.24 1.90 1.90 1.93 1.89 2.07 1.84 1.49 2 HGG3 4912315 1.91 1.24 to 2.49 1.82 1.83 1.92 1.57 2.25 1.70 2.49 2.36 1.24 2 HGG3 4253809 2.11 1.73 to 2.66 2.05 1.73 2.07 2.24 2.06 2.06 2.28 2.66 1.81 2 HGG3 2972013 1.43 1.04 to 1.68 1.40 1.04 1.37 1.68 1.56 1.60 1.54 1.18 1.47 2 HGG3 748477 1.55 1.01 to 1.85 1.38 1.01 1.65 1.85 1.71 1.71 1.79 1.52 1.34 2 HGG3 5102731 1.83 1.39 to 2.25 1.71 1.39 1.88 2.25 1.76 1.87 2.02 1.82 1.75 2 HGG3 3732960 0.62 0.01 to 2.45 0.17 0.71 0.50 0.04 0.61 0.01 0.48 2.45 0.66 3 HGG3 4232507 0.73 0.00 to 1.76 0.00 1.17 0.65 0.00 0.00 1.76 0.00 1.36 1.60 3 HGG3 4247396 0.51 0.00 to 1.47 0.00 0.95 1.10 0.00 1.47 0.00 0.00 1.09 0.00 3 HGG3 1482166 0.23 −0.12 to 1.51  0.15 0.10 −0.12 −0.05 0.24 0.00 0.11 0.16 1.51 3 HGG3 1560380 0.31 0.00 to 1.48 0.00 1.33 1.48 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG3 569348 0.42 0.00 to 2.84 0.00 0.56 0.40 0.00 0.00 0.00 0.00 2.84 0.00 3 HGG3 2195427 0.17 0.00 to 1.49 0.00 1.49 0.00 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG3 646463 0.37 0.00 to 1.36 0.00 0.87 1.07 0.00 0.00 1.36 0.00 0.00 0.00 3 HGG3 2707635 0.66 −0.16 to 2.79  0.23 0.53 0.29 0.22 0.44 0.07 −0.16 2.79 1.49 3 HGG3 5275515 −0.17 −1.82 to 0.30  0.00 0.30 0.00 −1.82 0.00 0.00 0.00 0.00 0.00 3 HGG3 3411051 −0.14 −1.60 to 0.15  0.09 0.15 0.12 0.00 −1.60 0.00 0.00 0.00 0.00 3 HGG3 699113 0.49 0.00 to 2.57 0.00 1.83 0.00 0.00 0.00 0.00 0.00 2.57 0.00 3 HGG3 3569151 0.16 0.00 to 1.46 0.00 1.46 0.00 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG3 3729593 0.41 0.00 to 1.36 0.00 1.14 1.18 0.00 0.00 0.00 0.00 0.00 1.36 3 HGG3 3172265 3.66 3.35 to 4.09 3.84 3.47 3.95 4.09 3.44 3.42 3.72 3.62 3.35 4 HGG3 3069190 3.84 3.47 to 4.15 3.88 3.47 3.91 4.03 3.89 4.15 4.06 3.65 3.54 4 HGG3 3068978 1.99 0.00 to 3.47 0.00 2.28 2.58 0.00 3.47 3.29 3.12 0.00 3.19 5 HGG3 872017 1.46 0.00 to 1.86 1.68 1.42 1.58 0.00 1.85 1.86 1.81 1.40 1.57 6 HGG3 1259841 1.09 0.55 to 1.50 0.88 0.55 0.91 1.23 1.13 1.50 1.22 1.07 1.29 0 HGG4 439415 1.06 0.81 to 1.40 0.87 0.95 1.07 1.40 1.10 0.95 0.81 1.08 1.34 0 HGG4 434751 1.84 1.55 to 2.04 1.95 1.55 1.95 2.00 1.88 2.04 1.88 1.71 1.58 0 HGG4 409209 1.06 0.68 to 1.47 0.98 0.68 1.10 1.07 1.27 1.47 1.32 0.71 0.95 0 HGG4 1448572 0.91 0.68 to 1.41 0.68 0.70 0.69 1.18 0.91 1.08 0.78 0.78 1.41 0 HGG4 4077648 1.38 0.66 to 1.98 0.89 0.66 1.13 1.56 1.62 1.98 1.46 1.25 1.85 0 HGG4 1611629 0.89 0.68 to 1.40 0.74 0.69 0.92 1.40 0.74 0.92 0.80 0.68 1.16 0 HGG4 2196870 1.16 0.88 to 1.72 0.99 0.88 1.26 1.72 0.99 1.30 1.03 0.97 1.26 0 HGG4 2227273 1.37 0.77 to 1.81 1.14 0.77 1.15 1.72 1.50 1.81 1.51 1.35 1.33 0 HGG4 1716458 1.09 0.67 to 1.43 0.86 0.67 1.09 1.31 1.18 1.43 1.11 0.92 1.20 0 HGG4 2428314 1.01 0.61 to 1.33 0.61 0.89 1.06 1.17 0.99 1.21 0.94 0.91 1.33 0 HGG4 1740179 1.04 0.73 to 1.49 0.82 0.73 1.04 1.49 1.10 1.33 0.93 0.75 1.15 0 HGG4 346017 0.78 0.40 to 1.40 0.40 0.40 0.55 1.40 0.83 1.25 0.70 0.61 0.89 0 HGG4 3449615 0.76 0.30 to 1.43 0.50 0.30 0.50 1.04 0.79 1.14 0.64 0.53 1.43 0 HGG4 1913334 1.56 1.16 to 2.06 1.34 1.16 1.66 1.94 1.73 2.06 1.53 1.24 1.33 0 HGG4 2350594 1.35 0.95 to 1.86 0.95 1.10 1.41 1.86 1.12 1.68 1.23 1.23 1.54 0 HGG4 2408333 1.55 0.00 to 2.55 1.52 1.47 1.89 2.55 1.56 0.00 1.71 1.62 1.63 0 HGG4 2756747 1.00 0.80 to 1.53 0.86 0.80 1.11 1.53 0.94 1.11 0.80 0.80 1.01 0 HGG4 2756587 1.08 0.80 to 1.65 0.80 0.81 1.13 1.65 1.04 1.27 0.90 0.93 1.15 0 HGG4 1965856 1.64 1.22 to 2.37 1.43 1.22 1.65 1.91 1.78 2.37 1.74 1.44 1.26 0 HGG4 2006043 1.49 1.12 to 2.03 1.31 1.12 1.32 1.89 1.53 2.03 1.47 1.34 1.39 0 HGG4 2007730 1.40 0.71 to 2.21 0.88 0.71 0.99 1.48 1.59 2.21 1.47 1.35 1.88 0 HGG4 2669871 1.02 0.81 to 1.44 0.94 0.86 1.19 0.97 0.86 1.30 0.81 0.82 1.44 0 HGG4 2619275 1.33 0.76 to 1.79 1.02 0.76 1.19 1.54 1.44 1.79 1.41 1.19 1.66 0 HGG4 2062085 1.32 0.87 to 1.85 0.97 0.87 1.26 1.61 1.41 1.85 1.47 1.44 1.01 0 HGG4 2106010 1.65 1.32 to 2.16 1.38 1.32 1.83 2.16 1.63 1.94 1.53 1.47 1.63 0 HGG4 2110482 1.48 0.97 to 2.18 1.06 0.97 1.32 1.61 1.66 2.18 1.72 1.42 1.36 0 HGG4 5101167 1.07 0.60 to 1.47 0.88 0.60 1.11 1.47 1.23 1.45 0.93 0.78 1.18 0 HGG4 5690026 1.50 1.13 to 2.03 1.26 1.18 1.55 2.03 1.61 1.80 1.37 1.13 1.55 0 HGG4 761282 1.04 0.72 to 1.44 1.00 0.75 1.13 1.44 1.03 1.17 1.05 1.03 0.72 0 HGG4 998615 0.85 0.00 to 1.62 0.87 0.66 1.07 1.45 1.20 1.62 0.00 0.76 0.00 0 HGG4 1946155 0.64 0.00 to 1.41 0.78 0.76 0.96 1.41 0.92 0.00 0.00 0.91 0.00 1 HGG4 2266959 0.29 0.00 to 1.50 0.00 1.09 1.50 0.00 0.00 0.00 0.00 0.00 0.00 1 HGG4 2267466 0.43 0.00 to 1.39 1.29 1.16 1.39 0.00 0.00 0.00 0.00 0.00 0.00 1 HGG4 2268803 0.40 0.00 to 2.13 0.53 0.42 0.56 0.00 0.00 0.00 0.00 0.00 2.13 1 HGG4 2405487 0.63 0.00 to 1.44 0.90 0.80 1.20 1.44 0.00 0.00 0.00 1.29 0.00 1 HGG4 2404746 0.49 0.00 to 1.74 0.86 0.80 0.98 1.74 0.00 0.00 0.00 0.00 0.00 1 HGG4 2410066 0.70 0.00 to 1.66 1.00 1.01 1.29 1.66 0.00 0.00 0.00 1.33 0.00 1 HGG4 3149570 0.68 0.00 to 1.64 0.97 0.95 1.24 1.64 0.00 0.00 0.00 1.31 0.00 1 HGG4 3220149 0.31 0.00 to 1.47 0.00 1.30 1.47 0.00 0.00 0.00 0.00 0.00 0.00 1 HGG4 3253978 0.36 0.00 to 2.67 0.00 0.30 0.25 2.67 0.00 0.00 0.00 0.00 0.00 1 HGG4 3522739 0.38 0.00 to 1.33 1.13 0.97 1.33 0.00 0.00 0.00 0.00 0.00 0.00 1 HGG4 417432 0.57 0.00 to 1.56 0.86 0.80 1.10 1.56 0.00 0.00 0.00 0.85 0.00 1 HGG4 509839 1.02 0.00 to 2.10 1.25 1.35 1.74 2.10 1.38 0.00 0.00 1.36 0.00 1 HGG4 1645304 0.53 0.00 to 1.42 0.78 0.77 0.94 1.42 0.00 0.00 0.00 0.88 0.00 1 HGG4 1683583 0.59 0.00 to 1.49 0.75 0.68 1.00 1.49 0.83 0.00 0.00 0.55 0.00 1 HGG4 1730026 0.85 0.00 to 1.49 0.91 1.06 1.06 1.49 1.17 0.00 1.04 0.95 0.00 1 HGG4 1927771 0.52 0.00 to 1.39 0.78 0.54 0.79 0.00 1.15 1.39 0.00 0.00 0.00 1 HGG4 3042227 −1.70 −2.22 to −0.96 −1.83 −1.50 −1.61 −1.91 −1.64 −2.22 −1.73 −0.96 −1.88 2 HGG4 1953051 −1.08 −1.40 to −0.70 −0.98 −1.19 −1.04 −1.40 −1.10 −1.34 −1.23 −0.70 −0.78 2 HGG4 2786442 −1.40 −1.83 to −0.77 −1.83 −1.39 −1.36 −1.68 −1.46 −1.40 −1.77 −0.77 −0.92 2 HGG4 693783 −0.87 −1.52 to 0.00  −1.16 −0.70 −0.81 −1.00 −1.03 −1.52 0.00 −0.68 −0.96 2 HGG4 2055569 −1.15 −1.62 to −0.08 −0.76 −1.43 −1.38 −0.85 −1.27 −1.61 −0.08 −1.36 −1.62 2 HGG4 3254430 −0.77 −1.35 to 0.00  −1.23 −0.72 −0.91 −1.17 −0.97 −1.35 0.00 −0.60 0.00 2 HGG4 1857850 −2.07 −2.40 to −1.48 −2.37 −1.83 −2.15 −2.33 −2.00 −2.40 −2.29 −1.48 −1.76 2 HGG4 1857664 −0.92 −1.50 to 0.02  −1.50 −0.69 −0.81 −1.32 −0.69 −1.06 −1.44 0.02 −0.75 2 HGG4 2806983 −0.88 −1.40 to 0.00  −1.05 −1.00 −0.80 0.00 −0.97 −1.40 −1.02 −0.74 −0.91 2 HGG4 1449819 −1.30 −1.97 to −0.27 −0.65 −1.79 −1.85 −0.27 −1.64 −1.71 −0.48 −1.35 −1.97 2 HGG4 1383138 −1.03 −1.35 to −0.69 −0.86 −1.17 −1.03 −0.69 −1.34 −1.35 −0.71 −1.07 −1.09 2 HGG4 269310 −0.89 −1.38 to −0.61 −0.84 −0.73 −0.64 −0.64 −0.89 −1.38 −0.96 −0.61 −1.31 2 HGG4 495808 −1.04 −1.35 to −0.40 −1.19 −1.21 −1.12 −1.23 −1.02 −1.35 −0.98 −0.40 −0.86 2 HGG4 2278772 3.17 2.41 to 4.02 2.51 2.41 2.88 3.23 3.21 4.02 3.44 3.46 3.34 3 HGG4 3191030 2.29 1.80 to 2.54 2.07 1.80 2.54 2.45 2.35 2.40 2.26 2.39 2.32 3 HGG4 2581075 4.02 3.39 to 4.52 3.75 3.39 3.90 4.30 4.11 4.52 4.21 3.92 4.11 3 HGG4 1964758 2.34 1.91 to 2.75 2.04 1.91 2.36 2.64 2.43 2.75 2.43 2.18 2.34 3 HGG4 1365045 2.00 1.53 to 2.57 1.83 1.53 1.90 2.11 2.08 2.57 1.98 1.80 2.18 3 HGG4 1370137 2.31 0.00 to 3.07 2.24 2.12 2.72 3.07 2.67 2.76 0.00 2.25 2.95 3 HGG4 3016137 2.06 1.35 to 2.55 1.62 1.35 1.73 2.28 2.15 2.55 2.24 2.30 2.37 3 HGG4 435549 0.81 0.00 to 4.32 0.33 0.37 0.48 4.32 1.82 0.00 0.00 0.00 0.00 4 HGG4 489820 −0.27 −2.46 to 0.19  0.02 −0.15 0.02 0.19 0.02 −2.46 −0.01 −0.10 0.00 5 HGG4 2013251 1.58 0.00 to 2.51 1.69 1.59 2.14 2.51 2.17 2.37 0.00 1.80 0.00 6 HGG4

TABLE 10 mean mean mean mean DE DE DE DE mean DE mean DE mean DE mean DE mean DE t/Bude t/Bude t/Bude t/Bude t/Bude t/Bude t/Bude t/Bude t/Bude Ave DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clus- Clone ID t/Bude Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr ter GEM 1004382 1.27 1.08 to 1.36 1.28 1.33 1.34 1.34 1.36 1.08 1.28 1.14 1.25 0 HGG 1 1210839 1.35 1.16 to 1.50 1.45 1.45 1.50 1.32 1.39 1.20 1.39 1.16 1.26 0 HGG 1 1241484 1.42 1.20 to 1.58 1.55 1.58 1.54 1.40 1.54 1.27 1.40 1.20 1.34 0 HGG 1 1268277 1.27 0.97 to 1.59 1.41 1.44 1.57 1.17 1.59 1.12 1.08 0.97 1.04 0 HGG 1 4203937 0.76 0.41 to 1.35 1.35 1.27 1.21 0.60 0.41 0.44 0.54 0.53 0.50 0 HGG 1 4251117 0.98 0.69 to 1.33 1.27 1.26 1.33 0.99 0.93 0.82 0.85 0.72 0.69 0 HGG 1 4284384 1.13 0.85 to 1.48 1.42 1.42 1.48 1.20 0.95 0.85 1.04 0.96 0.88 0 HGG 1 2482388 1.19 0.98 to 1.52 1.32 1.39 1.52 1.22 1.26 0.98 1.02 0.98 1.03 0 HGG 1  136073 1.25 0.97 to 1.60 1.60 1.55 1.44 1.09 1.00 0.97 1.37 1.10 1.10 0 HGG 1  139949 1.35 0.98 to 1.72 1.68 1.28 1.28 1.46 1.22 1.23 1.72 1.25 0.98 0 HGG 1  143765 1.07 0.72 to 1.35 1.21 1.35 1.33 0.93 1.17 1.14 0.95 0.72 0.80 0 HGG 1 1944123 1.31 1.07 to 1.55 1.55 1.53 1.54 1.28 1.34 1.16 1.24 1.07 1.07 0 HGG 1 1956982 1.38 1.02 to 1.74 1.72 1.74 1.48 1.12 1.12 1.02 1.45 1.44 1.35 0 HGG 1 4289063 1.22 0.91 to 1.54 1.54 1.44 1.41 1.16 1.23 1.15 1.15 0.91 0.99 0 HGG 1 4403805 1.12 0.83 to 1.44 1.33 1.39 1.44 1.05 1.18 0.92 1.03 0.90 0.83 0 HGG 1 4554722 1.08 0.71 to 1.42 1.42 1.16 1.35 1.09 1.37 1.10 0.82 0.71 0.73 0 HGG 1 1521272 1.40 1.16 to 1.53 1.50 1.48 1.53 1.41 1.41 1.16 1.43 1.33 1.31 0 HGG 1 4978708 1.41 1.20 to 1.61 1.56 1.60 1.61 1.40 1.49 1.20 1.30 1.23 1.26 0 HGG 1 2061171 1.26 1.14 to 1.41 1.41 1.32 1.30 1.29 1.36 1.18 1.19 1.15 1.14 0 HGG 1 1604437 1.18 1.02 to 1.39 1.20 1.18 1.15 1.23 1.39 1.02 1.23 1.08 1.15 0 HGG 1 1609387 1.32 1.09 to 1.48 1.48 1.44 1.42 1.27 1.44 1.20 1.43 1.09 1.11 0 HGG 1 1610828 1.28 1.12 to 1.46 1.46 1.39 1.37 1.29 1.32 1.18 1.19 1.12 1.17 0 HGG 1  531505 1.24 0.95 to 1.40 1.38 1.33 1.37 1.21 1.40 1.29 1.16 0.95 1.08 0 HGG 1 5397446 1.22 1.05 to 1.33 1.16 1.30 1.22 1.30 1.26 1.05 1.12 1.23 1.33 0 HGG 1  622565 1.20 1.02 to 1.45 1.45 1.32 1.40 1.23 1.21 1.03 1.10 1.02 1.04 0 HGG 1 2697275 1.45 1.20 to 1.72 1.57 1.63 1.72 1.38 1.53 1.20 1.37 1.32 1.31 0 HGG 1 2756333 1.42 1.21 to 1.66 1.58 1.58 1.66 1.38 1.59 1.23 1.36 1.23 1.21 0 HGG 1  279898 1.30 0.03 to 2.45 0.26 1.46 1.65 0.03 1.45 1.42 0.98 1.99 2.45 0 HGG 1 3075994 1.18 1.01 to 1.38 1.22 1.19 1.24 1.32 1.38 1.02 1.18 1.01 1.09 0 HGG 1 3108506 1.04 0.60 to 1.48 1.13 1.28 1.48 0.97 1.34 1.15 0.77 0.60 0.61 0 HGG 1 3497231 1.39 1.16 to 1.72 1.63 1.72 1.60 1.35 1.31 1.29 1.29 1.17 1.16 0 HGG 1 3606947 1.19 0.89 to 1.47 1.47 1.47 1.47 1.15 0.99 0.89 1.20 1.01 1.03 0 HGG 1 3687607 1.17 0.98 to 1.32 1.32 1.29 1.20 1.20 1.25 1.02 1.23 0.98 1.04 0 HGG 1  371201 1.17 0.92 to 1.38 1.01 1.06 0.92 1.38 1.22 1.15 1.37 1.18 1.21 0 HGG 1 4021009 1.27 1.02 to 1.48 1.44 1.47 1.48 1.30 1.27 1.02 1.19 1.12 1.10 0 HGG 1 2403438 1.21 0.93 to 1.38 1.33 1.24 0.93 1.17 1.38 1.24 1.08 1.24 1.31 0 HGG 1 2055814 −1.23 −1.38 to −0.94 −1.18 −1.31 −1.14 −1.26 −1.38 −1.30 −0.94 −1.25 −1.29 1 HGG 1  891072 −1.46 −1.77 to −1.25 −1.46 −1.35 −1.25 −1.48 −1.77 −1.37 −1.52 −1.56 −1.33 1 HGG 1 2061528 −1.41 −1.74 to −1.16 −1.61 −1.31 −1.34 −1.30 −1.16 −1.25 −1.74 −1.59 −1.42 1 HGG 1 3126622 −1.27 −1.51 to −1.02 −1.35 −1.33 −1.24 −1.41 −1.51 −1.04 −1.02 −1.30 −1.20 1 HGG 1 1441245 −1.29 −1.50 to −1.10 −1.38 −1.29 −1.28 −1.10 −1.16 −1.10 −1.46 −1.50 −1.31 1 HGG 1 2623304 −1.19 −1.45 to −0.93 −1.16 −1.06 −0.93 −1.14 −1.24 −1.19 −1.27 −1.45 −1.31 1 HGG 1 3397390 −1.07 −1.38 to −0.62 −1.05 −1.19 −0.96 −1.09 −0.62 −1.07 −0.92 −1.35 −1.38 1 HGG 1 3408804 −1.24 −1.41 to −1.00 −1.33 −1.36 −1.30 −1.05 −1.27 −1.00 −1.20 −1.41 −1.22 1 HGG 1 3451645 −1.28 −1.76 to −0.80 −1.04 −1.29 −1.22 −1.27 −1.76 −1.38 −0.80 −1.41 −1.38 1 HGG 1 2132606 −1.17 −1.47 to −0.93 −1.47 −1.34 −1.14 −1.28 −1.19 −1.09 −1.02 −1.04 −0.93 1 HGG 1 2132607 −1.25 −1.47 to −1.02 −1.21 −1.16 −1.02 −1.29 −1.47 −1.02 −1.36 −1.47 −1.27 1 HGG 1 3679667 −1.36 −1.57 to −1.18 −1.36 −1.33 −1.31 −1.22 −1.33 −1.18 −1.40 −1.57 −1.49 1 HGG 1 1619292 −1.38 −1.56 to −1.10 −1.46 −1.45 −1.39 −1.13 −1.10 −1.40 −1.41 −1.56 −1.56 1 HGG 1 2287724 −1.06 −1.34 to −0.85 −1.34 −1.21 −1.06 −0.98 −1.11 −1.02 −0.92 −1.02 −0.85 1 HGG 1 1652328 −1.34 −1.74 to −1.15 −1.24 −1.41 −1.15 −1.51 −1.74 −1.15 −1.16 −1.34 −1.32 1 HGG 1 3681722 −1.23 −1.54 to −1.05 −1.54 −1.46 −1.10 −1.26 −1.17 −1.22 −1.06 −1.21 −1.05 1 HGG 1 3686603 −1.13 −1.52 to −0.84 −1.14 −1.15 −0.90 −1.28 −1.52 −0.84 −1.25 −1.18 −0.88 1 HGG 1 3721985 −1.10 −1.39 to −0.88 −1.11 −1.12 −0.88 −1.15 −1.39 −1.03 −1.10 −1.16 −0.94 1 HGG 1 1740474 −1.46 −1.55 to −1.35 −1.43 −1.45 −1.38 −1.55 −1.53 −1.50 −1.35 −1.55 −1.44 1 HGG 1  380006 −1.05 −1.38 to −0.86 −1.09 −1.06 −0.86 −1.00 −1.38 −1.08 −0.89 −1.12 −0.98 1 HGG 1 1807155 −1.07 −1.39 to −0.75 −0.75 −1.03 −0.96 −1.00 −1.30 −1.12 −0.77 −1.31 −1.39 1 HGG 1 1833362 −1.25 −1.49 to −0.96 −1.12 −1.37 −0.96 −1.36 −1.39 −0.96 −1.29 −1.49 −1.29 1 HGG 1 1840426 −1.36 −1.58 to −1.09 −1.48 −1.43 −1.18 −1.58 −1.55 −1.09 −1.28 −1.41 −1.22 1 HGG 1  41479 −1.41 −1.91 to −0.97 −1.32 −1.41 −1.27 −1.57 −1.91 −1.39 −0.97 −1.55 −1.31 1 HGG 1 2471835 −1.03 −1.36 to −0.83 −1.36 −1.22 −1.10 −0.93 −0.86 −1.06 −0.89 −1.05 −0.83 1 HGG 1 2839946 −1.08 −1.35 to −0.86 −0.95 −1.05 −1.19 −1.06 −1.35 −1.06 −1.11 −1.07 −0.86 1 HGG 1 5291518 −1.28 −1.54 to −1.09 −1.32 −1.23 −1.09 −1.16 −1.10 −1.17 −1.48 −1.46 −1.54 1 HGG 1 1910401 −1.39 −1.51 to −1.23 −1.40 −1.31 −1.23 −1.40 −1.47 −1.31 −1.47 −1.51 −1.39 1 HGG 1 1930847 −1.09 −1.63 to −0.76 −1.19 −1.22 −0.81 −1.35 −1.63 −0.76 −0.99 −1.09 −0.78 1 HGG 1 2767579 −1.22 −1.40 to −1.05 −1.40 −1.34 −1.19 −1.30 −1.15 −1.25 −1.10 −1.05 −1.17 1 HGG 1 2769888 −0.95 −1.68 to −0.54 −0.61 −0.84 −1.17 −0.63 −0.68 −1.02 −0.54 −1.41 −1.68 1 HGG 1 3606046 1.91 1.61 to 2.18 2.18 2.11 2.15 1.80 2.01 1.61 1.89 1.72 1.73 2 HGG 1 3595618 1.56 1.25 to 1.83 1.77 1.83 1.77 1.61 1.56 1.41 1.54 1.25 1.34 2 HGG 1 2511277 1.62 1.35 to 1.85 1.66 1.76 1.69 1.64 1.81 1.85 1.41 1.35 1.37 2 HGG 1 1342744 1.78 1.45 to 2.13 2.10 2.13 2.03 1.66 1.70 1.45 1.82 1.55 1.57 2 HGG 1 4092112 1.54 1.21 to 1.98 1.98 1.94 1.95 1.39 1.36 1.23 1.42 1.40 1.21 2 HGG 1 2516950 1.82 1.45 to 2.11 2.08 2.11 2.02 1.83 1.73 1.45 1.80 1.72 1.62 2 HGG 1 1459743 1.71 1.49 to 1.89 1.88 1.85 1.89 1.69 1.74 1.68 1.68 1.52 1.49 2 HGG 1 5509134 1.88 1.64 to 2.28 2.03 2.11 2.28 1.84 1.78 1.64 1.82 1.68 1.78 2 HGG 1 1560906 1.66 1.43 to 1.86 1.77 1.66 1.67 1.74 1.86 1.56 1.69 1.58 1.43 2 HGG 1  671717 1.51 1.28 to 1.71 1.66 1.65 1.71 1.52 1.65 1.28 1.49 1.31 1.35 2 HGG 1 3821432 1.54 1.18 to 1.86 1.86 1.79 1.76 1.48 1.40 1.18 1.63 1.40 1.41 2 HGG 1 2833342 1.55 1.34 to 1.75 1.71 1.75 1.74 1.59 1.51 1.34 1.56 1.35 1.40 2 HGG 1 1684617 1.79 1.56 to 2.05 1.93 1.90 2.05 1.73 2.05 1.63 1.69 1.56 1.58 2 HGG 1 3687719 1.70 1.36 to 1.98 1.98 1.92 1.86 1.82 1.59 1.36 1.69 1.46 1.57 2 HGG 1 2778441 1.82 1.58 to 2.13 2.09 2.13 2.06 1.76 1.69 1.64 1.70 1.70 1.58 2 HGG 1 1756875 1.51 1.27 to 1.80 1.72 1.67 1.80 1.37 1.57 1.27 1.52 1.34 1.36 2 HGG 1 2313349 1.76 1.52 to 1.96 1.94 1.96 1.94 1.70 1.77 1.52 1.83 1.58 1.62 2 HGG 1 2445967 1.61 1.30 to 1.78 1.75 1.78 1.63 1.70 1.54 1.30 1.72 1.55 1.54 2 HGG 1 2459765 1.48 1.25 to 1.76 1.76 1.74 1.75 1.41 1.42 1.27 1.47 1.29 1.25 2 HGG 1  459372 1.95 1.79 to 2.16 1.86 1.90 1.79 2.16 1.92 1.82 2.11 2.01 1.95 2 HGG 1  548114 1.81 1.70 to 1.88 1.82 1.83 1.8& 1.87 1.80 1.70 1.79 1.78 1.87 2 HGG 1 1890576 −1.55 −1.82 to −1.28 −1.82 −1.71 −1.49 −1.59 −1.49 −1.52 −1.55 −1.49 −1.28 3 HGG 1 1596220 −1.81 −2.19 to −1.52 −1.76 −1.75 −1.64 −2.02 −2.19 −1.52 −1.84 −1.95 −1.64 3 HGG 1 2042056 −1.64 −2.07 to −1.05 −1.99 −1.77 −1.37 −1.72 −1.55 −1.44 −2.07 −1.79 −1.05 3 HGG 1 2047730 −1.56 −1.87 to −1.32 −1.37 −1.50 −1.32 −1.65 −1.87 −1.56 −1.60 −1.64 −1.55 3 HGG 1 3975209 −1.59 −1.82 to −1.41 −1.82 −1.41 −1.52 −1.76 −1.42 −1.49 −1.75 −1.51 −1.64 3 HGG 1 1868536 −1.66 −1.91 to −1.38 −1.38 −1.46 −1.47 −1.71 −1.91 −1.75 −1.59 −1.82 −1.86 3 HGG 1 2506973 −1.82 −2.19 to −1.42 −1.88 −1.96 −1.66 −2.19 −2.06 −1.42 −1.77 −1.87 −1.53 3 HGG 1 1876456 −1.52 −1.74 to −1.21 −1.74 −1.62 −1.42 −1.56 −1.52 −1.21 −1.63 −1.63 −1.35 3 HGG 1 2886955 −1.70 −1.85 to −1.55 −1.79 −1.67 −1.55 −1.77 −1.60 −1.59 −1.83 −1.85 −1.66 3 HGG 1 2912637 −2.18 −2.46 to −1.89 −2.46 −2.40 −2.10 −2.35 −1.91 −1.89 −2.06 −2.34 −2.14 3 HGG 1 3001212 −1.80 −2.40 to −1.43 −1.84 −1.73 −1.50 −2.10 −2.40 −1.43 −1.77 −1.86 −1.56 3 HGG 1 4408943 −1.76 −1.99 to −1.57 −1.60 −1.64 −1.57 −1.81 −1.93 −1.64 −1.75 −1.94 −1.99 3 HGG 1 3031022 −1.91 −2.12 to −177 −1.89 −1.95 −1.84 −1.78 −1.88 −1.88 −1.77 −2.09 −2.12 3 HGG 1 5047895 −1.67 −1.97 to −1.35 −1.70 −1.56 −1.48 −1.35 −1.65 −1.72 −1.72 −1.85 −1.97 3 HGG 1 5541828 −1.96 −2.07 to −1.81 −2.05 −1.96 −1.81 −1.89 −2.04 −1.83 −2.07 −2.00 −2.02 3 HGG 1  560115 −2.04 −2.47 to −1.81 −1.88 −2.22 −1.81 −1.89 −2.47 −1.93 −1.88 −2.33 −1.95 3 HGG 1 1614014 −1.01 −1.45 to −0.53 −1.19 −1.08 −0.58 −1.32 −1.45 −0.53 −1.16 −1.13 −0.63 4 HGG 1 1697719 −0.81 −1.51 to 0.00  0.00 0.00 0.00 −1.43 −1.51 −1.08 −1.14 −1.18 −0.97 4 HGG 1 1868738 −0.82 −1.36 to 0.00  −0.88 −0.78 0.00 −1.22 −1.36 −0.57 −0.87 −1.03 −0.71 4 HGG 1 2055857 −0.81 −1.40 to −0.16 −0.40 −0.84 −0.74 −0.39 −1.38 −0.97 −0.16 −1.40 −0.98 4 HGG 1 2078880 −0.80 −1.34 to 0.00  −0.70 0.00 0.00 −1.23 −1.34 −1.03 −0.86 −1.14 −0.92 4 HGG 1 3497137 −0.94 −1.33 to −0.57 −1.15 −1.03 −0.67 −1.33 −1.19 −0.58 −1.07 −0.83 −0.57 4 HGG 1 3770530 −0.98 −1.37 to −0.62 −1.15 −1.05 −0.70 −1.34 −1.37 −0.67 −1.05 −0.87 −0.62 4 HGG 1 2382190 −0.77 −1.50 to 0.00  0.00 0.00 0.00 −1.12 −1.50 −0.97 −0.94 −1.23 −1.16 4 HGG 1 2239738 −0.20 −1.84 to 0.09  0.08 0.00 −0.06 −0.09 −0.10 −1.84 0.05 0.09 0.05 4 HGG 1 4089291 −1.00 −1.45 to −0.72 −1.01 −0.99 −0.90 −1.15 −1.45 −0.88 −0.72 −0.98 −0.91 4 HGG 1 3139631 −0.97 −1.47 to −0.55 −1.20 −1.11 −0.88 −1.23 −1.47 −0.74 −0.76 −0.78 −0.55 4 HGG 1 2131958 −0.99 −1.48 to −0.72 −0.95 −1.02 −0.79 −1.18 −1.48 −0.87 −0.72 −1.00 −0.87 4 HGG 1 2818476 2.55 2.19 to 2.94 2.94 2.92 2.73 2.41 2.31 2.19 2.69 2.52 2.21 5 HGG 1 2823767 2.05 1.84 to 2.29 2.29 2.19 2.09 2.02 2.06 1.92 2.16 1.89 1.84 5 HGG 1 3792988 2.27 1.98 to 2.54 2.54 2.40 2.54 2.17 2.41 1.98 2.33 2.02 2.01 5 HGG 1 3068809 2.28 1.96 to 2.61 2.61 2.51 2.55 2.21 2.33 2.04 2.28 1.96 2.00 5 HGG 1 1320685 2.03 1.87 to 2.21 2.08 2.07 1.91 2.12 2.01 1.87 2.21 1.96 2.03 5 HGG 1 5501676 2.11 1.58 to 2.71 2.46 2.71 2.61 1.73 1.63 1.58 2.26 2.15 1.87 5 HGG 1 1457424 2.47 2.34 to 2.64 2.64 2.60 2.56 2.46 2.42 2.38 2.47 2.34 2.38 5 HGG 1 4287327 2.49 2.31 to 2.76 2.35 2.41 2.43 2.37 2.76 2.31 2.56 2.68 2.58 5 HGG 1 2956444 2.23 1.91 to 2.62 2.59 2.62 2.57 2.02 2.22 2.04 2.14 1.96 1.91 5 HGG 1  617587 2.13 1.82 to 2.36 2.36 2.25 2.32 2.09 2.07 1.82 2.23 2.04 1.99 5 HGG 1 2110430 2.27 1.89 to 2.48 2.44 2.20 2.23 2.48 2.27 1.89 2.47 2.22 2.21 5 HGG 1 2520894 2.32 1.99 to 2.58 2.58 2.49 2.57 2.18 2.34 1.99 2.40 2.17 2.17 5 HGG 1  408442 0.35 0.00 to 1.59 0.00 0.00 0.00 0.50 0.19 0.42 0.00 0.41 1.59 6 HGG 1 1513566 0.61 0.05 to 1.38 0.05 0.56 0.62 0.17 0.72 0.64 0.32 1.00 1.38 6 HGG 1 1299246 0.50 −0.25 to 1.59  −0.25 0.43 0.49 −0.08 0.47 0.50 0.26 1.06 1.59 6 HGG 1 4858420 0.47 −0.18 to 1.49  −0.18 0.38 0.43 −0.12 0.53 0.51 0.25 0.98 1.49 6 HGG 1 1308729 0.55 −0.14 to 1.66  −0.14 0.42 0.39 −0.02 0.59 0.52 0.44 1.13 1.66 6 HGG 1 5038177 0.57 −0.06 to 1.53  −0.06 0.49 0.48 0.04 0.58 0.56 0.35 1.12 1.53 6 HGG 1 1737512 0.24 0.00 to 1.32 1.32 0.00 0.01 0.22 0.10 0.12 0.00 0.14 0.23 6 HGG 1  305751 1.04 0.00 to 1.76 0.00 0.00 0.00 1.76 1.49 1.43 1.71 1.47 1.52 7 HGG 1 1447306 0.41 0.00 to 2.44 0.00 0.00 0.00 0.38 2.44 0.55 0.00 0.07 0.26 7 HGG 1 2579218 0.85 0.00 to 1.36 0.00 0.00 1.36 1.09 1.07 0.86 1.17 1.06 1.01 7 HGG 1 2358261 0.62 0.00 to 1.60 0.00 0.00 0.00 1.60 1.35 1.15 0.00 1.49 0.00 7 HGG 1 4630674 0.97 0.00 to 1.76 0.00 0.00 0.00 1.76 1.41 1.37 1.45 1.40 1.37 7 HGG 1 3391835 0.96 0.00 to 1.76 0.00 0.00 0.00 1.56 1.12 1.12 1.76 1.52 1.61 7 HGG 1 2494284 1.41 1.03 to 1.76 1.14 1.03 1.03 1.76 1.72 1.31 1.69 1.46 1.59 8 HGG 1 2120743 1.47 1.37 to 1.57 1.48 1.57 1.37 1.57 1.57 1.37 1.43 1.46 1.40 8 HGG 1 2070126 1.57 1.31 to 1.81 1.68 1.50 1.31 1.74 1.59 1.52 1.81 1.48 1.54 8 HGG 1 5046235 1.33 0.89 to 1.70 1.09 0.89 0.90 1.70 1.67 1.39 1.64 1.24 1.43 8 HGG 1 1630990 2.65 2.45 to 2.95 2.95 2.95 2.69 2.48 2.50 2.45 2.85 2.55 2.47 9 HGG 1 4549259 3.31 2.92 to 3.58 3.58 3.53 3.41 3.39 3.10 2.92 3.44 3.20 3.22 9 HGG 1 2755836 2.96 2.57 to 3.53 3.03 3.34 3.53 2.57 2.76 2.97 2.85 2.78 2.77 9 HGG 1 2057513 1.13 0.93 to 1.37 1.22 1.30 1.37 0.93 1.18 1.04 1.06 0.96 1.15 0 HGG 2 1988540 1.65 1.40 to 1.94 1.94 1.91 1.68 1.70 1.50 1.46 1.80 1.47 1.40 0 HGG 2 2499976 1.22 1.00 to 1.42 1.33 1.14 1.13 1.42 1.27 1.00 1.38 1.10 1.20 0 HGG 2 2018315 1.33 0.00 to 1.91 0.00 0.00 1.91 1.79 1.91 1.45 1.79 1.48 1.67 0 HGG 2 2021989 1.26 0.95 to 1.58 1.29 1.50 1.37 1.40 1.58 1.07 1.14 0.95 1.07 0 HGG 2 2057265 1.06 0.68 to 1.42 1.20 1.32 1.42 0.97 0.88 0.68 1.01 1.06 0.97 0 HGG 2 1407125 1.45 1.33 to 1.70 1.42 1.43 1.41 1.70 1.52 1.33 1.46 1.38 1.41 0 HGG 2 2234266 1.88 0.00 to 2.65 0.00 0.00 2.65 2.59 2.40 2.31 2.43 2.17 2.37 0 HGG 2 1559844 1.40 1.17 to 1.58 1.53 1.49 1.38 1.58 1.45 1.36 1.35 1.17 1.26 0 HGG 2 3206352 1.81 1.44 to 2.14 2.14 1.84 1.93 1.71 1.72 1.44 1.97 1.72 1.80 0 HGG 2  626471 1.52 0.00 to 249 0.00 0.00 2.49 1.88 2.26 1.82 1.91 1.69 1.63 0 HGG 2  755223 1.34 1.13 to 1.55 1.47 1.46 1.55 1.24 1.35 1.13 1.39 1.18 1.28 0 HGG 2 2173973 1.08 0.71 to 1.68 1.44 1.68 1.50 0.79 1.07 0.96 0.84 0.71 0.72 0 HGG 2 1679595 1.10 0.96 to 1.32 1.11 0.95 1.00 1.32 1.15 0.97 1.30 0.97 1.15 0 HGG 2 1709709 1.38 1.17 to 1.53 1.52 1.38 1.42 1.42 1.41 1.17 1.53 1.29 1.32 0 HGG 2  757514 1.09 0.82 to 1.33 1.33 1.25 1.28 1.00 1.13 0.82 1.13 0.87 0.98 0 HGG 2  835756 0.94 0.66 to 1.41 1.19 1.41 1.20 0.93 0.84 0.66 0.83 0.66 0.76 0 HGG 2  870396 1.10 0.84 to 1.37 1.17 1.15 1.32 1.13 1.37 0.99 1.00 0.84 0.93 0 HGG 2  960604 1.73 1.39 to 2.14 2.12 2.14 2.08 1.52 1.66 1.64 1.57 1.43 1.39 0 HGG 2 1911819 1.17 1.01 to 1.38 1.38 1.29 1.19 1.06 1.28 1.01 1.16 1.06 1.11 0 HGG 2 2230608 1.32 1.12 to 1.54 1.54 1.41 1.52 1.22 1.40 1.12 1.30 1.13 1.27 0 HGG 2 1961617 1.63 0.00 to 2.47 2.47 0.00 0.00 2.15 2.19 1.88 2.17 1.97 1.81 0 HGG 2 1305249 −0.98 −1.37 to −0.82 −0.82 −0.82 −0.86 −0.99 −1.21 −0.91 −0.85 −1.37 −1.00 1 HGG 2 2453558 −1.38 −1.60 to −1.20 −1.35 −1.20 −1.24 −1.34 −1.40 −1.44 −1.43 −1.60 −1.45 1 HGG 2 3421730 −0.95 −1.39 to −0.52 −0.66 −0.93 −1.28 −0.65 −0.65 −1.39 −0.52 −1.26 −1.25 1 HGG 2  523797 −1.05 −1.49 to −0.61 −0.61 −0.68 −0.75 −1.19 −1.49 −1.31 −0.85 −1.28 −1.25 1 HGG 2 1973123 −1.23 −1.86 to 0.00  −1.34 0.00 −1.13 −1.49 −1.86 −1.13 −1.37 −1.64 −1.11 1 HGG 2 2529162 −0.96 −1.35 to −0.69 −0.89 −0.69 −0.83 −1.04 −1.35 −1.09 −0.98 −0.96 −0.83 1 HGG 2 2703122 −1.61 −1.86 to −1.30 −1.39 −1.30 −1.51 −1.76 −1.86 −1.59 −1.53 −1.76 −1.76 1 HGG 2 2794866 −1.33 −1.85 to 0.00  0.00 −1.06 −1.51 −1.52 −1.85 −1.38 −1.44 −1.67 −1.53 1 HGG 2 2253868 −1.20 −1.65 to −0.75 −1.38 −1.20 −0.88 −1.47 −1.65 −0.99 −1.25 −1.26 −0.75 1 HGG 2 3029474 −0.99 −1.45 to −0.75 −0.76 −0.75 −0.88 −1.09 −1.45 −1.06 −0.95 −1.04 −0.96 1 HGG 2 1823946 −1.10 −1.33 to −0.95 −1.04 −0.95 −1.16 −0.99 −1.14 −1.15 −0.96 −1.33 −1.23 1 HGG 2 3100048 −0.88 −1.64 to 0.08  −0.27 −1.06 −1.29 −0.35 −0.75 −1.18 0.08 −1.64 −1.50 1 HGG 2 1988774 −1.18 −1.82 to −0.42 −0.78 −1.43 −1.16 −0.64 −1.59 −1.57 −0.42 −1.82 −1.24 1 HGG 2 2293494 −0.69 −1.35 to 0.00  0.00 0.00 0.00 −0.91 −0.93 −1.07 −1.03 −1.35 −0.93 2 HGG 2 1401312 −1.09 −2.08 to 0.00  0.00 0.00 −0.76 −1.58 −2.08 −1.38 −1.38 −1.44 −1.17 2 HGG 2 1604650 −0.70 −1.51 to 0.00  0.00 0.00 0.00 0.00 −1.14 −1.51 −1.23 −1.46 −0.98 2 HGG 2 1616048 −0.87 −1.36 to 0.00  0.00 0.00 −0.85 −1.00 −1.25 −1.28 −0.86 −1.36 −1.26 2 HGG 2 1662870 −0.93 −1.59 to 0.00  0.00 0.00 0.00 −1.30 −1.44 −1.40 −1.46 −1.59 −1.17 2 HGG 2 1753283 −1.24 −1.96 to 0.00  0.00 −1.04 0.00 −1.81 −1.96 −1.63 −1.59 −1.68 −1.45 2 HGG 2 2703282 −1.01 −1.59 to 0.00  0.00 0.00 −1.12 −1.27 −1.59 −1.22 −1.19 −1.43 −1.24 2 HGG 2 2706669 −0.87 −1.76 to 0.00  0.00 0.00 −0.71 −1.11 −1.76 −1.10 −0.94 −1.44 −0.78 2 HGG 2 1799078 −0.70 −1.40 to 0.00  0.00 0.00 0.00 −0.86 −1.01 −1.39 −0.66 −1.02 −1.40 2 HGG 2 3426776 0.61 0.00 to 1.33 0.00 0.00 0.00 0.00 1.33 0.83 1.21 1.00 1.15 3 HGG 2 1926934 0.72 0.00 to 1.71 0.00 0.00 0.00 0.00 1.68 1.55 1.71 1.54 0.00 3 HGG 2 2725369 0.87 0.26 to 1.48 0.38 0.29 0.26 1.48 1.07 0.58 1.43 1.05 1.27 3 HGG 2 2226309 0.71 0.00 to 1.63 0.00 0.00 0.00 0.00 1.63 1.35 1.19 1.11 1.10 3 HGG 2 2222155 0.58 0.00 to 1.59 0.00 0.00 0.00 0.00 1.59 0.86 0.86 0.89 0.99 3 HGG 2 1303862 1.28 0.00 to 2.64 0.00 0.00 0.00 0.00 2.20 1.81 2.33 2.64 2.57 3 HGG 2 1515346 0.87 0.00 to 1.51 0.00 0.00 0.00 1.35 1.40 1.13 1.51 1.22 1.21 3 HGG 2 1670407 0.67 0.00 to 1.42 0.00 0.00 0.00 1.29 1.42 0.95 0.00 1.22 1.20 3 HGG 2 2246915 0.39 0.00 to 194 0.00 0.00 0.00 0.00 1.94 1.53 0.00 0.00 0.00 4 HGG 2  686993 0.51 0.00 to 1.80 0.00 0.00 0.00 0.00 1.80 1.26 0.00 1.50 0.00 4 HGG 2 3229449 0.39 0.00 to 1.49 0.00 0.00 0.00 0.00 1.17 0.89 0.00 1.49 0.00 4 HGG 2 2760615 0.23 0.00 to 1.46 0.00 0.00 0.00 0.00 1.46 0.62 0.00 0.00 0.00 4 HGG 2  868678 0.39 0.00 to 1.58 0.00 0.00 0.00 0.00 1.58 0.81 0.00 1.08 0.00 4 HGG 2 2837006 0.37 0.00 to 1.88 0.00 0.00 0.00 0.00 1.88 1.46 0.00 0.00 0.00 4 HGG 2 1316801 2.58 2.28 to 2.90 2.69 2.63 2.65 2.67 2.90 2.37 2.68 2.28 2.35 5 HGG 2  660142 2.99 2.61 to 3.34 3.01 2.99 3.31 3.14 3.34 2.85 2.94 2.72 2.61 5 HGG 2 2544622 2.51 0.00 to 3.33 3.33 0.00 3.26 2.82 2.59 2.58 2.77 2.65 2.57 5 HGG 2 1326255 2.78 2.39 to 3.06 3.05 3.06 2.90 2.87 2.39 2.55 2.85 2.64 2.67 5 HGG 2 2124056 2.61 2.39 to 2.92 2.53 2.41 2.47 2.92 2.83 2.68 2.67 2.39 2.64 5 HGG 2 2215282 0.55 0.00 to 1.60 0.00 0.56 0.53 0.51 0.49 0.32 1.60 0.48 0.44 6 HGG 2 1798594 0.69 0.23 to 1.35 1.35 1.34 1.23 0.29 0.58 0.42 0.48 0.23 0.28 6 HGG 2 2189061 0.15 0.00 to 1.32 0.00 0.00 0.00 0.00 0.00 1.32 0.00 0.00 0.00 6 HGG 2 1317428 0.19 −0.18 to 1.49  0.00 0.00 0.00 0.00 0.17 −0.18 0.18 0.03 1.49 6 HGG 2 1251065 1.38 1.05 to 1.62 1.53 1.62 1.55 1.46 1.40 1.05 1.53 1.18 1.12 0 HGG 3 4252872 1.24 0.96 to 1.52 1.31 1.27 1.29 1.52 1.38 1.04 1.40 0.97 0.96 0 HGG 3 4855265 1.14 0.81 to 1.43 1.29 1.43 1.35 1.26 1.12 0.91 1.17 0.81 0.95 0 HGG 3 4863677 1.11 0.81 to 1.35 1.20 1.35 1.24 1.21 1.14 0.81 1.12 0.97 0.99 0 HGG 3 4912315 1.60 1.36 to 1.92 1.89 1.92 1.82 1.65 1.43 1.36 1.58 1.38 1.40 0 HGG 3 2170820 1.17 1.01 to 1.38 1.28 1.26 1.38 1.22 1.13 1.04 1.15 1.01 1.09 0 HGG 3 5322365 1.49 1.23 to 1.73 1.58 1.73 1.69 1.52 1.47 1.23 1.56 1.26 1.41 0 HGG 3  554654 0.99 0.67 to 1.34 1.34 1.19 0.91 0.94 0.67 0.70 1.02 1.15 1.03 0 HGG 3 2343836 0.93 0.65 to 1.36 0.65 1.29 1.36 0.75 0.69 0.95 1.05 0.78 0.86 0 HGG 3  615776 1.06 0.68 to 1.48 1.35 1.48 1.47 1.04 0.91 0.80 1.01 0.68 0.81 0 HGG 3  689296 1.05 0.84 to 1.33 1.14 1.28 1.33 0.89 0.91 0.84 0.91 1.03 1.10 0 HGG 3 2545486 1.46 1.06 to 1.74 1.67 1.51 1.72 1.74 1.23 1.33 1.51 1.06 1.35 0 HGG 3 3332232 1.08 0.81 to 1.38 1.38 1.20 1.03 1.16 1.06 0.84 1.21 0.81 1.02 0 HGG 3 2660756 1.13 0.84 to 1.75 1.12 1.75 1.25 1.20 1.19 0.88 1.03 0.84 0.92 0 HGG 3 2687356 1.26 0.93 to 1.47 1.47 1.45 1.36 1.43 1.33 1.07 1.24 0.93 1.06 0 HGG 3 3495173 1.52 1.18 to 1.69 1.66 1.69 1.66 1.67 1.63 1.42 1.43 1.18 1.30 0 HGG 3  748477 1.42 1.12 to 1.63 1.59 1.63 1.41 1.38 1.32 1.12 1.34 1.39 1.57 0 HGG 3 2871076 1.30 0.92 to 1.63 1.40 1.60 1.63 1.36 1.10 0.92 1.40 1.07 1.19 0 HGG 3 2972013 1.49 1.14 to 1.74 1.60 1.74 1.66 1.59 1.45 1.40 1.55 1.14 1.31 0 HGG 3 3034889 1.51 1.26 to 1.75 1.56 1.75 1.65 1.55 1.51 1.26 1.61 1.31 1.37 0 HGG 3 3974247 1.47 1.17 to 1.78 1.66 1.78 1.77 1.42 1.44 1.19 1.59 1.17 1.18 0 HGG 3 3973687 1.31 1.01 to 1.52 1.37 1.52 1.49 1.37 1.46 1.18 1.34 1.01 1.06 0 HGG 3 4215034 1.20 0.83 to 1.45 1.44 1.34 1.45 1.18 1.26 0.83 1.19 1.02 1.07 0 HGG 3 3090808 −1.14 −1.75 to 0.00  0.00 −0.97 −0.85 −1.55 −1.75 −1.25 −1.18 −1.53 −1.18 1 HGG 3 5089438 −1.09 −1.44 to −0.44 −1.07 −1.06 −0.79 −1.44 −1.28 −1.43 −0.44 −1.06 −1.25 1 HGG 3 1911443 −0.98 −1.56 to −0.42 −0.42 −0.73 −1.36 −0.63 −0.80 −1.56 −0.56 −1.43 −1.38 1 HGG 3 3097624 −1.19 −1.33 to −1.03 −1.15 −1.20 −1.20 −1.20 −1.03 −1.33 −1.20 −1.30 −1.05 1 HGG 3 3120209 −1.45 −2.05 to −0.91 −2.05 −1.47 −0.91 −2.01 −1.29 −0.98 −1.94 −1.40 −0.96 1 HGG 3 3135460 −1.36 −1.97 to −0.81 −0.94 −1.17 −1.46 −1.11 −1.43 −1.82 −0.81 −1.51 −1.97 1 HGG 3 3778404 −1.77 −2.06 to −1.34 −1.34 −1.81 −1.63 −1.85 −1.97 −1.92 −1.49 −1.90 −2.00 1 HGG 3 4715924 −1.35 −1.81 to −0.92 −1.50 −1.42 −1.06 −1.55 −1.81 −1.14 −1.36 −1.40 −0.92 1 HGG 3  654246 −1.08 −1.34 to −0.65 −0.65 −1.02 −0.98 −1.15 −1.28 −1.33 −0.78 −1.20 −1.34 1 HGG 3 5573549 −1.49 −1.59 to −1.42 −1.46 −1.52 −1.49 −1.48 −1.42 −1.54 −1.59 −1.46 −1.48 1 HGG 3 4289557 −2.09 −2.41 to −1.71 −1.71 −1.87 −1.88 −2.26 −2.33 −2.41 −1.96 −2.10 −2.27 1 HGG 3 5427710 −1.96 −2.07 to −1.80 −1.80 −2.07 −1.92 −1.99 −1.86 −2.06 −1.89 −2.03 −2.05 1 HGG 3 5166479 −1.43 −1.71 to −1.02 −1.27 −1.68 −1.71 −1.12 −1.54 −1.58 −1.02 −1.65 −1.26 1 HGG 3 5044351 −0.88 −1.44 to 0.00  0.00 −0.91 −0.64 −0.97 −1.44 −0.99 −0.70 −1.43 −0.85 1 HGG 3 3084204 −1.56 −1.80 to −1.40 −1.40 −1.46 −1.49 −1.80 −1.60 −1.64 −1.41 −1.55 −1.70 1 HGG 3 5508135 1.66 0.00 to 2.20 0.00 2.20 2.11 2.09 1.79 1.48 2.13 1.64 1.55 2 HGG 3 1786554 1.64 1.34 to 2.03 1.94 2.03 1.80 1.68 1.55 1.34 1.58 1.38 1.45 2 HGG 3 5512044 1.91 1.62 to 2.20 1.92 2.09 2.20 2.09 1.91 1.65 1.92 1.62 1.81 2 HGG 3 4402555 2.38 1.95 to 2.61 2.49 2.61 2.56 2.60 2.39 2.15 2.30 1.95 2.33 2 HGG 3 2343348 1.92 1.76 to 2.21 1.85 2.10 2.21 1.91 1.92 1.90 1.88 1.79 1.76 2 HGG 3  621543 1.87 1.47 to 2.25 2.03 2.25 2.06 1.98 1.78 1.47 1.87 1.69 1.72 2 HGG 3 3074113 2.17 1.89 to 2.55 2.15 255 2.40 2.23 2.15 2.02 2.16 1.89 1.99 2 HGG 3 3158828 1.97 1.53 to 2.34 2.26 2.33 2.34 2.14 1.99 1.71 1.84 1.53 1.56 2 HGG 3 3957354 1.89 0.00 to 291 0.00 2.91 2.79 2.21 2.29 2.38 0.00 2.22 2.20 2 HGG 3 5102731 1.86 1.66 to 2.19 1.94 2.19 1.98 1.66 2.00 1.68 1.82 1.68 1.80 2 HGG 3 4253809 1.98 1.81 to 2.17 1.94 2.04 1.97 2.17 2.02 1.81 2.05 1.87 1.95 2 HGG 3 3091135 0.01 −0.37 to 1.52  1.52 0.11 0.09 −0.15 −0.33 −0.36 −0.20 −0.37 −0.26 3 HGG 3 4232507 0.50 0.00 to 1.43 0.00 0.00 0.00 1.43 0.00 1.09 0.00 0.84 1.15 3 HGG 3 2195427 0.15 0.00 to 1.34 0.00 0.00 0.00 0.00 0.00 1.34 0.0a 0.00 0.00 3 HGG 3 2399169 0.21 −0.11 to 2.01  2.01 0.00 0.00 0.00 −0.03 −0.11 0.00 0.04 0.00 3 HGG 3 2611889 0.15 0.00 to 1.33 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.33 3 HGG 3  699113 0.20 0.00 to 1.78 0.00 0.00 0.00 0.00 0.00 1.78 0.00 0.00 0.00 3 HGG 3 3979665 −0.04 −2.67 to 0.60  0.00 −2.67 0.27 0.00 0.60 0.36 0.59 0.48 0.00 3 HGG 3 2539933 −0.16 −1.76 to 0.16  0.00 0.00 0.00 0.00 0.14 0.03 −1.76 0.16 0.00 3 HGG 3 3068978 0.19 0.00 to 1.67 0.00 0.00 0.00 0.00 0.00 1.67 0.00 0.00 0.00 3 HGG 3 2726759 −0.02 −0.39 to 1.47  1.47 0.00 0.09 −0.22 −0.38 −0.37 −0.26 −0.39 −0.08 3 HGG 3 1560380 0.68 0.00 to 1.59 0.00 0.00 0.00 0.00 1.59 1.49 0.00 1.52 1.52 4 HGG 3  664625 0.83 0.00 to 1.79 0.00 0.00 0.00 0.00 1.45 1.24 1.79 1.48 1.53 4 HGG 3  517374 1.04 0.00 to 1.69 0.00 0.00 1.69 1.41 1.42 1.16 1.42 1.16 1.13 4 HGG 3 5326983 0.94 0.00 to 1.61 0.00 0.00 1.61 1.30 1.28 0.92 1.26 1.01 1.06 4 HGG 3 4508879 0.91 0.00 to 1.51 0.00 0.00 1.48 0.00 1.31 1.20 1.20 1.51 1.50 4 HGG 3  621216 0.79 0.00 to 1.40 0.00 0.00 1.40 1.01 0.99 0.86 1.14 0.85 0.85 4 HGG 3  872017 1.26 0.00 to 2.00 0.00 0.00 2.00 1.75 1.66 1.53 1.53 1.35 1.52 4 HGG 3 3172265 3.11 2.90 to 3.39 3.01 3.18 3.39 3.07 3.23 3.11 3.04 2.90 3.02 5 HGG 3 3069190 3.87 3.57 to 4.20 3.82 3.86 3.76 4.20 4.01 3.76 4.01 3.57 3.86 5 HGG 3 5266015 2.58 2.24 to 2.77 2.65 2.77 2.70 2.73 2.68 2.29 2.62 2.24 2.50 5 HGG 3 2702786 0.19 −0.19 to 2.06  −0.07 −0.12 −0.18 −0.18 −0.19 −0.18 2.06 0.29 0.25 6 HGG 3 2169433 0.29 0.00 to 2.50 0.00 0.00 0.00 0.00 0.00 0.10 2.50 0.00 0.00 6 HGG 3  439415 1.23 1.01 to 1.53 1.36 1.53 1.41 1.25 1.20 1.14 1.07 1.01 1.09 0 HGG 4 1942785 0.85 0.47 to 1.32 1.32 0.89 0.70 0.82 1.06 0.70 0.74 0.47 0.91 0 HGG 4 2751922 1.28 0.97 to 1.56 1.56 1.18 1.26 1.25 1.34 1.14 1.33 0.97 1.46 0 HGG 4 2062085 1.30 1.11 to 1.47 1.32 1.47 1.41 1.44 1.27 1.16 1.31 1.11 1.20 0 HGG 4  409209 1.18 1.03 to 1.44 1.26 1.18 1.04 1.31 1.44 1.06 1.24 1.08 1.03 0 HGG 4 1448572 1.29 1.06 to 1.71 1.71 1.26 1.26 1.09 1.41 1.06 1.30 1.06 1.42 0 HGG 4 5101167 1.29 0.00 to 1.80 1.80 1.58 1.37 1.51 1.62 1.36 0.00 1.06 1.29 0 HGG 4 5102951 0.84 0.00 to 1.54 1.54 0.00 1.12 1.16 0.00 0.92 1.07 0.72 1.02 0 HGG 4 3449615 1.05 0.59 to 1.65 1.65 1.13 1.05 0.92 1.23 0.82 1.03 0.59 1.04 0 HGG 4 1611629 1.19 0.84 to 1.53 1.37 1.19 1.35 1.29 1.53 1.02 0.99 0.84 1.09 0 HGG 4 5507406 0.95 0.00 to 1.53 1.53 0.00 1.08 0.85 1.06 0.91 1.08 0.85 1.17 0 HGG 4 3016137 1.41 0.93 to 1.79 1.34 1.79 0.93 1.72 1.06 1.28 1.46 1.51 1.61 0 HGG 4 1716458 1.24 1.00 to 1.42 1.37 1.42 1.36 1.31 1.25 1.01 1.26 1.00 1.22 0 HGG 4 2158661 0.91 0.50 to 1.38 1.38 0.95 0.84 0.86 1.03 0.96 0.70 0.50 0.97 0 HGG 4 1730026 1.31 0.87 to 1.57 1.57 1.36 1.56 1.35 1.51 1.04 1.22 0.87 1.33 0 HGG 4 2196870 1.19 0.99 to 1.40 1.30 1.40 1.10 1.27 1.26 1.24 0.99 1.02 1.17 0 HGG 4 2227273 1.05 0.59 to 1.58 0.69 0.81 0.59 1.58 1.23 0.98 1.18 1.03 1.34 0 HGG 4 2756587 1.22 0.96 to 1.45 1.24 1.30 1.45 1.40 1.22 1.05 1.21 0.96 1.19 0 HGG 4 1365045 2.17 1.86 to 2.40 2.39 2.22 2.18 2.18 2.40 1.86 2.24 1.99 2.12 1 HGG 4  434751 1.75 1.50 to 2.03 1.66 1.78 1.50 2.03 1.88 1.69 1.85 1.65 1.76 1 HGG 4 2106010 1.72 1.43 to 1.97 1.89 1.64 1.92 1.82 1.97 1.57 1.61 1.43 1.66 1 HGG 4 2110482 1.48 1.27 to 1.79 1.60 1.61 1.79 1.49 1.57 1.27 1.32 1.30 1.39 1 HGG 4 4077648 1.47 0.99 to 1.79 1.63 1.39 0.99 1.79 1.66 1.41 1.56 1.22 1.54 1 HGG 4 3191030 1.97 1.73 to 2.19 2.08 2.00 1.76 1.98 2.10 1.73 2.19 1.87 2.01 1 HGG 4 2007730 1.67 1.24 to 2.09 2.09 1.84 1.64 1.67 1.95 1.56 1.49 1.24 1.54 1 HGG 4 2619275 1.62 1.31 to 1.92 1.92 1.74 1.64 1.67 1.85 1.44 1.49 1.31 1.56 1 HGG 4 2350594 1.49 1.22 to 1.67 1.63 1.51 1.67 1.52 1.65 1.22 1.26 1.41 1.53 1 HGG 4 2408333 1.53 0.00 to 2.04 1.42 0.00 1.41 1.80 1.00 1.54 1.91 1.74 2.04 1 HGG 4 1913334 1.66 1.34 to 1.79 1.79 1.79 1.77 1.65 1.71 1.43 1.74 1.34 1.71 1 HGG 4 1965856 1.56 1.23 to 1.69 1.53 1.68 1.65 1.64 1.58 1.23 1.69 1.53 1.55 1 HGG 4 2006043 1.41 0.00 to 177 1.77 0.00 1.60 1.68 1.75 1.40 1.66 1.36 1.49 1 HGG 4 5690026 1.57 1.30 to 1.89 1.62 1.57 1.70 1.72 1.89 1.32 1.48 1.30 1.53 1 HGG 4 1876829 −1.13 −1.44 to −0.88 −1.14 −1.03 −0.88 −1.18 −1.22 −1.44 −1.19 −1.11 −1.02 2 HGG 4 1953051 −1.16 −1.42 to −0.94 −1.42 −1.38 −1.34 −0.95 −1.11 −1.12 −1.04 −1.11 −0.94 2 HGG 4 2055569 −1.00 −1.75 to −0.20 −0.55 −1.14 −1.48 −0.69 −0.38 −1.54 −0.20 −1.24 −1.75 2 HGG 4 2346851 −0.97 −1.33 to −0.76 −0.76 −0.86 −0.82 −1.04 −1.33 −1.02 −0.96 −1.06 −0.86 2 HGG 4 2747179 −0.99 −1.41 to −0.65 −1.03 −1.00 −0.86 −1.27 −1.41 −0.88 −1.14 −0.70 −0.65 2 HGG 4 2786442 −1.55 −1.87 to −1.15 −1.87 −1.68 −1.15 −1.74 −1.69 −1.30 −1.65 −1.00 −1.27 2 HGG 4 3042227 −1.90 −2.37 to −1.67 −2.03 −1.95 −1.73 −1.96 −2.37 −1.67 −1.77 −1.83 −1.78 2 HGG 4  495808 −1.16 −1.44 to −0.94 −1.44 −1.41 −1.04 −0.94 −1.18 −1.11 −1.12 −1.17 −1.01 2 HGG 4 1383138 −1.14 −1.93 to −0.54 −0.54 −1.12 −1.20 −0.73 −1.93 −1.30 −0.62 −1.46 −1.34 2 HGG 4 1449819 −1.23 −2.05 to −0.11 −0.62 −1.11 −1.88 −0.11 −1.25 −2.05 −0.44 −1.90 −1.71 2 HGG 4 5280239 −1.02 −1.41 to −0.47 −1.18 −1.11 −0.47 −1.20 −1.41 −0.64 −1.12 −1.11 −0.97 2 HGG 4 1721320 −0.97 −1.56 to −0.74 −0.74 −0.78 −0.90 −0.93 −1.56 −1.01 −0.94 −0.97 −0.90 2 HGG 4 1857850 −2.23 −2.73 to −1.90 −1.90 −1.95 −2.07 −2.34 −2.73 −2.28 −2.25 −2.26 −2.31 2 HGG 4 1900173 0.78 0.00 to 1.44 1.44 0.00 0.00 1.18 1.06 0.82 0.89 0.71 0.91 3 HGG 4  278100 0.21 0.00 to 1.88 0.00 0.00 0.00 0.00 1.88 0.00 0.00 0.00 0.00 3 HGG 4 2013251 0.91 0.00 to 2.15 0.00 0.00 0.00 2.07 2.15 2.14 0.00 1.82 0.00 3 HGG 4 2803833 0.42 0.00 to 3.75 3.75 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG 4 1495947 0.46 0.00 to 4.15 4.15 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 3 HGG 4 2404746 0.42 0.00 to 1.71 0.00 0.00 0.00 1.12 0.00 1.71 0.00 0.99 0.00 3 HGG 4 3149570 0.85 0.00 to 1.76 0.00 0.00 1.76 1.59 1.71 1.32 0.00 1.29 0.00 3 HGG 4 3188860 0.61 0.00 to 1.39 1.39 0.00 0.00 0.78 0.92 0.90 0.00 0.56 0.98 3 HGG 4  417432 0.65 0.00 to 1.33 0.00 0.00 0.00 1.33 1.20 0.00 1.27 0.89 1.19 3 HGG 4 2405487 0.58 0.00 to 1.46 0.00 0.00 0.00 1.41 1.46 1.21 0.00 1.12 0.00 3 HGG 4  509839 0.77 0.00 to 2.01 0.00 0.00 0.00 1.76 0.00 1.64 0.00 1.49 2.01 3 HGG 4 2399665 −0.70 −1.66 to 0.00  0.00 0.00 0.00 −1.66 0.00 −1.32 −1.15 −1.17 −0.98 4 HGG 4 1707037 −0.23 −1.89 to 0.00  −1.89 0.00 0.00 0.00 0.00 0.00 0.00 −0.16 0.00 4 HGG 4 1662632 −0.62 −2.06 to 0.00  −0.34 0.00 0.00 −0.77 −2.06 −0.45 −0.51 −0.83 −0.61 4 HGG 4 2347684 −0.30 −2.70 to 0.00  0.00 0.00 0.00 −2.70 0.00 0.00 0.00 0.00 0.00 4 HGG 4  380041 −0.37 −1.33 to −0.06 −0.06 −0.29 −0.18 −0.35 −1.33 −0.31 −0.24 −0.27 −0.30 4 HGG 4 4003460 −0.71 −1.63 to 0.00  −0.29 0.00 −0.32 −0.78 −1.63 −0.94 −0.88 −0.77 −0.80 4 HGG 4 4248767 −0.51 −1.38 to −0.14 −0.14 −0.22 −0.59 −0.23 −1.38 −0.72 −0.26 −0.55 −0.51 4 HGG 4 1446475 −0.70 −1.43 to −0.34 −0.34 −0.46 −0.64 −0.46 −1.43 −0.84 −0.46 −0.73 −0.91 4 HGG 4 5424122 −0.87 −1.47 to −0.35 −0.83 −0.81 −0.35 −1.19 −1.47 −0.71 −1.07 −0.92 −0.45 4 HGG 4 1964758 2.52 2.21 to 2.77 2.77 2.67 2.57 2.52 2.65 2.21 2.51 2.30 2.47 5 HGG 4 2581075 4.07 3.77 to 4.29 4.28 4.24 4.06 4.15 4.29 3.95 3.77 3.85 4.04 5 HGG 4 1370137 2.80 2.51 to 2.97 2.97 2.92 2.89 2.79 2.91 2.80 2.64 2.51 2.80 5 HGG 4 2278772 3.00 2.46 to 3.50 3.02 3.50 2.94 3.27 3.28 3.03 2.63 2.46 2.87 5 HGG 4 1597837 0.46 −0.02 to 3.03  0.14 0.14 0.23 0.13 −0.02 0.02 3.03 0.12 0.39 6 HGG 4 1211357 0.19 −0.15 to 1.80  0.23 0.00 0.03 −0.15 −0.05 −0.09 1.80 −0.03 −0.02 6 HGG 4 5867032 0.19 0.00 to 1.71 0.00 0.00 0.00 0.00 0.00 0.00 1.71 0.03 0.00 6 HGG 4

TABLE 11 3031022 −1.79 −2.03 to −1.57 −1.74 −2.03 −1.78 −1.90 −1.64 −1.82 −1.57 −1.76 −1.84 0 HGG 1 3001212 −1.43 −1.87 to −1.12 −1.40 −1.56 −1.20 −1.64 −1.32 −1.37 −1.87 −1.38 −1.12 0 HGG 1 2042056 −1.64 −1.92 to −1.37 −1.68 −1.76 −1.45 −1.75 −1.50 −1.51 −1.92 −1.78 −1.37 0 HGG 1 2047730 −1.22 −1.55 to −0.94 −1.09 −1.38 −0.95 −1.03 −0.94 −1.18 −1.42 −1.42 −1.55 0 HGG 1 2055867 −0.88 −1.32 to −0.42 −0.43 −1.19 −0.96 −0.52 −0.91 −1.14 −0.42 −1.32 −1.01 0 HGG 1 2061528 −1.38 −1.53 to −1.26 −1.26 −1.46 −1.39 −1.53 −1.27 −1.26 −1.34 −1.40 −1.51 0 HGG 1 2912637 −2.17 −2.59 to −1.77 −2.39 −2.32 −1.79 −2.59 −1.77 −1.95 −2.41 −2.18 −2.13 0 HGG 1 2495131 −1.08 −1.44 to −0.67 −1.19 −1.44 −1.10 −1.22 −1.17 −1.04 −0.82 −1.06 −0.67 0 HGG 1 2252884 −1.03 −1.33 to −0.59 −1.13 −1.33 −0.81 −1.03 −0.59 −1.07 −1.06 −1.00 −1.24 0 HGG 1 2285521 −1.09 −1.36 to −0.63 −1.18 1.36 −0.94 −1.20 −0.63 −1.05 −1.17 −1.07 −1.17 0 HGG 1 2506973 −1.31 −1.69 to 0.00  −1.41 −1.69 −1.22 −1.65 −1.31 −1.36 0.00 −1.60 −1.52 0 HGG 1 2886955 −1.62 −1.89 to −1.35 −1.55 −1.64 −1.52 −1.89 −1.35 −1.51 −1.79 −1.70 −1.65 0 HGG 1  41479 −1.21 −1.49 to −0.94 −1.20 −1.36 −0.94 −0.96 −1.21 −1.24 −1.49 −1.24 −1.22 0 HGG 1 4408943 −1.54 −1.66 to −1.37 −1.37 −1.66 −1.37 −1.43 −1.52 −1.62 −1.58 −1.62 −1.65 0 HGG 1 4098018 −1.03 −1.32 to −0.84 −0.86 −0.99 −0.92 −1.12 −0.84 −0.88 −1.15 −1.25 −1.32 0 HGG 1 5047895 −1.44 −1.81 to −1.22 −1.22 −1.40 −1.32 −1.23 −1.27 −1.62 −1.46 −1.61 −1.81 0 HGG 1 5291518 −1.26 −1.41 to −1.09 −1.24 −1.41 −1.22 −1.09 −1.23 −1.29 −1.20 −1.31 −1.34 0 HGG 1 5541828 −1.74 −2.18 to −1.50 −1.50 −1.63 −1.54 −1.66 −1.53 −1.63 −1.93 −2.04 −2.18 0 HGG 1  560115 −1.93 −2.46 to −1.69 −1.69 −2.01 −1.87 −1.75 −1.80 −1.98 −1.78 −2.46 −2.03 0 HGG 1  891072 −1.14 −1.33 to −0.96 −0.99 −1.33 −1.03 −1.28 −0.96 −1.15 −1.09 −1.14 −1.23 0 HGG 1 1560906 1.28 0.91 to 1.62 1.42 1.44 1.14 1.62 1.29 0.91 1.38 1.07 1.26 1 HGG 1 1609387 1.02 0.75 to 1.35 1.08 1.15 0.82 1.25 0.91 0.75 1.35 0.80 1.03 1 HGG 1 1610828 1.09 0.81 to 1.49 1.12 1.16 0.81 1.49 1.03 0.95 1.31 0.88 1.07 1 HGG 1 2459765 1.17 0.96 to 1.38 1.23 1.29 0.96 1.20 1.16 1.05 1.22 1.03 1.38 1 HGG 1 2311213 1.06 0.71 to 1.37 1.02 0.88 0.71 0.97 1.05 1.04 1.32 1.17 1.37 1 HGG 1 1899766 0.91 0.66 to 1.35 0.69 0.98 1.10 0.93 1.35 0.83 0.95 0.66 0.68 1 HGG 1 1944123 1.14 0.97 to 1.38 1.14 1.24 0.97 1.38 1.20 1.00 1.26 0.97 1.07 1 HGG 1  305751 1.18 0.00 to 1.85 1.31 0.00 1.45 1.53 0.00 1.44 1.85 1.50 1.55 1 HGG 1 4286760 1.20 0.98 to 1.50 1.07 1.05 1.50 1.08 1.26 1.23 0.98 1.27 1.38 1 HGG 1 4289063 1.03 0.70 to 1.39 1.37 1.28 0.81 1.39 1.09 0.88 0.95 0.70 0.84 1 HGG 1 1004382 1.21 1.00 to 1.48 1.20 1.28 1.00 1.25 1.00 1.19 1.48 1.18 1.29 1 HGG 1 4021009 1.09 0.78 to 1.38 1.15 1.16 0.83 1.26 0.97 0.78 1.38 1.08 1.21 1 HGG 1 4978708 1.14 0.97 to 1.43 1.15 1.14 0.97 1.31 1.17 1.07 1.43 1.01 1.03 1 HGG 1 1241484 1.24 1.07 to 1.41 1.36 1.34 1.09 1.40 1.23 1.07 1.41 1.09 1.20 1 HGG 1  143765 1.24 0.86 to 1.43 1.34 1.28 0.86 1.38 1.12 1.15 1.41 1.22 1.43 1 HGG 1  531505 1.21 0.94 to 1.56 1.39 1.46 0.94 1.56 1.24 1.18 1.18 0.94 0.99 1 HGG 1 5397446 0.96 0.46 to 1.41 0.88 1.26 0.80 1.02 1.41 0.46 1.25 0.72 0.87 1 HGG 1 3497231 1.14 0.89 to 1.34 1.29 1.28 0.89 1.11 0.96 1.00 1.30 1.06 1.34 1 HGG 1 5543385 1.00 0.76 to 1.39 0.89 1.05 1.07 1.01 1.39 0.94 1.07 0.76 0.86 1 HGG 1 1521272 1.20 1.02 to 1.47 1.20 1.26 1.08 1.32 1.13 1.02 1.47 1.14 1.20 1 HGG 1 2756333 1.18 0.77 to 1.45 1.25 1.28 0.77 1.19 1.09 0.96 1.42 1.20 1.45 1 HGG 1 3595618 1.39 1.18 to 1.57 1.51 1.43 1.18 1.52 1.37 1.33 1.57 1.19 1.42 2 HGG 1 3606046 1.61 1.14 to 1.89 1.73 1.73 1.14 1.84 1.37 1.40 1.85 1.51 1.89 2 HGG 1 3687719 1.35 1.10 to 1.56 1.34 1.56 1.27 1.52 1.53 1.24 1.44 1.20 1.10 2 HGG 1  371201 1.27 0.97 to 1.53 0.97 1.41 1.08 1.27 1.07 1.19 1.53 1.40 1.49 2 HGG 1 3821432 1.37 1.05 to 1.64 1.42 1.49 1.05 1.44 1.19 1.27 1.53 1.27 1.64 2 HGG 1 1342744 1.50 1.24 to 1.70 1.60 1.70 1.24 1.56 1.46 1.35 1.64 1.32 1.60 2 HGG 1 1459743 1.45 1.17 to 1.66 1.48 1.66 1.17 1.56 1.43 1.25 1.59 1.28 1.62 2 HGG 1 1684617 1.54 1.07 to 1.86 1.60 1.63 1.07 1.80 1.25 1.22 1.84 1.57 1.86 2 HGG 1 1756875 1.26 0.88 to 1.68 1.21 1.32 0.88 1.33 1.15 1.05 1.46 1.28 1.68 2 HGG 1 2070126 1.49 1.24 to 1.76 1.37 1.65 1.40 1.59 1.24 1.47 1.76 1.45 1.47 2 HGG 1 2120743 1.36 0.97 to 1.85 1.35 1.56 0.97 1.34 1.04 1.08 1.85 1.49 1.59 2 HGG 1 5046235 1.28 0.86 to 1.68 0.86 1.33 1.35 1.13 1.17 1.19 1.68 1.42 1.44 2 HGG 1 2313349 1.50 1.26 to 1.69 1.55 1.67 1.26 1.65 1.44 1.35 1.69 1.35 1.55 2 HGG 1 2445967 1.37 1.13 to 1.68 1.49 1.51 1.28 1.68 1.29 1.23 1.48 1.13 1.19 2 HGG 1 2494284 1.57 0.97 to 2.27 1.16 1.63 1.21 1.34 0.97 1.39 2.27 2.09 2.11 2 HGG 1 2511277 1.57 1.19 to 1.86 1.57 1.56 1.19 1.78 1.65 1.31 1.86 1.56 1.65 2 HGG 1 2516950 1.54 1.30 to 1.80 1.63 1.67 1.30 1.80 1.37 1.35 1.70 1.42 1.60 2 HGG 1 2697275 1.32 0.85 to 1.72 1.38 1.38 0.85 1.22 0.94 1.23 1.72 1.44 1.70 2 HGG 1 2778441 1.45 1.21 to 1.62 1.51 1.57 1.26 1.62 1.48 1.28 1.46 1.21 1.62 2 HGG 1  671717 1.38 1.00 to 1.72 1.39 1.46 1.00 1.46 1.26 1.30 1.72 1.30 1.53 2 HGG 1 2833342 1.38 1.12 to 1.54 1.50 1.54 1.12 1.43 1.21 1.31 1.54 1.25 1.54 2 HGG 1 1457424 2.30 1.93 to 2.70 2.70 2.68 1.93 2.58 2.17 2.12 2.28 1.98 2.24 3 HGG 1  617587 1.89 1.53 to 2.31 1.67 1.96 1.54 1.90 1.89 1.53 2.24 1.95 2.31 3 HGG 1  459372 1.86 1.59 to 2.10 2.07 2.07 1.59 2.10 1.60 1.61 2.05 1.82 1.81 3 HGG 1 2956444 1.76 1.38 to 2.10 1.98 1.94 1.38 2.10 1.66 1.55 1.87 1.50 1.87 3 HGG 1 3792988 1.88 1.58 to 2.19 1.92 1.96 1.58 2.19 1.71 1.59 2.12 1.78 2.04 3 HGG 1 2823767 1.77 1.47 to 2.07 1.89 1.96 1.47 2.07 1.61 1.64 1.90 1.48 1.87 3 HGG 1 1320685 1.85 1.57 to 2.05 1.85 2.05 1.72 1.84 1.57 1.80 2.04 1.80 1.95 3 HGG 1 1956982 1.71 1.28 to 2.11 1.96 1.84 1.83 1.90 2.11 1.65 1.44 1.35 1.28 3 HGG 1 3068809 1.94 1.67 to 2.15 2.05 2.01 1.82 2.15 2.03 1.82 2.05 1.67 1.84 3 HGG 1 2520894 2.04 1.54 to 2.48 1.99 2.14 1.54 2.21 1.85 1.73 2.40 2.06 2.48 3 HGG 1  548114 1.79 1.34 to 2.20 1.84 1.84 1.34 1.79 1.67 1.48 2.20 1.95 2.05 3 HGG 1 4287327 2.18 1.78 to 2.68 1.78 2.06 2.08 1.79 2.45 1.90 2.25 2.68 2.61 3 HGG 1 5509134 2.11 1.75 to 2.56 2.24 2.08 1.96 2.56 2.29 1.96 2.21 1.75 1.91 3 HGG 1 2110430 1.97 1.65 to 2.27 1.91 2.17 1.84 2.17 2.00 1.65 2.27 1.81 1.87 3 HGG 1 2908212 0.42 0.00 to 1.79 1.79 0.00 0.00 0.00 0.00 1.09 0.00 0.89 0.00 4 HGG 1 3049285 −0.37 −4.42 to 0.44  0.24 0.00 0.44 0.00 0.00 0.25 0.00 0.16 −4.42 4 HGG 1 2019910 0.19 0.00 to 1.39 0.00 0.00 0.00 0.00 0.00 1.39 0.00 0.34 0.00 4 HGG 1  168848 −0.24 −4.65 to 0.67  0.67 0.00 0.58 0.63 0.00 0.63 0.00 −4.65 0.00 4 HGG 1 2018808 0.21 −0.11 to 1.40  0.08 0.13 0.04 0.05 −0.11 1.40 0.27 0.01 0.06 4 HGG 1 2358261 0.31 0.00 to 1.51 0.00 0.00 0.00 0.00 0.00 1.51 0.00 1.25 0.00 4 HGG 1 2403438 1.35 0.00 to 2.03 1.75 1.67 1.16 2.03 1.19 1.18 0.00 1.55 1.62 5 HGG 1 4630674 0.86 0.00 to 1.46 1.26 1.45 1.33 1.46 0.00 1.06 0.00 1.22 0.00 5 HGG 1 3391835 1.34 0.00 to 2.04 1.79 1.78 1.50 1.51 0.00 1.46 0.00 1.95 2.04 5 HGG 1 1210839 1.11 0.00 to 1.56 1.39 1.47 0.92 1.25 0.98 1.14 0.00 1.28 1.56 5 HGG 1 4092112 1.17 0.00 to 1.60 1.31 1.36 0.99 1.51 1.44 1.12 0.00 1.23 1.60 5 HGG 1 2818476 2.70 2.27 to 3.31 2.85 2.77 2.27 3.31 2.69 2.45 2.60 2.57 2.80 6 HGG 1 4549259 2.98 2.64 to 3.27 3.03 3.12 2.64 3.15 2.79 2.72 3.23 2.90 3.27 6 HGG 1 1630990 2.94 2.39 to 3.84 3.60 3.48 2.43 3.84 2.79 2.60 2.72 2.39 2.57 6 HGG 1 2755836 3.39 2.78 to 4.04 3.76 3.64 2.78 4.04 3.29 3.17 3.39 3.06 3.40 6 HGG 1 1527302 0.67 0.00 to 2.21 0.76 0.00 0.75 0.71 0.00 2.21 0.00 0.77 0.85 7 HGG 1  279898 0.97 0.07 to 1.83 0.27 1.11 1.83 0.07 1.29 1.48 0.64 0.93 1.10 7 HGG 1  136073 0.81 0.00 to 1.42 1.01 1.23 0.77 0.00 0.93 0.90 0.00 1.04 1.42 7 HGG 1 5501676 1.79 0.00 to 3.00 2.73 2.53 1.66 3.00 2.35 1.85 0.00 2.00 0.00 8 HGG 1 2499976 1.00 0.71 to 1.38 1.00 1.00 0.71 1.21 0.93 0.89 1.38 0.90 0.98 0 HGG 2 1709709 1.27 0.99 to 1.55 1.33 1.35 0.99 1.54 1.18 1.10 1.55 1.15 1.27 0 HGG 2 2230608 1.11 0.76 to 1.37 1.18 1.18 0.76 1.30 0.99 1.00 1.37 1.04 1.17 0 HGG 2 1559844 1.20 0.99 to 1.38 1.32 1.30 0.99 1.32 1.27 0.99 1.38 1.10 1.12 0 HGG 2 1679595 0.99 0.68 to 1.33 0.97 1.08 0.68 1.18 0.86 1.00 1.33 0.91 0.95 0 HGG 2 1407125 1.44 1.17 to 1.73 1.57 1.60 1.17 1.59 1.44 1.24 1.73 1.33 1.30 0 HGG 2 1988540 1.72 1.36 to 2.13 2.13 1.93 1.55 2.09 1.68 1.45 1.87 1.36 1.43 0 HGG 2 2021989 1.06 0.00 to 1.43 1.16 1.25 1.01 1.43 1.31 1.13 0.00 1.21 1.07 0 HGG 2 2725369 1.16 0.83 to 1.78 0.83 1.33 1.10 1.02 0.89 1.06 1.78 1.25 1.17 0 HGG 2 2837006 0.95 0.00 to 1.73 0.00 0.00 0.00 1.68 1.20 1.15 1.73 1.30 1.50 0 HGG 2 3206352 1.62 1.23 to 2.07 1.69 1.72 1.23 2.07 1.63 1.45 1.80 1.44 1.59 0 HGG 2  755223 1.13 0.89 to 1.44 1.24 1.23 0.89 1.20 0.91 1.06 1.44 1.06 1.18 0 HGG 2  870396 0.93 0.63 to 1.40 1.24 1.20 0.63 1.40 0.90 0.74 1.00 0.63 0.66 0 HGG 2  960604 1.34 0.00 to 1.71 1.67 1.47 1.21 1.70 1.71 1.48 0.00 1.37 1.46 0 HGG 2 2086783 −1.13 −1.37 to −0.75 −1.37 −1.26 −1.05 −1.20 −0.75 −1.18 −1.10 −1.15 −1.16 1 HGG 2 2269058 −1.06 −1.37 to −0.68 −1.17 −1.37 −0.96 −1.12 −0.68 −1.10 −1.07 −0.98 −1.06 1 HGG 2 2253102 −1.13 −1.36 to −0.77 −1.36 −1.28 −1.05 −1.17 −0.77 −1.14 −1.08 −1.17 −1.14 1 HGG 2 2088104 −1.15 −1.37 to −0.78 −1.34 −1.37 −1.03 −1.18 −0.78 −1.15 −1.18 −1.16 −1.19 1 HGG 2 2095329 −1.21 −1.48 to −0.87 −1.45 −1.48 −1.10 −1.26 −0.87 −1.21 −1.15 −1.19 −1.18 1 HGG 2 1401312 −0.82 −1.42 to 0.00  −1.10 −1.17 −0.57 −1.42 −0.73 −0.70 0.00 −0.82 −0.88 1 HGG 2 2469891 −1.14 −1.44 to −0.87 −1.36 −1.44 −1.05 −1.30 −0.87 −1.18 −0.90 −1.09 −1.05 1 HGG 2 3421730 −1.07 −1.45 to −0.30 −1.04 −1.08 −1.45 −0.86 −1.13 −1.27 −0.30 −1.20 −1.26 1 HGG 2 2453558 −1.28 −1.43 to −0.97 −1.37 −1.32 −1.26 −1.31 0.97 −1.27 −1.32 −1.43 −1.30 1 HGG 2 2287703 −1.07 −1.32 to −0.71 −1.28 −1.32 −0.93 −1.16 −0.71 −1.12 −1.01 −1.06 −1.05 1 HGG 2 1753283 −1.16 −1.69 to 0.00  −1.05 −1.43 −1.28 −1.69 −0.68 −1.36 0.00 −1.47 −1.51 1 HGG 2 2544622 2.44 0.00 to 3.28 3.28 2.88 2.22 3.28 2.73 2.57 0.00 2.39 2.61 2 HGG 2 1303862 2.71 0.00 to 3.98 3.98 3.49 2.41 3.81 3.06 2.37 0.00 2.59 2.69 2 HGG 2 1316801 1.87 0.00 to 2.61 0.00 2.34 1.92 2.61 1.75 1.87 2.39 1.84 2.12 2 HGG 2 1326255 3.31 2.93 to 3.65 3.10 3.39 2.93 3.47 3.62 3.46 3.65 3.02 3.13 2 HGG 2 1961617 1.84 0.00 to 3.29 0.00 2.92 1.92 3.29 2.12 2.12 0.00 2.04 2.13 2 HGG 2  660142 2.53 2.08 to 3.11 2.63 2.65 2.08 3.11 2.28 2.24 2.81 2.49 2.47 2 HGG 2 2124056 2.52 2.25 to 2.94 2.45 2.74 2.50 2.54 2.25 2.48 2.94 2.37 2.42 2 HGG 2 2234266 2.01 0.00 to 3.42 0.00 3.17 2.29 3.42 2.45 2.42 0.00 2.11 2.27 2 HGG 2 2394990 1.67 0.00 to 2.38 2.37 2.12 1.72 2.38 2.13 1.72 0.00 1.30 1.33 2 HGG 2 1926934 0.54 0.00 to 1.73 0.00 0.00 1.45 0.00 0.00 0.00 0.00 1.63 1.73 3 HGG 2 2817244 0.20 −0.30 to 2.39  0.00 2.39 0.00 0.00 0.00 0.00 0.00 −0.30 −0.25 3 HGG 2 2018315 0.90 0.00 to 1.69 1.34 1.69 1.19 0.00 0.00 1.23 0.00 1.30 1.31 3 HGG 2 2607834 0.29 0.00 to 1.72 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.93 1.72 3 HGG 2 1487428 0.73 0.00 to 2.24 0.00 2.24 1.78 0.00 0.00 0.00 0.00 1.27 1.31 3 HGG 2 1418276 0.24 0.00 to 1.92 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.23 1.92 3 HGG 2  626471 0.76 0.00 to 1.51 0.00 0.00 1.15 0.00 1.26 1.39 0.00 1.51 1.50 3 HGG 2 1235345 0.20 0.00 to 1.48 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.36 1.48 3 HGG 2 3100048 −1.13 −1.78 to −0.07 −0.50 −1.50 −1.32 −0.59 −1.52 −1.31 −0.07 −1.78 −1.56 4 HGG 2 1988774 −1.45 −1.97 to −0.93 −1.21 −1.75 −1.42 −0.95 −1.61 −1.65 −0.93 −1.97 −1.56 4 HGG 2 2703122 −1.54 −1.78 to −1.33 −1.59 −1.78 −1.56 −1.62 −1.33 −1.59 −1.50 1.51 −1.41 4 HGG 2 1251065 1.18 0.92 to 1.42 1.33 1.31 1.00 1.39 0.93 1.42 0.92 1.18 0 HGG 3 5266376 1.04 0.79 to 1.45 1.08 1.01 0.80 1.19 0.79 1.45 0.92 1.10 0 HGG 3 1570534 1.01 0.58 to 1.47 1.43 1.33 0.80 1.47 0.77 1.03 0.58 0.68 0 HGG 3 1786554 1.42 1.02 to 1.72 1.64 1.72 1.20 1.66 1.02 1.65 1.12 1.35 0 HGG 3 1905006 0.85 0.59 to 1.46 0.59 0.71 0.65 0.94 0.61 1.46 0.85 0.97 0 HGG 3 5508135 1.02 0.00 to 2.06 1.82 2.06 0.00 0.00 1.26 0.00 1.40 1.62 0 HGG 3 4543123 1.27 0.82 to 1.62 1.56 1.48 1.36 1.62 1.17 1.20 0.82 0.94 0 HGG 3 4508879 0.78 0.00 to 1.38 1.38 0.00 0.80 1.26 0.59 0.70 0.58 0.90 0 HGG 3 4252872 0.77 0.00 to 1.38 1.17 1.38 0.00 0.00 0.62 1.07 0.78 1.15 0 HGG 3 3960194 1.01 0.79 to 1.43 1.20 1.03 0.80 0.93 0.79 1.43 1.05 0.83 0 HGG 3  554654 0.89 0.27 to 1.82 1.82 1.27 0.61 1.03 0.63 1.06 0.44 0.27 0 HGG 3  748477 1.20 0.98 to 1.57 1.12 1.14 0.98 1.34 1.22 1.57 1.01 1.24 0 HGG 3 2871076 1.11 0.61 to 1.50 1.45 1.49 0.96 1.50 0.61 1.07 0.68 1.11 0 HGG 3 2972013 1.38 1.01 to 1.82 1.82 1.72 1.01 1.58 1.07 1.48 1.04 1.32 0 HGG 3 3068978 1.21 0.00 to 3.53 0.00 0.00 0.00 0.00 3.53 0.00 2.86 3.27 0 HGG 3 3034889 1.21 0.88 to 1.62 1.45 1.62 0.92 1.28 0.88 1.41 0.97 1.12 0 HGG 3 5322365 1.40 1.03 to 1.75 1.68 1.75 1.03 1.51 1.07 1.59 1.19 1.38 0 HGG 3 3495173 1.25 0.86 to 1.54 1.46 1.54 1.27 1.43 0.86 1.39 0.95 1.09 0 HGG 3 1560380 0.39 0.00 to 1.57 0.00 0.00 0.00 0.00 1.57 0.00 1.56 0.00 1 HGG 3 2195427 0.17 0.00 to 1.34 0.00 0.00 0.00 0.00 0.00 0.00 1.34 0.00 1 HGG 3 3456829 0.44 0.00 to 2.15 0.44 2.15 0.28 0.00 0.44 0.00 0.21 0.00 1 HGG 3 3478570 0.49 0.17 to 1.38 0.33 0.35 0.26 0.54 0.17 1.38 0.41 0.48 1 HGG 3 5326983 0.50 0.00 to 1.36 1.13 1.36 0.00 0.00 0.66 0.00 0.82 0.00 1 HGG 3 2769732 0.33 −0.14 to 2.05  −0.14 2.05 0.11 0.11 0.02 0.29 0.06 0.16 1 HGG 3 2836703 0.65 0.00 to 1.87 1.87 1.50 0.46 0.00 0.35 0.53 0.13 0.36 1 HGG 3 3974247 0.63 0.00 to 1.52 1.44 1.52 0.00 0.00 0.98 0.00 1.09 0.00 1 HGG 3 4208369 0.12 −0.28 to 1.40  0.00 0.00 −0.28 −0.01 −0.07 1.40 −0.08 0.00 1 HGG 3  626254 0.35 0.00 to 2.57 0.00 0.00 0.00 0.00 0.26 0.00 2.57 0.00 1 HGG 3  664625 0.36 0.00 to 1.62 1.62 0.00 0.00 0.00 0.00 0.00 1.23 0.00 1 HGG 3 3031872 0.15 −0.17 to 1.53  −0.02 −0.10 −0.17 0.00 −0.07 1.53 −0.02 0.07 1 HGG 3  872017 0.61 0.00 to 1.83 1.83 0.00 0.00 0.00 1.53 0.00 1.53 0.00 1 HGG 3 4253809 1.82 1.49 to 2.12 2.09 1.89 1.49 1.95 1.52 2.12 1.79 1.73 2 HGG 3 4402555 2.21 1.93 to 2.54 2.22 2.27 2.19 2.54 1.93 2.19 2.06 2.25 2 HGG 3 4912315 1.99 1.41 to 2.90 2.47 2.08 1.89 2.90 1.41 1.80 1.46 1.94 2 HGG 3 5102731 1.55 1.09 to 2.28 2.28 2.09 1.14 1.61 1.09 1.53 1.23 1.46 2 HGG 3 5266015 2.38 2.00 to 2.65 2.36 2.44 2.18 2.62 2.00 2.65 2.27 2.50 2 HGG 3 5293028 1.87 1.24 to 2.47 2.47 2.10 1.83 2.44 1.79 1.66 1.24 1.41 2 HGG 3 5512044 1.71 1.41 to 2.02 1.74 1.72 1.81 2.02 1.43 1.85 1.41 1.68 2 HGG 3 2343348 1.71 1.29 to 2.29 2.13 1.89 1.43 2.29 1.29 1.64 1.42 1.62 2 HGG 3  621543 1.74 1.39 to 2.10 1.58 1.79 1.59 2.10 1.49 1.91 1.39 2.04 2 HGG 3 2545486 2.07 1.60 to 2.39 2.10 2.32 2.33 2.39 1.87 1.92 1.60 2.04 2 HGG 3 3074113 2.13 1.78 to 2.67 2.43 2.27 1.90 2.67 1.87 2.08 1.78 2.05 2 HGG 3 3158828 1.66 1.30 to 2.20 1.61 1.63 1.48 2.20 1.30 1.85 1.44 1.77 2 HGG 3 3957354 1.84 0.00 to 3.42 3.42 3.36 0.00 0.00 2.71 0.00 2.48 2.75 2 HGG 3 3125211 −1.14 −1.54 to −0.90 −1.22 −1.20 −0.90 −1.54 −1.11 −1.10 −0.97 −1.06 3 HGG 3 5166479 −1.56 −1.87 to −0.89 −1.54 −1.79 −1.87 −1.42 −1.87 −0.89 −1.70 −1.43 3 HGG 3 2698777 −1.25 −1.45 to −1.00 −1.10 −1.33 −1.31 −1.45 −1.31 −1.00 −1.21 −1.27 3 HGG 3 1911443 −1.07 −1.50 to −0.43 −0.69 −1.19 −1.47 −0.92 −1.30 −0.43 −1.07 −1.50 3 HGG 3 4266051 −0.90 −1.39 to −0.69 −0.75 −0.69 −0.98 −1.39 −0.85 −0.78 −0.75 −1.04 3 HGG 3 3097624 −1.34 −1.66 to −1.17 −1.37 −1.24 −1.40 −1.66 −1.26 −1.17 −1.36 −1.30 3 HGG 3 4894508 −1.03 −1.36 to −0.87 0.87 −1.09 −1.01 −1.36 −0.99 −0.97 −1.02 −0.95 3 HGG 3 3135460 −1.33 −1.69 to −0.93 −1.01 −1.44 −1.50 −1.06 −1.69 −0.93 −1.34 −1.65 3 HGG 3 5091002 −1.22 −1.58 to −0.87 −1.03 −0.87 −1.29 −1.51 −1.19 −1.16 −1.16 −1.58 3 HGG 3 4289557 −1.97 −2.44 to −1.77 −1.89 −2.12 −1.84 −2.44 −1.77 −1.87 −1.82 −1.98 4 HGG 3 5573549 −1.70 −2.00 to −1.51 −1.69 −1.86 −1.78 −2.00 −1.55 −1.51 −1.53 −1.67 4 HGG 3 3120209 −1.75 −2.64 to −1.23 −2.06 −1.57 −1.23 −2.64 −1.31 −2.24 −1.60 −1.35 4 HGG 3 3778404 −1.68 −1.94 to −1.41 −1.41 −1.75 −1.51 −1.94 −1.55 −1.85 −1.74 −1.68 4 HGG 3 3084204 −1.55 −1.94 to −1.33 −1.51 −1.61 −1.43 −1.94 −1.39 −1.61 −1.33 −1.55 4 HGG 3 5427710 −2.08 −2.48 to −1.82 −2.09 −1.99 −1.88 −2.48 −1.82 −2.13 −1.99 −2.22 4 HGG 3 3069190 3.73 3.22 to 4.08 3.59 3.92 3.60 4.08 3.22 4.03 3.57 3.80 5 HGG 3 3172265 3.81 3.07 to 4.74 4.16 4.02 4.08 4.74 3.44 3.56 3.07 3.42 5 HGG 3 3629043 0.73 0.38 to 1.38 0.68 0.75 0.49 0.71 0.65 0.70 1.38 0.83 0.38 0 HGG 4 1946155 0.92 0.59 to 1.56 0.94 0.99 0.74 1.01 0.61 0.82 1.56 0.98 0.59 0 HGG 4  417432 0.93 0.56 to 1.46 0.97 1.04 0.80 1.13 0.83 0.78 1.46 0.84 0.56 0 HGG 4 1448572 1.00 0.53 to 1.44 0.86 1.05 0.98 0.82 1.44 1.01 1.41 0.86 0.53 0 HGG 4  409209 0.86 0.58 to 1.66 0.72 0.74 0.58 0.89 0.59 0.63 1.66 0.92 0.98 0 HGG 4 2756587 1.01 0.59 to 1.50 1.14 1.09 0.80 1.23 0.91 0.86 1.50 0.92 0.59 0 HGG 4 1611629 0.94 0.68 to 1.57 0.85 1.03 0.83 1.05 0.73 0.81 1.57 0.96 0.68 0 HGG 4 1716458 1.03 0.73 to 1.39 1.20 1.19 0.73 1.13 1.00 0.76 1.39 0.92 0.96 0 HGG 4 1730026 1.04 0.72 to 1.73 1.02 1.09 0.72 1.18 0.85 0.90 1.73 0.95 0.91 0 HGG 4 1740179 0.86 0.65 to 1.35 0.95 0.91 0.65 0.97 0.67 0.73 1.35 0.76 0.78 0 HGG 4 2007730 1.18 0.97 to 1.76 1.13 1.22 0.97 1.07 1.14 1.20 1.76 1.09 1.07 0 HGG 4 2751922 1.09 0.62 to 1.53 0.87 1.25 1.18 1.08 1.39 1.00 1.53 0.87 0.62 0 HGG 4 2062085 1.05 0.77 to 1.54 1.02 1.14 0.77 1.21 0.79 1.16 1.54 0.91 0.93 0 HGG 4 2196870 1.05 0.81 to 1.52 1.00 1.04 0.81 1.09 1.02 1.08 1.52 0.88 0.98 0 HGG 4 2227273 1.01 0.76 to 1.66 0.80 1.09 0.93 0.89 0.76 1.01 1.66 1.06 0.88 0 HGG 4 2734007 0.88 0.37 to 1.47 0.68 0.94 0.95 0.95 1.10 0.75 1.47 0.70 0.37 0 HGG 4 2669871 1.03 0.71 to 1.42 1.42 1.21 0.94 1.09 1.23 1.04 0.91 0.75 0.71 0 HGG 4 5101167 1.03 0.79 to 1.40 1.08 1.11 0.79 1.09 0.99 0.93 1.40 0.83 1.08 0 HGG 4 5102951 0.85 0.68 to 1.33 0.78 0.82 0.69 0.78 0.91 0.83 1.33 0.79 0.68 0 HGG 4  998615 0.91 0.60 to 1.42 0.93 0.99 0.60 0.97 0.69 0.81 1.42 0.94 0.86 0 HGG 4 2013251 1.54 0.00 to 2.28 2.15 2.12 1.56 2.18 0.00 1.90 2.28 1.66 0.00 1 HGG 4 1365045 1.89 1.62 to 2.35 1.95 2.02 1.62 1.97 1.80 1.78 2.35 1.72 1.79 1 HGG 4 4077648 1.29 1.10 to 1.92 1.16 1.32 1.10 1.17 1.12 1.17 1.92 1.49 1.16 1 HGG 4 2106010 1.53 1.23 to 2.09 1.62 1.73 1.23 1.65 1.23 1.35 2.09 1.50 1.37 1 HGG 4 2110482 1.32 0.96 to 1.86 1.38 1.38 0.96 1.49 1.07 1.14 1.86 1.34 1.27 1 HGG 4 2619275 1.34 1.12 to 1.84 1.40 1.47 1.13 1.38 1.20 1.25 1.84 1.30 1.12 1 HGG 4 1913334 1.39 1.07 to 1.79 1.48 1.56 1.07 1.47 1.14 1.23 1.79 1.30 1.48 1 HGG 4 3149570 1.19 0.00 to 1.75 1.48 1.40 1.05 1.47 0.00 1.17 1.75 1.32 1.05 1 HGG 4 3016137 1.61 1.30 to 2.06 1.56 1.56 1.37 1.55 1.67 1.74 2.06 1.30 1.66 1 HGG 4 2350594 1.37 1.04 to 1.82 1.58 1.65 1.19 1.36 1.09 1.06 1.82 1.50 1.04 1 HGG 4 2408333 1.72 1.33 to 2.26 1.74 1.93 1.61 1.86 1.46 1.62 2.26 1.69 1.33 1 HGG 4  439415 1.40 1.18 to 1.60 1.44 1.34 1.37 1.45 1.60 1.41 1.48 1.29 1.18 1 HGG 4 1965856 1.41 1.12 to 1.85 1.52 1.55 1.12 1.67 1.12 1.29 1.85 1.33 1.26 1 HGG 4 2006043 1.33 1.09 to 1.92 1.39 1.46 1.16 1.35 1.12 1.26 1.92 1.24 1.09 1 HGG 4 5690026 1.29 0.97 to 1.92 1.39 1.39 0.97 1.57 1.00 1.02 1.92 1.29 1.03 1 HGG 4  434751 1.62 1.37 to 1.92 1.81 1.75 1.37 1.78 1.43 1.44 1.92 1.44 1.62 1 HGG 4 1872858 0.24 −0.07 to 1.75  −0.05 0.00 0.05 0.01 1.75 −0.07 0.00 0.10 0.39 2 HGG 4 2381040 −0.18 −1.96 to 0.36  −1.96 0.00 0.00 0.00 0.00 0.00 0.00 0.36 0.00 2 HGG 4 2415118 0.22 0.00 to 1.59 0.00 0.00 0.00 0.00 0.00 0.10 1.59 0.01 0.30 2 HGG 4 5109437 0.01 −0.29 to 1.43  −0.20 −0.16 −0.20 −0.29 0.00 −0.25 1.43 −0.23 −0.01 2 HGG 4 2759015 0.73 0.00 to 4.24 0.00 0.00 0.00 0.00 0.00 0.00 4.24 2.31 0.00 2 HGG 4 5700537 −0.16 −1.40 to 0.00  0.00 0.00 0.00 0.00 0.00 0.00 0.00 −1.40 0.00 2 HGG 4 4223315 0.19 0.00 to 1.40 0.00 0.00 0.00 0.00 0.00 0.00 1.40 0.26 0.00 2 HGG 4 2410066 0.99 0.00 to 1.47 1.47 1.35 1.09 1.40 0.00 1.29 0.00 1.24 1.09 3 HGG 4 2405487 0.95 0.00 to 1.43 1.27 1.30 0.97 1.43 0.00 1.17 0.00 1.32 1.13 3 HGG 4 3999352 0.71 0.00 to 3.77 3.77 1.73 0.00 0.48 0.00 0.00 0.00 0.28 0.13 3 HGG 4  509839 1.22 0.00 to 1.88 1.88 1.86 1.27 1.87 0.00 1.40 0.00 1.49 1.18 3 HGG 4 1951845 0.79 0.00 to 1.34 1.33 1.34 1.08 1.30 0.00 0.00 0.00 1.11 0.95 3 HGG 4 2753371 0.52 0.00 to 4.09 0.00 4.09 0.00 0.00 0.00 0.00 0.00 0.58 0.00 3 HGG 4 3522739 1.05 0.00 to 1.72 1.72 1.55 1.17 1.55 0.00 1.18 0.00 1.10 1.16 3 HGG 4 5325802 0.27 0.00 to 2.00 0.00 0.00 0.00 2.00 0.00 0.00 0.00 0.40 0.00 4 HGG 4 5859590 −0.23 −1.95 to 0.08  0.08 0.00 −0.05 0.02 −0.14 −1.95 0.02 −0.13 0.05 4 HGG 4  198959 0.18 −0.20 to 1.34  0.12 0.13 0.06 0.04 0.01 0.05 0.03 1.34 −0.20 4 HGG 4 1496011 0.51 0.00 to 1.47 1.47 0.00 0.00 1.43 0.00 0.00 0.00 0.95 0.71 4 HGG 4 1329625 0.42 0.00 to 1.89 1.89 0.00 0.00 0.00 0.00 0.00 0.00 1.11 0.82 4 HGG 4 2430165 0.23 0.00 to 1.33 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.74 1.33 4 HGG 4 2267466 0.75 0.00 to 1.63 1.51 0.00 1.13 1.63 0.00 0.00 0.00 1.24 1.27 4 HGG 4 2786442 −1.49 −1.85 to −1.15 −1.85 −1.62 −1.20 −1.76 −1.29 −1.41 −1.77 −1.32 −1.15 5 HGG 4 1857850 −1.82 −2.30 to −1.44 −1.75 −1.77 −1.50 −1.88 −1.44 −1.96 −2.30 −1.92 −1.83 5 HGG 4 3042227 −1.57 −2.05 to −1.17 −1.63 −1.72 −1.17 −1.67 −1.25 −1.58 −2.05 −1.64 −1.41 5 HGG 4 2055569 −1.03 −1.81 to −0.09 −0.68 −1.03 −1.43 −0.83 −1.09 −1.81 −0.09 −1.12 −1.23 5 HGG 4  495808 −1.21 −1.43 to −0.97 −1.41 −1.43 −1.04 −1.21 −0.97 −1.31 −1.21 −1.14 −1.19 5 HGG 4 1449819 −1.70 −2.63 to −0.59 −0.96 −2.16 −2.27 −0.75 −2.07 −2.63 −0.59 −2.38 −1.49 5 HGG 4 2581075 3.67 3.29 to 4.13 3.76 3.75 3.36 3.84 3.88 3.57 4.13 3.29 3.48 6 HGG 4 1964758 2.25 1.86 to 2.81 2.41 2.43 1.86 2.56 2.00 2.04 2.81 2.15 2.04 6 HGG 4 3191030 2.23 1.65 to 2.95 2.87 2.42 1.65 2.95 2.31 1.90 2.43 1.72 1.82 6 HGG 4 2278772 2.68 2.05 to 3.37 2.90 2.71 2.21 2.91 2.28 3.04 3.37 2.63 2.05 6 HGG 4 1370137 2.60 2.01 to 3.14 3.14 2.89 2.05 3.12 2.51 2.43 2.92 2.32 2.01 6 HGG 4

TABLE 11 mean mean mean mean mean mean mean mean mean DE DE DE DE DE DE DE DE DE t/Prdsne t/Prdsne t/Prdsne t/Prdsne t/Prdsne t/Prdsne t/Prdsne t/Prdsne t/Prdsne Ave DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clone ID t/Prdsne Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr Cluster GEM 1910401 −1.13 −1.34 to −0.95 −1.13 −1.30 −1.08 −1.34 −0.95 −1.02 −0.99 −1.21 −1.18 0 HGG 1 3126622 −1.07 −1.37 to −0.80 −1.11 −1.17 −0.80 −1.00 −1.02 −1.06 −1.37 −1.05 −1.04 0 HGG 1 1740474 −1.40 −1.70 to −1.08 −1.59 −1.54 −1.23 −1.61 −1.08 −1.33 −1.70 −1.31 −1.21 0 HGG 1 3975209 −1.49 −1.81 to −1.21 −1.65 −1.41 −1.48 −1.81 −1.30 −1.46 −1.70 −1.21 −1.40 0 HGG 1 2769888 −1.07 −1.49 to −0.51 −0.69 −1.18 −1.31 −0.82 −1.04 −1.33 −0.51 −1.29 −1.49 0 HGG 1 3681722 −1.15 −1.45 to −0.94 −1.36 −1.45 −1.06 −1.25 −0.94 −1.09 −1.09 −1.05 −1.11 0 HGG 1 2471835 −1.10 −1.35 to −0.82 −1.09 −1.35 −1.07 −1.24 −0.82 −1.07 −1.06 −1.12 −1.08 0 HGG 1 3679667 −1.29 −1.50 to −1.15 −1.19 −1.21 −1.19 −1.36 −1.28 −1.26 −1.15 −1.50 −1.49 0 HGG 1 2767579 −1.12 −1.35 to −0.89 −1.25 −1.35 −1.25 −1.24 −1.11 −1.11 −0.94 −0.96 −0.89 0 HGG 1 1833362 −0.92 −1.39 to −0.48 −0.86 −1.13 −0.48 −0.91 −0.78 −0.71 −0.87 −1.13 −1.39 0 HGG 1 1840426 −1.18 −1.44 to −0.90 −1.37 −1.44 −1.19 −1.36 −0.90 −1.23 −1.19 −0.95 −0.99 0 HGG 1 1868536 −1.42 −1.58 to −1.23 −1.23 −1.36 −1.39 −1.54 −1.35 −1.50 −1.35 −1.46 −1.58 0 HGG 1 1596220 −1.51 −1.86 to −1.12 −1.28 −1.57 −1.12 −1.55 −1.32 −1.41 −1.76 −1.86 −1.76 0 HGG 1 1876456 −1.46 −1.66 to −1.17 −1.48 −1.66 −1.17 −1.56 −1.30 −1.33 −1.65 −1.53 −1.49 0 HGG 1 1890576 −1.59 −1.83 to −1.28 −1.76 −1.73 −1.28 −1.83 −1.42 −1.37 −1.76 −1.67 −1.47 0 HGG 1 1614014 −0.81 −1.37 to −0.27 −0.99 −1.00 −0.27 −0.93 −0.56 −0.66 −1.37 −0.95 −0.60 0 HGG 1 1619292 −1.50 −1.90 to −1.17 −1.46 −1.60 −1.28 −1.59 −1.17 −1.39 −1.47 −1.64 −1.90 0 HGG 1 3397390 −1.15 −1.50 to −0.78 −0.97 −1.25 −1.18 −1.07 −1.09 −1.27 −0.78 −1.26 −1.50 0 HGG 1

TABLE 12 mean mean mean mean mean mean DE DE DE DE DE DE mean DE mean DE mean DE t/Dex t/Dex t/Dex t/Dex t/Dex t/Dex t/Dex t/Dex t/Dex Ave DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM 100 μM 100 μM Clone ID t/Dex Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr Cluster GEM 1004382 1.24 0.99 to 1.64 1.64 1.02 1.11 1.25 1.63 1.07 1.01 0.99 1.47 0 HGG 1 2823767 1.60 1.24 to 1.92 1.77 1.47 1.42 1.72 1.92 1.24 1.53 1.52 1.84 0 HGG 1 2830240 1.05 0.74 to 1.67 1.09 0.74 0.93 1.13 1.67 0.96 0.76 0.75 1.45 0 HGG 1 1241484 1.20 0.84 to 1.67 1.53 0.98 0.93 1.25 1.48 0.84 0.91 1.25 1.67 0 HGG 1 1268277 0.89 0.56 to 1.33 1.19 0.81 0.56 0.91 1.14 0.58 0.61 0.86 1.33 0 HGG 1 1275616 0.97 0.71 to 1.33 1.18 0.71 0.83 1.06 1.33 0.89 0.83 0.75 1.19 0 HGG 1 1320685 1.65 1.35 to 2.00 1.89 1.43 1.43 1.68 2.00 1.35 1.56 1.61 1.90 0 HGG 1 2070126 1.36 0.96 to 1.75 1.75 1.39 1.31 1.55 1.62 0.96 1.17 1.04 1.44 0 HGG 1 1342744 1.34 0.98 to 1.77 1.77 1.25 1.03 1.38 1.68 0.98 1.21 1.28 1.52 0 HGG 1 2833342 1.26 0.92 to 1.58 1.58 1.06 0.92 1.24 1.55 1.06 1.29 1.10 1.49 0 HGG 1 3057272 0.98 0.71 to 1.39 1.18 1.00 0.71 0.88 1.07 0.81 0.79 0.96 1.39 0 HGG 1 3068809 1.63 1.25 to 2.00 1.80 1.49 1.25 1.60 1.84 1.39 1.66 1.66 2.00 0 HGG 1 143765 1.07 0.81 to 1.48 1.48 1.18 0.81 1.23 1.08 0.90 0.90 0.91 1.13 0 HGG 1 3108506 0.82 0.42 to 1.47 0.95 0.60 0.42 0.67 0.98 0.53 0.75 0.97 1.47 0 HGG 1 2120743 1.55 1.24 to 2.09 1.74 1.37 1.24 1.77 2.09 1.33 1.39 1.25 1.75 0 HGG 1 1459743 1.51 1.05 to 1.93 1.78 1.41 1.25 1.59 1.73 1.05 1.33 1.47 1.93 0 HGG 1 3381870 0.88 0.50 to 1.42 1.09 0.59 0.70 0.94 1.42 0.89 0.58 0.50 1.18 0 HGG 1 2148703 1.01 0.56 to 1.54 1.00 0.56 0.82 1.09 1.54 1.09 0.80 0.75 1.39 0 HGG 1 2173002 0.75 0.41 to 1.40 1.40 0.69 0.53 0.79 0.41 0.46 0.45 0.88 1.14 0 HGG 1 1521272 1.08 0.75 to 1.58 1.58 1.11 0.98 1.10 1.29 0.75 0.79 0.90 1.23 0 HGG 1 3497231 1.11 0.90 to 1.36 1.36 0.96 1.05 1.16 1.33 0.94 1.07 0.90 1.24 0 HGG 1 1573840 0.86 0.39 to 1.37 1.20 0.71 0.63 1.13 1.37 0.39 0.72 0.54 1.06 0 HGG 1 3595618 1.22 0.89 to 1.59 1.59 1.14 0.90 1.27 1.46 0.89 1.22 1.15 1.38 0 HGG 1 3687719 1.01 0.62 to 1.53 1.53 0.93 0.62 0.94 1.23 0.73 0.92 1.00 1.21 0 HGG 1 371201 1.50 1.21 to 1.91 1.39 1.27 1.21 1.45 1.91 1.37 1.58 1.57 1.77 0 HGG 1 3818422 0.91 0.58 to 1.38 0.94 0.58 0.82 0.99 1.38 0.97 0.70 0.65 1.14 0 HGG 1 3821432 1.27 0.98 to 1.61 1.61 1.15 0.99 1.35 1.60 0.98 1.15 1.12 1.46 0 HGG 1 4018288 0.94 0.44 to 1.37 1.29 0.90 0.79 1.08 1.12 0.44 0.60 0.87 1.37 0 HGG 1 2311213 1.13 0.85 to 1.42 1.39 1.19 0.91 1.01 1.23 0.92 0.85 1.21 1.42 0 HGG 1 2313349 1.33 1.01 to 1.65 1.55 1.17 1.01 1.33 1.65 1.14 1.31 1.26 1.59 0 HGG 1 4021009 1.16 0.91 to 1.49 1.49 1.01 1.00 1.15 1.43 0.92 0.91 1.11 1.43 0 HGG 1 2445967 1.14 0.82 to 1.64 1.64 1.02 0.82 1.17 1.45 0.92 1.02 0.99 1.23 0 HGG 1 419492 1.08 0.79 to 1.47 1.17 0.94 0.79 0.97 1.25 0.96 1.05 1.08 1.47 0 HGG 1 2459765 1.07 0.78 to 1.33 1.31 0.93 0.78 1.05 1.33 0.84 1.08 1.03 1.27 0 HGG 1 4377432 0.87 0.51 to 1.45 1.08 0.52 0.67 0.98 1.45 0.91 0.64 0.51 1.11 0 HGG 1 494905 0.75 0.43 to 1.33 0.68 0.65 0.70 1.11 1.33 0.43 0.57 0.56 0.68 0 HGG 1 5046235 1.17 0.91 to 1.70 1.11 0.91 0.92 1.05 1.40 1.03 1.08 1.31 1.70 0 HGG 1 2504870 1.02 0.67 to 1.64 1.36 0.71 0.73 1.25 1.64 0.90 0.91 0.67 1.03 0 HGG 1 5098879 0.91 0.39 to 1.43 1.43 0.92 0.74 0.98 1.15 0.39 0.45 0.89 1.23 0 HGG 1 2511277 1.45 1.05 to 1.95 1.40 1.05 1.19 1.56 1.79 1.17 1.36 1.61 1.95 0 HGG 1 2516950 1.47 1.11 to 1.93 1.93 1.41 1.25 1.49 1.78 1.11 1.25 1.35 1.67 0 HGG 1 1956982 1.13 0.94 to 1.51 1.51 1.28 0.96 1.24 1.12 0.94 1.13 0.97 1.04 0 HGG 1 531505 0.96 0.68 to 1.39 1.39 0.96 0.68 0.91 0.91 0.68 0.83 1.07 1.23 0 HGG 1 671717 1.39 1.13 to 1.83 1.83 1.22 1.24 1.37 1.58 1.18 1.13 1.19 1.81 0 HGG 1 2697275 1.31 1.10 to 1.60 1.54 1.10 1.15 1.35 1.60 1.16 1.17 1.19 1.58 0 HGG 1 2756333 1.35 1.00 to 1.79 1.59 1.12 1.09 1.35 1.71 1.06 1.00 1.40 1.79 0 HGG 1 2778441 1.31 1.02 to 1.59 1.59 1.22 1.05 1.32 1.55 1.02 1.27 1.19 1.54 0 HGG 1 279898 0.87 −0.25 to 1.64  0.02 1.10 1.53 −0.08 1.64 1.24 −0.25 1.04 1.63 0 HGG 1 2822027 0.82 0.42 to 1.33 1.11 0.72 0.60 1.01 1.33 0.60 0.66 0.42 0.95 0 HGG 1 509758 −1.16 −1.34 to −0.90 −1.32 −1.34 −1.24 −1.24 −1.30 −0.90 −0.90 −1.03 −1.22 1 HGG 1 1235535 −1.12 −1.32 to −0.98 −1.23 −1.32 −1.11 −1.07 −0.98 −1.07 −1.03 −1.11 −1.14 1 HGG 1 1331853 −1.16 −1.54 to −0.81 −1.54 −1.40 −1.21 −1.07 −0.81 −1.09 −1.02 −1.13 −1.14 1 HGG 1 2132606 −1.23 −1.56 to −1.01 −1.52 −1.26 −1.01 −1.20 −1.56 −1.08 −1.12 −1.06 −1.27 1 HGG 1 4698018 −1.12 −1.35 to −0.84 −1.35 −1.16 −0.99 −1.16 −1.09 −0.95 −0.84 −1.19 −1.31 1 HGG 1 2095144 −1.24 −1.42 to −1.05 −1.42 −1.26 −1.20 −1.23 −1.42 −1.08 −1.11 −1.05 −1.42 1 HGG 1 1441245 −1.25 −1.48 to −0.80 −1.45 −1.30 −1.11 −1.48 −1.44 −0.87 −0.80 −1.36 −1.45 1 HGG 1 2769888 −1.21 −1.56 to −0.67 −0.67 −1.41 −1.56 −0.83 −1.26 −1.45 −0.81 −1.44 −1.47 1 HGG 1 167081 −1.10 −1.52 to −0.40 −1.39 −1.15 −1.13 −0.81 −0.40 −1.52 −1.18 −1.14 −1.20 1 HGG 1 2252884 −1.19 −1.38 to −0.97 −1.32 −1.29 −1.16 −1.15 −1.31 −0.99 −1.10 −0.97 −1.38 1 HGG 1 1501410 −1.16 −1.38 to −0.92 −1.06 −1.31 −1.38 −1.18 −1.09 −1.13 −0.92 −1.18 −1.21 1 HGG 1 2285521 −1.22 −1.47 to −1.03 −1.47 −1.30 −1.11 −1.23 −1.42 −1.05 −1.08 −1.03 −1.27 1 HGG 1 2287724 −1.16 −1.50 to −0.90 −1.50 −1.24 −1.04 −1.23 −1.32 −0.90 −0.95 −0.95 −1.28 1 HGG 1 1840426 −1.15 −1.55 to −0.87 −1.29 −1.25 −0.87 −1.33 −1.55 −0.95 −0.90 −0.91 −1.32 1 HGG 1 2623304 −1.18 −1.47 to −0.92 −1.15 −1.47 −1.27 −1.29 −1.07 −0.92 −0.97 −1.25 −1.21 1 HGG 1 1910401 −1.16 −1.46 to −0.22 −1.35 −1.46 −1.30 −1.28 −1.16 −1.03 −0.22 −1.24 −1.38 1 HGG 1 2495131 −1.25 −1.55 to −0.71 −1.55 −1.46 −1.25 −1.20 −0.71 −1.45 −1.09 −1.16 −1.40 1 HGG 1 3397390 −1.32 −1.57 to −1.06 −1.09 −1.47 −1.57 −1.34 −1.06 −1.45 −1.40 −1.25 −1.30 1 HGG 1 2767579 −1.20 −1.32 to −1.04 −1.32 −1.23 −1.11 −1.23 −1.24 −1.08 −1.04 −1.25 −1.32 1 HGG 1 2055814 −1.17 −1.55 to −0.84 −0.84 −1.16 −1.19 −1.16 −1.55 −1.26 −1.01 −1.03 −1.38 1 HGG 1 4884214 −0.77 −1.40 to −0.48 −0.95 −0.48 −0.53 −0.73 −1.40 −0.63 −0.69 −0.65 −0.85 2 HGG 1 4284270 −0.88 −1.36 to −0.37 −0.98 −1.01 −0.94 −0.99 −1.36 −0.67 −0.37 −0.68 −0.89 2 HGG 1 2293496 −0.82 −1.40 to −0.43 −0.43 −0.80 −0.81 −0.64 −1.40 −0.84 −0.50 −0.88 −1.07 2 HGG 1 4089291 −0.77 −1.39 to −0.55 −0.65 −0.84 −0.65 −0.81 −1.39 −0.60 −0.55 −0.62 −0.85 2 HGG 1 3686603 −0.86 −1.38 to −0.44 −0.94 −0.86 −0.65 −1.18 −1.38 −0.44 −0.71 −0.85 −0.72 2 HGG 1 2850323 −0.76 −1.54 to −0.47 −0.80 −0.74 −0.67 −0.84 −1.54 −0.51 −0.50 −0.47 −0.73 2 HGG 1 3451645 −1.03 −1.92 to −0.64 −0.74 −1.01 −0.99 −1.05 −1.92 −1.07 −0.64 −0.86 −1.00 2 HGG 1 2946292 −0.87 −1.40 to −0.64 −0.78 −0.64 −0.80 −0.89 −1.40 −0.77 −0.91 −0.72 −0.90 2 HGG 1 1614014 −0.90 −1.50 to −0.48 −1.26 −0.89 −0.48 −1.20 −1.50 −0.59 −0.76 −0.66 −0.81 2 HGG 1 2239236 −0.74 −1.40 to −0.39 −0.75 −0.71 −0.39 −1.03 −1.40 −0.42 −0.72 −0.56 −0.67 2 HGG 1 1652328 −0.93 −1.59 to −0.56 −0.88 −0.81 −0.79 −1.17 −1.59 −0.74 −0.56 −0.79 −1.00 2 HGG 1 1979756 −1.06 −1.61 to −0.83 −1.25 −0.95 −0.83 −1.15 −1.61 −0.88 −0.87 −0.94 −1.07 2 HGG 1 3139631 −0.82 −1.57 to −0.56 −0.83 −0.76 −0.75 −0.85 −0.57 −0.58 −0.56 −0.63 −0.84 2 HGG 1 5506170 −0.74 −1.39 to −0.29 −0.29 −0.81 −0.69 −0.70 −1.39 −0.65 −0.34 −0.82 −0.94 2 HGG 1 1667220 −0.97 −1.45 to −0.63 −1.17 −1.08 −0.79 −1.21 −1.45 −0.63 −0.69 −0.86 −0.85 2 HGG 1 380006 −0.98 −1.41 to −0.63 −1.06 −0.88 −0.87 −1.22 −1.41 −0.81 −0.63 −0.80 −1.16 2 HGG 1 2055867 −0.70 −1.33 to −0.02 −0.09 −1.33 −0.91 −0.20 −1.15 −0.77 −0.02 −0.95 −0.87 2 HGG 1 459372 2.04 1.72 to 2.37 2.29 2.06 1.76 2.06 2.37 2.00 1.94 1.72 2.13 3 HGG 1 2755836 3.41 2.62 to 4.02 3.89 3.26 2.62 3.35 3.89 3.33 3.14 3.17 4.02 3 HGG 1 548114 2.00 1.70 to 2.39 2.06 1.80 1.70 2.12 2.39 2.05 1.96 1.86 2.09 3 HGG 1 5501676 1.79 0.00 to 3.22 3.22 2.66 1.99 2.96 0.00 0.00 2.32 0.00 2.99 3 HGG 1 1457424 2.10 1.68 to 2.64 2.64 2.26 1.82 2.19 2.34 1.68 1.89 1.79 2.25 3 HGG 1 617587 1.99 0.00 to 2.83 2.43 2.22 2.04 2.44 0.00 1.92 1.70 2.30 2.83 3 HGG 1 2494284 1.87 1.58 to 2.24 1.86 1.58 1.94 1.83 2.24 1.78 1.69 1.74 2.12 3 HGG 1 2520894 2.34 1.93 to 2.76 2.65 2.19 2.13 2.46 2.66 1.93 1.93 2.36 2.76 3 HGG 1 2818476 2.59 0.00 to 3.84 3.84 3.02 2.25 2.95 0.00 2.71 2.59 2.49 3.47 3 HGG 1 3606046 1.78 1.35 to 2.15 2.15 1.60 1.49 1.89 2.12 1.35 1.52 1.74 2.15 3 HGG 1 1630990 2.73 2.13 to 3.40 3.40 2.49 2.13 2.84 2.91 2.42 2.69 2.51 3.16 3 HGG 1 1684617 1.89 1.28 to 2.42 2.42 1.95 1.75 2.00 2.17 1.40 1.28 1.81 2.27 3 HGG 1 3792988 1.99 1.43 to 2.51 2.38 1.96 1.70 2.13 2.23 1.43 1.54 2.01 2.51 3 HGG 1 2956444 1.68 1.00 to 2.23 2.23 1.74 1.57 1.98 1.85 1.00 1.35 1.47 1.96 3 HGG 1 4287327 2.15 1.54 to 2.65 2.05 2.18 2.22 2.03 2.45 1.54 1.91 2.65 2.33 3 HGG 1 4549259 2.99 2.57 to 3.42 3.33 2.95 2.70 3.19 3.42 2.57 2.81 2.63 3.26 3 HGG 1 1210839 1.32 0.00 to 1.91 1.91 1.30 1.31 1.67 0.00 1.39 1.32 1.29 1.72 4 HGG 1 136073 0.89 0.00 to 1.70 1.70 1.26 0.95 1.08 0.00 0.91 1.14 0.99 0.00 4 HGG 1 2061171 0.79 0.00 to 1.36 0.00 1.11 1.03 1.06 0.00 0.90 0.86 0.83 1.36 4 HGG 1 139949 1.06 0.00 to 1.59 1.59 1.21 1.23 1.27 0.00 0.84 0.99 1.09 1.29 4 HGG 1 4554722 0.94 0.00 to 1.77 1.28 0.93 0.76 0.98 0.00 0.70 0.78 1.26 1.77 4 HGG 1 1944123 0.94 0.00 to 1.41 1.32 1.13 0.76 1.04 0.00 0.83 0.94 1.00 1.41 4 HGG 1 1560906 1.25 0.00 to 2.31 2.31 1.37 1.22 1.70 0.00 0.90 0.86 1.17 1.70 4 HGG 1 2403438 1.58 0.00 to 2.29 2.29 1.78 1.70 1.84 0.00 1.46 1.49 1.62 2.07 4 HGG 1 4286760 1.08 −0.04 to 1.41  1.26 1.28 1.41 0.63 −0.04 1.33 1.30 1.23 1.36 4 HGG 1 2110430 1.62 0.00 to 2.41 2.41 1.97 1.63 1.98 0.00 1.35 1.51 1.58 2.10 4 HGG 1 4092112 0.92 0.00 to 1.59 1.59 1.45 1.16 1.25 0.00 0.91 1.08 0.86 0.00 4 HGG 1 1756875 1.28 0.00 to 1.86 1.73 1.38 1.32 1.66 0.00 1.05 1.09 1.39 1.86 4 HGG 1 3391835 0.92 0.00 to 2.68 2.68 2.09 1.75 0.00 0.00 0.00 1.78 0.00 0.00 4 HGG 1 5509134 1.60 0.00 to 2.30 2.30 1.57 1.41 1.68 0.00 1.73 1.86 1.62 2.20 4 HGG 1 305751 1.46 0.00 to 1.92 1.86 1.47 1.33 1.64 0.00 1.53 1.77 1.58 1.92 4 HGG 1 2506973 −1.62 −2.00 to −1.33 −1.90 −1.65 −1.45 −1.88 −2.00 −1.33 −1.39 −1.37 −1.62 5 HGG 1 3001212 −1.49 −2.25 to −1.06 −1.82 −1.47 −1.22 −1.97 −2.25 −1.06 −1.16 −1.17 −1.35 5 HGG 1 41479 −1.38 −2.35 to −1.14 −1.32 −1.30 −1.14 −1.40 −2.35 −1.20 −1.16 −1.16 −1.39 5 HGG 1 2471835 −1.39 −1.82 to −1.19 −1.82 −1.54 −1.33 −1.40 −1.20 −1.19 −1.20 −1.25 −1.60 5 HGG 1 2061528 −1.52 −1.78 to −1.18 −1.68 −1.71 −1.49 −1.78 −1.45 −1.18 −1.41 −1.37 −1.59 5 HGG 1 508943 −1.26 −1.56 to −0.97 −1.56 −1.25 −1.24 −1.53 −1.54 −1.02 −0.97 −1.04 −1.22 5 HGG 1 5291518 −1.46 −1.60 to −1.31 −1.40 −1.60 −1.57 −1.47 −1.44 −1.44 −1.31 −1.52 −1.42 5 HGG 1 1868536 −1.43 −1.76 to −1.03 −1.56 −1.43 −1.44 −1.60 −1.76 −1.20 −1.03 −1.23 −1.61 5 HGG 1 1876456 −1.55 −1.86 to −1.21 −1.86 −1.63 −1.36 −1.80 −1.84 −1.21 −1.39 −1.28 −1.59 5 HGG 1 3126622 −1.25 −2.00 to −0.95 −1.33 −1.23 −0.97 −1.44 −2.00 −1.17 −0.95 −0.96 −1.21 5 HGG 1 3679667 −1.54 −1.81 to −1.25 −1.47 −1.78 −1.57 −1.46 −1.42 −1.34 −1.25 −1.74 −1.81 5 HGG 1 2047730 −1.42 −1.88 to −1.02 −1.46 −1.30 −1.34 −1.61 −1.88 −1.33 −1.17 −1.02 −1.67 5 HGG 1 3681722 −1.40 −1.64 to −1.12 −1.64 −1.49 −1.16 −1.57 −1.62 −1.12 −1.38 −1.15 −1.52 5 HGG 1 293477 −1.35 −1.76 to −1.11 −1.76 −1.51 −1.28 −1.38 −1.21 −1.11 −1.16 −1.19 −1.54 5 HGG 1 891072 −1.31 −1.61 to −0.91 −1.31 −1.45 −1.24 −1.50 −1.61 −0.91 −1.08 −1.21 −1.48 5 HGG 1 4408943 −1.68 −1.90 to −1.25 −1.62 −1.90 −1.79 −1.79 −1.73 −1.49 −1.25 −1.70 −1.79 6 HGG 1 3031022 −1.83 −2.06 to −1.57 −1.83 −1.95 −1.75 −1.75 −1.97 −1.73 −1.57 −1.84 −2.06 6 HGG 1 2042056 −1.96 −2.38 to −1.55 −2.05 −2.38 −1.86 −2.29 −1.86 −1.72 −1.86 −2.10 −1.55 6 HGG 1 1596220 −1.66 −1.99 to −1.42 −1.72 −1.66 −1.45 −1.91 −1.99 −1.42 −1.50 −1.45 −1.84 6 HGG 1 1619292 −1.67 −2.03 to −1.35 −2.03 −1.78 −1.72 −1.61 −1.43 −1.65 −1.59 −1.35 −1.89 6 HGG 1 5047895 −1.79 −1.99 to −1.49 −1.72 −1.97 −1.98 −1.99 −1.73 −1.55 −1.49 −1.84 −1.87 6 HGG 1 1740474 −1.67 −2.25 to −1.37 −1.75 −1.64 −1.43 −1.73 −2.25 −1.54 −1.64 −1.37 −1.68 6 HGG 1 2886955 −1.91 −2.24 to −1.69 −2.13 −2.05 −1.73 −2.00 −1.90 −1.76 −1.69 −1.69 −2.24 6 HGG 1 1890576 −1.77 −2.36 to −1.33 −2.36 −1.83 −1.69 −1.74 −1.33 −1.80 −1.52 −1.60 −2.06 6 HGG 1 3975209 −1.66 −2.07 to −1.23 −2.07 −1.46 −1.66 −1.92 −1.66 −1.56 −1.49 −1.23 −1.92 6 HGG 1 2912637 −2.28 −2.82 to −1.98 −2.82 −2.24 −1.98 −2.53 −2.42 −2.05 −2.13 −1.98 −2.39 6 HGG 1 5541828 −2.05 −2.48 to −1.56 −2.04 −2.10 −2.19 −2.22 −2.38 −1.62 −1.56 −1.82 −2.48 6 HGG 1 560115 −2.00 −2.59 to −1.50 −1.50 −2.59 −2.10 −2.02 −2.28 −1.70 −1.74 −2.32 −1.72 6 HGG 1 2095268 −1.00 −1.42 to −0.76 −1.42 −1.07 −0.84 −0.99 −1.17 −0.76 −0.83 −0.82 −1.14 7 HGG 1 4246966 −1.07 −1.42 to −0.76 −1.23 −1.42 −0.86 −1.18 −0.97 −0.76 −0.97 −1.35 −0.89 7 HGG 1 2060823 −1.09 −1.58 to −0.69 −1.58 −1.08 −0.97 −1.12 −0.69 −0.99 −1.14 −0.93 −1.33 7 HGG 1 2051966 −1.04 −1.56 to −0.74 −1.56 −1.24 −0.86 −1.04 −1.18 −0.74 −0.78 −0.76 −1.15 7 HGG 1 1886928 −0.60 −1.40 to 0.00  −1.40 −0.73 −0.69 −0.81 0.00 −0.52 0.00 −0.71 −0.51 7 HGG 1 5198045 −0.95 −1.39 to −0.61 −1.39 −1.25 −0.92 −0.91 −1.85 −0.61 −0.82 −0.87 −0.92 7 HGG 1 3747901 −0.99 −1.42 to −0.75 −1.42 −1.26 −0.88 −1.05 −0.85 −0.76 −0.75 −0.94 −1.04 7 HGG 1 3973887 −1.06 −1.48 to −0.73 −1.48 −1.39 −1.03 −1.15 −0.73 −0.85 −0.85 −1.07 −0.97 7 HGG 1 2458526 −0.89 −1.40 to −0.54 −1.40 −1.05 −0.83 −0.93 −0.67 −0.71 −0.54 −0.83 −1.02 7 HGG 1 2947188 −0.98 −1.33 to −0.71 −1.27 −1.02 −0.71 −1.26 −1.33 −1.75 −0.85 −0.71 −0.93 7 HGG 1 223436 −0.97 −1.33 to −0.75 −1.33 −1.10 −0.85 −0.94 −1.04 −0.85 −0.83 −0.75 −1.04 7 HGG 1 2095728 −1.01 −1.33 to −0.80 −1.33 −1.03 −0.89 −1.16 −0.99 −0.80 −0.89 −0.93 −1.05 7 HGG 1 1366040 0.15 0.00 to 1.35 0.00 0.00 1.35 0.00 0.00 0.00 0.00 0.00 0.00 8 HGG 1 1478855 −0.19 −1.67 to 0.00  0.00 0.00 0.00 0.00 0.00 −1.67 0.00 0.00 0.00 8 HGG 1 3187903 0.22 0.00 to 2.00 0.00 0.00 0.01 0.00 0.00 0.00 0.00 2.00 0.00 8 HGG 1 1700074 0.45 −0.16 to 1.39  0.35 0.31 1.39 −0.06 −0.16 0.89 0.21 0.18 0.94 8 HGG 1 5374705 0.33 0.00 to 2.71 0.00 0.00 0.30 0.00 2.71 0.00 0.00 0.00 0.00 8 HGG 1 3566941 0.24 0.00 to 1.62 0.00 0.00 0.50 0.00 1.62 0.00 0.00 0.00 0.00 8 HGG 1 1500810 −0.70 −1.58 to −0.38 −0.85 −0.71 −0.40 −0.88 −1.58 −0.38 −0.38 −0.44 −0.74 9 HGG 1 1930847 −0.67 −1.74 to −0.29 −0.75 −0.55 −0.40 −0.98 −1.74 −0.29 −0.36 −0.39 −0.58 9 HGG 1 41247 −0.34 −1.42 to 0.12  −0.25 −0.31 −0.22 −0.29 −1.42 −0.01 −0.12 −0.25 −0.37 9 HGG 1 526319 −0.49 −1.33 to −0.03 −0.03 −0.40 −0.37 −0.56 −1.33 −0.48 −0.25 −0.41 −0.52 9 HGG 1 2273944 −0.45 −1.36 to −0.14 −0.33 −0.26 −0.29 −0.72 −1.36 −0.14 −0.18 −0.51 −0.26 9 HGG 1 0.00 to 0.00 0.00 to 0.00 2287426 −1.16 −1.46 to −0.89 −1.46 −1.23 −1.07 −1.26 −1.17 −1.04 −0.89 −1.19 0 HGG 2 2287703 −1.24 −1.51 to −1.05 −1.51 −1.36 −1.18 −1.31 −1.05 −1.08 −1.07 −1.34 0 HGG 2 2345426 −1.08 −1.49 to −0.67 −1.49 −1.28 −0.76 −1.32 −0.67 −1.18 −1.04 −0.91 0 HGG 2 2453558 −1.32 −1.42 to −1.13 −1.41 −1.38 −1.13 −1.42 −1.34 −1.30 −1.24 −1.39 0 HGG 2 2469891 −1.56 −1.88 to −1.35 −1.88 −1.57 −1.64 −1.47 −1.52 −1.45 −1.35 −1.59 0 HGG 2 1437552 −1.15 −1.48 to −0.72 −1.48 −1.14 −1.27 −1.45 −0.72 −0.99 −1.02 −1.16 0 HGG 2 2055279 −1.21 −1.42 to −1.00 −1.42 −1.28 −1.12 −1.29 −1.34 −1.04 −1.00 −1.18 0 HGG 2 2703122 −1.66 −1.84 to −1.54 −1.04 −1.55 −1.66 −1.76 −1.66 −1.54 −1.58 −1.84 0 HGG 2 2086783 −1.18 −1.50 to −0.90 −1.50 −1.33 −1.16 −1.29 −1.00 −1.05 −0.90 −1.25 0 HGG 2 2088104 −1.20 −1.58 to −0.88 −1.58 −1.32 −1.15 −1.31 −1.21 −0.91 −0.88 −1.22 0 HGG 2 2089176 −1.10 −1.42 to −0.83 −1.42 −1.34 −0.99 −1.18 −1.01 −0.87 −0.83 −1.15 0 HGG 2 2095329 −1.37 −1.68 to −1.15 −1.68 −1.50 −1.32 −1.46 −1.20 −1.15 −1.18 −1.50 0 HGG 2 2954059 −1.22 −1.71 to −0.98 −1.71 −1.37 −1.11 −1.37 −1.02 −1.08 −1.14 −0.98 0 HGG 2 3115505 −1.10 −1.42 to −0.86 −1.42 −1.26 −1.03 −1.27 −0.86 −0.97 −0.99 −1.05 0 HGG 2 2253868 −1.07 −1.53 to −0.70 −1.53 −1.17 −0.76 −1.48 −0.70 −0.91 −1.03 −0.97 0 HGG 2 2253102 −1.20 −1.58 to −0.91 −1.58 −1.30 −1.22 −1.25 −1.11 −1.03 −0.91 −1.23 0 HGG 2 2268923 −1.18 −1.51 to −1.02 −1.51 −1.22 −1.10 −1.15 −1.18 −1.02 −1.04 −1.20 0 HGG 2 1728013 −1.11 −1.39 to −0.85 −1.20 −1.27 −0.94 −1.39 −0.85 −1.08 −1.10 −1.08 0 HGG 2 2269058 −1.15 −1.37 to −0.81 −1.37 −1.32 −1.08 −1.19 −0.81 −0.96 −1.12 −1.33 0 HGG 2 2284694 −1.07 −1.42 to −0.77 −1.42 −1.26 −0.96 −1.11 −0.92 −0.77 −0.86 −1.24 0 HGG 2 1823946 −1.20 −1.36 to −0.99 −1.33 −1.36 −1.15 −1.31 −1.11 −0.99 −1.00 −1.32 0 HGG 2 2285181 −1.27 −1.50 to −1.04 −1.50 −1.34 −1.30 −1.33 −1.21 −1.08 −1.04 −1.40 0 HGG 2 2285721 −1.12 −1.35 to −0.86 −1.35 −1.23 −1.05 −1.17 −1.03 −0.98 −0.86 −1.26 0 HGG 2 2286360 −1.26 −1.55 to −1.11 −1.55 −1.31 −1.12 −1.29 −1.32 −1.13 −1.11 −1.24 0 HGG 2 626471 0.71 0.00 to 1.80 1.80 1.28 1.08 1.55 0.00 0.00 0.00 0.00 1 HGG 2 755223 0.91 0.60 to 1.40 1.40 0.79 0.76 1.09 0.82 0.79 0.60 1.00 1 HGG 2 1323616 0.89 0.00 to 1.36 1.16 0.64 0.60 1.24 0.00 1.36 0.98 1.16 1 HGG 2 757514 0.89 0.00 to 1.48 1.15 0.57 0.60 1.18 0.00 1.10 1.04 1.48 1 HGG 2 869702 0.55 0.00 to 1.32 1.32 1.07 0.91 1.06 0.00 0.00 0.00 0.00 1 HGG 2 1501809 0.33 −0.17 to 2.49  −0.09 −0.17 0.09 0.35 0.00 0.00 2.49 0.00 1 HGG 2 2018315 0.63 0.00 to 1.62 1.62 1.08 1.09 1.26 0.00 0.00 0.00 0.00 1 HGG 2 1515346 0.52 0.00 to 1.36 1.36 0.86 0.87 1.05 0.00 0.00 0.00 0.00 1 HGG 2 2044184 0.14 −0.15 to 1.34  −0.11 0.05 −0.05 −0.08 1.34 0.11 0.02 −0.15 1 HGG 2 1559844 0.96 0.00 to 1.34 1.34 0.97 0.75 1.21 0.00 1.28 0.83 1.27 1 HGG 2 2025128 0.90 0.00 to 1.40 1.19 0.65 0.66 0.95 0.00 1.21 1.10 1.40 1 HGG 2 2230608 1.04 0.75 to 1.39 1.39 0.77 0.75 1.11 1.13 0.91 0.93 1.31 1 HGG 2 1670407 0.56 0.00 to 1.56 1.56 0.93 0.81 1.21 0.00 0.00 0.00 0.00 1 HGG 2 1696552 0.41 −0.18 to 3.25  0.18 −0.16 −0.18 0.21 0.00 3.25 0.00 0.00 1 HGG 2 2499976 0.76 0.31 to 1.52 1.52 0.79 0.85 1.02 0.40 0.53 0.31 0.67 1 HGG 2 2394990 0.89 0.00 to 1.51 1.36 0.87 0.76 1.19 0.00 1.51 0.00 1.40 1 HGG 2 2725369 0.85 0.33 to 1.53 1.53 1.11 1.11 1.06 0.39 0.50 0.33 0.76 1 HGG 2 1822143 0.28 −0.23 to 2.58  −0.02 −0.23 −0.13 2.58 0.00 0.00 0.00 0.00 1 HGG 2 620879 0.31 −0.01 to 2.30  0.08 0.08 −0.01 0.02 0.00 2.30 0.00 0.00 1 HGG 2 1911819 0.48 −0.20 to 1.39  1.39 0.89 0.77 0.56 −0.20 −0.01 0.13 0.31 1 HGG 2 2021989 1.06 0.00 to 1.74 1.19 0.76 0.86 1.17 0.00 1.74 1.24 1.50 2 HGG 2 1961617 2.02 0.00 to 3.29 2.47 1.76 1.46 2.46 0.00 2.33 2.36 3.29 2 HGG 2 1326255 2.29 1.58 to 2.83 2.83 2.44 2.26 2.42 2.33 2.19 1.58 2.24 2 HGG 2 1407125 1.38 1.21 to 1.64 1.64 1.21 1.22 1.43 1.25 1.37 1.31 1.62 2 HGG 2 1988540 1.23 0.72 to 1.66 1.64 1.22 0.96 1.66 1.15 1.13 0.72 1.37 2 HGG 2 960604 1.25 1.03 to 1.48 1.48 1.19 1.03 1.32 1.13 1.27 1.25 1.32 2 HGG 2 2837006 1.20 0.00 to 1.87 1.50 1.08 0.99 1.50 0.00 1.33 1.33 1.87 2 HGG 2 2124056 2.03 1.73 to 2.38 2.38 1.98 1.91 2.26 1.73 1.78 1.83 2.33 2 HGG 2 3206352 1.37 0.00 to 1.94 1.94 1.34 1.30 1.70 0.00 1.59 1.50 1.64 2 HGG 2 1709709 1.19 0.00 to 1.68 1.44 0.91 1.11 1.52 0.00 1.48 1.38 1.68 2 HGG 2 2544622 2.43 0.00 to 3.15 3.15 2.56 2.12 3.01 0.00 3.00 2.55 3.01 2 HGG 2 1848722 −1.21 −1.43 to −0.84 −1.18 −1.16 −0.84 −1.16 −1.43 −1.16 −1.36 −1.35 3 HGG 2 1988593 −1.07 −1.42 to −0.77 −1.10 −1.01 −0.77 −1.15 −1.42 −1.09 −1.02 −0.99 3 HGG 2 1511262 −1.28 −1.49 to −1.04 −1.17 −1.22 −1.04 −1.19 −1.35 −1.41 −1.34 −1.49 3 HGG 2 2394616 −0.95 −1.32 to −0.64 −0.64 −0.97 −0.91 −0.77 −1.32 −1.02 −0.97 −0.96 3 HGG 2 1594179 −0.93 −1.36 to −0.61 −0.68 −1.04 −0.61 −1.05 −1.36 −1.01 −0.85 −0.88 3 HGG 2 2925373 −1.10 −1.39 to −0.95 −1.06 −1.13 −0.95 −1.04 −1.18 −0.96 −1.09 −1.39 3 HGG 2 1706751 −1.10 −1.54 to −0.85 −1.12 −1.54 −1.10 −0.95 −0.95 −0.85 −1.31 −0.97 3 HGG 2 1988774 −1.07 −1.83 to −0.60 −0.60 −1.83 −1.27 −0.78 −1.23 −0.79 −1.09 −1.00 3 HGG 2 3284411 −1.16 −1.48 to −0.92 −1.00 −1.25 −0.94 −1.05 −1.38 −1.27 −1.48 −0.92 3 HGG 2 3421730 −1.04 −1.36 to −0.57 −0.57 −1.36 −1.19 −0.79 −1.29 −0.82 −1.12 −1.18 3 HGG 2 2914439 −1.11 −1.37 to −0.83 −0.95 −1.05 −0.83 −1.05 −1.24 −1.37 −1.15 −1.28 3 HGG 2 1520151 −0.83 −1.34 to 0.00  −0.84 −0.97 −1.06 −0.78 0.00 −0.73 −0.89 −1.34 4 HGG 2 1616048 −0.99 −1.48 to 0.00  −1.14 −1.48 −1.12 −1.07 0.00 −0.63 −1.03 −1.42 4 HGG 2 1753283 −0.85 −1.56 to 0.00  −1.56 −1.40 −1.25 −1.38 0.00 0.00 0.00 −1.23 4 HGG 2 2703282 −0.86 −1.40 to 0.00  −1.40 −1.24 −0.98 −1.23 0.00 0.00 −0.63 −1.40 4 HGG 2 2294968 −0.94 −1.37 to 0.00  −0.90 −1.08 −0.83 −1.28 0.00 −1.08 −0.95 −1.37 4 HGG 2 660142 1.94 0.00 to 3.08 2.95 2.40 2.18 2.60 0.00 0.00 2.29 3.08 5 HGG 2 2234266 1.15 0.00 to 2.86 2.86 1.94 1.64 0.00 0.00 0.00 0.00 2.80 5 HGG 2 1303862 1.58 0.00 to 3.10 3.10 2.37 1.66 2.51 0.00 0.00 0.00 3.00 5 HGG 2 1316801 1.28 0.00 to 2.43 2.43 1.99 1.70 2.24 0.00 0.00 0.00 1.84 5 HGG 2 2705256 −0.20 −1.40 to 0.16  0.16 −0.23 −0.12 0.00 0.00 0.00 −1.40 0.02 6 HGG 2 3100048 −0.99 −2.17 to 0.08  0.08 −1.53 −1.27 −0.30 −1.10 −0.47 −2.17 −1.19 6 HGG 2 0.00 to 0.00 0.00 to 0.00 1306062 0.18 0.00 to 1.46 0.00 0.00 0.00 0.00 0.00 1.46 0.00 0.00 0 HGG 3 4291619 0.17 0.00 to 1.36 0.00 0.00 0.00 0.00 0.00 1.36 0.00 0.00 0 HGG 3 1560380 0.20 0.00 to 1.62 0.00 0.00 0.00 0.00 0.00 1.62 0.00 0.00 0 HGG 3 3957354 0.31 0.00 to 2.51 0.00 0.00 0.00 0.00 0.00 2.51 0.00 0.00 0 HGG 3 4307290 0.17 0.00 to 1.36 0.00 0.00 0.00 0.00 0.00 1.36 0.00 0.00 0 HGG 3 1786554 0.46 0.00 to 1.48 0.00 0.00 0.90 0.00 0.00 1.26 0.00 1.48 0 HGG 3 4221092 0.18 0.00 to 1.42 0.00 0.00 0.00 0.00 0.00 1.42 0.00 0.00 0 HGG 3 872017 0.18 0.00 to 1.41 0.00 0.00 0.00 0.00 0.00 1.41 0.00 0.00 0 HGG 3 621543 0.21 0.00 to 1.68 0.00 0.00 0.00 0.00 0.00 1.68 0.00 0.00 0 HGG 3 5323022 0.17 0.00 to 1.33 0.00 0.00 0.00 0.00 0.00 1.33 0.00 0.00 0 HGG 3 4249090 0.17 0.00 to 1.36 0.00 0.00 0.00 0.00 0.00 1.36 0.00 0.00 0 HGG 3 2908546 0.18 0.00 to 1.41 0.00 0.00 0.00 0.00 0.00 1.41 0.00 0.00 0 HGG 3 5291215 0.17 0.00 to 1.40 0.00 0.00 0.00 0.00 0.00 1.40 0.00 0.00 0 HGG 3 5262558 0.20 0.00 to 1.64 0.00 0.00 0.00 0.00 0.00 1.64 0.00 0.00 0 HGG 3 5206821 0.17 0.00 to 1.33 0.00 0.00 0.00 0.00 0.00 1.33 0.00 0.00 0 HGG 3 3074113 0.46 0.00 to 1.92 0.00 0.00 0.00 0.00 0.00 1.79 0.00 1.92 0 HGG 3 5138591 0.19 0.00 to 1.53 0.00 0.00 0.00 0.00 0.00 1.53 0.00 0.00 0 HGG 3 4252768 0.17 0.00 to 1.36 0.00 0.00 0.00 0.00 0.00 1.36 0.00 0.00 0 HGG 3 5115293 0.18 0.00 to 1.45 0.00 0.00 0.00 0.00 0.00 1.45 0.00 0.00 0 HGG 3 4717363 0.18 0.00 to 1.47 0.00 0.00 0.00 0.00 0.00 1.47 0.00 0.00 0 HGG 3 5106915 0.19 0.00 to 1.48 0.00 0.00 0.00 0.00 0.00 1.48 0.00 0.00 0 HGG 3 4611240 0.17 0.00 to 1.33 0.00 0.00 0.00 0.00 0.00 1.33 0.00 0.00 0 HGG 3 4505265 0.18 0.00 to 1.42 0.00 0.00 0.00 0.00 0.00 1.42 0.00 0.00 0 HGG 3 5038604 0.19 0.00 to 1.53 0.00 0.00 0.00 0.00 0.00 1.53 0.00 0.00 0 HGG 3 4883207 0.17 0.00 to 1.38 0.00 0.00 0.00 0.00 0.00 1.38 0.00 0.00 0 HGG 3 3408939 0.17 0.00 to 1.35 0.00 0.00 0.00 0.00 0.00 1.35 0.00 0.00 0 HGG 3 4872725 0.18 0.00 to 1.46 0.00 0.00 0.00 0.00 0.00 1.46 0.00 0.00 0 HGG 3 3736815 0.26 0.00 to 2.06 0.00 0.00 0.00 0.00 0.00 2.06 0.00 0.00 0 HGG 3 1319021 −1.14 −1.57 to −0.94 −1.57 −1.26 −1.02 −0.94 −1.14 −1.01 −1.16 −1.06 1 HGG 3 608725 −1.04 −1.42 to −0.79 −1.42 −1.30 −0.88 −1.24 −0.84 −0.79 −0.88 −0.94 1 HGG 3 678955 −1.02 −1.48 to −0.78 −1.02 −1.48 −1.09 −1.02 −1.01 −0.92 −0.78 −0.85 1 HGG 3 1911443 −1.11 −1.62 to −0.45 −0.82 −1.38 −1.62 −0.82 −1.35 −0.45 −1.00 −1.41 1 HGG 3 2863211 −1.17 −1.50 to −1.03 −1.50 −1.28 −1.14 −1.07 −1.15 −1.03 −1.17 −1.05 1 HGG 3 3086833 −1.06 −1.38 to −0.75 −1.38 −1.33 −1.11 −1.29 −0.77 −0.75 −0.91 −0.94 1 HGG 3 3098189 −1.11 −1.46 to −0.67 −1.46 −1.33 −1.22 −1.26 −0.67 −0.96 −0.81 −1.13 1 HGG 3 3125211 −1.16 −1.65 to −0.79 −1.65 −1.19 −1.15 −1.39 −0.83 −0.86 −0.79 −1.38 1 HGG 3 3135460 −1.11 −1.78 to −0.66 −0.93 −1.11 −1.78 −1.05 −1.14 −0.66 −0.78 −1.44 1 HGG 3 3778404 −1.31 −1.67 to −0.87 −1.45 −1.40 −1.46 −1.57 −1.16 −0.87 −0.91 −1.67 1 HGG 3 3983862 −0.98 −1.38 to −0.78 −1.38 −1.20 −0.84 −0.92 −0.82 −0.78 −0.93 −0.99 1 HGG 3 4334474 −1.07 −1.40 to −0.92 −1.40 −1.32 −0.98 −1.06 −0.92 −0.94 −0.98 −0.92 1 HGG 3 4464538 −1.05 −1.45 to −0.67 −1.45 −1.22 −0.99 −1.30 −0.67 −0.83 −0.82 −1.12 1 HGG 3 4860060 −1.29 −1.50 to −1.20 −1.50 −1.42 −1.20 −1.29 −1.21 −1.22 −1.23 −1.30 1 HGG 3 5399371 −1.27 −1.57 to −0.95 −1.42 −1.23 −1.31 −0.95 −1.57 −1.46 −1.13 −1.08 1 HGG 3 5426158 −1.03 −1.44 to −0.62 −1.06 −1.44 −1.10 −0.71 −0.99 −0.62 −1.28 −1.01 1 HGG 3 5322365 1.21 0.89 to 1.64 1.64 1.19 0.89 1.24 1.04 1.24 1.06 1.34 2 HGG 3 2545486 2.03 0.00 to 3.28 0.00 2.65 2.15 2.77 0.00 3.28 2.53 2.87 2 HGG 3 4253809 1.72 1.44 to 1.97 1.97 1.44 1.59 1.79 1.69 1.85 1.56 1.89 2 HGG 3 4402555 1.88 0.00 to 2.68 0.00 1.93 2.12 2.68 1.90 1.94 1.95 2.53 2 HGG 3 3069190 3.29 0.00 to 4.14 0.00 3.58 3.53 3.89 3.58 3.82 3.73 4.14 2 HGG 3 3172265 3.74 3.15 to 4.12 3.98 3.69 3.15 3.72 3.66 4.12 3.63 3.99 2 HGG 3 4912315 1.38 0.00 to 2.62 0.00 2.01 1.33 2.59 0.00 2.49 0.00 2.62 2 HGG 3 3158828 1.61 0.95 to 2.12 1.91 1.85 1.73 2.12 0.95 1.39 1.16 1.75 2 HGG 3 2343348 1.50 1.18 to 2.02 2.02 1.67 1.23 1.60 1.18 1.45 1.38 1.47 2 HGG 3 5266015 2.28 2.05 to 2.62 2.62 2.14 2.12 2.57 2.05 2.08 2.08 2.56 2 HGG 3 2972013 1.19 0.90 to 1.69 1.69 1.31 0.94 1.47 0.90 1.00 0.96 1.26 2 HGG 3 5293028 1.16 0.70 to 1.55 1.35 1.11 0.70 1.15 1.08 1.31 1.03 1.55 2 HGG 3 1636594 0.25 0.00 to 1.38 0.00 1.38 0.00 0.00 0.00 0.62 0.00 0.00 3 HGG 3 5321996 0.47 0.00 to 1.64 0.00 1.64 0.63 0.40 0.00 0.53 0.00 0.59 3 HGG 3 3614283 0.46 0.00 to 1.39 0.00 0.43 0.27 1.39 0.22 0.44 0.57 0.37 3 HGG 3 3003980 0.22 0.00 to 1.79 0.00 0.00 0.00 1.79 0.00 0.00 0.00 0.00 3 HGG 3 5102731 0.52 −0.22 to 1.36 0.00 0.87 −0.22 1.09 0.00 1.08 0.00 1.36 3 HGG 3 4288091 −0.05 −1.36 to 0.95 0.00 0.00 −1.36 0.00 0.00 0.95 0.00 0.00 3 HGG 3 4339883 −0.21 −1.67 to 0.00 0.00 0.00 −1.67 0.00 0.00 0.00 0.00 0.00 3 HGG 3 630375 −0.19 −1.54 to 0.00 0.00 0.00 −1.54 0.00 0.00 0.00 0.00 0.00 3 HGG 3 641510 −0.26 −2.05 to 0.00 0.00 0.00 −2.05 0.00 0.00 0.00 0.00 0.00 3 HGG 3 748477 0.91 0.42 to 1.33 1.33 0.42 0.54 1.27 1.08 0.75 0.82 1.05 3 HGG 3 777716 −0.20 −1.57 to 0.00  0.00 0.00 −1.57 0.00 0.00 0.00 0.00 0.00 3 HGG 3 2698777 −1.48 −1.74 to −1.17 −1.55 −1.66 −1.58 −1.74 −1.17 −1.36 −1.28 −1.50 4 HGG 3 4289557 −1.92 −2.45 to −1.40 −2.03 −2.11 −2.00 −2.28 −1.44 −1.66 −1.40 −2.45 4 HGG 3 5573549 −1.80 −2.16 to −1.44 −2.16 −2.01 −1.69 −1.93 −1.47 −1.44 −1.69 −2.01 4 HGG 3 5091002 −1.42 −1.93 to −1.03 −1.61 −1.54 −1.79 −1.93 −1.03 −1.07 −1.07 −1.35 4 HGG 3 3097624 −1.53 −1.82 to −1.22 −1.79 −1.82 −1.42 −1.76 −1.22 −1.37 −1.37 −1.49 4 HGG 3 3084204 −1.51 −1.76 to −1.15 −1.70 −1.53 −1.50 −1.73 −1.37 −1.32 −1.15 −1.76 4 HGG 3 5166479 −1.58 −2.16 to −1.08 −1.26 −2.16 −1.73 −1.52 −1.64 −1.23 −2.03 −1.08 4 HGG 3 4715924 −0.93 −1.45 to −0.63 −1.23 −0.98 −0.78 −1.45 −0.63 −0.72 −0.73 −0.91 5 HGG 3 1732792 −0.91 −1.33 to 0.60  −1.33 −1.20 −0.89 −1.16 −0.66 −0.63 −0.60 −0.81 5 HGG 3 5281739 −0.85 −1.44 to −0.39 −0.87 −0.98 −0.88 −1.44 −0.47 −0.82 −0.39 −0.92 5 HGG 3 3120209 −1.91 −2.77 to −1.04 −2.55 −2.30 −1.26 −2.77 −1.17 −2.46 −1.73 −1.04 6 HGG 3 5427710 −1.99 −2.31 to −1.50 −2.17 −2.16 −1.97 −2.08 −1.50 −1.90 −1.79 −2.31 6 HGG 3 0.00 to 0.00 0.00 to 0.00 1259841 0.84 0.35 to 1.35 0.96 0.35 0.70 1.07 1.35 0.68 0.60 0.80 1.06 0 HGG 4 1365045 1.30 0.00 to 1.89 1.89 1.31 1.19 1.56 0.00 1.13 1.38 1.44 1.82 0 HGG 4 1370137 1.19 0.00 to 2.55 0.00 2.08 2.00 2.55 0.00 1.88 2.18 0.00 0.00 0 HGG 4 439415 1.23 1.12 to 1.38 1.38 1.12 1.16 1.25 1.21 1.28 1.23 1.17 1.30 0 HGG 4 1913334 1.31 0.74 to 1.74 1.74 1.04 1.08 1.34 1.68 0.74 1.13 1.32 1.74 0 HGG 4 1946155 0.93 0.68 to 1.33 1.33 0.86 0.75 0.98 1.09 0.68 0.75 0.78 1.09 0 HGG 4 409209 0.69 0.30 to 1.50 1.00 0.36 0.35 0.91 1.50 0.40 0.62 0.30 0.78 0 HGG 4 3016137 1.46 1.04 to 1.93 1.66 1.15 1.04 1.38 1.93 1.90 1.65 1.11 1.29 0 HGG 4 1965856 1.17 0.91 to 1.69 1.46 0.91 0.95 1.33 1.69 0.97 0.96 0.97 1.25 0 HGG 4 2007730 1.06 0.82 to 1.34 1.34 0.82 0.86 1.00 1.27 0.85 1.05 1.17 1.21 0 HGG 4 2408333 0.91 0.00 to 1.51 1.51 0.93 0.96 1.27 0.00 0.81 1.15 0.68 0.93 0 HGG 4 2619275 0.99 0.00 to 1.43 1.43 0.91 0.92 1.16 0.00 0.95 1.03 1.24 1.31 0 HGG 4 2106010 1.25 0.00 to 1.83 1.75 1.14 1.14 1.45 0.00 1.16 1.43 1.37 1.83 0 HGG 4 2110482 1.48 0.98 to 1.94 1.85 0.98 1.37 1.51 1.70 1.15 1.25 1.57 1.94 0 HGG 4 5101167 0.99 0.69 to 1.38 1.38 0.81 0.90 1.07 1.23 0.69 0.87 0.81 1.12 0 HGG 4 5690026 1.02 0.00 to 1.79 1.79 1.11 1.35 1.49 0.00 1.02 1.12 1.31 0.00 0 HGG 4 198719 −1.19 −1.53 to −0.94 −1.48 −1.19 −1.13 −1.39 −1.53 −0.94 −1.00 −1.02 −1.00 1 HGG 4 1416978 −1.04 −1.36 to −0.91 −1.36 −1.19 −1.10 −1.04 −0.91 −0.94 −0.91 −0.93 −1.01 1 HGG 4 1805836 −1.02 −1.43 to −0.79 −1.43 −1.17 −0.94 −1.16 −0.79 −0.83 −1.02 −0.93 −0.88 1 HGG 4 3042227 −1.75 −2.23 to −1.30 −1.92 −1.74 −1.53 −1.85 −2.23 −1.74 −1.58 −1.30 −1.85 1 HGG 4 1857850 −1.95 −2.18 to −1.62 −2.18 −2.07 −1.85 −2.02 −2.08 −1.62 −1.96 −1.71 −2.10 1 HGG 4 1953051 −1.49 −1.80 to −1.23 −1.74 −1.57 −1.26 −1.80 −1.79 −1.23 −1.27 −1.35 −1.35 1 HGG 4 495808 −1.18 −1.51 to −0.89 −1.51 −1.39 −1.12 −1.18 −1.42 −1.05 −1.10 −0.89 −0.99 1 HGG 4 496946 −1.08 −1.41 to −0.83 −1.41 −1.28 −0.92 −1.07 −1.27 −1.05 −1.02 −0.83 −0.89 1 HGG 4 2786442 −1.57 −2.20 to −1.16 −2.20 −1.68 −1.18 −1.91 −2.04 −1.25 −1.52 −1.23 −1.16 1 HGG 4 562585 −1.21 −1.50 to −1.04 −1.50 −1.37 −1.23 −1.20 −1.18 −1.07 −1.07 −1.04 −1.21 1 HGG 4 1383138 −1.14 −1.53 to −0.66 −0.66 −1.53 −1.35 −0.88 −1.30 −1.24 −0.79 −1.15 −1.34 1 HGG 4 3144511 0.26 0.00 to 2.30 0.00 0.00 0.00 0.00 0.00 2.30 0.00 0.00 0.00 2 HGG 4 3149570 0.39 0.00 to 1.44 0.00 0.99 1.08 1.44 0.00 0.00 0.00 0.00 0.00 2 HGG 4 3926757 0.48 0.00 to 1.36 0.12 1.36 1.04 0.47 0.00 0.46 0.34 0.34 0.17 2 HGG 4 4003219 0.19 0.00 to 1.67 0.00 0.00 1.67 0.00 0.00 0.00 0.00 0.00 0.00 2 HGG 4 2009252 0.20 0.00 to 1.38 0.00 1.38 0.40 0.00 0.00 0.00 0.00 0.00 0.00 2 HGG 4 220378 0.39 0.00 to 1.34 0.00 1.01 0.00 1.34 0.00 1.14 0.00 0.00 0.00 2 HGG 4 509839 0.64 0.00 to 1.44 0.00 1.26 0.90 1.44 0.00 0.94 1.23 0.00 0.00 2 HGG 4 2405487 0.69 0.00 to 1.53 0.00 1.06 1.28 1.53 0.00 1.05 1.25 0.00 0.00 2 HGG 4 2410066 0.45 0.00 to 1.65 0.00 1.14 1.24 1.65 0.00 0.00 0.00 0.00 0.00 2 HGG 4 2571644 0.28 0.00 to 2.54 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 2.54 2 HGG 4 4792726 −0.70 −1.34 to 0.00  −1.34 −1.10 −0.59 −0.91 0.00 −0.78 −0.96 −0.65 0.00 3 HGG 4 1876829 −0.94 −1.40 to −0.64 −1.16 −1.40 −0.81 −0.95 −0.78 −0.87 −1.01 −0.89 −0.64 3 HGG 4 1857664 −0.71 −1.39 to −0.23 −1.00 −0.73 −0.23 −1.02 −1.39 −0.48 −0.71 −0.35 −0.46 3 HGG 4 2420388 −0.17 −1.50 to 0.00  0.00 0.00 0.00 0.00 0.00 0.00 0.00 −1.50 0.00 3 HGG 4 1377668 −0.81 −1.34 to −0.43 −1.34 −0.94 −0.71 −0.99 −0.43 −0.59 −0.91 −0.68 −0.74 3 HGG 4 2581075 3.38 2.87 to 4.02 3.81 3.09 2.87 3.41 4.02 3.12 3.37 3.26 3.46 4 HGG 4 3191030 1.97 1.28 to 2.65 2.65 1.67 1.28 2.03 2.38 1.74 2.01 1.65 2.35 4 HGG 4 1964758 1.84 0.00 to 2.52 2.52 1.83 1.89 2.24 0.00 1.89 1.94 1.93 2.30 4 HGG 4 434751 1.69 1.31 to 2.21 1.89 1.49 1.31 1.73 2.21 1.63 1.69 1.40 1.86 4 HGG 4 2278772 1.94 1.54 to 2.44 2.18 1.65 1.54 2.22 2.44 1.83 1.94 1.99 1.70 4 HGG 4 2055569 −1.29 −2.08 to −0.57 −0.61 −1.36 −1.89 −0.94 −0.57 −2.08 −1.14 −1.59 −1.43 5 HGG 4 1449819 −1.47 −2.15 to −0.37 −0.68 −1.95 −2.15 −0.37 −1.18 −2.14 −0.73 −2.14 −1.93 5 HGG 4

TABLE 13 mean mean mean DE DE DE mean DE mean DE mean DE mean DE mean DE t/Betam t/Betam t/Betam t/Betam t/Betam t/Betam t/Betam t/Betam Ave DE 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clone ID t/Betam Range 1 hr 3 hr 6 hr 1 hr 6 hr 1 hr 3 hr 6 hr Cluster GEM 2886955 −1.69 −1.94 to −1.20 −1.76 −1.66 −1.71 −1.20 −1.91 −1.94 −1.64 −1.69 0 HGG 1 1807155 −0.87 −1.40 to −0.16 −0.34 −0.80 −1.27 −0.16 −1.40 −0.68 −1.12 −1.18 0 HGG 1 4698018 −1.21 −1.43 to −0.98 −1.14 −1.14 −1.13 −0.98 −1.43 −1.16 −1.27 −1.40 0 HGG 1 4408943 −1.52 −1.92 to −0.82 −1.34 −1.70 −1.74 −0.82 −1.92 −1.39 −1.62 −1.63 0 HGG 1 1833362 −1.08 −1.41 to −0.42 −0.85 −1.19 −1.33 −0.42 −1.41 −1.01 −1.21 −1.22 0 HGG 1 1840426 −1.09 −1.36 to −0.72 −0.84 −0.96 −1.31 −0.72 −1.36 −1.13 −1.19 −1.19 0 HGG 1 41479 −0.98 −1.34 to −0.41 −0.76 −0.97 −1.19 −0.41 −1.22 −0.93 −1.34 −0.98 0 HGG 1 2769888 −1.03 −1.49 to −0.50 −0.75 −1.20 −1.49 −0.74 −1.35 −0.50 −0.98 −1.23 0 HGG 1 1868536 −1.12 −1.63 to 0.00  −0.84 −1.23 −1.49 0.00 −1.63 −1.10 −1.28 −1.40 0 HGG 1 1876456 −1.47 −1.60 to −1.27 −1.60 −1.37 −1.48 −1.55 −1.50 −1.52 −1.45 −1.27 0 HGG 1 1890576 −1.52 −1.85 to −1.10 −1.47 −1.35 −1.41 −1.10 −1.85 −1.77 −1.63 −1.57 0 HGG 1 1910401 −1.27 −1.62 to −0.72 −1.00 −1.32 −1.35 −0.72 −1.62 −1.35 −1.30 −1.47 0 HGG 1 2506973 −1.52 −1.98 to −0.88 −1.38 −1.32 −1.63 −0.88 −1.98 −1.66 −1.78 −1.54 0 HGG 1 2839946 −1.04 −1.35 to −0.78 −0.78 −1.07 −1.08 −0.85 −1.15 −1.02 −1.05 −1.35 0 HGG 1 2132607 −1.10 −1.33 to −0.78 −0.89 −1.10 −1.22 −0.78 −1.33 −1.11 −1.21 −1.20 0 HGG 1 2471835 −1.03 −1.37 to −0.61 −0.95 −0.61 −0.88 −1.13 −1.21 −1.37 −0.96 −1.12 0 HGG 1 1441245 −1.38 −1.48 to −1.18 −1.48 −1.42 −1.38 −1.18 −1.45 −1.35 −1.35 −1.42 0 HGG 1 3975209 −1.45 −1.68 to −1.14 −1.68 −1.14 −1.53 −1.41 −1.55 −1.65 −1.26 −1.42 0 HGG 1 3679667 −1.39 −1.53 to −1.22 −1.48 −1.52 −1.46 −1.53 −1.31 −1.22 −1.31 −1.28 0 HGG 1 3451645 −0.93 −1.38 to −0.27 −0.56 −0.90 −1.38 −0.27 −1.09 −0.72 −1.27 −1.25 0 HGG 1 1501410 −0.98 −1.33 to −0.72 −0.94 −1.15 −1.33 −0.90 −1.10 −0.72 −0.85 −0.87 0 HGG 1 3031022 −1.83 −2.19 to −1.46 −1.48 −1.71 −2.00 −1.46 −2.19 −1.87 −1.87 −2.09 0 HGG 1 2042056 −1.53 −1.89 to −1.20 −1.89 −1.72 −1.44 −1.52 −1.37 −1.62 −1.46 −1.20 0 HGG 1 3001212 −1.28 −1.68 to −0.91 −1.11 −1.01 −1.25 −0.91 −1.50 −1.41 −1.68 −1.38 0 HGG 1 2047730 −1.29 −1.70 to −0.43 −0.96 −1.31 −1.70 −0.43 −1.55 −1.29 −1.53 −1.53 0 HGG 1 2912637 −2.17 −2.37 to −1.94 −2.30 −1.94 −1.98 −1.98 −2.35 −2.37 −2.28 −2.13 0 HGG 1 1596220 −1.65 −2.05 to −0.89 −1.40 −1.63 −1.82 −0.89 −2.05 −1.73 −1.84 −1.88 0 HGG 1 2061528 −1.34 −1.58 to −1.07 −1.54 −1.45 −1.58 −1.22 −1.26 −1.40 −1.22 −1.07 0 HGG 1 891072 −1.38 −1.59 to −0.95 −1.30 −1.50 −1.59 −0.95 −1.50 −1.31 −1.50 −1.40 0 HGG 1 1619292 −1.45 −1.66 to −1.23 −1.41 −1.29 −1.49 −1.23 −1.66 −1.50 −1.48 −1.54 0 HGG 1 560115 −1.87 −2.18 to −1.19 −1.50 −2.17 −1.98 −1.19 −2.14 −1.78 −2.18 −2.03 0 HGG 1 5541828 −1.95 −2.29 to −1.58 −2.00 −2.11 −2.29 −1.58 −2.04 −1.87 −1.84 −1.88 0 HGG 1 5291518 −1.30 −1.57 to −0.99 −1.50 −1.57 −1.51 −1.44 −1.25 −1.18 −1.00 −0.99 0 HGG 1 1652328 −0.88 −1.40 to 0.00  −0.39 −0.90 −1.23 0.00 −1.40 −0.70 −1.37 −1.08 0 HGG 1 2078880 −0.75 −1.35 to 0.00  −0.31 −0.65 −1.11 0.00 −1.10 −0.41 −1.08 −1.35 0 HGG 1 5047895 −1.35 −1.64 to −1.06 −1.07 −1.36 −1.64 −1.06 −1.63 −1.23 −1.37 −1.42 0 HGG 1 1740474 −1.49 −1.87 to −1.01 −1.41 −1.25 −1.48 −1.01 −1.87 −1.50 −1.67 −1.77 0 HGG 1 2516950 1.79 1.55 to 2.00 1.73 1.55 1.71 1.59 2.00 1.91 1.96 1.88 1 HGG 1 1944123 1.37 1.10 to 1.53 1.33 1.21 1.10 1.35 1.47 1.53 1.44 1.52 1 HGG 1 1956982 1.72 1.56 to 1.88 1.88 1.68 1.80 1.80 1.72 1.60 1.56 1.73 1 HGG 1 1241484 1.25 0.94 to 1.49 1.06 0.94 1.12 1.15 1.49 1.43 1.40 1.43 1 HGG 1 2120743 1.35 1.10 to 1.66 1.29 1.10 1.32 1.27 1.47 1.40 1.66 1.31 1 HGG 1 1268277 1.35 0.91 to 1.76 0.97 0.91 1.03 1.19 1.76 1.62 1.59 1.74 1 HGG 1 2697275 1.44 0.00 to 1.78 1.54 0.00 1.38 1.54 1.76 1.77 1.72 1.78 1 HGG 1 2313349 1.69 1.53 to 1.85 1.53 1.56 1.64 1.69 1.77 1.82 1.85 1.68 1 HGG 1 2445967 1.34 1.18 to 1.47 1.46 1.18 1.33 1.21 1.40 1.41 1.47 1.28 1 HGG 1 1320685 1.60 1.27 to 1.88 1.70 1.88 1.80 1.51 1.42 1.68 1.52 1.27 1 HGG 1 1342744 1.70 1.49 to 1.95 1.65 1.49 1.56 1.95 1.75 1.81 1.78 1.61 1 HGG 1 2459765 1.51 1.08 to 1.86 1.41 1.08 1.22 1.86 1.65 1.68 1.58 1.61 1 HGG 1 3108506 1.35 0.81 to 1.73 0.99 0.81 0.96 1.25 1.68 1.68 1.73 1.72 1 HGG 1 3595618 1.43 1.13 to 1.59 1.38 1.13 1.33 1.56 1.51 1.59 1.54 1.42 1 HGG 1 3687719 1.58 1.29 to 1.75 1.66 1.29 1.45 1.68 1.59 1.68 1.75 1.51 1 HGG 1 3821432 1.43 1.17 to 1.87 1.43 1.17 1.26 1.87 1.46 1.53 1.46 1.22 1 HGG 1 4021009 1.31 1.00 to 1.66 1.10 1.00 1.03 1.20 1.66 1.49 1.53 1.50 1 HGG 1 4289063 1.26 1.00 to 1.51 1.09 1.00 1.12 1.09 1.51 1.34 1.45 1.45 1 HGG 1 4978708 1.44 1.05 to 1.70 1.27 1.05 1.20 1.49 1.58 1.62 1.70 1.58 1 HGG 1 2833342 1.50 1.22 to 1.68 1.45 1.22 1.32 1.62 1.59 1.68 1.65 1.45 1 HGG 1 531505 1.38 1.08 to 1.64 1.08 1.23 1.14 1.35 1.48 1.53 1.64 1.57 1 HGG 1 5397446 1.27 1.02 to 1.45 1.25 1.02 1.29 1.20 1.45 1.17 1.39 1.41 1 HGG 1 1609387 1.49 1.19 to 1.77 1.34 1.19 1.31 1.37 1.77 1.69 1.59 1.64 1 HGG 1 1684617 1.75 1.34 to 2.20 1.34 1.64 1.63 1.34 2.20 2.05 1.95 1.80 1 HGG 1 2511277 1.77 0.00 to 2.33 1.62 0.00 1.58 2.15 2.20 2.33 2.24 2.03 1 HGG 1 2005266 0.28 0.00 to 1.38 1.38 0.00 0.57 0.00 0.23 0.00 0.08 0.00 2 HGG 1 275757 0.35 0.00 to 1.48 1.48 0.00 0.60 0.00 0.11 0.32 0.27 0.02 2 HGG 1 3474091 0.23 0.00 to 1.36 1.36 0.00 0.48 0.00 0.00 0.00 0.00 0.00 2 HGG 1 3479268 0.43 0.00 to 1.33 1.33 0.00 0.59 0.00 0.50 0.46 0.30 0.24 2 HGG 1 126877 0.50 0.00 to 1.55 1.55 0.00 0.79 0.00 0.42 0.54 0.44 0.23 2 HGG 1 128891 0.48 0.00 to 1.39 1.39 0.00 0.86 0.00 0.40 0.58 0.51 0.09 2 HGG 1 1306222 0.16 −0.15 to 1.39  0.17 0.00 −0.08 1.39 −0.15 0.03 −0.01 −0.08 2 HGG 1 13504 0.40 0.00 to 1.36 1.36 0.00 0.61 0.00 0.39 0.48 0.34 0.05 2 HGG 1 1415119 0.37 0.00 to 1.33 1.33 0.00 0.62 0.00 0.32 0.39 0.15 0.16 2 HGG 1 262712 0.43 0.00 to 1.42 1.42 0.00 0.61 0.00 0.36 0.49 0.38 0.19 2 HGG 1 5372104 0.34 0.00 to 1.33 1.33 0.00 0.67 0.00 0.00 0.40 0.31 0.00 2 HGG 1 566093 0.27 0.00 to 1.34 1.34 0.00 0.52 0.00 0.19 0.00 0.11 0.00 2 HGG 1 819036 0.51 0.00 to 1.34 1.34 0.00 0.69 0.00 0.47 0.51 0.51 0.53 2 HGG 1 3607580 0.51 0.00 to 1.35 1.35 0.00 0.68 0.00 0.46 0.73 0.52 0.32 2 HGG 1 3659618 0.18 0.00 to 1.46 1.46 0.00 0.00 0.00 0.00 0.00 0.00 0.00 2 HGG 1 1571861 0.23 −0.17 to 1.43  1.43 0.00 0.31 0.00 0.15 0.12 0.03 −0.17 2 HGG 1 1578941 0.43 0.00 to 1.33 1.33 0.00 0.63 0.00 0.40 0.52 0.35 0.23 2 HGG 1 89691 0.49 0.00 to 1.36 1.36 0.00 0.77 0.00 0.46 0.61 0.49 0.21 2 HGG 1 2008331 0.50 0.00 to 1.45 1.45 0.00 0.79 0.00 0.45 0.70 0.48 0.12 2 HGG 1 2382190 −0.40 −1.42 to 0.07 0.07 0.00 −0.74 0.00 −1.42 0.00 −1.14 0.00 2 HGG 1 2132784 0.53 0.00 to 1.40 1.40 0.00 0.76 0.00 0.53 0.62 0.50 0.39 2 HGG 1 3187861 0.36 0.00 to 1.39 1.39 0.00 0.52 0.00 0.37 0.00 0.34 0.26 2 HGG 1 451090 0.49 0.00 to 1.43 1.43 0.00 0.66 0.00 0.52 0.67 0.46 0.17 2 HGG 1 339737 0.51 0.00 to 1.49 1.49 0.00 0.66 0.00 0.58 0.55 0.49 0.27 2 HGG 1 1820105 0.28 0.00 to 1.32 1.32 0.00 0.57 0.00 0.00 0.23 0.07 0.04 2 HGG 1 1001486 0.87 0.43 to 1.36 0.81 0.43 0.68 1.20 0.73 1.36 0.91 0.85 3 HGG 1 4403805 1.19 0.68 to 1.61 0.89 0.68 0.93 1.01 1.61 1.47 1.46 1.51 3 HGG 1 1266985 0.74 0.38 to 1.41 0.87 0.38 0.45 1.41 0.54 1.03 0.66 0.58 3 HGG 1 143765 1.15 0.91 to 1.42 0.94 0.96 1.00 0.91 1.42 1.26 1.29 1.40 3 HGG 1 2933175 1.05 0.69 to 1.34 0.92 0.69 0.72 1.34 1.17 1.22 1.19 1.18 3 HGG 1 1637145 0.94 0.71 to 1.37 0.87 0.71 0.88 1.37 0.72 1.24 0.84 0.92 3 HGG 1 2252906 0.94 0.57 to 1.33 0.59 0.57 0.69 0.85 1.25 1.33 1.15 1.13 3 HGG 1 172023 0.87 0.36 to 1.47 1.25 1.22 0.74 1.47 0.36 0.88 0.48 0.58 3 HGG 1 1521272 1.20 1.02 to 1.36 1.16 1.21 1.10 1.02 1.36 1.35 1.36 1.07 3 HGG 1 3606947 1.16 0.77 to 1.68 1.08 0.77 0.91 1.68 1.31 1.27 1.18 1.07 3 HGG 1 5098879 1.15 0.63 to 1.53 1.04 0.63 0.78 1.20 1.53 1.38 1.37 1.26 3 HGG 1 2148703 1.09 0.77 to 1.34 0.99 0.77 0.99 0.99 1.34 1.07 1.28 1.30 3 HGG 1 4018288 1.14 0.89 to 1.59 0.97 0.89 0.94 1.11 1.59 1.32 1.15 1.20 3 HGG 1 2482388 1.14 0.81 to 1.33 1.00 0.81 0.97 1.26 1.30 1.27 1.33 1.15 3 HGG 1 4087621 1.09 0.77 to 1.46 1.46 1.34 1.08 1.27 0.77 1.06 0.77 0.96 3 HGG 1 5398701 1.10 0.78 to 1.43 1.43 1.26 1.03 1.27 0.87 1.07 0.78 1.07 3 HGG 1 5543385 1.15 0.97 to 1.46 1.10 0.97 1.06 1.46 0.98 1.39 1.19 1.05 3 HGG 1 622565 1.17 0.96 to 1.44 0.96 0.97 1.04 0.97 1.44 1.28 1.33 1.34 3 HGG 1 4195203 0.81 0.46 to 1.33 0.81 0.46 0.77 1.33 0.58 1.07 0.78 0.67 3 HGG 1 1610828 1.24 1.03 to 1.35 1.32 1.25 1.03 1.23 1.24 1.35 1.33 1.20 3 HGG 1 4286760 1.04 0.68 to 1.49 1.28 0.87 0.92 1.49 0.81 1.16 0.68 1.09 3 HGG 1 1981569 0.58 0.00 to 1.42 1.42 0.00 0.69 0.00 0.73 0.73 0.57 0.47 4 HGG 1 428897 0.71 0.00 to 1.68 1.68 0.00 1.06 0.00 0.68 0.76 0.80 0.66 4 HGG 1 1824860 0.70 0.00 to 1.46 1.46 0.00 1.08 0.00 0.89 0.75 0.80 0.64 4 HGG 1 4695453 0.77 0.00 to 1.42 1.42 0.00 0.98 0.00 0.93 1.07 0.95 0.82 4 HGG 1 5285915 0.66 0.00 to 1.49 1.49 0.00 0.85 0.00 0.69 0.98 0.70 0.55 4 HGG 1 1214989 0.54 0.00 to 1.39 1.39 0.00 0.69 0.00 0.66 0.57 0.56 0.46 4 HGG 1 1496066 0.68 0.00 to 1.33 1.33 0.00 0.90 0.00 0.92 0.80 0.74 0.76 4 HGG 1 1635877 0.78 0.00 to 1.54 1.54 0.00 1.01 0.00 0.89 1.15 0.91 0.72 4 HGG 1 1503162 0.61 0.00 to 1.37 1.37 0.00 0.95 0.00 0.75 0.64 0.63 0.51 4 HGG 1 1852354 0.85 0.00 to 1.44 1.44 0.00 1.15 0.00 1.18 1.06 0.97 0.99 4 HGG 1 2046717 0.83 0.00 to 1.46 1.46 0.00 1.25 0.00 1.21 0.82 1.03 0.88 4 HGG 1 3391835 0.90 0.00 to 1.82 1.82 0.00 1.37 0.00 0.98 0.86 1.11 1.08 4 HGG 1 3434166 0.65 0.00 to 1.48 1.48 0.00 0.81 0.00 0.69 1.00 0.70 0.53 4 HGG 1 3571607 0.85 0.00 to 1.34 1.34 0.00 1.16 0.00 1.14 1.02 1.12 0.99 4 HGG 1 2956444 2.48 2.06 to 2.84 2.27 2.27 2.37 2.06 2.84 2.75 2.57 2.70 5 HGG 1 2778441 1.97 1.60 to 2.20 1.72 1.60 1.80 2.05 2.19 2.20 2.02 2.18 5 HGG 1 548114 1.97 1.79 to 2.11 2.11 1.93 1.89 1.79 2.05 2.02 1.92 2.08 5 HGG 1 5509134 2.26 1.95 to 2.50 2.19 2.23 1.95 1.95 2.41 2.35 2.50 2.49 5 HGG 1 4287327 2.30 2.13 to 2.65 2.24 2.32 2.30 2.28 2.26 2.13 2.65 2.20 5 HGG 1 3606046 2.27 1.87 to 2.68 2.18 1.87 2.01 2.25 2.68 2.46 2.32 2.36 5 HGG 1 2823767 2.06 1.44 to 2.30 2.02 2.25 2.22 1.44 2.30 2.28 2.15 1.81 5 HGG 1 3068809 2.27 1.94 to 2.49 2.09 1.94 2.17 2.34 2.39 2.49 2.40 2.34 5 HGG 1 617587 2.35 1.76 to 2.59 2.52 2.33 2.59 2.24 2.58 2.41 2.35 1.76 5 HGG 1 459372 2.00 1.82 to 2.12 2.07 1.94 1.87 1.82 2.12 2.10 1.99 2.10 5 HGG 1 1459743 1.92 1.65 to 2.21 1.78 1.65 1.70 1.78 2.21 2.18 1.95 2.06 5 HGG 1 1457424 2.33 1.85 to 2.62 2.28 2.26 2.19 1.85 2.62 2.39 2.53 2.55 5 HGG 1 2756333 1.92 1.40 to 2.31 1.65 1.40 1.59 2.01 2.31 2.13 2.13 2.17 5 HGG 1 2695371 0.95 0.00 to 1.56 1.14 0.00 0.92 0.00 1.56 1.36 1.27 1.33 6 HGG 1 1210839 0.99 0.00 to 1.50 1.44 0.00 1.18 0.00 1.50 1.33 1.31 1.12 6 HGG 1 4228236 0.87 0.00 to 1.41 1.17 0.00 1.20 0.00 1.41 1.34 1.17 0.63 6 HGG 1 136073 0.99 0.00 to 1.50 1.47 0.00 1.36 0.00 1.42 1.50 1.14 1.04 6 HGG 1 1756875 1.24 0.00 to 1.80 1.74 0.00 1.37 0.00 1.80 1.73 1.62 1.65 6 HGG 1 1857044 0.89 0.00 to 1.33 1.19 0.00 1.02 0.00 1.33 1.18 1.15 1.21 6 HGG 1 1979363 0.85 0.00 to 1.34 0.89 0.00 0.94 0.00 1.34 1.22 1.23 1.16 6 HGG 1 2061171 1.14 0.00 to 1.79 1.40 0.00 1.32 0.00 1.79 1.60 1.52 1.53 6 HGG 1 671717 1.11 0.00 to 1.77 1.29 0.00 1.24 0.00 1.77 1.46 1.61 1.52 6 HGG 1 305751 0.95 0.00 to 1.53 1.24 0.00 1.04 0.00 1.31 1.30 1.22 1.53 6 HGG 1 2173002 0.98 0.00 to 1.45 1.21 0.00 1.21 0.00 1.45 1.34 1.31 1.33 6 HGG 1 2631261 0.97 0.00 to 1.40 1.00 0.62 0.76 0.00 1.35 1.40 1.32 1.33 6 HGG 1 2823478 1.11 0.00 to 1.50 0.97 1.16 0.90 0.00 1.44 1.43 1.45 1.50 7 HGG 1 3075994 1.14 0.72 to 1.38 1.06 0.98 0.99 0.72 1.38 1.32 1.37 1.33 7 HGG 1 5521873 0.77 0.00 to 1.33 1.33 1.08 0.88 0.00 0.89 0.56 0.65 0.79 7 HGG 1 2497692 0.93 0.00 to 1.37 0.88 0.85 0.94 0.00 1.37 1.18 1.07 1.13 7 HGG 1 139949 0.97 0.00 to 1.69 1.69 1.21 1.19 0.00 0.75 1.25 1.01 0.67 7 HGG 1 592085 0.95 0.46 to 1.33 0.79 0.61 0.77 0.46 1.33 1.29 1.13 1.17 7 HGG 1 2403438 0.95 0.46 to 1.78 0.67 0.75 1.78 0.46 1.13 1.19 1.07 0.52 7 HGG 1 2110430 1.25 0.00 to 1.84 1.84 1.81 1.84 0.00 1.04 1.21 1.37 0.88 7 HGG 1 830408 1.04 0.00 to 1.39 1.34 1.01 1.13 0.00 1.39 1.19 1.16 1.06 7 HGG 1 279898 1.30 0.19 to 2.06 0.41 1.85 1.84 0.19 2.06 0.88 1.32 1.90 7 HGG 1 4549259 3.14 2.78 to 3.43 3.43 3.02 3.12 3.39 3.23 3.10 3.06 2.78 8 HGG 1 1630990 3.25 2.92 to 3.50 3.14 3.19 3.17 2.92 3.50 3.21 3.41 3.47 8 HGG 1 2755836 3.57 3.18 to 3.89 3.49 3.50 3.36 3.18 3.89 3.53 3.79 3.84 8 HGG 1 5501676 2.66 0.00 to 3.40 3.31 3.40 2.99 0.00 3.38 2.62 2.80 2.78 8 HGG 1 3792988 2.70 2.24 to 3.05 2.58 2.24 2.41 2.71 3.05 2.90 2.78 2.89 8 HGG 1 2520894 2.77 2.55 to 3.06 2.65 2.55 2.66 2.70 3.06 2.89 2.87 2.83 8 HGG 1 2818476 3.27 3.15 to 3.43 3.43 3.41 3.23 3.15 3.24 3.19 3.29 3.25 8 HGG 1 4092112 1.61 0.00 to 2.07 1.93 1.84 1.57 0.00 2.07 1.97 1.82 1.71 9 HGG 1 1560906 1.53 0.00 to 2.38 1.99 0.00 1.99 0.00 2.38 1.95 2.04 1.88 9 HGG 1 4554722 1.42 0.00 to 1.91 1.53 1.32 1.08 0.00 1.85 1.91 1.79 1.84 9 HGG 1 3497231 1.41 0.00 to 1.89 1.41 1.42 1.56 0.00 1.89 1.72 1.63 1.68 9 HGG 1 686993 0.51 0.00 to 1.81 0.00 0.00 0.00 1.81 0.00 0.00 1.72 0 HGG 2 2173973 0.81 0.00 to 1.85 0.00 0.00 0.00 1.85 1.30 1.16 1.36 0 HGG 2 2189061 0.23 0.00 to 1.58 0.00 0.00 0.00 1.58 0.00 0.00 0.00 0 HGG 2 1364694 0.52 0.00 to 1.61 0.00 0.00 0.00 0.21 1.26 1.61 0.60 0 HGG 2 2189237 0.37 0.00 to 2.27 0.00 0.00 2.27 0.20 0.11 0.01 0.02 0 HGG 2 1469028 1.16 0.89 to 1.58 0.94 0.93 0.89 1.58 1.30 1.34 1.16 0 HGG 2 1515346 0.69 0.00 to 1.43 0.00 0.00 0.00 1.43 1.16 1.32 0.95 0 HGG 2 2222155 0.50 0.00 to 1.99 0.00 0.00 0.00 1.50 0.00 0.00 1.99 0 HGG 2 1569904 0.75 0.00 to 1.41 0.00 0.00 0.00 1.10 1.40 1.41 1.37 0 HGG 2 1670407 0.59 0.00 to 1.47 0.00 0.00 0.00 1.47 1.19 0.00 1.44 0 HGG 2 2246915 0.53 0.00 to 2.14 0.00 0.00 0.00 2.14 0.00 0.00 1.54 0 HGG 2 2394990 0.77 0.00 to 1.48 0.00 0.00 0.00 1.27 1.20 1.43 1.48 0 HGG 2 2837006 1.13 0.00 to 1.80 1.44 0.00 0.00 1.52 1.57 1.61 1.80 0 HGG 2 1816768 0.24 0.00 to 1.66 0.00 0.00 0.00 1.66 0.00 0.00 0.00 0 HGG 2 1833010 0.25 0.0o to 1.76 0.00 0.00 0.00 1.76 0.00 0.00 0.00 0 HGG 2 2874881 0.64 0.00 to 1.71 0.00 0.00 0.00 1.71 1.43 0.00 1.36 0 HGG 2 2881039 0.50 0.00 to 1.40 0.00 0.00 0.00 1.38 1.40 0.00 0.73 0 HGG 2 1960822 0.75 0.00 to 2.91 0.00 0.00 0.00 0.26 2.91 1.62 0.43 0 HGG 2 2948678 0.26 0.00 to 1.79 0.00 0.00 0.00 1.79 0.00 0.00 0.00 0 HGG 2 3045419 1.14 0.78 to 1.53 0.90 0.78 0.91 1.25 1.13 1.53 1.44 0 HGG 2 3229449 1.05 0.00 to 2.74 0.00 0.00 0.00 2.74 2.45 0.00 2.15 0 HGG 2 2018315 0.93 0.00 to 1.72 0.00 0.00 0.00 1.71 1.59 1.72 1.52 0 HGG 2 3876612 0.19 0.00 to 1.36 0.00 0.00 0.00 1.36 0.00 0.00 0.00 0 HGG 2 619447 0.33 0.00 to 1.37 0.00 0.00 0.00 1.37 0.00 0.00 0.92 0 HGG 2 2025128 1.20 0.92 to 1.44 1.09 1.02 0.92 1.44 1.30 1.38 1.23 1 HGG 2 2124056 2.11 1.69 to 2.57 2.57 2.30 2.22 1.98 1.97 2.06 1.69 1 HGG 2 1326255 2.91 2.24 to 3.67 3.65 3.67 3.14 2.68 2.58 2.42 2.24 1 HGG 2 1407125 1.71 1.44 to 1.85 1.73 1.59 1.44 1.85 1.78 1.75 1.84 1 HGG 2 1559844 1.32 0.00 to 1.69 1.58 0.00 1.36 1.47 1.58 1.59 1.69 1 HGG 2 1709709 1.49 1.33 to 1.70 1.50 1.33 1.40 1.51 1.53 1.70 1.46 1 HGG 2 2230608 1.30 1.09 to 1.47 1.32 1.09 1.16 1.47 1.34 1.43 1.31 1 HGG 2 3206352 1.78 1.69 to 2.03 1.77 1.74 1.70 1.76 1.77 2.03 1.69 1 HGG 2 1911819 1.50 1.26 to 1.95 1.47 1.26 1.41 1.95 1.47 1.48 1.43 1 HGG 2 660142 3.20 2.84 to 3.47 3.15 2.84 2.95 3.47 3.44 3.40 3.18 1 HGG 2 870396 1.29 1.06 to 1.56 1.19 1.17 1.06 1.56 1.32 1.41 1.33 1 HGG 2 1988540 1.82 1.31 to 2.08 2.08 1.89 1.85 1.85 1.95 1.84 1.31 1 HGG 2 960604 2.12 1.86 to 2.57 1.86 1.88 1.87 2.14 2.13 2.40 2.57 1 HGG 2 2021989 1.57 1.25 to 1.83 1.51 1.36 1.25 1.55 1.72 1.75 1.83 1 HGG 2 1303862 1.78 0.00 to 3.65 0.00 0.00 0.00 2.96 2.51 3.65 3.35 2 HGG 2 2226309 1.94 0.00 to 3.99 0.00 0.00 0.00 3.14 2.86 3.57 3.99 2 HGG 2 2234266 1.87 0.00 to 3.50 0.00 0.00 0.00 3.24 3.01 3.34 3.50 2 HGG 2 1798594 1.37 0.00 to 2.41 0.99 0.00 0.91 1.95 1.53 1.79 2.41 2 HGG 2 1926934 1.48 0.00 to 2.75 0.00 0.00 0.00 2.56 2.35 2.75 2.73 2 HGG 2 626471 1.37 0.00 to 2.85 0.00 0.00 0.00 2.85 2.31 2.24 2.22 2 HGG 2 2453558 −1.02 −1.41 to 0.00  0.00 −1.00 −1.27 −1.15 −1.12 −1.19 −1.41 3 HGG 2 1988774 −1.12 −1.47 to 1.49  −0.49 −1.31 −1.32 −1.14 −0.65 −1.44 −1.47 3 HGG 2 3100048 −1.00 −1.78 to 1.07  −1.12 −1.07 −1.20 −1.27 −0.07 −1.50 −1.78 3 HGG 2 2703122 −1.38 −1.63 to −1.25 −1.35 −1.37 −1.63 −1.25 −1.26 −1.42 −1.36 3 HGG 2 2669337 −0.70 −1.97 to −0.24 −0.29 −0.24 −0.62 −0.55 −0.34 −1.97 −0.91 4 HGG 2 2703282 −0.85 −1.53 to 0.00  0.00 0.00 −0.96 −1.05 −0.91 −1.53 −1.47 4 HGG 2 2794866 −0.75 −1.53 to 0.00  0.00 0.00 0.00 −1.33 −0.92 −1.49 −1.53 4 HGG 2 1753283 −1.18 −1.73 to 0.00  −1.00 0.00 −1.26 −1.58 −1.15 −1.73 −1.56 4 HGG 2 1316801 1.97 0.00 to 2.98 0.00 0.00 2.56 2.98 2.72 2.86 2.65 5 HGG 2 1961617 2.18 0.00 to 3.54 0.00 0.00 2.36 3.04 2.96 3.37 3.54 5 HGG 2 2544622 2.46 0.00 to 3.82 0.00 0.00 3.16 3.39 3.28 3.82 3.58 5 HGG 2 1251065 1.37 1.19 to 1.52 1.19 1.30 1.46 1.34 1.42 1.52 0 HGG 3 5322365 1.46 1.18 to 1.65 1.33 1.18 1.65 1.41 1.61 1.59 0 HGG 3 5512044 1.90 1.60 to 2.18 1.60 1.73 1.95 1.86 2.06 2.18 0 HGG 3 3973687 1.47 1.12 to 1.82 1.14 1.12 1.56 1.54 1.63 1.82 0 HGG 3 4215034 1.50 0.82 to 1.99 0.94 0.82 1.78 1.65 1.84 1.99 0 HGG 3 3158828 1.82 1.25 to 2.12 1.25 1.65 2.09 1.83 1.99 2.12 0 HGG 3 2170820 1.30 0.75 to 1.58 0.75 0.93 1.58 1.55 1.49 1.53 0 HGG 3 4112181 0.97 0.68 to 1.37 0.68 0.74 1.06 0.87 1.08 1.37 0 HGG 3 2343348 1.96 1.66 to 2.18 1.76 1.66 2.06 1.98 2.11 2.18 0 HGG 3 4312860 1.14 0.83 to 1.48 0.83 1.13 0.91 1.30 1.18 1.48 0 HGG 3 4373333 1.12 0.70 to 1.38 0.78 0.70 1.38 1.25 1.30 1.32 0 HGG 3 2660756 1.26 0.90 to 1.51 0.90 1.08 1.51 1.19 1.42 1.48 0 HGG 3 2687356 1.23 0.85 to 1.40 0.85 1.18 1.36 1.30 1.40 1.31 0 HGG 3 3495173 1.67 1.35 to 1.98 1.53 1.35 1.89 1.50 1.79 1.98 0 HGG 3 2972013 1.63 1.27 to 1.94 1.28 1.27 1.73 1.71 1.87 1.94 0 HGG 3 3034889 1.64 1.40 to 1.77 1.54 1.40 1.77 1.63 1.77 1.73 0 HGG 3 4855265 1.24 0.80 to 1.53 0.80 1.08 1.33 1.26 1.46 1.53 0 HGG 3 5266376 1.38 1.06 to 1.67 1.15 1.06 1.50 1.48 1.67 1.42 0 HGG 3 5293028 1.34 0.99 to 1.66 1.66 0.99 1.40 1.07 1.44 1.45 0 HGG 3 1560380 0.92 0.00 to 1.97 1.62 0.00 1.96 0.00 0.00 1.97 1 HGG 3 538427 0.69 0.00 to 1.49 1.49 0.00 1.29 0.00 0.00 1.35 1 HGG 3 4232507 0.74 0.00 to 1.83 1.19 0.00 1.42 0.00 0.00 1.83 1 HGG 3 3068978 0.60 0.00 to 1.87 0.00 0.00 1.73 0.00 0.00 1.87 1 HGG 3 1831454 0.63 0.00 to 1.36 1.24 0.00 1.36 0.00 0.00 1.20 1 HGG 3 2195427 0.48 0.00 to 1.45 0.00 0.00 1.45 0.00 0.00 1.44 1 HGG 3 2343836 0.63 0.00 to 1.50 0.83 0.00 1.50 0.00 0.00 1.44 1 HGG 3 2545486 0.96 0.00 to 1.55 1.32 0.00 1.48 1.38 0.00 1.55 1 HGG 3 4247396 0.78 0.00 to 1.72 1.72 0.00 1.55 0.00 0.00 1.41 1 HGG 3 3528232 0.80 0.00 to 1.75 1.75 0.00 1.39 0.00 0.00 1.65 1 HGG 3 4508879 0.95 0.00 to 2.11 1.64 0.00 1.92 0.00 0.00 2.11 1 HGG 3 664625 0.74 0.00 to 1.68 1.19 0.00 1.56 0.00 0.00 1.68 1 HGG 3 699113 1.22 0.00 to 3.18 3.18 0.00 1.90 0.00 0.00 2.25 1 HGG 3 3090808 −0.99 −1.37 to −0.37 −0.83 −0.37 −1.37 −0.93 −1.14 −1.32 2 HGG 3 3120209 −0.99 −1.82 to −0.43 −1.16 −1.82 −0.43 −1.10 −0.82 −0.63 2 HGG 3 3135460 −1.04 −1.51 to −0.59 −0.97 −0.59 −1.43 −0.79 −0.96 −1.51 2 HGG 3 5166479 −1.36 −1.58 to −0.87 −1.58 −1.47 −1.37 −0.87 −1.49 −1.38 2 HGG 3 3778404 −1.50 −1.75 to −1.19 −1.72 −1.19 −1.75 −1.28 −1.43 −1.63 2 HGG 3 5573549 −1.35 −1.48 to −1.08 −1.08 −1.45 −1.48 −1.39 −1.30 −1.40 2 HGG 3 5427710 −1.82 −2.23 to −1.48 −1.55 −1.48 −2.01 −1.84 −1.81 −2.23 2 HGG 3 5399371 −0.78 −1.33 to −0.35 −0.79 −1.33 −0.91 −0.62 −0.35 −0.72 2 HGG 3 4289557 −1.79 −2.17 to −1.54 −1.78 −1.68 −1.82 −1.54 −1.75 −2.17 2 HGG 3 3084204 −1.38 −1.56 to −1.21 −1.31 −1.46 −1.44 −1.21 −1.28 −1.56 2 HGG 3 3729593 0.55 0.00 to 1.41 1.41 0.00 0.97 0.00 0.00 0.93 3 HGG 3 3967255 0.23 0.00 to 1.40 1.40 0.00 0.00 0.00 0.00 0.00 3 HGG 3 4606503 0.50 0.00 to 1.75 0.73 1.75 0.49 0.00 0.00 0.00 3 HGG 3 5186846 0.11 −0.39 to 1.98  1.98 −0.39 −0.29 −0.27 −0.24 −0.16 3 HGG 3 5206821 0.50 0.00 to 1.39 1.39 0.00 0.80 0.00 0.00 0.84 3 HGG 3 554654 0.63 0.33 to 1.60 1.60 0.36 0.48 0.33 0.53 0.45 3 HGG 3 3369213 0.29 0.00 to 1.44 1.44 0.00 0.22 0.00 0.00 0.08 3 HGG 3 3410101 0.31 0.00 to 1.87 1.87 0.00 0.00 0.00 0.00 0.00 3 HGG 3 854872 0.44 0.00 to 1.69 0.96 0.00 0.00 0.00 0.00 1.69 3 HGG 3 5508135 1.38 0.00 to 1.87 1.50 0.00 1.62 1.61 1.87 1.69 4 HGG 3 1697855 0.85 0.00 to 1.56 0.96 0.00 0.94 0.58 1.05 1.56 4 HGG 3 615776 1.11 0.00 to 1.60 0.90 0.00 1.35 1.24 1.56 1.60 4 HGG 3 621543 1.52 0.00 to 2.08 1.26 0.00 1.91 2.03 1.81 2.08 4 HGG 3 5094042 0.98 0.00 to 1.46 0.50 0.00 1.32 1.29 1.34 1.46 4 HGG 3 3974247 1.47 0.00 to 2.06 1.34 0.00 1.90 1.66 1.83 2.06 4 HGG 3 689296 1.12 0.45 to 1.45 0.72 0.45 1.44 1.45 1.34 1.35 4 HGG 3 2871076 1.25 0.00 to 1.82 1.15 0.00 1.82 1.24 1.50 1.80 4 HGG 3 1786554 1.29 0.00 to 1.78 1.51 0.00 1.71 1.35 1.39 1.78 4 HGG 3 4402555 2.40 1.80 to 2.66 1.80 2.39 2.64 2.33 2.66 2.56 5 HGG 3 3172265 3.82 3.69 to 4.07 4.07 3.69 3.71 3.70 3.89 3.84 5 HGG 3 5266015 2.42 2.12 to 2.69 2.12 2.36 2.51 2.44 2.69 2.42 5 HGG 3 4253809 2.14 1.87 to 2.30 1.96 1.87 2.24 2.24 2.26 2.30 5 HGG 3 4912315 2.23 1.90 to 2.40 2.06 2.27 2.36 1.90 2.39 2.40 5 HGG 3 3069190 3.66 3.51 to 3.89 3.52 3.51 3.57 3.63 3.89 3.84 5 HGG 3 3957354 2.57 0.00 to 3.46 2.96 0.00 3.16 2.75 3.09 3.46 6 HGG 3 1661892 1.61 0.00 to 2.85 0.70 0.00 2.27 1.90 1.97 2.85 6 HGG 3 5102731 1.77 0.00 to 2.42 1.59 0.00 2.40 2.13 2.42 2.08 6 HGG 3 3074113 2.00 0.00 to 2.75 1.86 0.00 2.45 2.40 2.53 2.75 6 HGG 3 872107 1.63 0.00 to 2.19 1.45 0.00 2.02 2.00 2.10 2.19 6 HGG 3 2110482 1.36 0.97 to 1.56 0.97 1.11 1.56 1.53 1.54 1.46 0 HGG 4 2196870 1.35 1.23 to 1.41 1.33 1.41 1.36 1.34 1.40 1.23 0 HGG 4 2756587 1.26 1.16 to 1.36 1.16 1.27 1.25 1.36 1.32 1.21 0 HGG 4 2267466 1.20 0.00 to 1.55 1.55 1.49 1.43 1.41 0.00 1.31 0 HGG 4 1448572 1.20 0.97 to 1.49 1.17 1.12 0.97 1.49 1.42 1.05 0 HGG 4 3016137 1.26 0.85 to 2.05 2.05 1.77 0.91 0.91 1.08 0.85 0 HGG 4 3149570 1.41 1.22 to 1.52 1.40 1.38 1.49 1.47 1.52 1.22 0 HGG 4 417432 1.35 1.13 to 1.48 1.39 1.47 1.48 1.29 1.34 1.13 0 HGG 4 4738532 1.37 1.15 to 1.53 1.15 1.30 1.37 1.39 1.53 1.46 0 HGG 4 1730026 1.32 1.21 to 1.46 1.23 1.24 1.46 1.43 1.35 1.21 0 HGG 4 5101167 1.31 1.10 to 1.60 1.10 1.21 1.41 1.31 1.60 1.25 0 HGG 4 2404746 1.46 1.13 to 1.94 1.89 1.94 1.13 1.24 1.24 1.34 0 HGG 4 1951845 1.02 0.00 to 1.43 1.43 1.28 1.17 0.00 1.21 1.01 0 HGG 4 2405487 1.27 1.18 to 1.38 1.20 1.18 1.35 1.29 1.38 1.21 0 HGG 4 2408333 1.36 1.00 to 1.78 1.78 1.70 1.16 1.13 1.37 1.00 0 HGG 4 1965856 1.45 1.37 to 1.52 1.37 1.48 1.51 1.42 1.52 1.41 0 HGG 4 2006043 1.35 1.14 to 1.46 1.38 1.46 1.44 1.31 1.41 1.14 0 HGG 4 2410066 1.27 1.17 to 1.38 1.25 1.20 1.34 1.28 1.38 1.17 0 HGG 4 2619275 1.42 1.28 to 1.57 1.28 1.34 1.50 1.57 1.50 1.30 0 HGG 4 2734007 1.04 0.86 to 1.47 0.95 0.87 0.86 1.47 1.13 0.98 0 HGG 4 2751922 1.24 1.08 to 1.55 1.18 1.10 1.08 1.55 1.39 1.12 0 HGG 4 1323327 1.00 0.00 to 1.69 1.69 1.61 1.37 0.00 0.00 1.32 1 HGG 1329625 0.91 0.00 to 1.52 1.52 1.47 1.10 0.00 0.00 1.36 1 HGG 4 2271648 0.33 0.00 to 1.38 1.38 0.00 0.27 0.00 0.00 0.34 1 HGG 4 4000614 0.50 0.00 to 1.49 1.49 0.00 0.71 0.00 0.00 0.79 1 HGG 4 3686411 0.41 −0.02 to 1.56  0.85 0.00 0.05 0.00 1.56 −0.02 1 HGG 4 1495730 0.47 0.00 to 1.57 0.00 0.00 1.27 0.00 0.00 1.57 1 HGG 4 1496011 0.60 0.00 to 1.38 1.38 0.00 1.03 0.00 0.00 1.16 1 HGG 4 1600180 0.77 0.00 to 1.68 1.68 0.00 1.29 0.00 0.00 1.62 1 HGG 4 3508345 0.46 0.00 to 1.35 1.35 0.00 0.64 0.00 0.00 0.78 1 HGG 4 2273619 0.36 0.00 to 1.33 1.33 0.00 0.39 0.00 0.00 0.44 1 HGG 4 2430165 0.68 0.00 to 1.50 1.50 0.00 1.29 0.00 0.00 1.28 1 HGG 4 2933127 0.49 0.00 to 1.35 1.35 0.00 0.82 0.00 0.00 0.74 1 HGG 4 2276895 0.66 0.00 to 1.43 1.43 1.10 0.77 0.00 0.00 0.67 1 HGG 4 2915217 0.84 0.00 to 1.51 1.46 1.51 0.74 0.78 0.00 0.55 1 HGG 4 278939 0.39 0.00 to 1.37 1.37 0.00 0.51 0.00 0.00 0.45 1 HGG 4 2407620 0.02 −1.38 to 0.77  0.77 0.44 0.23 0.00 −1.38 0.03 1 HGG 4 220378 0.57 0.00 to 1.44 1.44 0.00 1.02 0.00 0.00 0.97 1 HGG 4 2753065 0.75 0.00 to 1.92 1.92 0.00 1.43 0.00 0.00 1.14 1 HGG 4 2753963 0.34 0.00 to 1.36 1.36 0.00 0.37 0.00 0.00 0.32 1 HGG 4 964939 0.53 0.00 to 1.34 1.34 0.92 0.51 0.00 0.00 0.43 1 HGG 4 2106010 1.56 1.27 to 1.68 1.55 1.60 1.68 1.67 1.59 1.27 2 HGG 4 2350594 1.53 1.29 to 1.74 1.29 1.46 1.56 1.74 1.73 1.43 2 HGG 4 2669871 1.59 1.22 to 2.12 1.42 1.39 1.58 1.22 1.83 2.12 2 HGG 4 3522739 1.61 1.44 to 1.86 1.44 1.62 1.55 1.44 1.86 1.78 2 HGG 4 434751 1.73 1.51 to 1.89 1.56 1.51 1.84 1.75 1.83 1.89 2 HGG 4 1365045 1.93 1.80 to 2.12 1.80 1.92 1.93 1.99 2.12 1.80 2 HGG 4 509839 2.02 1.79 to 2.16 1.81 1.79 2.16 2.04 2.15 2.15 2 HGG 4 1913334 1.50 1.25 to 1.65 1.25 1.38 1.58 1.62 1.65 1.51 2 HGG 4 5690026 1.65 1.57 to 1.78 1.57 1.68 1.78 1.67 1.62 1.59 2 HGG 4 2007730 1.52 1.17 to 1.91 1.17 1.29 1.61 1.65 1.91 1.47 2 HGG 4 2581075 3.94 3.80 to 4.14 3.91 3.88 3.95 3.80 4.14 3.99 3 HGG 4 3191030 2.58 2.20 to 2.99 2.36 2.20 2.75 2.36 2.99 2.83 3 HGG 4 2013251 2.32 2.11 to 2.53 2.11 2.16 2.49 2.29 2.53 2.31 3 HGG 4 1964758 2.31 2.16 to 2.44 2.22 2.29 2.37 2.44 2.37 2.16 3 HGG 4 2278772 2.51 2.03 to 2.87 2.87 2.72 2.36 2.03 2.63 2.48 3 HGG 4 1370137 2.86 2.77 to 2.97 2.77 2.80 2.93 2.81 2.97 2.90 3 HGG 4 3042227 −1.53 −1.64 to −1.35 −1.35 −1.62 −1.64 −1.60 −1.56 −1.40 4 HGG 4 1857850 −2.00 −2.38 to −1.71 −1.71 −2.05 −1.98 −1.90 −2.00 −2.38 4 HGG 4 2786442 −1.36 −1.62 to −1.13 −1.36 −1.33 −1.25 −1.62 −1.45 −1.13 4 HGG 4 1449819 −1.51 −2.02 to −0.50 −1.58 −2.02 −1.75 −0.50 −1.45 −1.79 4 HGG 4 2055569 −0.86 −1.38 to −0.27 −0.73 −1.38 −1.00 −0.27 −0.61 −1.15 4 HGG 4 195943 0.48 −0.23 to 3.17  3.17 0.24 −0.23 −0.09 −0.09 −0.14 5 HGG 4 309006 0.78 0.29 to 2.29 2.29 0.58 0.29 0.56 0.56 0.40 5 HGG 4

TABLE 14 mean mean mean mean mean mean mean mean mean DE DE DE DE DE DE DE DE DE t/ t/ t/ t/ t/ t/ t/ t/ t/ Ave De Danazol Danazol Danazol Danazol Danazol Danazol Danazol Danazol Danazol t/ 1 μM, 1 μM, 1 μM, 10 μM, 10 μM, 10 μM, 100 μM, 100 μM, 100 μM, Clone ID Danazol Range 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr 1 hr 3 hr 6 hr Cluster GEM  960496 −0.34 −2.51 to 0.13   0.06 0.09 −0.07 0.00 −0.19 0.13 0.00 −2.51 −0.52 0 HGG 1 1219506 −0.36 −2.91 to 0.04   −0.04 0.04 −0.02 −0.06 −0.15 0.00 0.00 −2.91 −0.09 0 HGG 1 3278632 −0.16 −1.49 to 0.34   0.34 0.12 −0.20 0.09 −0.24 0.00 0.00 −1.49 −0.08 0 HGG 1  932244 −0.31 −2.80 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 −2.80 0.00 0 HGG 1 5405691 −0.26 −2.67 to 0.47   0.47 0.00 −0.10 0.00 0.00 0.00 0.00 −2.67 0.00 0 HGG 1 5326338 −0.34 −2.70 to 0.05   0.03 0.05 0.03 0.00 −0.16 −0.17 0.00 −2.70 −0.11 0 HGG 1 1310337 −0.20 −1.43 to 0.07   0.03 −0.08 −0.06 −0.03 −0.15 −0.20 0.00 −1.43 0.07 0 HGG 1 2444740 −0.24 −2.12 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 −2.12 0.00 0 HGG 1 4110976 −0.36 −3.24 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 −3.24 0.00 0 HGG 1 5207486 −0.24 −1.66 to 0.13   0.13 0.06 −0.12 −0.04 −0.11 −0.21 −0.07 −1.66 −0.13 0 HGG 1 3474091 −0.29 −2.01 to 0.25   0.25 0.00 −0.05 0.00 −0.27 0.00 0.00 −2.01 −0.55 0 HGG 1 2927479 −0.34 −1.49 to 0.04   0.04 −0.19 −0.26 −0.03 −0.37 0.00 −0.33 −1.49 −0.40 0 HGG 1 4759669 −0.27 −2.64 to 0.31   0.31 0.04 −0.05 0.08 −0.27 0.02 0.00 −2.64 0.07 0 HGG 1 2203570 −0.29 −2.60 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 −2.60 0.00 0 HGG 1 4741591 −0.41 −2.48 to 0.00   −0.10 −0.05 −0.27 −0.18 −0.27 0.00 0.00 −2.48 −0.34 0 HGG 1 1638756 −0.18 −1.47 to 0.13   0.07 −0.15 0.12 −0.27 −0.03 0.00 0.00 −1.47 0.13 0 HGG 1 4587665 −0.20 −1.74 to 0.16   0.16 0.02 −0.05 0.02 −0.20 −0.18 0.00 −1.74 0.13 0 HGG 1 4292488 −0.35 −2.07 to 0.00   −0.01 −0.16 −0.22 −0.21 −0.32 0.00 0.00 −2.07 −0.15 0 HGG 1  997480 −0.24 −2.29 to 0.13   0.13 0.01 0.08 0.10 −0.09 0.00 0.00 −2.29 −0.07 0 HGG 1 1328741 −0.39 −1.82 to −0.11 −0.11 −0.18 −0.16 −0.22 −0.18 −0.24 −0.49 −0.13 −1.82 1 HGG 1 1350683 −0.16 −1.60 to 0.18   0.00 0.00 0.18 0.00 0.00 0.00 0.00 0.00 −1.60 1 HGG 1 1500810 −0.41 −2.02 to 0.02   −0.21 −0.27 −0.40 0.02 −0.05 −0.19 −0.05 −0.54 −2.02 1 HGG 1 1506930 −0.25 −2.34 to 0.07   0.07 0.00 0.00 0.00 0.00 0.00 0.00 0.00 −2.34 1 HGG 1 1518310 −0.47 −2.62 to 0.00   −0.22 −0.70 −0.69 0.00 0.00 0.00 0.00 0.00 −2.62 1 HGG 1 1802939 −0.33 −1.66 to 0.00   −0.10 −0.16 −0.16 0.00 −0.32 −0.27 0.00 −0.31 −1.66 1 HGG 1 1804503 −0.44 −1.94 to −0.13 −0.19 −0.13 −0.17 −0.30 −0.25 −0.25 −0.31 −0.46 −1.94 1 HGG 1 1853116 −0.55 −1.76 to −0.29 −0.46 −0.32 −0.31 −0.41 −0.29 −0.42 −0.39 −0.55 −1.76 1 HGG 1 1904987 −0.35 −1.49 to −0.10 −0.36 −0.20 −0.16 −0.22 −0.10 −0.20 −0.22 −0.22 −1.49 1 HGG 1 2158674 −0.42 −1.92 to 0.00   −0.07 −0.28 −0.36 0.00 −0.23 −0.52 −0.16 −0.24 −1.92 1 HGG 1 2174951 −0.16 −1.49 to 0.28   0.28 0.08 −0.14 0.00 −0.21 0.00 0.00 0.00 −1.49 1 HGG 1 2216323 −0.42 −1.41 to −0.03 −0.23 −0.53 −0.46 −0.03 −0.37 −0.33 −0.08 −0.36 −1.41 1 HGG 1 2500872 −0.23 −1.68 to 0.06   0.06 −0.08 −0.12 0.00 −0.28 0.00 0.00 0.00 −1.68 1 HGG 1 2794808 −0.53 −4.31 to 0.39   0.39 −0.39 −0.44 0.00 0.00 0.00 0.00 0.00 −4.31 1 HGG 1 2956670 −0.35 −3.15 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 −3.15 1 HGG 1  322933 −0.29 −2.64 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 −2.64 1 HGG 1  389558 −0.37 −1.62 to 0.00   −0.27 −0.39 −0.18 −0.23 −0.32 0.00 −0.36 0.00 −1.62 1 HGG 1  746910 −0.19 −1.88 to 0.21   0.21 −0.07 0.00 0.00 0.00 0.00 0.00 0.00 −1.88 1 HGG 1 1269921 −0.39 −3.49 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 −3.49 1 HGG 1 1715374 −0.78 −1.40 to 0.04   0.04 −0.76 −1.10 −0.15 −0.81 −1.40 −0.58 −0.89 −1.36 2 HGG 1 2055867 −0.50 −1.71 to 0.19   0.17 −0.92 −0.01 0.19 −1.24 −0.09 −0.16 −1.71 −0.77 2 HGG 1 1833362 −0.64 −1.41 to −0.30 −0.50 −0.37 −0.63 −0.30 −0.48 −0.60 −0.46 −1.00 −1.41 2 HGG 1 3715059 −0.77 −1.34 to −0.08 −0.10 −0.88 −0.85 −0.08 −1.17 −1.12 −0.23 −1.34 −1.21 2 HGG 1 5208013 −0.51 −1.33 to −0.03 −0.17 −0.22 −0.69 −0.03 −0.44 −0.74 −0.19 −0.81 −1.33 2 HGG 1 2890141 −0.70 −1.46 to −0.19 −0.19 −0.51 −1.09 −0.31 −0.49 −1.05 −0.42 −0.76 −1.46 2 HGG 1 1807155 −0.71 −1.49 to 0.02   0.02 −0.79 −0.60 −0.24 −1.17 −0.71 −0.24 −1.49 −1.21 2 HGG 1 5047895 −0.95 −1.99 to −0.03 −0.03 −1.07 −1.10 −0.05 −1.08 −1.20 −0.05 −1.96 −1.99 2 HGG 1 1781411 −0.74 −1.57 to −0.24 −0.24 −0.57 −0.46 −0.59 −0.87 −0.57 −0.75 −1.57 −1.03 2 HGG 1 4408943 −0.92 −1.82 to −0.13 −0.35 −1.06 −0.82 −0.13 −1.33 −0.77 −0.55 −1.82 −1.40 2 HGG 1  120110 −0.62 −1.54 to 0.01   0.01 −0.57 −0.33 −0.24 −0.74 −0.76 −0.25 −1.54 −1.19 2 HGG 1 4287327 1.27 0.26 to 2.12 0.40 1.91 1.42 0.42 1.99 1.30 0.26 2.12 1.60 3 HGG 1 1513566 0.76 0.10 to 1.51 0.10 0.79 0.79 0.13 1.26 0.97 0.32 1.51 0.92 3 HGG 1 4858420 0.78 0.20 to 1.54 0.28 0.76 0.79 0.40 1.54 0.80 0.20 1.37 0.86 3 HGG 1 4896168 0.44 −0.31 to 1.46   −0.31 0.32 1.08 −0.31 0.46 1.46 −0.18 0.17 1.27 3 HGG 1 5033671 0.48 −0.53 to 1.62   −0.53 0.25 1.48 −0.30 0.61 1.62 −0.38 0.07 1.53 3 HGG 1 5038177 0.74 0.21 to 1.57 0.21 0.70 0.65 0.24 1.33 0.85 0.37 1.57 0.79 3 HGG 1 1405844 0.49 −0.35 to 1.42   0.14 0.99 1.42 0.25 1.29 0.65 −0.35 0.00 0.06 3 HGG 1 1308729 0.85 0.22 to 1.65 0.22 0.86 0.85 0.33 1.54 1.01 0.28 1.65 0.96 3 HGG 1 1299246 0.79 0.11 to 1.77 0.11 0.85 0.58 0.16 1.41 1.00 0.33 1.77 0.87 3 HGG 1  279898 1.83 0.40 to 2.85 0.40 2.51 2.12 0.83 2.67 2.10 0.79 2.85 2.24 3 HGG 1 3724351 −0.14 −1.44 to 0.30   0.30 −0.01 −0.10 −1.44 0.00 0.00 0.00 0.00 0.00 4 HGG 1 2327230 −0.37 −1.56 to 0.17   0.17 −0.37 −0.70 −0.34 −0.49 0.00 −1.56 0.00 0.00 4 HGG 1 1274378 −0.25 −2.28 to 0.00   0.00 0.00 0.00 −2.28 0.00 0.00 0.00 0.00 0.00 4 HGG 1  560115 −1.24 −2.69 to −0.19 −1.08 −1.77 −0.19 −0.84 −2.23 −0.40 −1.03 −2.69 −0.97 5 HGG 1 1619292 −1.14 −1.33 to −0.89 −1.15 −1.12 −1.19 −0.89 −1.02 −1.20 −1.02 −1.30 −1.33 5 HGG 1 2769888 −1.40 −1.92 to −0.74 −0.74 −1.84 −1.42 −0.77 −1.84 −1.54 −0.92 −1.92 −1.62 5 HGG 1 1552522 0.04 −1.73 to 0.58   0.39 0.22 0.39 0.58 0.23 0.00 0.05 0.24 −1.73 0 HGG 2  757370 −0.28 −2.56 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 −2.56 0 HGG 2 1740788 −0.19 −1.67 to 0.25   0.17 −0.18 0.03 0.25 −0.13 0.02 −1.67 −0.18 −0.03 0 HGG 2 2314164 −0.03 −1.54 to 0.58   0.58 0.30 0.42 0.00 0.00 0.00 −1.54 0.00 0.00 0 HGG 2 1995136 −0.14 −1.82 to 0.57   0.57 0.31 0.17 −1.82 −0.62 0.00 0.10 0.00 0.00 0 HGG 2 2444137 −0.10 −2.63 to 0.32   0.32 0.24 0.15 0.31 0.14 0.21 0.20 0.13 −2.63 0 HGG 2 1735702 −0.36 −1.93 to 0.36   0.00 0.00 0.36 −1.93 −1.66 0.00 0.00 0.00 0.00 1 HGG 2 3100048 −1.22 −2.22 to −0.49 −0.49 −2.22 −1.12 −0.65 −1.79 −1.39 −0.67 −1.39 −1.20 1 HGG 2 1988774 −0.57 −1.47 to 0.02   −0.12 −0.86 −0.15 0.02 −0.97 −0.19 −0.61 −1.47 −0.82 1 HGG 2 2607834 0.92 0.00 to 1.85 0.00 1.02 1.70 0.42 1.30 1.85 0.28 0.00 1.71 2 HGG 2 3409540 −0.13 −1.33 to 0.13   0.00 −1.33 −0.04 0.13 0.00 0.03 0.05 −0.04 0.07 0 HGG 3 3639747 −0.14 −1.52 to 0.23   0.00 −1.52 0.23 0.00 0.00 0.00 0.00 0.00 0.00 0 HGG 3 4247951 −0.22 −1.96 to 0.00   0.00 −1.96 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0 HGG 3 5166479 −0.37 −2.16 to 0.00   −1.18 −2.16 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0 HGG 3 1911443 −0.96 −1.56 to −0.22 −0.22 −1.10 −1.10 −0.49 −1.06 −1.56 −0.53 −1.11 −1.46 1 HGG 3 5427710 −0.90 −1.48 to −0.46 −0.62 −0.72 −1.32 −0.46 −0.67 −1.48 −0.71 −0.79 −1.30 1 HGG 3 3120209 −1.11 −1.63 to −0.52 −1.33 −1.14 −0.60 −1.36 −1.30 −0.81 −1.63 −1.26 −0.52 1 HGG 3 3135460 −0.73 −1.43 to −0.26 −0.46 −1.31 −0.63 −0.37 −1.43 −0.65 −0.26 −1.07 −0.40 1 HGG 3 2047312 −0.14 −1.75 to 0.29   0.00 −1.75 0.11 0.00 0.00 0.00 0.12 0.00 0.29 2 HGG 3 5024212 −0.17 −2.18 to 0.32   0.00 −2.18 0.12 0.00 0.00 0.00 0.32 0.00 0.18 2 HGG 3 4181663 −0.04 −1.61 to 0.28   0.00 −1.61 0.21 0.22 0.01 0.25 0.18 0.07 0.28 2 HGG 3 3481841 0.05 −1.47 to 0.39   0.35 −1.47 0.12 0.24 0.13 0.36 0.18 0.15 0.39 2 HGG 3 2407620 −0.26 −2.26 to 0.14   0.04 −0.14 −0.05 0.08 0.14 −2.26 −0.16 −0.07 0.12 0 HGG 4 2750849 −0.15 −1.39 to 0.11   0.11 −0.11 0.02 −1.39 0.00 0.00 0.00 0.00 0.00 0 HGG 4 1495907 −0.14 −1.53 to 0.18   0.00 0.08 0.18 −1.53 0.00 0.00 0.00 0.00 0.00 0 HGG 4 3143494 −0.23 −2.10 to 0.00   0.00 0.00 0.00 −2.10 0.00 0.00 0.00 0.00 0.00 0 HGG 4 3451296 −0.15 −1.38 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 −1.38 0.00 0.00 0 HGG 4  951433 −0.14 −1.37 to 0.07   0.00 0.05 0.07 −1.37 0.00 0.00 0.00 0.00 0.00 0 HGG 4 2322243 −0.23 −2.09 to 0.00   0.00 0.00 0.00 0.00 0.00 0.00 −2.09 0.00 0.00 0 HGG 4 4970829 0.20 −0.04 to 1.57   0.16 −0.04 0.12 1.57 0.00 0.00 0.00 0.00 0.00 1 HGG 4 3253462 0.25 0.00 to 1.54 0.39 0.07 0.26 1.54 0.00 0.00 0.00 0.00 0.00 1 HGG 4 1834257 −0.14 −1.58 to 0.22   0.00 0.09 0.22 0.00 0.00 0.00 0.00 0.00 −1.58 1 HGG 4 2110035 −0.12 −1.82 to 0.29   0.29 0.17 0.22 0.00 0.19 0.00 −0.13 0.00 −1.82 1 HGG 4 3880722 −0.55 −2.28 to 0.24   −0.02 −0.49 −0.62 0.24 −0.52 −1.09 −0.15 0.00 −2.28 1 HGG 4 1357231 −0.74 −1.42 to −0.23 −0.24 −0.53 −1.42 −0.23 −0.84 −1.04 −0.33 −1.00 −1.05 2 HGG 4 1449819 −0.83 −1.82 to 0.32   0.32 −1.27 −0.72 −0.05 −1.61 −0.92 −0.29 −1.82 −1.14 2 HGG 4 2055569 −1.37 −2.10 to −0.74 −0.74 −2.10 −1.34 −0.80 −2.07 −1.47 −0.78 −1.45 −1.56 2 HGG 4

TABLE 15 Ave DE [log2] Clone GenBank (C3A treated ID ID Annotation with steroid) Steroid 279898 187530 Human metallothionein-II pseudogene (mt- 1.40 Mifepristone 279898 187530 Human metallothionein-II pseudogene (mt- 1.52 progesterone 279898 187530 Human metallothionein-II pseudogene (mt- 1.06 beclomethasone 279898 187530 Human metallothionein-II pseudogene (mt- 1.43 MAH 279898 187530 Human metallothionein-II pseudogene (mt- 1.30 budesonide 279898 187530 Human metallothionein-II pseudogene (mt- 0.97 prednisone 279898 187530 Human metallothionein-II pseudogene (mt- 0.87 dexamethasone 279898 187530 Human metallothionein-II pseudogene (mt- 1.30 betamethasone 279898 187530 Human metallothionein-II pseudogene (mt- 1.83 danazol 560115 1778716 Human chemokine exodus-1 mRNA, −1.45 Mifepristone 560115 1778716 Human chemokine exodus-1 mRNA, −2.08 progesterone 560115 1778716 Human chemokine exodus-1 mRNA, −1.89 beclomethasone 560115 1778716 Human chemokine exodus-1 mRNA, −2.07 MAH 560115 1778716 Human chemokine exodus-1 mRNA, −2.04 budesonide 560115 1778716 Human chemokine exodus-1 mRNA, −1.93 prednisone 560115 1778716 Human chemokine exodus-1 mRNA, −2.00 dexamethasone 560115 1778716 Human chemokine exodus-1 mRNA, −1.87 betamethasone 560115 1778716 Human chemokine exodus-1 mRNA, −1.24 danazol 1619292 30302 Human mRNA for cytochrome cl. −0.93 Mifepristone 1619292 30302 Human mRNA for cytochrome cl. −1.28 progesterone 1619292 30302 Human mRNA for cytochrome cl. −1.57 beclomethasone 1619292 30302 Human mRNA for cytochrome cl. −1.52 MAH 1619292 30302 Human mRNA for cytochrome cl. −1.38 budesonide 1619292 30302 Human mRNA for cytochrome cl. −1.50 prednisone 1619292 30302 Human mRNA for cytochrome cl. −1.67 dexamethasone 1619292 30302 Human mRNA for cytochrome cl. −1.45 betamethasone 1619292 30302 Human mRNA for cytochrome cl. −1.14 danazol 2769888 587201 Human HK2 mRNA for hexokinase II. −1.29 Mifepristone 2769888 587201 Humon HK2 mRNA for hexokinase II. −1.11 progesterone 2769888 587201 Human HK2 mRNA for hexokinase II. −1.15 beclomethasone 2769888 587201 Human HK2 mRNA for hexokinase II. −1.22 MAH 2769888 587201 Human HK2 mRNA for hexokinase II. −0.95 budesonide 2769888 587201 Human HK2 mRNA for hexokinase II. −1.07 prednisone 2769888 587201 Human HK2 mRNA for hexokinase II. −1.21 dexamethasone 2769888 587201 Human HK2 mRNA for hexokinase II. −1.03 betamethasone 2769888 587201 Human HK2 mRNA for hexokinase II. −1.40 danazol 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.24 Mifepristone 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.43 progesterone 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.53 beclomethasone 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.51 MAH 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.45 budesonide 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.75 prednisone 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.91 dexamethasone 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −0.99 betamethasone 3120209 g7020644 Human cDNA FLJ20500 fis, clone KAT09159. −1.11 danazol 3135460 g6708478 formin-like protein −1.04 Mifepristone 3135460 g6708478 formin-like protein −1.02 progesterone 3135460 g6708478 formin-like protein −1.22 beclomethasone 3135460 g6708478 formin-like protein −1.37 MAH 3135460 g6708478 formin-like protein −1.36 budesonide 3135460 g6708478 formin-like protein −1.33 prednisone 3135460 g6708478 formin-like protein −1.11 dexamethasone 3135460 g6708478 formin-like protein −1.04 betamethasone 3135460 g6708478 formin-like protein −0.73 danazol 4287327 452443 Human glucose-6-phosphatase mRNA, 1.26 Mifepristone complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 2.26 progesterone complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 2.43 beclomethasone complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 2.29 MAH complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 2.49 budesonide complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 2.18 prednisone complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 2.15 dexamethasone complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 2.30 betamethasone complete cds. 4287327 452443 Human glucose-6-phosphatase mRNA, 1.27 danazol complete cds. {Incvte:A287327} 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −0.96 Mifepristone mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −1.85 progesterone mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −1.55 beclomethasone mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −1.93 MAH mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −1.76 budesonide mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −1.54 prednisone mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −1.68 dexamethasone mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −1.52 betamethasone mRNA, complete cds. 4408943 5732679 Human amino acid transporter B0+ (ATB0+) −0.92 danazol mRNA, complete cds. 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.19 Mifepristone 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.62 progesterone 5547895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.65 beclomethasone 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.71 MAH 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.67 budesonide 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.44 prednisone 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.79 dexamethasone 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −1.35 betamethasone 5047895 6049603 Human dickkopf-1 (DKK-1) mRNA, complete −0.95 danazol 5166479 1806039 Human mRNA for adipophilin. −1.28 Mifepristone 5166479 1806039 Human mRNA for adipophilin. −1.50 progesterone 5166479 1806039 Human mRNA for adipophilin. −1.42 beclomethasone 5166479 1806039 Human mRNA for adipophilin. −1.47 MAH 5166479 1806039 Human mRNA for adipophilin. −1.43 budesonide 5166479 1806039 Human mRNA for adipophilin. −1.56 prednisone 5166479 1806039 Human mRNA for adipophilin. −1.58 dexamethasone 5166479 1806039 Human mRNA for adipophilin. −1.36 betamethasone 5166479 1806039 Human mRNA for adipophilin. −0.37 danazol 5427710 g7293114 CG8198 gene product −0.94 Mifepristone 5427710 g7293114 CG8198 gene product −1.76 progesterone 5427710 g7293114 CG8198 gene product −1.99 beclomethasone 5427710 g7293114 CG8198 gene product −2.13 MAH 5427710 g7293114 CG8198 gene product −1.96 budesonide 5427710 g7293114 CG8198 gene product −2.08 prednisone 5427710 g7293114 CG8198 gene product −1.99 dexamethasone 5427710 g7293114 CG8198 gene product −1.82 betamethasone 5427710 g7293114 CG8198 gene product −0.90 danazol

TABLE 16 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 435610 0.80 beclomethasone 597555 0.96 beclomethasone 1236305 0.89 beclomethasone 1425150 1.03 beclomethasone 1547122 0.21 beclomethasone 1636015 0.51 beclomethasone 2110103 0.36 beclomethasone 2252501 0.28 beclomethasone 2364257 0.37 beclomethasone 2370756 0.58 beclomethasone 2447829 −0.67 beclomethasone 2667438 0.86 beclomethasone 2724032 0.68 beclomethasone 2797740 0.32 beclomethasone 2836470 −0.18 beclomethasone 2874010 −0.59 beclomethasone 2908777 −0.32 beclomethasone 3123530 0.77 beclomethasone 3915205 1.23 beclomethasone 4070403 −1.00 beclomethasone 4091186 0.94 beclomethasone 4222957 0.26 beclomethasone 4223734 −0.38 beclomethasone 4297813 −1.09 beclomethasone 4298848 −0.19 beclomethasone 4312603 −0.30 beclomethasone 5275693 1.00 beclomethasone 13504 0.40 betamethasone 89691 0.49 betamethasone 126877 0.50 betamethasone 128891 0.48 betamethasone 172023 0.87 betamethasone 195943 0.48 betamethasone 262712 0.43 betamethasone 275757 0.35 betamethasone 278939 0.39 betamethasone 309006 0.78 betamethasone 339737 0.51 betamethasone 428897 0.71 betamethasone 451090 0.49 betamethasone 538427 0.69 betamethasone 566093 0.27 betamethasone 592085 0.95 betamethasone 819036 0.51 betamethasone 830408 1.04 betamethasone 854872 0.44 betamethasone 964939 0.53 betamethasone 1001486 0.87 betamethasone 1214989 0.54 betamethasone 1266985 0.74 betamethasone 1306222 0.16 betamethasone 1316801 1.97 betamethasone 1364694 0.52 betamethasone 1415119 0.37 betamethasone 1469028 1.16 betamethasone 1495730 0.47 betamethasone 1496066 0.68 betamethasone 1503162 0.61 betamethasone 1569904 0.75 betamethasone 1571861 0.23 betamethasone 1578941 0.43 betamethasone 1635877 0.78 betamethasone 1637145 0.94 betamethasone 1661892 1.61 betamethasone 1697855 0.85 betamethasone 1820105 0.28 betamethasone 1831454 0.63 betamethasone 1833010 0.25 betamethasone 1852354 0.85 betamethasone 1960822 0.75 betamethasone 1979363 0.85 betamethasone 1981569 0.58 betamethasone 2005266 0.28 betamethasone 2008331 0.50 betamethasone 2132784 0.53 betamethasone 2189237 0.37 betamethasone 2252906 0.94 betamethasone 2271648 0.33 betamethasone 2273619 0.36 betamethasone 2276895 0.66 betamethasone 2497692 0.93 betamethasone 2631261 0.97 betamethasone 2669337 −0.70 betamethasone 2753963 0.34 betamethasone 2823478 1.11 betamethasone 2874881 0.64 betamethasone 2881039 0.50 betamethasone 2915217 0.84 betamethasone 2933127 0.49 betamethasone 2933175 1.05 betamethasone 2948678 0.26 betamethasone 3045419 1.14 betamethasone 3187861 0.36 betamethasone 3369213 0.29 betamethasone 3410101 0.31 betamethasone 3434166 0.65 betamethasone 3479268 0.43 betamethasone 3508345 0.46 betamethasone 3571607 0.85 betamethasone 3607580 0.51 betamethasone 3659618 0.18 betamethasone 3686411 0.41 betamethasone 3967255 0.23 betamethasone 4000614 0.50 betamethasone 4112181 0.97 betamethasone 4195203 0.81 betamethasone 4228236 0.87 betamethasone 4312860 1.14 betamethasone 4373333 1.12 betamethasone 4606503 0.50 betamethasone 4695453 0.77 betamethasone 4738532 1.37 betamethasone 5094042 0.98 betamethasone 5186846 0.11 betamethasone 5285915 0.66 betamethasone 5372104 0.34 betamethasone 278100 0.21 budesonide 380041 −0.37 budesonide 408442 0.35 budesonide 523797 −1.05 budesonide 621216 0.79 budesonide 835756 0.94 budesonide 868678 0.39 budesonide 1211357 0.19 budesonide 1305249 −0.98 budesonide 1317428 0.19 budesonide 1446475 −0.70 budesonide 1447306 0.41 budesonide 1495947 0.46 budesonide 1597837 0.46 budesonide 1604650 −0.70 budesonide 1662632 −0.62 budesonide 1707037 −0.23 budesonide 1721320 −0.97 budesonide 1737512 0.24 budesonide 1799078 −0.70 budesonide 1868738 −0.82 budesonide 1900173 0.78 budesonide 1942785 0.85 budesonide 2057265 1.06 budesonide 2131956 −0.99 budesonide 2156661 0.91 budesonide 2169433 0.29 budesonide 2215282 0.55 budesonide 2239738 −0.20 budesonide 2293494 −0.69 budesonide 2346851 −0.97 budesonide 2347684 −0.30 budesonide 2399169 0.21 budesonide 2399665 −0.70 budesonide 2529162 −0.96 budesonide 2539933 −0.16 budesonide 2579218 0.85 budesonide 2611889 0.15 budesonide 2702786 0.19 budesonide 2706669 −0.87 budesonide 2726759 −0.02 budesonide 2747179 −0.99 budesonide 2760615 0.23 budesonide 2803833 0.42 budesonide 3029474 −0.99 budesonide 3091135 0.01 budesonide 3188660 0.61 budesonide 3332232 1.08 budesonide 3979665 −0.04 budesonide 4003460 −0.71 budesonide 4203937 0.76 budesonide 4248767 −0.51 budesonide 4251117 0.98 budesonide 4284384 1.13 budesonide 5044351 −0.88 budesonide 5280239 −1.02 budesonide 5424122 −0.87 budesonide 5507406 0.95 budesonide 5867032 0.19 budesonide 120110 −0.62 danazol 322933 −0.29 danazol 389558 −0.37 danazol 746910 −0.19 danazol 757370 −0.28 danazol 932244 −0.31 danazol 951433 −0.14 danazol 960496 −0.34 danazol 997480 −0.24 danazol 1219506 −0.36 danazol 1269921 −0.39 danazol 1274378 −0.25 danazol 1310337 −0.20 danazol 1328741 −0.39 danazol 1350683 −0.16 danazol 1357231 −0.74 danazol 1405844 0.49 danazol 1495907 −0.14 danazol 1506930 −0.25 danazol 1518310 −0.47 danazol 1552522 0.04 danazol 1638756 −0.18 danazol 1715374 −0.78 danazol 1735702 −0.36 danazol 1740788 −0.19 danazol 1802939 −0.33 danazol 1804503 −0.44 danazol 1834257 −0.14 danazol 1853116 −0.55 danazol 1904987 −0.35 danazol 1995136 −0.14 danazol 2047312 −0.14 danazol 2110035 −0.12 danazol 2158674 −0.42 danazol 2174951 −0.16 danazol 2203570 −0.29 danazol 2216323 −0.42 danazol 2314164 −0.03 danazol 2322243 −0.23 danazol 2327230 −0.37 danazol 2444137 −0.10 danazol 2444740 −0.24 danazol 2500872 −0.23 danazol 2750849 −0.15 danazol 2794808 −0.53 danazol 2927479 −0.34 danazol 2956670 −0.35 danazol 3143494 −0.23 danazol 3253462 0.25 danazol 3278632 −0.16 danazol 3409540 −0.13 danazol 3451296 −0.15 danazol 3481841 0.05 danazol 3639747 −0.14 danazol 3724351 −0.14 danazol 3880722 −0.55 danazol 4181663 −0.04 danazol 4247951 −0.22 danazol 4292488 −0.35 danazol 4587665 −0.20 danazol 4741591 −0.41 danazol 4759669 −0.27 danazol 4896168 0.44 danazol 4970829 0.20 danazol 5024212 −0.17 danazol 5033671 0.48 danazol 5207486 −0.24 danazol 5326338 −0.34 danazol 5405691 −0.26 danazol 41247 −0.34 dexamethasone 198719 −1.19 dexamethasone 223436 −0.97 dexamethasone 293477 −1.35 dexamethasone 496946 −1.08 dexamethasone 509758 −1.16 dexamethasone 526319 −0.49 dexamethasone 562585 −1.21 dexamethasone 608725 −1.04 dexamethasone 620879 0.31 dexamethasone 630375 −0.19 dexamethasone 641510 −0.26 dexamethasone 678955 −1.02 dexamethasone 777716 −0.20 dexamethasone 1235535 −1.12 dexamethasone 1306062 0.18 dexamethasone 1319021 −1.14 dexamethasone 1331853 −1.16 dexamethasone 1366040 0.15 dexamethasone 1377668 −0.81 dexamethasone 1416978 −1.04 dexamethasone 1437552 −1.15 dexamethasone 1478855 −0.19 dexamethasone 1501809 0.33 dexamethasone 1511262 −1.28 dexamethasone 1520151 −0.83 dexamethasone 1594179 −0.93 dexamethasone 1636594 0.25 dexamethasone 1667220 −0.97 dexamethasone 1696552 0.41 dexamethasone 1700074 0.45 dexamethasone 1706751 −1.10 dexamethasone 1728013 −1.11 dexamethasone 1732792 −0.91 dexamethasone 1805836 −1.02 dexamethasone 1822143 0.28 dexamethasone 1848722 −1.21 dexamethasone 1886928 −0.60 dexamethasone 1979756 −1.06 dexamethasone 1988593 −1.07 dexamethasone 2009252 0.20 dexamethasone 2044184 0.14 dexamethasone 2051966 −1.04 dexamethasone 2060823 −1.09 dexamethasone 2089176 −1.10 dexamethasone 2095144 −1.24 dexamethasone 2095268 −1.00 dexamethasone 2095728 −1.01 dexamethasone 2239236 −0.74 dexamethasone 2268923 −1.18 dexamethasone 2273944 −0.45 dexamethasone 2284694 −1.07 dexamethasone 2286360 −1.26 dexamethasone 2287426 −1.16 dexamethasone 2345426 −1.08 dexamethasone 2394616 −0.95 dexamethasone 2420388 −0.17 dexamethasone 2458526 −0.89 dexamethasone 2504870 1.02 dexamethasone 2571644 0.28 dexamethasone 2705256 −0.20 dexamethasone 2822027 0.82 dexamethasone 2850323 −0.76 dexamethasone 2863211 −1.17 dexamethasone 2908546 0.18 dexamethasone 2914439 −1.11 dexamethasone 2925373 −1.10 dexamethasone 2946292 −0.87 dexamethasone 2954059 −1.22 dexamethasone 3003980 0.22 dexamethasone 3086833 −1.06 dexamethasone 3398189 −1.11 dexamethasone 3144511 0.26 dexamethasone 3187903 0.22 dexamethasone 3284411 −1.16 dexamethasone 3381870 0.88 dexamethasone 3408939 0.17 dexamethasone 3566941 0.24 dexamethasone 3614283 0.46 dexamethasone 3736815 0.26 dexamethasone 3747901 −0.99 dexamethasone 3818422 0.91 dexamethasone 3926757 0.48 dexamethasone 3983862 −0.98 dexamethasone 4003219 0.19 dexamethasone 4221092 0.18 dexamethasone 4249090 0.17 dexamethasone 4252768 0.17 dexamethasone 4288091 −0.06 dexamethasone 4291619 0.17 dexamethasone 4307290 0.17 dexamethasone 4334474 −1.07 dexamethasone 4339883 −0.21 dexamethasone 4464538 −1.05 dexamethasone 4505265 0.18 dexamethasone 4611240 0.17 dexamethasone 4717363 0.18 dexamethasone 4792726 −0.70 dexamethasone 4860060 −1.29 dexamethasone 4872725 0.18 dexamethasone 4883207 0.17 dexamethasone 5038604 0.19 dexamethasone 5106915 0.19 dexamethasone 5115293 0.18 dexamethasone 5138591 0.19 dexamethasone 5198045 −0.95 dexamethasone 5262558 0.20 dexamethasone 5281739 −0.85 dexamethasone 5291215 0.17 dexamethasone 5321996 0.47 dexamethasone 5323022 0.17 dexamethasone 5374705 0.33 dexamethasone 5506170 −0.74 dexamethasone 96752 −1.08 MAH 129775 0.97 MAH 269310 −0.89 MAH 301206 0.67 MAH 346017 0.78 MAH 435549 0.81 MAH 489820 −0.27 MAH 569348 0.42 MAH 641039 0.29 MAH 646463 0.37 MAH 693783 −0.87 MAH 761282 1.04 MAH 859218 0.96 MAH 893224 1.05 MAH 898741 0.47 MAH 916103 0.26 MAH 1209413 −0.15 MAH 1284155 −1.10 MAH 1482166 0.23 MAH 1645304 0.53 MAH 1700287 −1.11 MAH 1740975 −0.04 MAH 1741288 0.12 MAH 1888260 1.18 MAH 1909281 0.18 MAH 1927771 0.52 MAH 1930088 −0.16 MAH 1995767 1.00 MAH 1998317 −0.15 MAH 2051568 0.50 MAH 2176212 −0.74 MAH 2188005 −0.83 MAH 2260285 −0.18 MAH 2268803 0.40 MAH 2291665 −0.17 MAH 2302785 −0.19 MAH 2302810 0.34 MAH 2313581 −0.20 MAH 2383242 −0.15 MAH 2395112 0.20 MAH 2428314 1.01 MAH 2499418 0.84 MAH 2507552 −1.06 MAH 2619954 −1.05 MAH 2663164 −0.86 MAH 2675433 0.59 MAH 2707635 0.66 MAH 2742315 0.30 MAH 2756747 1.00 MAH 2761527 0.35 MAH 2780013 −1.09 MAH 2806983 −0.88 MAH 2811404 −0.92 MAH 2831351 −0.87 MAH 2838627 1.08 MAH 2864790 −1.00 MAH 2880819 −1.08 MAH 2891601 1.04 MAH 2927486 −0.90 MAH 2930673 −1.09 MAH 2956869 0.91 MAH 2959255 0.21 MAH 3035780 −0.30 MAH 3045790 −0.77 MAH 3057267 0.67 MAH 3068429 −0.86 MAH 3141607 −1.00 MAH 3170010 −0.46 MAH 3200811 −0.77 MAH 3230318 −0.88 MAH 3253978 0.36 MAH 3254430 −0.77 MAH 3334476 −0.99 MAH 3411051 −0.14 MAH 3566383 1.09 MAH 3569151 0.16 MAH 3616233 −0.86 MAH 3621521 0.42 MAH 3633707 0.73 MAH 3732960 0.62 MAH 3875135 −0.82 MAH 3890145 −1.09 MAH 4089755 1.19 MAH 4340307 0.63 MAH 4413637 −0.91 MAH 4423361 −0.90 MAH 4535971 −1.00 MAH 4590473 −0.96 MAH 4886605 −1.13 MAH 5004556 −0.93 MAH 5076842 −0.62 MAH 5275515 −0.17 MAH 739461 −0.22 Mifepristone 865145 −0.23 Mifepristone 1315663 −0.75 Mifepristone 1607203 −0.78 Mifepristone 1611445 −0.93 Mifepristone 1651008 −0.71 Mifepristone 2026270 −0.67 Mifepristone 2430750 0.60 Mifepristone 2515666 1.29 Mifepristone 4721130 0.85 Mifepristone 168848 −0.24 prednisone 198959 0.18 prednisone 626254 0.35 prednisone 1235345 0.20 prednisone 1418276 0.24 prednisone 1507302 0.67 prednisone 1570534 1.01 prednisone 1872858 0.24 prednisone 1899766 0.91 prednisone 1905006 0.85 prednisone 2018808 0.21 prednisone 2019910 0.19 prednisone 2381040 −0.18 prednisone 2415118 0.22 prednisone 2753371 0.52 prednisone 2759015 0.73 prednisone 2769732 0.33 prednisone 2817244 0.20 prednisone 2836703 0.65 prednisone 3031872 0.15 prednisone 3049285 −0.37 prednisone 3466829 0.44 prednisone 3478570 0.49 prednisone 3629043 0.73 prednisone 3999352 0.71 prednisone 4208369 0.12 prednisone 4223315 0.19 prednisone 4266051 −0.90 prednisone 5109437 0.01 prednisone 5325802 0.27 prednisone 5700537 −0.16 prednisone 5859590 −0.23 prednisone 21957 0.47 progesterone 481402 0.06 progesterone 531842 −0.26 progesterone 955538 0.28 progesterone 1337924 0.79 progesterone 1820882 0.26 progesterone 1841901 0.95 progesterone 1981929 0.24 progesterone 2013955 0.22 progesterone 2159706 0.23 progesterone 2233219 −0.31 progesterone 2277161 0.42 progesterone 2325802 0.76 progesterone 2427327 0.68 progesterone 2532033 0.25 progesterone 2579572 0.20 progesterone 2756910 −0.21 progesterone 2828647 −0.14 progesterone 2847188 0.26 progesterone 2847867 −0.10 progesterone 2918279 −0.21 progesterone 3001817 −0.17 progesterone 3098342 −0.12 progesterone 3136307 −0.28 progesterone 3188631 −0.17 progesterone 3188967 0.04 progesterone 3196654 0.07 progesterone 3221109 0.29 progesterone 3253556 −0.03 progesterone 3255873 0.03 progesterone 3390535 0.30 progesterone 3714088 −0.20 progesterone 3980695 0.59 progesterone 4002388 0.04 progesterone 4631069 0.37 progesterone 4822285 0.32 progesterone

TABLE 17 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 167081 −1.12 progesterone 167081 −1.00 MAH 167081 −1.10 dexamethasone 1679683 0.25 progesterone 1683583 0.59 MAH 1986919 0.65 progesterone 1986919 0.84 MAH 2266959 0.96 progesterone 2266959 0.29 MAH 2499905 1.24 progesterone 2499905 1.11 MAH 3220149 0.53 progesterone 3220149 0.31 MAH 3408804 −1.16 progesterone 3408804 −1.49 MAH 3408804 −1.24 budesonide 5045593 −1.02 progesterone 5045593 −1.03 MAH 1323327 0.83 progesterone 1323327 1.00 betamethasone 1600180 1.06 progesterone 1600180 0.77 betamethasone 1816768 0.28 progesterone 1816768 0.24 betamethasone 2753065 0.78 progesterone 2753065 0.75 betamethasone 3528232 0.99 progesterone 3528232 0.38 beclomethasone 3528232 0.80 betamethasone 3876612 0.26 progesterone 3876612 0.19 betamethasone 2655279 −1.03 progesterone 2655279 −1.21 dexamethasone

TABLE 18 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 1398105 −0.76 Mifepristone 1398105 −0.68 MAH 1781411 −0.98 Mifepristone 1781411 −0.74 danazol 2890141 −0.71 Mifepristone 2890141 −0.95 MAH 2890141 −0.70 danazol 3715059 −0.75 Mifepristone 3715059 −0.66 MAH 3715059 −0.77 danazol 4110976 −0.17 Mifepristone 4110976 −0.36 danazol 5208013 −0.76 Mifepristone 5208013 −0.99 MAH 5208013 −0.51 danazol 4543123 −1.20 Mifepristone 4543123 1.27 prednisone 5426158 −0.93 Mifepristone 5426158 −1.03 dexamethasone

TABLE 19 3715059 −0.75 Mifepristone 3715059 −0.66 MAH 3715059 −0.77 donazol 5208013 −0.76 Mifepristone 5208013 −0.99 MAH 5208013 −0.51 donazol 619447 0.81 MAH 619447 0.33 betamethasone 1824860 0.77 MAH 1824860 0.70 betamethasone 3729593 0.41 MAH 3729593 0.55 betamethasone 5521873 1.19 MAH 5521873 0.77 betamethasone 419492 1.07 MAH 419492 1.08 dexamethasone 494905 0.91 MAH 494905 0.75 dexamethasone 508943 −0.93 MAH 508943 −1.26 dexamethasone 869702 0.88 MAH 869702 0.55 dexamethasone 1259841 1.09 MAH 1259841 0.84 dexamethasone 1501410 −1.03 MAH 1501410 −1.16 dexamethasone 1501410 −0.98 dexamethasone 1857664 −0.92 MAH 1857664 −0.71 dexamethasone 2025128 0.93 MAH 2025128 0.90 dexamethasone 2025128 1.20 dexamethasone 1946155 0.64 MAH 1946155 0.92 prednisone 1946155 0.93 dexamethasone 2173002 0.99 MAH 2173002 0.75 dexamethasone 2173002 0.98 dexamethasone 2293496 −0.89 MAH 2293496 −0.82 dexamethasone 2698777 −0.99 MAH 2698777 −1.25 prednisone 2698777 −1.48 dexamethasone 3115505 −0.94 MAH 3115505 −1.10 dexamethasone 4377432 1.13 MAH 4377432 0.87 dexamethasone 4884214 −1.09 MAH 4884214 −0.77 dexamethasone 622565 1.20 MAH 622565 1.20 budesonide 622565 1.17 betamethasone 686993 0.36 MAH 686993 0.51 budesonide 686993 0.51 betamethasone 1401312 −1.06 MAH 1401312 −1.09 budesonide 1401312 −0.82 prednisone 1611629 0.89 MAH 1611629 1.19 budesonide 1611629 0.94 prednisone 1716458 1.09 MAH 1716458 1.24 budesonide 1716458 1.03 prednisone 1973123 −0.93 MAH 1973123 −1.23 budesonide 2057513 0.92 MAH 2057513 1.13 budesonide 2078880 −1.14 MAH 2078880 −0.80 budesonide 2078880 −0.75 betamethasone 2173973 1.04 MAH 2173973 1.08 budesonide 2173973 0.81 betamethasone 2227273 1.37 MAH 2227273 1.05 budesonide 2227273 1.01 prednisone 2434746 0.49 MAH 2434746 0.42 budesonide 2434746 1.46 betamethasone 3426776 0.81 MAH 3426776 0.61 budesonide 3449615 0.76 MAH 3449615 1.05 budesonide 3497137 −0.88 MAH 3497137 −0.94 budesonide 3721985 −1.05 MAH 3721985 −1.10 budesonide 3770530 −0.89 MAH 3770530 −0.98 budesonide 4252872 1.13 MAH 4252872 1.24 budesonide 4252872 0.77 prednisone 4630674 0.87 MAH 4630674 0.97 budesonide 4630674 0.86 prednisone 5038177 0.77 MAH 5038177 0.57 budesonide 5038177 0.74 danazol 998615 0.85 MAH 998615 0.91 prednisone 1740179 1.04 MAH 1740179 0.86 prednisone 2908212 0.46 MAH 2908212 0.42 prednisone 400654 1.06 beclomethasone 400654 1.15 MAH 517374 0.40 beclomethasone 517374 1.00 MAH 517374 1.04 budesonide 654246 −0.95 beclomethasone 654246 −1.22 MAH 654246 −1.08 budesonide 668460 1.23 beclomethasone 668400 1.28 MAH 963331 −1.01 beclomethasone 963331 −1.03 MAH 1573840 0.97 beclomethasone 1573840 0.90 MAH 1573840 0.86 dexamethasone 1604437 0.47 beclomethasone 1604437 1.18 MAH 1604437 1.18 budesonide 1697719 −0.69 beclomethasone 1697719 −0.86 MAH 1697719 −0.81 budesonide 1723834 0.47 beclomethasone 1723834 0.72 MAH 1857044 0.61 beclomethasone 1857044 0.96 MAH 1857044 0.89 betamethasone 1995520 0.82 beclomethasone 1995520 1.09 MAH 2046717 0.98 beclomethasone 2046717 1.52 MAH 2046717 0.83 betamethasone 2372040 −1.05 beclomethasone 2372040 −1.21 MAH 2506425 0.88 beclomethasone 2506425 1.38 MAH 2636759 0.51 beclomethasone 2636759 0.93 MAH 2695371 0.51 beclomethasone 2695371 0.70 MAH 2695371 0.95 betamethasone 2947188 −1.02 beclomethasone 2947188 −1.09 MAH 2947188 −0.98 dexamethasone 3047143 1.10 beclomethasone 3047143 1.08 MAH 3057272 0.83 beclomethasone 3057272 0.99 MAH 3057272 0.98 dexamethasone 3687607 1.03 beclomethasone 3687607 1.05 MAH 3687607 1.17 budesonide 3960194 1.00 beclomethasone 3960194 1.17 MAH 3960194 1.01 prednisone 4087621 0.89 beclomethasone 4087621 1.01 MAH 4087621 1.09 betamethasone 4253663 −0.70 beclomethasone 4253663 −0.96 MAH 4284270 −0.70 beclomethasone 4284270 −0.96 MAH 4284270 −0.88 dexamethasone 4863677 1.09 beclomethasone 4863677 1.12 MAH 4863677 1.11 budesonide 4894508 −0.93 beclomethasone 4894508 −0.99 MAH 4894508 −1.03 prednisone 5398701 0.82 beclomethasone 5398701 1.09 MAH 5398701 1.10 betamethasone

TABLE 19 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 167081 −1.12 progesterone 167081 −1.00 MAH 167081 −1.10 dexamethasone 1679683 0.25 progesterone 1683583 0.59 MAH 986919 0.65 progesterone 1986919 0.84 MAH 2266959 0.96 progesterone 2266959 0.29 MAH 2499905 1.24 progesterone 2499905 1.11 MAH 3220149 0.53 progesterone 3220149 0.31 MAH 3408804 −1.16 progesterone 3408804 −1.49 MAH 3408804 −1.24 budesonide 5045593 −1.02 progesterone 5045593 −1.03 MAH 1398105 −0.76 Mifepristone 1398105 −0.68 MAH 2890141 −0.71 Mifepristone 2890141 −0.95 MAH 2890141 −0.70 danazol

TABLE 20 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 1781411 −0.98 Mifepristone 1781411 −0.74 danazol 2890141 −0.71 Mifepristone 2890141 −0.95 MAH 2890141 −0.70 danazol 3715059 −0.75 Mifepristone 3715059 −0.66 MAH 3715059 −0.77 danazol 4110976 −0.17 Mifepristone 4110976 −0.36 danazol 5208013 −0.76 Mifepristone 5208013 −0.99 MAH 5208013 −0.51 danazol 2407620 0.02 betamethasone 2407620 −0.26 danazol 3474091 0.23 betamethasone 3474091 −0.29 danazol 1500810 −0.70 dexamethasone 1500810 −0.41 danazol 2607834 0.29 prednisone 2607834 0.92 danazol 5038177 0.77 MAH 5038177 0.57 budesonide 5038177 0.74 danazol

TABLE 21 Ave DE [log2] (C3A teested Clone ID with steroid) Steroid 1275616 0.94 beclomethasone 1275616 0.97 dexamethasone 1323616 1.09 beclomethasone 1323616 0.89 dexamethasone 1573840 0.97 beclomethasone 1573840 0.90 MAH 1573840 0.86 dexamethasone 1876829 −1.00 beclomethasone 1876829 −1.13 budesonide 1876829 −0.94 dexamethasone 2086783 −0.88 beclomethasone 2086783 −1.13 prednisone 2086783 −1.18 dexamethasone 2095329 −0.99 beclomethasone 2095329 −1.21 prednisone 2095329 −1.37 dexamethasone 2285181 −0.88 beclomethasone 2285181 −1.27 dexamethasone 2287703 −0.99 beclomethasone 2287703 −1.07 prednisone 2287703 −1.24 dexamethasone 2287724 −1.05 beclomethasone 2287724 −1.06 budesonide 2287724 −1.16 dexamethasone 2294968 −0.73 beclomethasone 2294968 −0.94 dexamethasone 2947188 −1.02 beclomethasone 2947188 −1.09 MAH 2947188 −0.98 dexamethasone 3057272 0.83 beclomethasone 3057272 0.99 MAH 3057272 0.98 dexamethasone 3973887 −0.91 beclomethasone 3973887 −1.06 dexamethasone 4284270 −0.70 beclomethasone 4284270 −0.96 MAH 4284270 −0.88 dexamethasone 5091002 −1.13 beclomethasone 5091002 −1.22 prednisone 5091002 −1.42 dexamethasone 1946155 0.64 MAH 1946155 0.92 prednisone 1946155 0.93 dexamethasone 2088104 −1.15 prednisone 2088104 −1.20 dexamethasone 2252884 −1.03 prednisone 2252884 −0.19 dexamethasone 2253102 −1.13 prednisone 2253102 −1.20 dexamethasane 2269058 −1.06 prednisone 2269058 −1.15 dexamethasone 2285521 −1.09 prednisone 2285521 −1.22 dexamethasone 2698777 −0.99 MAH 2698777 −1.25 prednisone 2698777 −1.48 dexamethasone 380006 −1.05 budesonide 380006 −0.98 dexamethasone 1823946 −1.10 budesonide 1823946 −1.20 dexamethasone 1930847 −1.09 budesonide 1930847 −0.67 dexamethasone 2703282 −1.01 budesonide 2703282 −0.86 dexamethasone 2703282 −0.85 betamethasone 3139631 −0.97 budesonide 3139631 −0.82 dexamethasone 4089291 −1.00 budesonide 4089291 −0.77 dexamethasone 419492 1.07 MAH 419492 1.08 dexamethasone 494905 0.91 MAH 494905 0.75 dexamethasone 508943 −0.93 MAH 508943 −1.26 dexamethasone 869702 0.88 MAH 869702 0.55 dexamethasone 1259841 1.09 MAH 1259841 0.84 dexamethasone 1501410 −1.03 MAH 1501410 −1.16 dexamethasone 1501410 −0.98 betamethasone 1857664 −0.92 MAH 1857664 −0.71 dexamethasone 2025128 0.93 MAH 2025128 0.90 dexamethasone 2025128 1.20 betamethasone 2173002 0.99 MAH 2173002 0.75 dexamethasone 2173002 0.98 betamethasone 2293496 −0.89 MAH 2293496 −0.82 dexamethasone 3115505 −0.94 MAH 3115505 −1.10 dexamethasone 4377432 1.13 MAH 4377432 0.87 dexamethasone 4884214 −1.09 MAH 4884214 −0.77 dexamethasone 167081 −1.12 progesterone 167081 −1.00 MAH 167081 −1.10 dexamethasone 2655279 −1.03 progesterone 2655279 −1.21 dexamethasone 5206821 0.17 dexamethasone 5206821 0.50 betamethasone 220378 0.39 dexamethasone 220378 0.57 betamethasone 1500810 −0.70 dexamethasone 1500810 −0.41 danazol 5426158 −0.93 Mifepristone 5426158 −1.03 dexamethasone

TABLE 22 Ave DE [log2] (C3A treated Clone ID witn steroid) Steroid 622565 1.20 MAH 622565 1.20 budesonide 622565 1.1 7 betamethasone 686993 0.36 MAH 686993 0.51 budesonide 686993 0.51 betamethasone 689296 1.08 budesonide 689296 1.12 betamethasone 1798594 0.69 budesonide 1798594 1.37 betamethasone 2078880 −1.14 MAH 2078880 −0.80 budesonide 2078880 −0.75 betamethasone 2170820 1.17 budesonide 2170820 1.30 betamethasone 2173973 1.04 MAH 2173973 1.08 budesonide 2173973 0.81 betamethasone 2189061 0.15 budesonide 2189061 0.23 betamethasone 2222155 0.58 budesonide 2222155 0.50 betamethasone 2343836 0.93 budesonide 2343836 0.63 betamethasone 2404746 0.40 MAH 2404746 0.42 budesonide 2404746 1.46 betamethasone 2482388 1.19 budesonide 2482388 1.14 betamethasone 2660756 1.13 budesonide 2660756 1.26 betamethasone 2687356 1.26 budesonide 2687356 1.23 betamethasone 2703282 −1.01 budesonide 2703282 −0.86 dexamethasone 2703282 −0.85 betamethasone 3229449 0.39 budesonide 3229449 1.05 betamethasone 4403805 1.12 budesonide 4403805 1.19 betamethasone 615776 1.01 beclomethasone 615776 1.06 budesonide 615776 1.11 betamethasone 1329625 0.35 beclomethasone 1329625 0.42 prednisone 1329625 0.91 betamethasone 1857044 0.61 beclomethasone 1857044 0.96 MAH 1857044 0.89 betamethasone 1951845 1.01 beclomethasone 1951845 0.79 prednisone 1951845 1.02 betamethasone 2046717 0.98 beclomethasone 2046717 1.52 MAH 2046717 0.83 betamethasone 2430165 1.04 beclomethasone 2430165 0.23 prednisone 2430165 0.68 betamethasone 2695371 0.51 beclomethasone 2695371 0.70 MAH 2695371 0.95 betamethasone 3973687 1.23 beclomethasone 3973687 1.31 budesonide 3973687 1.47 betamethasone 4087621 0.89 beclomethasone 4087621 1.01 MAH 4087621 1.09 betamethasone 4215034 1.13 beclomethasone 4215034 1.20 budesonide 4215034 1.50 betamethasone 4855265 1.00 beclomethasone 4855265 1.14 budesonide 4855265 1.24 betamethasone 5398701 0.82 beclomethasane 5398701 1.09 MAH 5398701 1.10 betamethasone 5543385 1.00 prednisone 5543385 1.15 betamethasone 1496011 0.51 prednisone 1496011 0.60 betamethasone 2734007 0.88 prednisone 2734007 1.04 betamethasone 220378 0.39 dexamethasone 220378 0.57 betamethasone 2025128 0.93 MAH 2025128 0.90 dexamethasone 2025128 1.20 betamethasone 2173002 0.99 MAH 2173002 0.75 dexamethasone 2173002 0.98 betamethasone 5206821 0.17 dexamethasone 5206821 0.50 betamethasone 1323327 0.83 progesterone 1323327 1.00 betamethasone 1600180 1.06 progesterone 1600180 0.77 betamethasone 1816768 0.28 progesterone 1816768 0.24 betamethasone 2753065 0.78 progesterone 2753065 0.75 betamethasone 3528232 0.99 progesterone 3528232 0.38 beclomethasone 3528232 0.80 betamethasone 3876612 0.26 progesterone 3876612 0.19 betamethasone 5521873 1.19 MAH 5521873 0.77 betamethasone 619447 0.81 MAH 619447 0.33 betamethasone 1824860 0.77 MAH 1824860 0.70 betamethasone 3729593 0.41 MAH 3729593 0.55 betamethasone 2407620 0.02 betamethasone 2407620 −0.26 donozol 3474091 0.23 betamethasone 3474091 −0.29 donozol

TABLE 23 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 1275616 0.94 beclomethasone 1275616 0.97 dexamethasone 1323616 1.09 beclomethasone 1323616 0.89 dexamethasone 1573840 0.97 beclomethasone 1573840 0.90 MAH 1573840 0.86 dexamethasone 1876829 −1.00 beclomethasone 1876829 −1.13 budetonide 1876829 −0.94 dexamethasone 2086783 −0.88 beclomethosone 2086783 −1.13 prednisone 2086783 −1.18 dexamethasone 2095329 −0.99 beclomethasone 2095329 −1.21 prednisone 2095329 −1.37 dexomethasone 2287724 −1.05 beclomethasone 2287724 −1.06 budesonide 2287724 −1.16 dexamethasone 2285181 −0.88 beclomethasone 2285181 −1.27 dexomethasone 2287703 −0.99 beclomethasone 2287703 −1.07 prednisone 2287703 −1.24 dexomethasone 2294968 −0.73 beclomethasone 2294968 −0.94 dexomethasone 2947188 −1.02 beclomethasone 2947188 −1.09 MAH 2947188 −0.98 dexomethasone 3057272 0.83 beclomethasone 3057272 0.99 MAH 3057272 0.98 dexamethasone 3973887 −0.91 beclcomethasone 3973887 −1.06 dexomethasone 4284270 −0.70 beclomethasone 4284270 −0.96 MAH 4284270 −0.88 dexomethasone 5091002 −1.13 beclomethasone 5091002 −1.22 prednisone 5091002 −1.42 dexomethasone 615776 1.01 beclomethasone 615776 1.06 budesonide 615776 1.11 betamethasone 1329625 0.35 beclomethasone 1329625 0.42 prednisone 1329625 0.91 betamethasone 1857044 0.61 beclomethasone 1857044 0.96 MAH 1857044 0.89 betamethasone 1951845 1.01 beclomethasone 1951845 0.79 prednisone 1951845 1.02 betamethasone 2046717 0.98 beclomethasone 2046717 1.52 MAH 2046717 0.83 betamethasone 3528232 0.99 progesterone 3528232 0.38 beclomethasone 3528232 0.80 betamethasone 2430165 1.04 beclomethasone 2430165 0.23 prednisone 2430165 0.68 betamethasone 2695371 0.51 beclomethasone 2695371 0.70 MAH 2695371 0.95 betamethasone 3973687 1.23 beclomethasone 3973687 1.31 budesonide 3973687 1.47 betamethasone 4087621 0.89 beclomethasone 4087621 1.01 MAH 4087621 1.09 betamethasone 4215034 1.13 beclomethasone 4215034 1.20 budesonide 4215034 1.50 betamethasone 4855265 1.00 beclomethasone 4855265 1.14 budesonide 4855265 1.24 betamethasone 5398701 0.82 beclomethasone 5398701 1.09 MAH 5398701 1.10 betamethasone 517374 0.40 beclomethasone 517374 1.00 MAH 517374 1.04 budesonide 654246 −0.95 beclomethasone 654246 −1.22 MAH 654246 −1.08 budesonide 1604437 0.47 beclomethasone 1604437 1.18 MAH 1604437 1.18 budesonide 1662870 −0.76 beclomethasone 1662870 −0.93 budesonide 1697719 −0.69 beclomethasone 1697719 −0.86 MAH 1697719 −0.81 budesonide 3687607 1.03 beclomethasone 3687607 1.05 MAH 3687607 1.17 budesonide 4863677 1.09 beclomethasone 4863677 1.12 MAH 4863677 1.11 budesonide 3960194 1.00 beclomethasone 3960194 1.17 MAH 3960194 1.01 prednisone 4894508 −0.93 beclomethasone 4894508 −0.99 MAH 4894508 −1.03 prednisone 400654 1.06 beclomethasone 400654 1.15 MAH 668460 1.23 beclomethasone 668460 1.28 MAH 963331 −1.01 beclomethasone 963331 −1.03 MAH 1723834 0.47 beclomethasone 1723834 0.72 MAH 1995520 0.82 beclomethasone 1995520 1.09 MAH 2372040 −1.05 beclomethasone 2372040 −1.21 MAH 2506425 0.88 beclomethasone 2506425 1.38 MAH 2636759 0.81 beclomethasone 2636759 0.93 MAH 3047143 1.10 beclomethasone 3047143 1.08 MAH 4253663 −0.70 beclomethasone 4253663 −0.96 MAH

TABLE 24 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 622565 1.20 MAH 622565 1.20 budesonide 622565 1.17 betamethasone 686993 0.36 MAH 686993 0.51 budesonide 686993 0.51 betamethasone 689296 1.05 budesonide 689296 1.12 betamethasone 1798594 0.69 budesonide 1798594 1.37 betamethasone 2078880 −1.14 MAH 2078880 −0.80 budesonide 2078880 −0.75 betamethasone 2170820 1.17 budesonide 2170820 1.30 betamethasone 2173973 1.04 MAH 2173973 1.08 budesonide 2173973 0.81 betamethasone 2189061 0.15 budesonide 2189061 0.23 betamethasone 2222155 0.58 budesonide 2222155 0.50 betamethasone 2343836 0.93 budesonide 2343836 0.63 betamethasone 2404746 0.49 MAH 2404746 0.42 budesonide 2404746 1.46 betamethasone 2482388 1.19 budesonide 2482388 1.14 betamethasone 2660756 1.13 budesonide 2660756 1.26 betamethasone 2687356 1.26 budesonide 2687356 1.23 betamethasone 3229449 0.39 budesonide 3229449 1.05 betamethasone 4403805 1.12 budesonide 4403805 1.19 betamethasone 380006 −1.05 budesonide 380006 −0.98 dexamethasone 1823946 −1.10 budesonide 1823946 −1.20 dexamethasone 1930847 −1.09 budesonide 1930847 −0.67 dexamethasone 3139631 −0.97 budesonide 3139631 −0.82 dexamethasone 2703282 −1.01 budesonide 2703282 −0.86 dexamethasone 2703282 −0.85 betamethasone 4089291 −1.00 budesonide 4089291 −0.77 dexamethasone 517374 0.40 beclomethasone 517374 1.00 MAH 517374 1.04 budesonide 615776 1.01 beclomethasone 615776 1.06 budesonide 615776 1.11 betamethasone 654246 −0.95 beclomethasone 654246 −1.22 MAH 654246 −1.08 budesonide 1604437 0.47 beclomethasone 1604437 1.18 MAH 1604437 1.18 budesonide 1662870 −0.76 beclomethasone 1662870 −0.93 budesonide 1697719 −0.69 beclomethasone 1697719 −0.86 MAH 1697719 −0.81 budesonide 1876829 −1.00 beclomethasone 1876829 −1.13 budesonide 1876829 −0.94 dexamethasone 2287724 −1.05 beclomethasone 2287724 −1.06 budesonide 2287724 −1.16 dexamethasone 3687607 1.03 beclomethasone 3687607 1.05 MAH 3687607 1.17 budesonide 3973687 1.23 beclomethasone 3973687 1.31 budesonide 3973687 1.47 betamethasone 4215034 1.13 beclomethasone 4215034 1.20 budesonide 4215034 1.50 betamethasone 4855265 1.00 beclomethasone 4855265 1.14 budesonide 4855265 1.24 betamethasone 4863677 1.09 beclomethasone 4863677 1.12 MAH 4863677 1.11 budesonide 1401312 −1.06 MAH 1401312 −1.09 budesonide 1401312 −0.82 prednisone 1611629 0.89 MAH 1611629 1.19 budesonide 1611629 0.94 prednisone 1679595 1.10 budesonide 1679595 0.99 prednisone 1716458 1.09 MAH 1716458 1.24 budesonide 1716458 1.03 prednisone 2227273 1.37 MAH 2227273 1.05 budesonide 2227273 1.01 prednisone 4252872 1.13 MAH 4252872 1.24 budesonide 4252872 0.77 prednisone 4630674 0.87 MAH 4630674 0.97 budesonide 4630674 0.86 prednisone 5102951 0.84 budesonide 5102951 0.85 prednisone 5326983 0.94 budesonide 5326983 0.50 prednisone 1973123 −0.93 MAH 1973123 −1.23 budesonide 2057513 0.92 MAH 2057513 1.13 budesonide 3426776 0.81 MAH 3426776 0.61 budesonide 3449615 0.76 MAH 3449615 1.05 budesonide 3497137 −0.88 MAH 3497137 −0.94 budesonide 3721985 −1.05 MAH 3721985 −1.10 budesonide 3770530 −0.89 MAH 3770530 −0.98 budesonide 3408804 −1.16 progesterone 3408804 −1.49 MAH 3408804 −1.24 budesonide 5038177 0.77 MAH 5038177 0.57 budesonide 5038177 0.74 danazol

TABLE 25 Ave DE [log2] (C3A treated Clone ID with steroid) Steroid 1401312 −1.06 MAH 1401312 −1.09 budesonide 1401312 −0.82 prednisone 1611629 0.89 MAH 1611629 1.19 budesonide 1611629 0.94 prednisone 1679595 1.10 budesonide 1679595 0.99 prednisone 1716458 1.09 MAH 1716458 1.24 budesonide 1716458 1.03 prednisone 2227273 1.37 MAH 2227273 1.05 budesonide 2227273 1.01 prednisone 4252872 1.13 MAH 4252872 1.24 budesonide 4252872 0.77 prednisone 4630674 0.87 MAH 4630674 0.97 budesonide 4630674 0.86 prednisone 5102951 0.84 budesonide 5102951 0.85 prednisone 5326983 0.94 budesonide 5326983 0.50 prednisone 1946155 0.64 MAH 1946155 0.92 prednisone 1946155 0.93 dexamethasone 2088104 −1.15 prednisone 2088104 −1.20 dexamethasone 2252884 −1.03 prednisone 2252884 −1.19 dexamethasone 2253102 −1.13 prednisone 2253102 −1.20 dexamethasone 2269058 −1.06 prednisone 2269058 −1.15 dexamethasone 2285521 −1.09 prednisone 2285521 −1.22 dexamethasone 2698777 −0.99 MAH 2698777 −1.25 prednisone 2698777 −1.48 dexamethasone 1329625 0.35 beclomethasone 1329625 0.42 prednisone 1329625 0.91 betamethasone 1951845 1.01 beclomethasone 1951845 0.79 prednisone 1951845 1.02 betamethasone 2086783 −0.88 beclomethasone 2086783 −1.13 prednisone 2086783 −1.18 dexamethasone 2095329 −0.99 beclomethasone 2095329 −1.21 prednisone 2095329 −1.37 dexamethasone 2287703 −0.99 beclomethasone 2287703 −1.07 prednisone 2287703 −1.24 dexamethasone 2430165 1.04 beclomethasone 2430165 0.23 prednisone 2430165 0.68 betamethasone 3960194 1.00 beclomethasone 3960194 1.17 MAH 3960194 1.01 prednisone 4894508 −0.93 beclomethasone 4894508 −0.99 MAH 4894508 −1.03 prednisone 5091002 −1.13 beclomethasone 5091002 −1.22 prednisone 5091002 −1.42 dexamethasone 1496011 0.51 prednisone 1496011 0.60 betamethasone 2734007 0.88 prednisone 2734007 1.04 betamethasone 5543385 1.00 prednisone 5543385 1.15 betamethasone 998615 0.85 MAH 998615 0.91 prednisone 1740179 1.04 MAH 1740179 0.86 prednisone 2908212 0.46 MAH 2908212 0.42 prednisone 4543123 −1.20 Mifepristone 4543123 1.27 prednisone 2607834 0.29 prednisone 2607834 0.92 danazol

SEQUENCE LISTING The patent contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/sequence.html?DocID=06673549B1). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3). 

What is claimed is:
 1. A combination comprising a plurality of cDNAs wherein the plurality of cDNAs are differentially expressed in response to steroid treatment and consist of the nucleic acid sequences of SEQ ID NOs:1-3, 5, 6, 8, 9, 11-14, 16-18, 20, 21, 23-34, 36, 38-40, 42-50, 52-63, 65, 66, 68-71, 73-75, 77-84, 86-111, 113-115, 117-126, 128-142, 145-160, 162-164, 166, 167, 169-172, 174-176, 178-186, 188-197, 199-202, 204-211, 213, 215, 217-228, 230-246, 248-251, 253-259, 261-266, 268-277, 279, 281, 283, 284, 286, 288-292, 294, 295, 297-300, 302-308, 310, 311, 313, 315-320, 322, 323, 325, 327-346, 348-350, 352-357, 359-368, 370-372, 374, 376, 378, 380-389, 391-400, 402, 403, 405-413, 415, 416, 418, 420, 422-426, 428, 429, 431-446, 448, 450-453, 455, 457, 459, 461, 463-466, 468-470, 472-478, 480-488, 490-492, 494-502, 504-506, 508-520, 522-526, 528-530, 532, 534, 535, 537-561, 563-565, 567, 569-575, 577, 579-581, 583, 585-589, 591-614, 616, 618, 619, 621, 623, 625, 627, 629-641, 643, 645-654, 656-663, 665-680, 682-698, 700-708, 710, 712-720, 722-725, 727-730, 732, 734, 735, 737-741, 743-754, 756, 758-768, 770-780, 782-786, 788-792, 794, 796-802, 804-806, 808, 809, 811-814, 816, 817, 819-829, 831, 833, 835, 836, 838-840, 842-888, 890-892, 894-908, 910, 912, 914-927, 929, 930, 932-937, 939-944, 946, 948-957, 959-964, 966-976, 978-988, 990-999, 1001-1008, 1010-1028, 1030-1034, 1036-1085, 1087-1096, 1098-1143 or a plurality of cDNAs consisting of the complements thereof.
 2. The combination of claim 1, wherein the cDNAs are immobilized on a substrate.
 3. A high throughput method for using a cDNA to detect differential expression of nucleic acids in a sample, the method comprising: a) hybridizing the combination of claim 1 with nucleic acids of the sample, thereby forming one or more hybridization complexes; b) detecting the hybridization complexes; and c) comparing the hybridization complexes with those of a standard, wherein differences between the standard and sample hybridization complexes indicate differential expression of cDNAs in the sample.
 4. The method of claim 3, where in the nucleic acids of the sample are amplified prior to hybridization.
 5. The method of claim 3, wherein the sample is from a subject with Wilson disease and comparison with a standard defines a stage of that disease.
 6. A high throughput method of screening a plurality of molecules or compounds to identify a ligand which specifically binds a cDNA, the method comprising: a) combining the combination of claim 1 with the plurality of molecules or compounds under conditions to allow specific binding; and b) detecting specific binding between each cDNA and at least one molecule or compound, thereby identifying a ligand that specifically binds to each cDNA.
 7. The method of claim 6 wherein the plurality of molecules or compounds are regulatory proteins. 